Cited by 197Exercise and Physiological ResponsesMuscle metabolism and nutritionCardiovascular and exercise physiology

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Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans

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Starkie, R. L., Arkinstall, M. J., Koukoulas, I., Hawley, J. A., Febbraio, M. A.·2001·The Journal of Physiology

DOI 10.1111/j.1469-7793.2001.0585a.xPMC PMC2278645

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Abstract

1. The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle and plasma IL-6 concentration. 2. Seven moderately trained men completed 60 min of exercise at a workload corresponding to each individual's lactate threshold on four randomised occasions. Two trials were conducted on a bicycle ergometer (Cyc) and two on a running treadmill (Run) either with (CHO) or without (Con) the ingestion of a CHO beverage throughout the exercise. Muscle biopsies were obtained from the vastus lateralis before and immediately after exercise and IL-6 gene expression in these samples was determined using real-time PCR. In addition, venous blood samples were collected at rest, and after 30 min during and at the cessation of exercise. These samples were analysed for plasma IL-6. 3. Irrespective of exercise mode or CHO ingestion, exercise resulted in a 21 +/- 4-fold increase (P < 0.01; main exercise effect) in IL-6 mRNA expression. In contrast, while the mode of exercise did not affect the exercise-induced increase in plasma IL-6, CHO ingestion blunted (P < 0.01) this response. 4. These data demonstrate that CHO ingestion attenuates the plasma IL-6 concentration during both cycling and running exercise. However, because IL-6 mRNA expression was unaffected by CHO ingestion, it is likely that the ingestion of CHO during exercise attenuates IL-6 production by tissues other than skeletal muscle.

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Authors: Starkie, R. L., Arkinstall, M. J., Koukoulas, I., Hawley, J. A., & Febbraio, M. A.
Affiliations: The University of Melbourne (AU)
RMIT University (AU)
Corresponding author: Febbraio, M. A.
ORCID: Starkie, R. L.
Koukoulas, I.
Hawley, J. A.
Febbraio, M. A.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2001-06
Volume: 533
Issue: 2
Pages: 585-591
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1111/j.1469-7793.2001.0585a.x
PMC: PMC2278645
OpenAlex: W2001955029
Cited by: 197
References: 30
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 13 · 2014: 8 · 2013: 15 · 2012: 5
FWCI: 18.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: carbohydrate intake, interleukin-6, physical activity, skeletal muscle gene expression, plasma cytokines, exercise mode, cycling, treadmill running, vastus lateralis, exercise-induced inflammation
MeSH terms: Adult, Biopsy, Blood Glucose, Dietary Carbohydrates, Exercise Test, Glycogen, Humans, Male, RNA, Messenger, Exercise, Interleukin-6, Gene Expression, Muscle, Skeletal

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Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans

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