Corticotropin-Releasing Factor Increases In Vitro Firing Rates of Serotonergic Neurons in the Rat Dorsal Raphe Nucleus: Evidence for Activation of a Topographically Organized Mesolimbocortical Serotonergic System

Lowry, Christopher A.; Rodda, Joanne E.; Lightman, Stafford L.; Ingram, Colin D.

doi:10.1523/jneurosci.20-20-07728.2000

Cited by 213Neuropeptides and Animal PhysiologyStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Corticotropin-Releasing Factor Increases In Vitro Firing Rates of Serotonergic Neurons in the Rat Dorsal Raphe Nucleus: Evidence for Activation of a Topographically Organized Mesolimbocortical Serotonergic System

Open access

Lowry, Christopher A., Rodda, Joanne E., Lightman, Stafford L., Ingram, Colin D.·2000·The Journal of Neuroscience

DOI 10.1523/jneurosci.20-20-07728.2000PMC PMC6772886

Open this paper in CoChat — free account Open PDF

Abstract

In vivo studies suggest that the stress-related neuropeptide corticotropin-releasing factor (CRF) modulates serotonergic neurotransmission. To investigate the underlying mechanisms for this interaction, the present study examined the effects of CRF in vitro on dorsal raphe neurons that displayed electrophysiological and pharmacological properties consistent with a serotonergic phenotype. In the presence of either 1 or 2 mm Ca(2+), perfusion of ovine CRF or rat/human CRF rapidly and reversibly increased firing rates of a subpopulation (19 of 70, 27%) of serotonergic neurons predominantly located in the ventral portion of the dorsal raphe nucleus. For a given responsive neuron, the excitatory effects of CRF were reproducible, and there was no tachyphylaxis. Excitatory effects were dose-dependent (over the range of 0.1-1.6 micrometer) and were completely absent after exposure to the competitive CRF receptor antagonists alpha-helical CRF(9-41) or rat/human [d-Phe(12), Nle(21, 38), alpha-Me-Leu(37)]-CRF(12-41). Both the proportion of responsive neurons and the magnitude of excitatory responses to CRF in the ventral portion of the caudal dorsal raphe nucleus were markedly potentiated in slices prepared from animals previously exposed to isolation and daily restraint stress for 5 d. Immunohistochemical staining of the recorded slices revealed close associations between CRF-immunoreactive varicose axons and tryptophan hydroxylase-immunoreactive neurons in the area of the recordings, providing anatomical evidence for potential direct actions of CRF on serotonergic neurons. The electrophysiological properties and the distribution of responsive neurons within the dorsal raphe nucleus are consistent with the hypothesis that endogenous CRF activates a topographically organized mesolimbocortical serotonergic system.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.20-20-07728.2000

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

DRN 5-HT neurons in different subregions express different G protein-coupled receptors and vesicular transporters.
“Although DRN 5-HT neurons share a common developmental lineage (Deneris and Gaspar, 2018; Jensen et al., 2008), DRN 5-HT neurons in different subregions express different G protein-coupled receptors and vesicular transporters, suggesting spatial clustering of functionally specialized neurons (Calizo et al., 2011; Fernandez et al., 2016; Lowry et al., 2000; Templin et al., 2012).”
From Molecular and anatomical organization of the dorsal raphe nucleus (2019) · cites this paper as Lowry et al., 2000
Even bona fide DRN 5-HT neurons are molecularly, anatomically, and physiologically heterogeneous.
“Even bona fide DRN 5-HT neurons are molecularly, anatomically, and physiologically heterogeneous.”
From Molecular and anatomical organization of the dorsal raphe nucleus (2019) · cites this paper as Lowry et al., 2000

