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Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring
Open accessAbstract
Background: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring. Methods: In a prospective cohort study, maternal red blood cell folate (RCF) was measured at 14 weeks of pregnancy and total folate intake (TFI) from food and supplements was assessed in early and late pregnancy. The offspring’s head circumference and body weight were measured at birth and in infancy, and 100 mothers reported on children’s behavioural difficulties at a mean age of 8.75 years using the Strengths and Difficulties Questionnaire. Results: Lower maternal RCF and TFI in early pregnancy were associated with higher childhood hyperactivity (RCF: beta = −.24; p = .013; TFI: beta = −.24; p = .022) and peer problems scores (RCF: beta = −.28; p = .004; TFI: beta = −.28; p = .009) in the offspring. Maternal gestational RCF was positively associated with head circumference at birth (adjusted for gestational age), and mediation analyses showed significant inverse indirect associations of RCF with hyperactivity/inattention and peer problems via fetal brain growth. Adjustment for mother’s smoking and drinking alcohol during pregnancy did not change the results. Conclusions: Although the associations are small and residual confounding is possible, our data provide preliminary support for the hypothesis that lower folate status in early pregnancy might impair fetal brain development and affect hyperactivity/inattention and peer problems in childhood.
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“There is wide evidence that pre and periconceptional folate supplementation supports neural and neurobehavioral development, bolstering social, cognitive and verbal functioning [235–237].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [236]
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Cites
The Strengths and Difficulties Questionnaire: A research note
Goodman, R. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01545.x · Cited by 14,908
Psychometric properties of the strengths and difficulties questionnaire
GOODMAN, R. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200111000-00015 · Cited by 6,813
Regression Models for Categorical and Limited Dependent Variables
Calvin, J. A., & Long, J. S. (1998) · Technometrics · doi:10.2307/1271407 · Cited by 5,290
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082
Rice, D., & Barone, S. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3511 · Cited by 2,944
Castellanos, F. X. (2002) · JAMA · doi:10.1001/jama.288.14.1740 · Cited by 1,646
Goodman, R., & Scott, S. (1999) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022658222914 · Cited by 1,420
McCann, D., Barrett, A., Cooper, A. J., Crumpler, D., Dalen, L., Grimshaw, K. E. C., Kitchin, E. M., Lok, K. Y. W., Porteous, L., Prince, E., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61306-3 · Cited by 1,159
Hibbeln, J. R., Davis, J. M., Steer, C., Emmett, P., Rogers, I., Williams, C., & Golding, J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60277-3 · Cited by 987
Developmental psychopathology: Concepts and challenges
Rutter, M. L., & Sroufe, L. A. (2000) · Development and Psychopathology · doi:10.1017/s0954579400003023 · Cited by 985
Nutrition and the developing brain: nutrient priorities and measurement
Georgieff, M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.614s · Cited by 885
The developmental origins of chronic adult disease
Barker, D. (2004) · Acta Paediatrica · doi:10.1111/j.1651-2227.2004.tb00236.x · Cited by 790 · cited 2×
“alterations and influence risk for disease later in life (Barker, 2004).”
