Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern?
Abstract
BACKGROUND AND PURPOSE: Optic nerve involvement is frequent in mitochondrial disease, and retinal abnormalities are described in Parkinson's disease (PD). METHODS: We evaluated retinal nerve fiber layer (RNFL) thickness by optical coherence tomography in 43 patients with PD and in 86 age-matched controls. We considered separately the eyes ipsilateral and contralateral to the most affected body side in patients with PD. ancova analysis, Pearson test, and multiple regression analysis were used (P < 0.05). RESULTS: Patients with PD showed significantly thinner temporal RNFL thickness compared to controls (P = 0.004), more evident in the eye contralateral to the most affected body side. Average RNFL thickness significantly correlated with age in both controls and patients with PD (P-values ranging from 0.001 to 0.019), whereas in patients with PD RNFL thickness did not correlate with clinical variables. CONCLUSIONS: Our study reveals a loss of retinal nerve fibers in the temporal quadrant in PD, which is typically susceptible in mitochondrial optic neuropathies.
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Abnormalities in visual function are reported in PD patients and correlated with changes in retinal tissue.
“Moreover, abnormalities in visual function have been reported (Bodis-Wollner, 1990; Nowacka et al., 2014) in PD patients and correlated with changes in retinal tissue (La Morgia et al., 2013; Yu et al., 2014) (Table 1).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as La Morgia et al., 2013
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Eye as an object of investigation of cognitive impairment in Parkinson's disease
Litvinenko, I., Dynin, P. S., Trufanov, A. G., Gimadutdinov, R. F., & Maltsev, D. S. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2018118062105 · Cited by 9 · see citing works
Reduction of Retinal Thickness Ipsilateral to Hippocampal Sclerosis in Epilepsy
Xiong, W., Lu, L., Chen, Q., Xiao, Y., An, D., Sander, J. W. A. S., Zhang, M., & Zhou, D. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.663559 · Cited by 8 · see citing works
The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up
Salobrar‐García, E., Ramirez, A. I., de Hoz, R., Rojas, P., Salazar, J. J., Rojas, B., Yubero, R., Gil, P., Triviño, A., & Ramirez, J. M. (2016) · InTech eBooks · doi:10.5772/64490 · Cited by 8 · see citing works
Yang, T., Xie, L.-Q., Zhang, Y., Liu, S.-M., Zeng, X., Luo, W., & Xu, G. (2023) · International Journal of Ophthalmology · doi:10.18240/ijo.2023.05.14 · Cited by 7 · see citing works
Wilson, D., Hallett, M., & Anderson, T. (2021) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13317 · Cited by 7 · see citing works
Donato, L., Scimone, C., Alibrandi, S., Vadalà, M., Castellucci, M., Bonfiglio, V. M. E., Scalinci, S. Z., Abate, G., D’Angelo, R., & Sidoti, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34756 · Cited by 6 · see citing works
Ocular and inflammatory markers associated with Gulf War illness symptoms
Kalahasty, K., Lee, Y., Locatelli, E. V. T., Djulbegovic, M. B., Cabrera, K., Pakravan, P., Goodman, C. S., Jensen, A., Aenlle, K. K., Klimas, N. G., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-30544-9 · Cited by 5 · see citing works
Neuro-ophthalmology of movement disorders
Waln, O., & Jankovic, J. J. (2018) · Expert Review of Ophthalmology · doi:10.1080/17469899.2018.1513328 · Cited by 5 · see citing works
Optical coherence tomography findings in chronic progressive external ophthalmoplegia
Wu, Y. F., Kang, L., Wu, H., Hou, Y., & Wang, Z.-X. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000262 · Cited by 4 · see citing works
Suciu, V.-I., Suciu, C.-I., Nicoară, S., & Perju‐Dumbravă, L. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12010080 · Cited by 4 · see citing works
Animal Models and Experimental Research in Medicine
Karapehlivan, M., Gelen, V., & Kükürt, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100993 · Cited by 4 · see citing works
Stroe, A. Z., Jurja, S., Stuparu, A. F., & Axelerad, A. D. (2023) · Neurology International · doi:10.3390/neurolint15010012 · Cited by 4 · see citing works
Svetel, M., Maric, G. D., Bozic, M. M., Lazić, U., Milovanović, A., Jakšić, J., Petrović, I. N., Dimitrijević, A., Knežević, M., & Pekmezovic, T. D. (2025) · Biomedicines · doi:10.3390/biomedicines13051227 · Cited by 3 · see citing works