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Précis of <i>The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system</i>
Gray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477 · see citing works
Structure and function of the brain serotonin system
Jacobs, B. L., & Azmitia, E. C. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.1.165 · Cited by 2,574 · see citing works
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
Vaughan, J. M., Donaldson, C. J., Bittencourt, J. C., Perrin, M. H., Lewis, K., Sutton, S. W., Chan, R. K. W., Turnbull, A. V., Lovejoy, D. A., RIVIER, C. L., et al. (1995) · Nature · doi:10.1038/378287a0 · Cited by 1,479 · see citing works
Physiology and pharmacology of corticotropin-releasing factor.
Owens, M. J., & Nemeroff, C. B. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06673-6 · Cited by 1,147 · see citing works
Pattern and time course of immediate early gene expression in rat brain following acute stress
Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056 · see citing works
Role of 5-HT in stress, anxiety, and depression
Graeff, F. G., Guimarães, F. S., De Andrade, T. G. C. S., & Deakin, J. F. W. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02135-3 · Cited by 984 · see citing works
Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression
Chalmers, D., Lovenberg, T. W., & Souza, E. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06340.1995 · Cited by 925 · see citing works
A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat
Vertes, R. P. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130409 · Cited by 842 · see citing works
Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment
Beck, C., & Fibiger, H. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00709.1995 · Cited by 547 · see citing works
Are different parts of the extended amygdala involved in fear versus anxiety?
Davis, M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00288-1 · Cited by 545 · see citing works
Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods
Peyron, C., Petit, J.-M., Rampon, C., Jouvet, M., & Luppi, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00268-6 · Cited by 509 · see citing works
Connections between the central nucleus of the amygdala and the midbrain periaqueductal gray: Topography and reciprocity
Rizvi, T. A., Ennis, M., Behbehani, M. M., & Shipley, M. T. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903030111 · Cited by 500 · see citing works
Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
VanderMaelen, C. P., & Aghajanian, G. K. (1983) · Brain Research · doi:10.1016/0006-8993(83)90011-2 · Cited by 499 · see citing works
Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study
Souza, E. B. D., Insel, T. R., Perrin, M. H., Rivier, J., Vale, W., & Kuhar, M. J. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-12-03189.1985 · Cited by 478 · see citing works
Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats
Weiss, F., Parsons, L. H., Schulteis, G., Hyytiä, P., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03474.1996 · Cited by 457 · see citing works
Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study
Cummings, S., Elde, R., Ells, J., & Lindall, A. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-07-01355.1983 · Cited by 414 · see citing works
Role of the amygdala in the coordination of behavioral, neuroendocrine, and prefrontal cortical monoamine responses to psychological stress in the rat
Goldstein, L. E., Rasmusson, A. M., Bunney, B. S., & Roth, R. H. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04787.1996 · Cited by 387 · see citing works
The organization of divergent axonal projections from the midbrain raphe nuclei in the rat
Imai, H., Steindler, D. A., & Kitai, S. T. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430307 · Cited by 369 · see citing works
Brainstem innervation of prefrontal and anterior cingulate cortex in the rhesus monkey revealed by retrograde transport of HRP
Porrino, L. J., & Goldman, P. S. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902050107 · Cited by 363 · see citing works
Projections of the bed nucleus of the stria terminalis to the mesencephalon, pons, and medulla oblongata in the cat
Holstege, G., Meiners, L. C., & Tan, K. (1985) · Experimental Brain Research · doi:10.1007/bf00235319 · Cited by 342 · see citing works
Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System
Bittencourt, J. C., & Sawchenko, P. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01142.2000 · Cited by 339 · see citing works
Distribution and efferent projections of corticotropin-releasing factor-like immunoreactivity in the rat amygdaloid complex
Sakanaka, M., Shibasaki, T., & Lederis, K. (1986) · Brain Research · doi:10.1016/0006-8993(86)91332-6 · Cited by 337 · see citing works
Corticotropin releasing factor‐like immunoreactivity in the rat brain as revealed by a modified cobalt‐glucose oxidase‐diaminobenzidine method
Sakanaka, M., Shibasaki, T., & Lederis, K. P. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902600209 · Cited by 335 · see citing works