Linnet, K. M., Dalsgaard, S., Obel, C., Wisborg, K., Henriksen, T. B., Rodriguez, A., Kotimaa, A., Moilanen, I., Thomsen, P. H., Olsen, J., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1028 · Cited by 778
Peer Functioning in Children With ADHD
Hoza, B. (2007) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsm024 · Cited by 654
Folic acid: influence on the outcome of pregnancy
Scholl, T. O., & Johnson, W. G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1295s · Cited by 617
Folate and neural tube defects
Pitkin, R. M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.285s · Cited by 443
Neugebauer, R. (1999) · JAMA · doi:10.1001/jama.282.5.455 · Cited by 430
Fetal origins of mental health: Evidence and mechanisms
Schlotz, W., & Phillips, D. I. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.02.001 · Cited by 420
Self-citationTamura, T., & Picciano, M. F. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.5.993 · Cited by 379
Bartholomeusz, H. H., Courchesne, E., & Karns, C. M. (2002) · Neuropediatrics · doi:10.1055/s-2002-36735 · Cited by 340
Brookes, K. J., Mill, J. S., Guindalini, C., Curran, S. R., Xu, X., Knight, J., Chen, C., Huang, Y., Sethna, V., Taylor, E. A., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.74 · Cited by 320
Kahn, R. S., Khoury, J. C., Nichols, W. C., & Lanphear, B. P. (2003) · The Journal of Pediatrics · doi:10.1016/s0022-3476(03)00208-7 · Cited by 290
Maternal DHA and the Development of Attention in Infancy and Toddlerhood
Colombo, J. A., Kannass, K. N., Shaddy, D. J., Kundurthi, S., Maikranz, J. M., Anderson, C. J., Blaga, O. M., & Carlson, S. E. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00737.x · Cited by 285
Dietary patterns in infancy: the importance of maternal and family influences on feeding practice
Robinson, S. M., Marriott, L. D., Poole, J., Crozier, S., Borland, S. E., Lawrence, W. T., Law, C., Godfrey, K. M., Cooper, C. C., Inskip, H. M., et al. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507750936 · Cited by 251
Self-citationBrown, A. S., Susser, E., Lin, S. P., Neugebauer, R., & Gorman, J. M. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.166.5.601 · Cited by 246
Godfrey, K. M., Walker-Bone, K. E., Robinson, S. M., Taylor, P., Shore, S., Wheeler, T., & Cooper, C. C. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1694 · Cited by 234
Self-citationReview article: Epigenetic control of fetal gene expression
Nafee, T. M., Farrell, W., Carroll, W. D., Fryer, A. A., & Ismail, K. (2007) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2007.01528.x · Cited by 224
Mill, J. S., & Petronis, A. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01909.x · Cited by 217
Fetal Growth and the Adrenocortical Response to Psychological Stress
Jones, A., Godfrey, K. M., Wood, P., Osmond, C., Goulden, P., & Phillips, D. I. W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2077 · Cited by 178
Self-citationCraciunescu, C. N., Brown, E. C., Mar, M.-H. H., Albright, C. D., Nadeau, M., & Zeisel, S. H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.162 · Cited by 177
Impact of educational attainment on the quality of young women's diets
Robinson, S. M., Crozier, S., Borland, S. E., Hammond, J., Barker, D. J. P., & Inskip, H. M. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601946 · Cited by 174
Self-citationIn utero physiology: role of folic acid in nutrient delivery and fetal development
Antony, A. C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.598s · Cited by 169
‘Junk food’ diet and childhood behavioural problems: results from the ALSPAC cohort
Wiles, N., Northstone, K., Emmett, P. M., & Lewis, G. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602967 · Cited by 146
Why does birthweight vary among ethnic groups in the UK? Findings from the Millennium Cohort Study
Kelly, Y. J., Panico, L., Bartley, M., Marmot, M. G., Nazroo, J. Y., & Sacker, A. (2008) · Journal of Public Health · doi:10.1093/pubmed/fdn057 · Cited by 137
Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid
Heseker, H., Mason, J. B., Selhub, J., Rosenberg, I. H., & Jacques, P. F. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508149200 · Cited by 131
Evaluation of a food frequency questionnaire used to assess nutrient intakes in pregnant women.