Optic Disc and Retinal Architecture Changes in Patients with Spinocerebellar Ataxia Type 2
Filho, F. M. R., Jurkutė, N., de Andrade, J. B. C., Marianelli, B. F., de Lima, F. D., França, M. C., Sallum, J. M. F., Yu‐Wai‐Man, P., Barsottini, O. G. P., & Pedroso, J. L. (2023) · Movement Disorders · doi:10.1002/mds.29675 · Cited by 3 · see citing works
Karatzetzou, S., Parissis, D., Ioannidis, S., Afrantou, T., & Ioannidis, P. (2024) · Applied Sciences · doi:10.3390/app14062491 · Cited by 3 · see citing works
Metabolic Deficits in the Retina of a Familial Dysautonomia Mouse Model
Costello, S. M., Schultz, A., Smith, D. E., Horan, D., Chaverra, M., Tripet, B., George, L., Bothner, B. B., Lefcort, F. B., & Copié, V. (2024) · Metabolites · doi:10.3390/metabo14080423 · Cited by 3 · see citing works
Miri, S., Glazman, S., & Bodis-Wollner, I. G. (2016) · Springer eBooks · doi:10.1007/978-3-319-24085-5_6 · Cited by 3 · see citing works
Clinical Updates and Recent Developments in Neuro-Ophthalmology
Vuppala, A.-A. D., & Miller, N. R. (2019) · Springer eBooks · doi:10.1007/978-3-030-25389-9_8 · Cited by 3 · see citing works
The search for Parkinson disease biomarkers
Adams, J., & Morgia, C. L. (2018) · Neurology · doi:10.1212/wnl.0000000000006148 · Cited by 3 · see citing works
OCT in Parkinson’s Disease and Related Disorders
Bodis-Wollner, I. G., Miri, S., Glazman, S., Shrier, E. M., & Deeb, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-26269-3_12 · Cited by 2 · see citing works
Dopaminergic Basis of Spatial Deficits in Early Parkinson’s Disease
Hanna‐Pladdy, B., Pahwa, R., & Lyons, K. E. (2021) · Cerebral Cortex Communications · doi:10.1093/texcom/tgab042 · Cited by 2 · see citing works
Neuro-Ophthalmologic Evaluation as a Biomarker for Diagnosis and Progression in Parkinson Disease
Satué, M., Polo, V., Otin, S., Larrosa, J. M., Obís, J., & García‐Martín, E. (2016) · InTech eBooks · doi:10.5772/62877 · Cited by 2 · see citing works
Retinal Imaging Techniques for Neurodegenerative Diseases: Parkinson's Disease and Beyond
Tang, C., Zhang, X., Miao, H., Wang, X., & Liu, J. (2025) · MedComm – Future Medicine · doi:10.1002/mef2.70034 · Cited by 1 · see citing works
Polekhina, N. V., Сурнина, З. В., & Zakharova, M. N. (2018) · Annals of Clinical and Experimental Neurology · doi:10.25692/acen.2018.3.9 · Cited by 1 · see citing works
Neurodegenerative changes of retina in Parkinson disease
Fedotova, E. Y., Полькина, Н. В., Mikhailova, E. N., & Illarioshkin, S. N. (2022) · Russian neurological Journal · doi:10.30629/2658-7947-2021-26-6-29-34 · Cited by 1 · see citing works
Manchanda, R., Samanta, R., Narayan, M. L., Kumar, M., Tiwari, A., Agarwal, A., Bahurupi, Y. A., Kumari, S., & Kumar, N. (2024) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_31_24 · Cited by 1 · see citing works
Reply to a Letter by Dr. Stefani and Colleagues on: “Auditory Dysfunction in Parkinson's Disease”
Jafari, Z., Kolb, B. E., & Mohajerani, M. H. (2020) · Movement Disorders · doi:10.1002/mds.28133 · Cited by 1 · see citing works
Animal Models in Neuro Ophthalmology
Normando, E. M., Brodie, J. T., & Cordeiro, M. F. (2016) · Springer eBooks · doi:10.1007/978-3-319-24085-5_13
Parkinson Hastalığı Olan Bir Olguda Optik Atrofi
Dadacı, Z., Doğanay, F., Acır, N. Ö., & Kadıyoran, C. (2019) · Selçuk Tıp Dergisi · doi:10.30733/std.2019.01058
- Authors
- La Morgia, C., Barboni, P., Rizzo, G., Carbonelli, M., Savini, G., Scaglione, C., Capellari, S., Bonazza, S., Giannoccaro, M. P., Calandra‐Buonaura, G., Liguori, R., Cortelli, P., Martinelli, P., Baruzzi, A., & Carelli, V.
- Affiliations
- University of Bologna (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Fondazione G.B. Bietti (IT)
- ORCID
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2012-03-21
- Volume
- 20
- Issue
- 1
- Pages
- 198-201
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2152613502
- Cited by
- 110
- References
- 18
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- Parkinson's disease, retinal nerve fiber layer thickness, temporal quadrant, mitochondrial optic neuropathy, mitochondrial disease, optic nerve involvement, retinal abnormalities, fellow eye
- MeSH terms
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Mutation, Nerve Fibers, Optic Nerve, Optic Nerve Diseases, Parkinson Disease, Retina, Case-Control Studies, Protein Serine-Threonine Kinases, Tomography, Optical Coherence
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