Identification of serotonin and non-serotonin-containing neurons of the mid-brain raphe projecting to the entorhinal area and the hippocampal formation. A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain
Köhler, C., & Steinbusch, H. W. M. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90054-9 · Cited by 330 · see citing works
The Role of Corticotropin-Releasing Factor and Corticosterone in Stress- and Cocaine-Induced Relapse to Cocaine Seeking in Rats
Erb, S. M., Shaham, Y., & Stewart, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05529.1998 · Cited by 329 · see citing works
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
Rocha, B. A. G., Scearce-Levie, K. A., Lucas, J. J., Hiroi, N., Castanon, N., Crabbe, J. C., Nestler, E. J., & Hen, R. (1998) · Nature · doi:10.1038/30259 · Cited by 322 · see citing works
Activity of Serotonergic Neurons in Behaving Animals
Jacobs, B. L. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00012-3 · Cited by 318 · see citing works
Corticotropin Releasing Factor Decreases Postburst Hyperpolarizations and Excites Hippocampal Neurons
Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W., & Siggins, G. R. (1983) · Science · doi:10.1126/science.6603658 · Cited by 309 · see citing works
Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats
Shaham, Y., Funk, D., Erb, S., Brown, T. J., Walker, C.-D., & Stewart, J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02605.1997 · Cited by 308 · see citing works
Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus
Kirby, L. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00093-7 · Cited by 307 · see citing works
Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor
Grahn, R. E., Will, M. J., Hammack, S. E., Maswood, S., McQueen, M. B., Watkins, L. R., & Maier, S. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01208-1 · Cited by 298 · see citing works
Afferent connections to the bed nucleus of the stria terminalis
Weller, K. L., & Smith, D. A. (1982) · Brain Research · doi:10.1016/0006-8993(82)90272-4 · Cited by 293 · see citing works
The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF.
Potter, E., Behan, D. P., Linton, E. A., Lowry, P. J., Sawchenko, P. E., & Vale, W. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4192 · Cited by 285 · see citing works
Activity of brain serotonergic neurons in the behaving animal.
Jacobs, B. L., & Fornal, C. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06675-x · Cited by 270 · see citing works
The efferent connection of the nucleus raphe dorsalis
Pierce, E. T., Foote, W. E., & Hobson, J. A. (1976) · Brain Research · doi:10.1016/0006-8993(76)90102-5 · Cited by 269 · see citing works
Autoradiographic analysis of ascending projections from the pontine and mesencephalic reticular formation and the median raphe nucleus in the rat
Vertes, R. P., & Martin, G. F. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902750404 · Cited by 267 · see citing works
Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens
Bockstaele, E. J. V., Biswas, A., & Pickel, V. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)90077-z · Cited by 266 · see citing works
Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain
Inoue, T., Tsuchiya, K., & Koyama, T. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90243-7 · Cited by 262 · see citing works
Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats
Sarnyai, Z., Bíró, É., Gardi, J., Vecsernyés, M., Julesz, J., & Telegdy, G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00043-p · Cited by 255 · see citing works
Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain
Kollack‐Walker, S., Watson, S. J., & Akil, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-22-08842.1997 · Cited by 253 · see citing works
Adaptation in patterns of c‐fos expression in the brain associated with exposure to either single or repeated social stress in male rats
Martı́nez, M., Phillips, P. J., & Herbert, J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00011.x · Cited by 253 · see citing works
Psychological stress increases serotonin release in the rat amygdala and prefrontal cortex assessed by in vivo microdialysis
Kawahara, H., Yoshida, M., Yokoo, H., Nishi, M., & Tanaka, M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90565-3 · Cited by 244 · see citing works
Stress-induced c-fos expression in the rat brain: activation mechanism of sympathetic pathway
Senba, E., Matsunaga, K., Tohyama, M., & Noguchi, K. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90225-z · Cited by 234 · see citing works
Induction of Fos immunoreactivity in the brain by exposure to the elevated plus-maze
Silveira, M. C. L., Sandner, G., & Graeff, F. G. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90028-o · Cited by 231 · see citing works
Comparative Study in the Rat of the Actions of Different Types of Stress on the Release of 5-HT in Raphe Nuclei and Forebrain Areas
Adell, A., CASANOVAS, J. M., & Artigas, F. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00048-8 · Cited by 229 · see citing works
Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression
Kennett, G. A., Dourish, C. T., & Curzon, G. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90357-8 · Cited by 229 · see citing works
Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 11Published on the World Wide Web on 27 November 1998.1
Contarino, A., Dellu-Hagedorn, F., Koob, G. F., Smith, G. W., Lee, K., Vale, W., & Gold, L. H. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01158-5 · Cited by 228 · see citing works
Neuroendocrine and Behavioral Responses and Brain Pattern of c‐<i>fos</i> Induction Associated with Audiogenic Stress
Campeau, S., & Watson, S. J. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00593.x · Cited by 227 · see citing works
Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal
Heinrichs, S. C., Menzaghi, F., Schulteis, G., Koob, G. F., & Stinus, L. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199501000-00011 · Cited by 226 · see citing works
Effects of Corticotropin-Releasing Factor on Brain Serotonergic Activity
M Price, B. A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00197-8 · Cited by 226 · see citing works
Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat
Amat, J., Matus-Amat, P., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00960-3 · Cited by 222 · see citing works
Chronic Stress Increases Serotonin and Noradrenaline in Rat Brain and Sensitizes Their Responses to a Further Acute Stress
Adell, A., Garcia‐Marquez, C., Armario, A., & Gelpi, E. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb02462.x · Cited by 220 · see citing works
Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.
Parsons, L. H., Koob, G. F., & Weiss, F. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10596-x · Cited by 218 · see citing works
Organization of amygdaloid projections to brainstem dopaminergic, noradrenergic, and adrenergic cell groups in the rat
Wallace, D. M., Magnuson, D. J., & Gray, T. S. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90046-z · Cited by 218 · see citing works
Subcortical afferent connections of the amygdala in the monkey
Mehler, W. R. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901900407 · Cited by 205 · see citing works
Amygdalopetal projections in the cat. II. Subcortical afferent connections. A study with retrograde tracing techniques
Russchen, F. T. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902070205 · Cited by 195 · see citing works
Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine
WALSH, S. L., & Cunningham, K. A. (1997) · Psychopharmacology · doi:10.1007/s002130050210 · Cited by 192 · see citing works
Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.
Behan, D. P., Grigoriadis, D. E., Lovenberg, T. W., Chalmers, D. T., Heinrichs, S. C., Liaw, C. W., & Souza, E. B. D. (1996) · PubMed · Cited by 191 · see citing works
The distribution and origin of serotonin‐containing fibers in the septal area: A combined immunohistochemical and fluorescent retrograde tracing study in the rat
Köhler, C., Chan‐Palay, V., & Steinbusch, H. W. M. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902090109 · Cited by 188 · see citing works
Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat
Maswood, S., Barter, J. E., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01313-9 · Cited by 173 · see citing works
A Critical Review of 5-HT Brain Microdialysis and Behavior
Rueter, L. E., Fornal, C. A., & Jacobs, B. L. (1997) · Reviews in the Neurosciences · doi:10.1515/revneuro.1997.8.2.117 · Cited by 172 · see citing works
Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro
Jolas, T., & Aghajanian, G. K. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00103-0 · Cited by 171 · see citing works
Regulation of Serotonin Release in the Lateral Septum and Striatum by Corticotropin-Releasing Factor
Price, M. L., & Lucki, I. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02833.2001 · Cited by 169 · see citing works
Stress-induced activation of nitric oxide-producing neurons in the rat brain
Krukoff, T. L., & Khalili, P. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970127)377:4 · Cited by 167 · see citing works
The nucleus raphe dorsalis of the rat and its projection upon the caudatoputamen. A combined cytoarchitectonic, immunohistochemical and retrograde transport study.
Steinbusch, H. W. M., Nieuwenhuys, R., Verhofstad, A. A. J., & Van der Kooy, D. (1981) · PubMed · Cited by 165 · see citing works
Activation of brainstem catecholaminergic neurons by conditioned and unconditioned aversive stimuli as revealed by c-Fos immunoreactivity
Pezzone, M. A., Lee, W.-S., Hoffman, G. E., Pezzone, K. M., & Rabin, B. S. (1993) · Brain Research · doi:10.1016/0006-8993(93)91472-5 · Cited by 162 · see citing works
Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat
Amat, J., Matus-Amat, P., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00368-0 · Cited by 158 · see citing works
Persistent c-fos expression in the brains of mice with chronic social stress
Matsuda, S., Peng, H., Yoshimura, H., Wen, T., Fukuda, T., & Sakanaka, M. (1996) · Neuroscience Research · doi:10.1016/s0168-0102(96)01088-7 · Cited by 157 · see citing works
Stress-induced release of 5-HT in the hippocampus and its dependence on increased tryptophan availability: an in vivo electrochemical study
