Advanced endoscopic techniques used in dysfunctional bleeding, fibroids and endometriosis, and the role of gonadotrophin-releasing hormone agonist treatment
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GnRH agonists cannot titrate E2 levels.
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [98]
GnRH agonists have unpredictable reversibility of treatment when injectable depot forms are used.
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [98]
GnRH agonists excessively suppress E2 to less than 20 pg/mL, with related unfavorable side effects.
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [98]
GnRH agonists have a delayed therapeutic impact because of the flare-up effect.
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [98]
GnRH agonists are effective at treating endometriosis symptoms.
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [98]
The mechanism of GnRH antagonists differs from that of GnRH agonists, which after a first phase of stimulation desensitize GnRH receptors, leading to full suppression of LH and FSH production and complete suppression of E2 to levels similar to those after bilateral oophorectomy.
“The mechanism is different from that of the GnRH agonist which, after a first phase of stimulation, desensitizes GnRH receptors, leading to full suppression of LH and FSH production and subsequently to complete suppression of E2 to levels similar to those observed after bilateral oophorectomy [95,96,97,98].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [98]
Linzagolix has a half-life of 15-18 h, high oral bioavailability, low volume of distribution, no food effects and an absence of interactions with transporters and CYP3A4 enzymes.
“Linzagolix has a half-life of 15–18 h, high oral bioavailability, low volume of distribution, no food effects and an absence of interactions with transporters and CYP3A4 enzymes [98,100].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [98]
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Surgery for endometriosis-associated infertility: a pragmatic approach
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- Authors
- Donnez, J., Nisolle, M., Clerckx, F., Casanas‐Roux, F., Saussoy, P., & Gillerot, S.
- Affiliations
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Donnez, J.
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 1994-05
- Volume
- 101
- Issue
- s10
- Pages
- 2-9
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2014564190
- Cited by
- 40
- References
- 32
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2017: 1 · 2015: 1
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- endoscopic technique, dysfunctional uterine bleeding, uterine fibroids, endometriosis, GnRH agonist, endometrial ablation, hysteroscopy
- MeSH terms
- Danazol, Endometriosis, Endometrium, Female, Follow-Up Studies, Humans, Leiomyoma, Menorrhagia, Preoperative Care, Uterine Neoplasms, Hysteroscopy, Hemostasis, Endoscopic, Treatment Outcome, Goserelin, Laser Therapy
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