The DOI matches its Crossref record; 54 of the 56 references it cites were found in a registry or an index.
EFNS guidelines on the diagnosis and management of orthostatic hypotension
Open accessAbstract
Orthostatic (postural) hypotension (OH) is a common, yet under diagnosed disorder. It may contribute to disability and even death. It can be the initial sign, and lead to incapacitating symptoms in primary and secondary autonomic disorders. These range from visual disturbances and dizziness to loss of consciousness (syncope) after postural change. Evidence based guidelines for the diagnostic workup and the therapeutic management (non‐pharmacological and pharmacological) are provided based on the EFNS guidance regulations. The final literature research was performed in March 2005. For diagnosis of OH, a structured history taking and measurement of blood pressure (BP) and heart rate in supine and upright position are necessary. OH is defined as fall in systolic BP below 20 mmHg and diastolic BP below 10 mmHg of baseline within 3 min in upright position. Passive head‐up tilt testing is recommended if the active standing test is negative, especially if the history is suggestive of OH, or in patients with motor impairment. The management initially consists of education, advice and training on various factors that influence blood pressure. Increased water and salt ingestion effectively improves OH. Physical measures include leg crossing, squatting, elastic abdominal binders and stockings, and careful exercise. Fludrocortisone is a valuable starter drug. Second line drugs include sympathomimetics, such as midodrine, ephedrine, or dihydroxyphenylserine. Supine hypertension has to be considered.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Funnekotter, B. (2005) · Amsterdam University Press eBooks · doi:10.1017/9789048505418.012 · Cited by 1,672
The Consensus Committee of the American Autonomic Society and the American Academy of Neurology (1996) · Neurology · doi:10.1212/wnl.46.5.1470 · Cited by 1,247
Guidelines on management (diagnosis and treatment) of syncope
Brignole, M. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2739 · Cited by 951
Low, P. A. (1997) · JAMA · doi:10.1001/jama.1997.03540370036033 · Cited by 425
Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine
Jankovic, J., Gilden, J. L., Hiner, B. C., Kaufmann, H., Brown, D. C., Coghlan, C. H., Rubin, M., & Fouad-Tarazi, F. M. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90230-m · Cited by 396
Brainin, M., Barnes, M., Baron, J., Ne, G., Hughes, R. A., Selmaj, K. W., & Waldemar, G. (2004) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00867.x · Cited by 373
A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension
Wright, R. A., Kaufmann, H. C., Perera, R., Opfer-Gehrking, T. L., McElligott, M. A., Sheng, K. N., & Low, P. A. (1998) · Neurology · doi:10.1212/wnl.51.1.120 · Cited by 331
Leone, M. A., Brainin, M., Boon, P., Pugliatti, M., Keindl, M., & Bassetti, C. L. (2013) · European Journal of Neurology · doi:10.1111/ene.12043 · Cited by 277
Treatment of Orthostatic Hypotension with Erythropoietin
Hoeldtke, R. D., & Streeten, D. H. P. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308263290904 · Cited by 226
Investigation of autonomic disorders
Mathias, C. J., Low, D. A., Iodice, V., & Bannister, R. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780198566342.003.0024 · Cited by 208
Self-citation
Cited by
Sorted by citations
Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association
Muntner, P., Shimbo, D., Carey, R. M., Charleston, J. B., Gaillard, T., Misra, S., Myers, M. G., Ogedegbe, G., Schwartz, J. E., Townsend, R. R., et al. (2019) · Hypertension · doi:10.1161/hyp.0000000000000087 · Cited by 1,512
The clinical symptoms of Parkinson's disease.
Sveinbjornsdottir, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13691 · Cited by 1,410
“This is defined as a fall in systolic blood pressure of > 20 mm Hg or in diastolic blood pressure > 10 mm Hg on either standing or head-up tilt to at least 60 degrees within 3 min (Lahrmann et al. 2006).”
BackgroundSpallone, V., Ziegler, D., Freeman, R., Bernardi, L., Frontoni, S., Pop‐Busui, R., Stevens, M., Kempler, P., Hilsted, J., Tesfaye, S., et al. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1239 · Cited by 957
“Other possible treatments include (1) desmopressin acetate, a vasopressin analogue useful to correct nocturnal polyuria and morning orthostatic hypotension; (2) somatostatin analogues aimed at inhibiting the release of vasoactive gastrointestinal peptides, enhancing cardiac output, and increasing forearm and splanchni…”
BackgroundAutonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies
Dani, M., Dirksen, A., Taraborrelli, P., Torocastro, M., Panagopoulos, D., Sutton, R., & Lim, P. B. (2020) · Clinical Medicine · doi:10.7861/clinmed.2020-0896 · Cited by 769
Seppi, K., Weintraub, D., Coelho, M., Perez‐Lloret, S., Fox, S. H., Katzenschlager, R., Hametner, E., Poewe, W., Rascol, O., Goetz, C. G., et al. (2011) · Movement Disorders · doi:10.1002/mds.23884 · Cited by 1,141
“5 L/day] and salt intake [>8 g or 150 mmol/day], and wearing support stockings) before initiating adjunct treatment with antihypotensive agents.(68)”
Method
Metadata
- Authors
- Lahrmann, H., Cortelli, P., Hilz, M., Mathias, C. J., Struhal, W., & Tassinari, M.
- Affiliations
- Kaiser-Franz-Josef-Spital (AT)
- University of Bologna (IT)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- St Mary's Hospital (GB)
- Corresponding author
- Lahrmann, H.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2006-08-23
- Volume
- 13
- Issue
- 9
- Pages
- 930-936
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W1983067632
- Cited by
- 334
- References
- 56
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 13 · 2023: 19 · 2022: 22 · 2021: 19 · 2020: 13 · 2019: 26 · 2018: 18 · 2017: 23 · 2016: 23 · 2015: 11 · 2014: 23 · 2013: 19 · 2012: 21
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Keywords
- orthostatic hypotension, autonomic dysfunction, syncope, head-up tilt, blood pressure measurement, fludrocortisone, midodrine, sympathomimetic drugs, non-pharmacological treatment, supine hypertension
- MeSH terms
- Diagnosis, Differential, Humans, Hypotension, Orthostatic, Practice Guidelines as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
