The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
A review of ageing and an examination of clinical methods in the assessment of ageing skin. Part I: Cellular and molecular perspectives of skin ageing
Open accessAbstract
The ageing process is noticeable within all organs of the body and manifests itself visibly in the skin. Skin ageing is influenced by several factors including genetics, environmental exposure, hormonal changes and metabolic processes. Together these factors lead to cumulative alterations of skin structure, function and appearance. The functioning of the central nervous, immune, endocrine and cardiovascular systems, as well as the skin is also impaired with age. Chronologically, aged skin is thin, relatively flattened, dry and unblemished, with some loss of elasticity and age-related loss of architectural regularity. General atrophy of the extracellular matrix is reflected by a decrease in the number of fibroblasts. Reduced levels of collagen and elastin, with impaired organization are primarily because of decreased protein synthesis affecting types I and III collagen in the dermis, with an increased breakdown of extracellular matrix proteins. Oxidative stress is considered of primary importance in driving the ageing process. The original free radical theory of ageing purported that the molecular basis of ageing was derived from a lifetime accumulation of oxidative damage to cells resulting from excess reactive oxygen species (ROS) produced as a consequence of aerobic metabolism. Although the skin possesses extremely efficient anti-oxidant activities, during ageing, ROS levels rise and anti-oxidant activities decline. The ROS are necessary in multiple MAP kinase pathways and the induction of AP-1, in turn, up-regulates expression of matrix-metalloproteinases providing a plausible mechanism for the increased collagen degradation in aged human skin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Oxygen-free radicals are ubiquitous in the process of cell metabolism and can interact with DNA, proteins, and polyunsaturated fatty acids in the body, causing breaks in the DNA chain and oxidative damage, protein–protein cross-linking, protein–DNA cross-linking, and lipid metabolism oxidation, etc.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [105]
In the citing paper
“According to free radical theory, lipid peroxidation, DNA damage, and inflammation are the primary causes of skin aging, disease, and dysfunction.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [105]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Cellular response to oxidative stress: Signaling for suicide and survival*
Martindale, J. L., & Holbrook, N. J. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,314
Mitochondrial Oxidative Stress: Implications for Cell Death
Orrenius, S., Gogvadze, V. G., & Zhivotovsky, B. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105122 · Cited by 1,294
Lamin A-dependent nuclear defects in human aging
Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,125
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
UV-light-induced signal cascades and skin aging
Rittié, L. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00024-7 · Cited by 1,001
The common biology of cancer and ageing
Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988
The Free Radical Theory of Aging
Harman, D. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310202 · Cited by 935
Regulation of matrix metalloproteinase gene expression
Yan, C., & Boyd, D. D. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20948 · Cited by 750
Free Radical Theory of Aging: An Update: Increasing the Functional Life Span
HARMAN, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.003 · Cited by 601
Cited by
Sorted by citations
Molecular aspects of skin ageing
Naylor, E. C., Watson, R. E. B., & Sherratt, M. J. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.04.011 · Cited by 567
Polyphenols as active ingredients for cosmetic products
Zillich, O. V., Schweiggert‐Weisz, U., Eisner, P., & Kerscher, M. (2015) · International Journal of Cosmetic Science · doi:10.1111/ics.12218 · Cited by 343
Phillip, J. M., Aifuwa, I., Walston, J. D., & Wirtz, D. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071114-040829 · Cited by 304
White adipose tissue dysfunction in obesity and aging
Reyes-Farias, M., Fos-Domenech, J., Serra, D., Herrero, L., & Sánchez-Infantes, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114723 · Cited by 250
Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231
Metadata
- Authors
- Callaghan, T. M., & Wilhelm, K. ‐.
- Affiliations
- Proderm (Germany) (DE)
- Corresponding author
- Wilhelm, K.‐P.
- ORCID
- Wilhelm, K.‐P.
- Venue
- International Journal of Cosmetic Science
- Publisher
- Wiley
- Published
- 2008-09-08
- Volume
- 30
- Issue
- 5
- Pages
- 313-322
- ISSN
- 0142-5463 (ISSN-L)
- 1468-2494
- OpenAlex
- W1988332584
- Cited by
- 149
- References
- 115
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 14 · 2015: 19 · 2014: 8 · 2013: 10 · 2012: 9
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cosmetic Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- skin aging, extracellular matrix, collagen degradation, elastin, fibroblasts, oxidative stress, reactive oxygen species, free radical theory of aging, antioxidant activity, matrix metalloproteinases, MAPK signaling, AP-1, dermis, skin atrophy
- MeSH terms
- Aging, Humans, Skin, Skin Physiological Phenomena, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
