The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Regional Grey Matter Changes in Patients With Migraine: A Voxel-Based Morphometry Study
Abstract
We used voxel-based morphometry (VBM) to compare grey matter volume (GMV) between 20 migraine patients (five with aura and 15 without aura) with normal conventional magnetic resonance imaging findings and 33 healthy controls matched for age and sex. A separate analysis was also performed to delineate a possible correlation between the GMV changes and the headache duration or lifetime headache frequency. When compared with controls, migraine patients had significant GMV reductions in the bilateral insula, motor/premotor, prefrontal, cingulate cortex, right posterior parietal cortex, and orbitofrontal cortex ( P < 0.001, uncorrected for multiple comparisons at a voxel level; corrected P < 0.05 after small volume corrections). All regions of the GMV changes were negatively correlated with headache duration and lifetime headache frequency ( P < 0.05, Pearson's correlation test). We found evidence for structural grey matter changes in patients with migraine. Our findings of progressive GMV reductions in relation to increasing headache duration and increasing headache frequency suggest that repeated migraine attacks over time result in selective damage to several brain regions involved in central pain processing.
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Citations
Cites
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
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Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
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Schmidt-Wilcke, T., Leinisch, E., Gänbauer, S., Draganski, B., Bogdahn, U., Altmeppen, J., & May, A. (2006) · Pain · doi:10.1016/j.pain.2006.05.004 · Cited by 413
Cited by
Pain and the brain: specificity and plasticity of the brain in clinical chronic pain
Apkarian, V. A., Hashmi, J. A., & Baliki, M. N. (2011) · Pain · doi:10.1016/j.pain.2010.11.010 · Cited by 782
Brain gray matter decrease in chronic pain is the consequence and not the cause of pain
Rodriguez-Raecke, R., Niemeier, A., Ihle, K., Ruether, W., & May, A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3687-09.2009 · Cited by 527
The dorsolateral prefrontal cortex in acute and chronic pain
Seminowicz, D. A., & Moayedi, M. (2017) · The Journal of Pain · doi:10.1016/j.jpain.2017.03.008 · Cited by 502
Gardner, A., & Boles, R. G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.030 · Cited by 333
Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain
Seminowicz, D. A., Shpaner, M., Keaser, M. L., Krauthamer, G. M., Mantegna, J., Dumas, J. A., Newhouse, P. A., Filippi, C. G., Keefe, F. J., & Naylor, M. R. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.07.020 · Cited by 305
“Some studies reported a correlation between reduced gray matter ([GM] which could include changes in GM volume [GMV] or GM density [GMD]) in these regions and the duration or intensity of symptoms.(1,37,39,64,65) The degree to which these structural abnormalities are reversible with surgical treatment was the subject…”
BackgroundGray matter volume reduction reflects chronic pain in trigeminal neuralgia
Obermann, M., Rodriguez-Raecke, R., Naegel, S., Holle, D., Mueller, D., Yoon, M.-S., Theysohn, N., Blex, S., Diener, H.-C., & Katsarava, Z. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.029 · Cited by 235
Hubbard, C. S., Khan, S. A., Keaser, M. L., Mathur, V. A., Goyal, M., & Seminowicz, D. A. (2014) · eneuro · doi:10.1523/eneuro.0006-14.2014 · Cited by 184
Gray matter changes related to chronic posttraumatic headache
Obermann, M., Nebel, K., Schumann, C., Holle, D., Gizewski, E. R., Maschke, M., Goadsby, P. J., Diener, H. C., & Katsarava, Z. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b8791a · Cited by 177
Structural brain correlates of human sleep oscillations
Saletin, J. M., van der Helm, E., & Walker, M. P. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.06.021 · Cited by 93
Structural basis of empathy and the domain general region in the anterior insular cortex
Mutschler, I., Reinbold, C., Wankerl, J., Seifritz, E., & Ball, T. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00177 · Cited by 92
Yoon, M.-S., Manack, A., Schramm, S., Fritsche, G., Obermann, M., Diener, H.-C., Moebus, S., & Katsarava, Z. (2013) · Pain · doi:10.1016/j.pain.2012.12.010 · Cited by 76
Neuroimaging Mechanism of Cognitive Behavioral Therapy in Pain Management
Bao, S., Qiao, M., Lu, Y., & Jiang, Y. (2022) · Pain Research and Management · doi:10.1155/2022/6266619 · Cited by 51
Metadata
- Authors
- Kim, J., Suh, S.-I., Seol, H., Oh, K., Seo, W.-K., Yu, S.-W., Park, K.-W., & Koh, S.-B.
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2008-06
- Volume
- 28
- Issue
- 6
- Pages
- 598-604
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W2137390397
- Cited by
- 324
- References
- 4
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- closed
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