Maternal imprints and the origins of variation
Open accessAbstract
The non-genomic transmission of maternal behavior from one generation to the next illustrates the pervasive influence of maternal care on offspring development and the high degree of plasticity within the developing maternal brain. Investigations of the mechanisms through which these maternal effects are achieved have demonstrated environmentally-induced changes in gene expression associated with epigenetic modifications within the promoter region of target genes. These findings raise challenging questions regarding the pathways linking experience to behavioral variation and the broader ecological/evolutionary implications of the dynamic changes in neuroendocrine function that emerge. This review will highlight studies in laboratory rodents which demonstrate plasticity in the maternal brain and the role of maternally-induced changes in DNA methylation in establishing the link between variations in maternal care and consequent developmental outcomes. The persistence of maternal effects across generations and the trade-offs in reproduction that are evident in female offspring who experience high vs. low levels of maternal care contribute to our understanding of the divergent strategies that are triggered by the quality of early-life experiences. Evolving concepts of inheritance and the interplay between genes and the environment may advance our understanding of the origins of individual differences in phenotype.
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Exposure to childhood adversity may result in abnormal development of the OT system in the offspring, as well as lead to poorer quality of parenting behavior later in adulthood.
“Although OT plays a role in stimulating the onset and maintenance of maternal behavior, exposure to childhood adversity may result in abnormal development of the OT system in the offspring, as well as lead to poorer quality of parenting behavior later in adulthood (Champagne and Meaney, 2001; Champagne, 2011; Champagne and Meaney, 2007).”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Champagne, 2011
Through epigenetic mechanisms, experiences in early life appear to modify gene and receptor expression in neuroendocrine systems, leading to changes in adult behavior, including drug seeking and addiction.
“Through epigenetic mechanisms, experiences in early life appear to modify gene and receptor expression in neuroendocrine systems, leading to changes in adult behavior, including drug seeking and addiction (Caldji et al., 2011; Champagne, 2011; Meaney et al., 2002; Sng and Meaney, 2009; Weaver et al., 2004).”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Champagne, 2011
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- Authors
- Champagne, F. A.
- Affiliations
- Columbia University (US)
- Corresponding author
- Champagne, Frances A.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 60
- Issue
- 1
- Pages
- 4-11
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3112299
- OpenAlex
- W2153971503
- Cited by
- 74
- References
- 89
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 7
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1dp2od001674-01)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- maternal care, maternal effects, epigenetic inheritance, DNA methylation, gene-environment interaction, early life experience, individual differences, neuroendocrine function, reproductive trade-offs, offspring development
- MeSH terms
- Animals, Brain, Female, Maternal Behavior, Neuronal Plasticity, Genomic Imprinting, DNA Methylation, Mice, Rats
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