Chronic Stress Increases Serotonin and Noradrenaline in Rat Brain and Sensitizes Their Responses to a Further Acute Stress
Abstract
The effects of 1 h/day restraint in plastic tubes for 24 days on the levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), tryptophan (TP), and noradrenaline (NA) in six regions of rat brain 20 h after the last restraint period were investigated. The levels of 5-HT, 5-HIAA, and NA but not TP increased in several regions. The effects of 1 h of immobilization on both control and chronically restrained rats were also studied. Immobilization per se did not alter brain 5-HT, 5-HIAA, and TP levels, but decreased NA in the pons plus medulla oblongata and hypothalamus. However, immobilization after chronic restraint decreased 5-HT, increased 5-HIAA, and decreased NA in most brain regions in comparison with values for the chronically restrained rats. We suggest that chronic restraint leads to compensatory increases of brain 5-HT and NA synthesis and sensitizes both monoaminergic systems to an additional acute stress. These changes may affect coping with stress demands.
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P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.
“Based on these findings, P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [95]
Cites
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
Glowinski, J., & Iversen, L. L. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb09873.x · Cited by 5,436 · see citing works
Selective activation of the mesocortical DA system by stress
Thierry, A. M., Tassin, J., BLANC, G., & Glowinski, J. (1976) · Nature · doi:10.1038/263242a0 · Cited by 1,033 · see citing works
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.173.3992.149 · Cited by 1,017 · see citing works
Smith, A. D. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb12034.x · Cited by 670 · see citing works
Adrenal and Urinary Catecholamines in Rats During Adaptation to Repeated Immobilization Stress
Květňanský, R., & MIKULAJ, L. (1970) · Endocrinology · doi:10.1210/endo-87-4-738 · Cited by 513 · see citing works
Partial Purification and Characterization of Tryptophan Hydroxylase from Rabbit Hindbrain
Friedman, P. A., Kappelman, A. H., & Kaufman, S. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45055-2 · Cited by 446 · see citing works
Depression: The predisposing influence of stress
Anisman, H., & Zacharko, R. M. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010633 · Cited by 433 · see citing works
Catecholamines and stress: Recent advances
Chalmers, J. P. (1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90040-6 · Cited by 355 · see citing works
Stress and brain noradrenaline: a review.
Glavin, G. (1985) · Neuroscience and Biobehavioral Reviews · doi:10.1016/0149-7634(85)90048-x · Cited by 322 · see citing works
EFFECTS OF IMMOBILIZATION AND FOOD DEPRIVATION ON RAT BRAIN TRYPTOPHAN METABOLISM
Curzon, G., Joseph, M. H., & Knott, P. J. (1972) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1972.tb01486.x · Cited by 307 · see citing works
Kennett, G. A., Chaouloff, F., Marcou, M., & Curzon, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)91355-7 · Cited by 301 · see citing works
Effects of Chronic Exposure to Stressors on Avoidance-Escape Behavior and on Brain Norepinephrine*
Weiss, J. M., Glazer, H. I., Pohorecky, L. A., Brick, J., & Miller, N. E. (1975) · Psychosomatic Medicine · doi:10.1097/00006842-197511000-00006 · Cited by 279 · see citing works
Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in rats
Kennett, G. A., Dickinson, S. L., & Curzon, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90684-5 · Cited by 254 · see citing works
Stone, E. A. (1975) · Springer eBooks · doi:10.1007/978-1-4684-3138-4_2 · Cited by 250 · see citing works
Cooper, S. J. (1982) · Medical Entomology and Zoology · Cited by 230 · see citing works
Roth, K. A., Mefford, I. N., & Barchas, J. D. (1982) · Brain Research · doi:10.1016/0006-8993(82)90519-4 · Cited by 210 · see citing works
Thierry, A. M., Fekete, M. I. K., & Glowinski, J. (1968) · European Journal of Pharmacology · doi:10.1016/0014-2999(68)90023-x · Cited by 203 · see citing works
Lehnert, H., Reinstein, D. K., Strowbridge, B. W., & Wurtman, R. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91207-1 · Cited by 170 · see citing works
Joseph, M. H., & Kennett, G. A. (1983) · Brain Research · doi:10.1016/0006-8993(83)90598-x · Cited by 151 · see citing works
Kennett, G. A., & Joseph, M. H. (1981) · Neuropharmacology · doi:10.1016/0028-3908(81)90039-3 · Cited by 148 · see citing works