Robinson, S. M., Godfrey, K. M., Osmond, C., Cox, V., & Barker, D. J. P. (1996) · PubMed · Cited by 129
Self-citationSmall body size at birth and behavioural symptoms of ADHD in children aged five to six years
Lahti, J. M. T., Räikkönen, K., Kajantie, E., Heinonen, K., Pesonen, A., Järvenpää, A., & Strandberg, T. E. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01661.x · Cited by 125
McNaughton, S. A., Mishra, G. D., Stephen, A. M., & Wadsworth, M. E. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.99 · Cited by 124
Zhou, S. J., Gibson, R. A., Crowther, C. A., Baghurst, P., & Makrides, M. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.5.1112 · Cited by 118
Galé, C. R., Robinson, S. M., Godfrey, K. M., Law, C., Schlotz, W., & O'Callaghan, F. J. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01908.x · Cited by 114
Self-citationPredictors of Red Cell Folate Level in Women Attempting Pregnancy
Brown, J. E. (1997) · JAMA · doi:10.1001/jama.1997.03540310046033 · Cited by 71
Lavı́n, A., Moore, H. M., & Grace, A. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300696 · Cited by 62
Xiao, S., Hansen, D. K., Horsley, E. T. M., Tang, Y.-S., Khan, R. A., Stabler, S. P., Jayaram, H. N., & Antony, A. O. C. (2005) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20105 · Cited by 59
Parsons, A. G., Zhou, S. J., Spurrier, N. J., & Makrides, M. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507853359 · Cited by 55
Helping Children Adjust—a Tri-Ministry Study: II. Program Effects
Hundert, J., Boyle, M. H., Cunningham, C. E., Duku, E., Heale, J., McDonald, J., Offord, D. R., & Racine, Y. A. (1999) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00524 · Cited by 55
Behavioral effects of prenatal folate deficiency in mice
Ferguson, S. A., Berry, K. J., Hansen, D. K., Wall, K. S., White, G. A., & Antony, A. C. (2005) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20111 · Cited by 55
Maternal Global Methylation Status and Risk of Congenital Heart Diseases
van Driel, L. M. J. W., de Jonge, R., Helbing, W. A., van Zelst, B. D., Ottenkamp, J. J., Steegers, E. A. P., & Steegers‐Theunissen, R. P. M. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31817dd058 · Cited by 50
Schlotz, W., Jones, A., Godfrey, K. M., & Phillips, D. I. W. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01946.x · Cited by 40
Self-citationNeurochemical and behavioral effects of diet related perinatal folic acid restriction
Middaugh, L. D., Grover, T. A., Blackwell, L. A., & Zemp, J. W. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90027-7 · Cited by 20
Predictors of red cell folate level in women attempting pregnancy
Brown, J. E. (1997) · JAMA · doi:10.1001/jama.277.7.548 · Cited by 17
Trends in Folic Acid Supplement Intake Among Women of Reproductive Age--California, 2002-2006
(2007) · PsycEXTRA Dataset · doi:10.1037/e715752007-003 · Cited by 11
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De‐Regil, L. M., Peña‐Rosas, J. P., Fernández‐Gaxiola, A. C., & Rayco‐Solon, P. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007950.pub3 · Cited by 841
The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509
Maternal lifestyle and environmental risk factors for autism spectrum disorders
Lyall, K., Schmidt, R. J., & Hertz-Picciotto, I. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt282 · Cited by 427
Schmidt, R. J., Tancredi, D. J., Ozonoff, S., Hansen, R. L., Hartiala, J., Allayee, H., Schmidt, L. C., Tassone, F., & Hertz-Picciotto, I. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.004416 · Cited by 408
Fetal origins of mental health: Evidence and mechanisms
Schlotz, W., & Phillips, D. I. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.02.001 · Cited by 420
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Metadata
- Authors
- Schlotz, W., Jones, A., Phillips, D. I. W., Gale, C. R., Robinson, S. M., & Godfrey, K. M.
- Affiliations
- University of Southampton (GB)
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 51
- Issue
- 5
- Pages
- 594-602
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- PMC
- PMC2862762
- OpenAlex
- W1722263777
- Cited by
- 165
- References
- 51
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 9 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 5 · 2012: 14
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Medical Research Council
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD041107, 1 R01 HD41107-01)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- maternal folate status, red blood cell folate, maternal nutrition, fetal brain development, hyperactive children, peer problems, prenatal exposure
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Child, Child Behavior, Child Behavior Disorders, Female, Folic Acid, Gestational Age, Head, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Sex Factors, Prenatal Nutritional Physiological Phenomena, Fetal Development
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