Joseph, M. H., & Kennett, G. A. (1983) · Brain Research · doi:10.1016/0006-8993(83)90598-x · Cited by 151 · see citing works
Effects of conditioned fear stress on 5-HT release in the rat prefrontal cortex
Yoshioka, M., Matsumoto, M., Togashi, H., & Saito, H. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00045-x · Cited by 149 · see citing works
Changes in plasma and brain tryptophan and brain serotonin and 5-hydroxyindoleacetic acid after footshock stress
Dunn, A. J. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90023-9 · Cited by 142 · see citing works
Serotonin, but not dopamine, metabolites are increased in selected brain regions of subordinate male rats in a colony environment
Blanchard, D. C., Cholvanich, P., Blanchard, R. J., Clow, D. W., Hammer, R. P., Rowlett, J. K., & Bardo, M. T. (1991) · Brain Research · doi:10.1016/0006-8993(91)91379-f · Cited by 130 · see citing works
Activity of serotonin-containing neurons in nucleus centralis superior of freely moving cats
Rasmussen, K., Heym, J. H., & Jacobs, B. L. (1984) · Experimental Neurology · doi:10.1016/s0014-4886(84)90100-6 · Cited by 127 · see citing works
CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: Ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents
Smith, Y., Kieval, J. Z., Couceyro, P. R., & Kuhar, M. J. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990517)407:4 · Cited by 122 · see citing works
Chemically defined collateral projections from the pons to the central nucleus of the amygdala and hypothalamic paraventricular nucleus in the rat
Petrov, T., Krukoff, T. L., & Jhamandas, J. H. (1994) · Cell and Tissue Research · doi:10.1007/bf00327776 · Cited by 118 · see citing works
Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain
Bonaz, B. L., & Rivest, S. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1438 · Cited by 111 · see citing works
Effect of conditioned fear stress on serotonin metabolism in the rat brain
Inoue, T., Koyama, T., & Yamashita, I. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90476-a · Cited by 104 · see citing works
Induction and habituation of c-fos and zif/268 by acute and repeated stressors
Watanabe, Y., Stone, E. A., & McEwen, B. S. (1994) · Neuroreport · doi:10.1097/00001756-199406270-00006 · Cited by 103 · see citing works
Electrophysiological actions of corticotropin-releasing factor in the central nervous system.
Siggins, G. R., Gruol, D. L., Aldenhoff, J. B., & Pittman, Q. J. (1985) · PubMed · Cited by 100 · see citing works
Central C-Fos Expression Following 20kHz/Ultrasound Induced Defence Behaviour in the Rat
Beckett, S. R. G., Duxon, M. S., Aspley, S., & Marsden, C. A. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00332-2 · Cited by 96 · see citing works
Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats
Chung, K. K. K., Martı́nez, M., & Herbert, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00028-7 · Cited by 89 · see citing works
Corticotropic-releasing hormone and serotonin interact in the human brainstem: behavioral implications
Ruggiero, D. A., Underwood, M. D., Rice, P. M., Mann, J. J., & Arango, V. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00703-9 · Cited by 87 · see citing works
Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat
Fulford, A. J., & Marsden, C. A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00423-5 · Cited by 83 · see citing works
c-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin
Chung, K. K. K., Martı́nez, M., & Herbert, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00459-5 · Cited by 83 · see citing works
Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: Evidence that this model identifies anxiolytic-like activity
Carli, M., Prontera, C., & SAMANIN, R. (1989) · Neuropharmacology · doi:10.1016/0028-3908(89)90081-6 · Cited by 83 · see citing works
Corticotropin-releasing factor suppresses the afterhyperpolarization in cerebellar Purkinje neurons
Fox, E. A., & Gruol, D. L. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90358-r · Cited by 82 · see citing works
Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland
Chamas, F., Serova, L. I., & Sabban, E. L. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00340-7 · Cited by 79 · see citing works
Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT
McBlane, J. W., & Handley, S. L. (1994) · Psychopharmacology · doi:10.1007/bf02245060 · Cited by 75 · see citing works
Time course of changes in serotonin and noradrenaline in rat brain after predictable or unpredictable shock
Adell, A., Trullás, R., & Gelpı́, E. (1988) · Brain Research · doi:10.1016/0006-8993(88)90285-5 · Cited by 70 · see citing works
Brain serotonin and catecholamine responses to repeated stress in rats
Souza, E. B. D., & Loon, G. R. V. (1986) · Brain Research · doi:10.1016/0006-8993(86)91581-7 · Cited by 67 · see citing works
Increased fos-like immunoreactivity in the periaqueductal gray of anaesthetised rats during opiate withdrawal
Chieng, B. C. H., Keay, K. A., & Christie, M. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(94)11119-4 · Cited by 67 · see citing works