Effect of immobilization stress on serotonin content and turnover in regions of the rat brain
MORGAN, W. W., Rudeen, P. K., & Pfeil, K. A. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90250-7 · Cited by 127 · see citing works
Chronic restraint stress elicits a positive antidepressant response on the forced swim test
Platt, J., & Stone, E. A. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90508-8 · Cited by 123 · see citing works
Coping Behavior and Neurochemical Changes
Weiss, J. M., Glazer, H. I., & Pohorecky, L. A. (1976) · Springer eBooks · doi:10.1007/978-1-4684-2184-2_9 · Cited by 87 · see citing works
Welch, B. L., & Welch, A. S. (1968) · Nature · doi:10.1038/218575a0 · Cited by 87 · see citing works
Adaptation to stress: Tyrosine hydroxylase activity and catecholamine release
Stone, E. A., & McCarty, R. C. (1983) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(83)90005-2 · Cited by 86 · see citing works
Kobayashi, R. M., Palkovits, M., Kizer, J. S., et al. (1976) · Elsevier eBooks · doi:10.1016/b978-0-08-020588-5.50011-4 · Cited by 80 · see citing works
Tanaka, M., Kohno, Y., Nakagawa, R., Ida, Y., Iimori, K., Hoaki, Y., Tsuda, A., & Nagasaki, N. (1982) · Life Science · doi:10.1016/0024-3205(82)90499-4 · Cited by 75 · see citing works
Hamon, M., Bourgoin, S., Artaud, F., et al. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb05239.x · Cited by 68 · see citing works
EFFECT OF STRESS ON SEROTONIN AND TRYPTOPHAN HYDROXYLASE ACTIVITY OF BRAIN NUCLEI
Palkovits, M., Brownsteint, M., Kizer, J. S., et al. (1976) · Elsevier eBooks · doi:10.1016/b978-0-08-020588-5.50013-8 · Cited by 55 · see citing works
Ida, Y., Tanaka, M., Tsuda, A., Kohno, Y., Hoaki, Y., Nakagawa, R., Iimori, K., & Nagasaki, N. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90422-3 · Cited by 55 · see citing works
Čulman, J., Kiss, A., & Květňanský, R. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1210309 · Cited by 45 · see citing works
Learned helplessness: Effects on brain monoamines and the pituitary-gonadal axis
Hellhammer, D. H., Rea, M. A., Bell, M., et al. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(84)80026-x · Cited by 38 · see citing works
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Perry, B. D., & Pollard, R. (1998) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(18)30258-x · Cited by 440 · see citing works
Markus, C. R., Olivier, B., Panhuysen, G. E., Van der Gugten, J., Alles, M. S., Tuiten, A., Westenberg, H. G., Fekkes, D., Koppeschaar, H. F., & de Haan, E. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1536 · Cited by 296 · see citing works
Stress-induced c-fos expression in the rat brain: activation mechanism of sympathetic pathway
Senba, E., Matsunaga, K., Tohyama, M., & Noguchi, K. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90225-z · Cited by 234 · see citing works
Lowry, C. A., Rodda, J. E., Lightman, S. L., & Ingram, C. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07728.2000 · Cited by 211 · see citing works
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Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works
Stress-induced sensitization: the hypothalamic–pituitary–adrenal axis and beyond
Belda, X., Fuentes, S., Daviu, N., Nadal, R., & Armario, A. (2015) · Stress · doi:10.3109/10253890.2015.1067678 · Cited by 123 · see citing works
Self-citationKarabeg, M. M., Grauthoff, S., Kollert, S. Y., Weidner, M., Heiming, R. S., Jansen, F., Popp, S., Kaiser, S., Lesch, K.-P., Sachser, N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078238 · Cited by 56 · see citing works
- Authors
- Adell, A., Garcia‐Marquez, C., Armario, A., & Gelpi, E.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Adell, Albert
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1988-06
- Volume
- 50
- Issue
- 6
- Pages
- 1678-1681
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2095422382
- Cited by
- 220
- References
- 32
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 1 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 9 · 2015: 1 · 2014: 7 · 2013: 8 · 2012: 4
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- chronic stress, restraint stress, serotonin, norepinephrine, 5-hydroxyindoleacetic acid, tryptophan, immobilization, monoaminergic systems, brain regions, stress coping, rats
- MeSH terms
- Animals, Brain, Corpus Striatum, Frontal Lobe, Hippocampus, Hydroxyindoleacetic Acid, Hypothalamus, Male, Medulla Oblongata, Mesencephalon, Norepinephrine, Pons, Rats, Inbred Strains, Restraint, Physical, Serotonin, Stress, Physiological, Tryptophan, Rats
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