Cited by 220Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Chronic Stress Increases Serotonin and Noradrenaline in Rat Brain and Sensitizes Their Responses to a Further Acute Stress

Adell, Albert, Garcia‐Marquez, Cristina, Armario, Antonio, Gelpi, Emilio·1988·Journal of Neurochemistry

Abstract

The effects of 1 h/day restraint in plastic tubes for 24 days on the levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), tryptophan (TP), and noradrenaline (NA) in six regions of rat brain 20 h after the last restraint period were investigated. The levels of 5-HT, 5-HIAA, and NA but not TP increased in several regions. The effects of 1 h of immobilization on both control and chronically restrained rats were also studied. Immobilization per se did not alter brain 5-HT, 5-HIAA, and TP levels, but decreased NA in the pons plus medulla oblongata and hypothalamus. However, immobilization after chronic restraint decreased 5-HT, increased 5-HIAA, and decreased NA in most brain regions in comparison with values for the chronically restrained rats. We suggest that chronic restraint leads to compensatory increases of brain 5-HT and NA synthesis and sensitizes both monoaminergic systems to an additional acute stress. These changes may affect coping with stress demands.

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Crossref · 10.1111/j.1471-4159.1988.tb02462.x

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  • P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.

    “Based on these findings, P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.”

    From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [95]

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Authors
Adell, A., Garcia‐Marquez, C., Armario, A., & Gelpi, E.
Affiliations
Universitat Autònoma de Barcelona (ES)
Corresponding author
Adell, Albert
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1988-06
Volume
50
Issue
6
Pages
1678-1681
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W2095422382
Cited by
220
References
32
Citations by year
2025: 2 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 1 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 9 · 2015: 1 · 2014: 7 · 2013: 8 · 2012: 4
FWCI
3.18
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
chronic stress, restraint stress, serotonin, norepinephrine, 5-hydroxyindoleacetic acid, tryptophan, immobilization, monoaminergic systems, brain regions, stress coping, rats
MeSH terms
Animals, Brain, Corpus Striatum, Frontal Lobe, Hippocampus, Hydroxyindoleacetic Acid, Hypothalamus, Male, Medulla Oblongata, Mesencephalon, Norepinephrine, Pons, Rats, Inbred Strains, Restraint, Physical, Serotonin, Stress, Physiological, Tryptophan, Rats

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