The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
Open accessAbstract
1. The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle and plasma IL-6 concentration. 2. Seven moderately trained men completed 60 min of exercise at a workload corresponding to each individual's lactate threshold on four randomised occasions. Two trials were conducted on a bicycle ergometer (Cyc) and two on a running treadmill (Run) either with (CHO) or without (Con) the ingestion of a CHO beverage throughout the exercise. Muscle biopsies were obtained from the vastus lateralis before and immediately after exercise and IL-6 gene expression in these samples was determined using real-time PCR. In addition, venous blood samples were collected at rest, and after 30 min during and at the cessation of exercise. These samples were analysed for plasma IL-6. 3. Irrespective of exercise mode or CHO ingestion, exercise resulted in a 21 +/- 4-fold increase (P < 0.01; main exercise effect) in IL-6 mRNA expression. In contrast, while the mode of exercise did not affect the exercise-induced increase in plasma IL-6, CHO ingestion blunted (P < 0.01) this response. 4. These data demonstrate that CHO ingestion attenuates the plasma IL-6 concentration during both cycling and running exercise. However, because IL-6 mRNA expression was unaffected by CHO ingestion, it is likely that the ingestion of CHO during exercise attenuates IL-6 production by tissues other than skeletal muscle.
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“According to these studies, the running model leads to a greater release of IL-6 because of the greater muscle damage which occurs due to its eccentric component being larger compared to that of cycling.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Starkie et al., 2001
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“Other studies comparing the IL-6 response in these two exercise models did not show significant differences (Starkie et al., 2001).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Starkie et al., 2001
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“Higher plasma levels of IL-6 have been reported in some studies that use running as a model of physical exercise compared to those which use cycling (Nieman et al., 1998; Starkie et al., 2001).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Starkie et al., 2001
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BackgroundCarbohydrate and the cytokine response to 2.5 h of running
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The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Self-citationMuscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
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Self-citationInterleukin-6 in acute exercise and training: what is the biological relevance?
Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817
Muscle‐derived interleukin‐6: possible biological effects
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Metadata
- Authors
- Starkie, R. L., Arkinstall, M. J., Koukoulas, I., Hawley, J. A., & Febbraio, M. A.
- Affiliations
- The University of Melbourne (AU)
- RMIT University (AU)
- Corresponding author
- Febbraio, M. A.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 533
- Issue
- 2
- Pages
- 585-591
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2278645
- OpenAlex
- W2001955029
- Cited by
- 197
- References
- 30
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 13 · 2014: 8 · 2013: 15 · 2012: 5
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- carbohydrate intake, interleukin-6, physical activity, skeletal muscle gene expression, plasma cytokines, exercise mode, cycling, treadmill running, vastus lateralis, exercise-induced inflammation
- MeSH terms
- Adult, Biopsy, Blood Glucose, Dietary Carbohydrates, Exercise Test, Glycogen, Humans, Male, RNA, Messenger, Exercise, Interleukin-6, Gene Expression, Muscle, Skeletal
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