Structural brain correlates of human sleep oscillations
Open accessAbstract
Sleep is strongly conserved within species, yet marked and perplexing inter-individual differences in sleep physiology are observed. Combining EEG sleep recordings and high-resolution structural brain imaging, here we demonstrate that the morphology of the human brain offers one explanatory factor of such inter-individual variability. Gray matter volume in interoceptive and exteroceptive cortices correlated with the expression of slower NREM sleep spindle frequencies, supporting their proposed role in sleep protection against conscious perception. Conversely, and consistent with an involvement in declarative memory processing, gray matter volume in bilateral hippocampus was associated with faster NREM sleep spindle frequencies. In contrast to spindles, gray matter volume in the homeostatic sleep-regulating center of the basal forebrain/hypothalamus, together with the medial prefrontal cortex, accounted for individual differences in NREM slow wave oscillations. Together, such findings indicate that the qualitative and quantitative expression of human sleep physiology is significantly related to anatomically specific differences in macroscopic brain structure.
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Slow-wave sleep decreases about 60% across adolescence, possibly reflecting synaptic pruning and resulting efficiency of network connectivity.
“Slow-wave sleep (SWS) decreases ~60% across adolescence (49), possibly reflecting synaptic pruning and resulting efficiency of network connectivity (50,51).”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [51]
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Old brains come uncoupled in sleep: slow wave-spindle synchrony, brain atrophy, and forgetting
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NREM sleep spindles are associated with dream recall
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- Authors
- Saletin, J. M., van der Helm, E., & Walker, M. P.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Walker, Matthew P.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 83
- Pages
- 658-668
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC4263481
- OpenAlex
- W2082883998
- Cited by
- 93
- References
- 123
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 14 · 2018: 1 · 2017: 10 · 2016: 5 · 2015: 5 · 2014: 7
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (RO1AG031164)
- National Institute of Mental Health (R01MH093537)
- National Science Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep oscillations, gray matter volume, slow oscillations, hippocampus, medial prefrontal cortex, hypothalamus, sleep homeostasis, declarative memory, conscious perception
- MeSH terms
- Adult, Brain, Brain Mapping, Electroencephalography, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Signal Processing, Computer-Assisted, Sleep, Polysomnography, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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