Differential effects of stress on presynaptic and postsynaptic 5-hydroxytryptamine-1A receptors in the rat brain: an in vitro electrophysiological study
Laaris, N., Poul, E. L., Laporte, A., Hamon, M., & Lanfumey, L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00674-5 · Cited by 64 · see citing works
Paradoxical activational effects of a corticotropin-releasing factor-binding protein “ligand inhibitor” in rat brain
Chan, R. K. W., Vale, W. W., & Sawchenko, P. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00322-5 · Cited by 63 · see citing works
Stress-induced changes of extracellular 5-hydroxyindoleacetic acid concentrations followed in the nucleus raphe dorsalis and the frontal cortex of the rat
Clement, H., Schäfer, F., Ruwe, C., Gemsa, D., & Wesemann, W. (1993) · Brain Research · doi:10.1016/0006-8993(93)91024-m · Cited by 62 · see citing works
Stress‐induced alterations of somatodendritic 5‐HT1Aautoreceptor sensitivity in the rat dorsal raphe nucleus — in vitro electrophysiological evidence
Laaris, N., Poul, E. L., Hamon, M., & Lanfumey, L. (1997) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1997.tb00187.x · Cited by 61 · see citing works
Behavioral sensitization to cocaine after a brief social stress is accompanied by changes in Fos expression in the murine brainstem
Nikulina, E. M., Marchand, J. E., Kream, R. M., & Miczek, K. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00925-1 · Cited by 57 · see citing works
Corticotropin-Releasing Factor Enhances Locomotion and Medullary Neuronal Firing in an Amphibian
Lowry, C. A., Rose, J. D., & Moore, F. L. (1996) · Hormones and Behavior · doi:10.1006/hbeh.1996.0008 · Cited by 55 · see citing works
Self-citation
Sources of cortical, hypothalamic and spinal serotonergic projections: Topical organization within the nucleus raphe dorsalis
Kazakov, V. N., Kravtsov, P. Y., Krakhotkina, E. D., & Maisky, V. A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90570-6 · Cited by 55 · see citing works
Effect of Stress on Serotonin Concentration and Tryptophan Hydroxylase Activity of Brain Nuclei
Palkovits, M., Brownstein, M. J., Kizer, J. S., Saavedra, J. M., & Kopin, I. J. (2008) · Neuroendocrinology · doi:10.1159/000122638 · Cited by 55 · see citing works
Neurotensin and the serotonergic system
Jolas, T., & Aghajanian, G. K. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00025-7 · Cited by 53 · see citing works
Bilateral serotonergic projections to the dorsal hippocampus of the rat: Simultaneous localization of 3H‐5HT and HRP after retrograde transport
Azmitia, E. C. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902030410 · Cited by 50 · see citing works
Activation of 5-HT neuronal activity during motor behavior
Jacobs, B. L., & Fornal, C. A. (1995) · Seminars in Neuroscience · doi:10.1016/1044-5765(95)90004-7 · Cited by 43 · see citing works
Effect of Aversive Stimulation on 5-Hydroxytryptamine and Dopamine Metabolism in the Rat Brain
Ge, J. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00024-5 · Cited by 40 · see citing works
Learned helplessness: Relationships with fear and anxiety.
Maier, S. F. (1993) · Cited by 40 · see citing works
Increase in cortical and midbrain tryptophan hydroxylase activity by intracerebroventricular administration of corticotropin releasing factor: block by adrenalectomy, by RU 38486 and by bilateral lesions to the central nucleus of the amygdala
Singh, V. K., HAOPHAN, T., Corley, K., & Boadle‐Biber, M. C. (1992) · Neurochemistry International · doi:10.1016/0197-0186(92)90129-f · Cited by 38 · see citing works
Effect of repeated immobilization on serotonin metabolism in different rat brain areas and on serum corticosterone
Clement, H.-W., Kirsch, M., Hasse, C., Opper, C., Gemsa, D., & Wesemann, W. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050119 · Cited by 31 · see citing works
Effect of Restraint Stress and Anxiolytics on 5-HT Turnover in Rat Brain
Mitchell, S. N., & Thomas, P. J. (2008) · Pharmacology · doi:10.1159/000138453 · Cited by 30 · see citing works
Differential Distribution of Corticotropin-Releasing Hormone Immunoreactive Axons in Monoaminergic Nuclei of the Human Brainstem
Austin, M. C. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00083-3 · Cited by 27 · see citing works
Distribution of c-Fos in guinea-pig brain following morphine withdrawal
Chahl, L. A., Leah, J. D., Herdegen, T., Trueman, L., & Lynch‐Frame, A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00041-8 · Cited by 19 · see citing works
Untitled work
Bayraktar (2000) · doi:10.1002/(sici)1096-9861(20000508)420:3

Flagged first, then by citations

1 of the 113 references couldn’t be matched to a known paper.

Sorted by citations

Neuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914 · see citing works
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor.
Maier, S. F., & Watkins, L. R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.021 · Cited by 737 · see citing works
Serotonergic neurons signal reward and punishment on multiple timescales
Cohen, J. Y., Amoroso, M. W., & Uchida, N. (2015) · eLife · doi:10.7554/elife.06346 · Cited by 388 · see citing works
Chronic stress: Implications for neuronal morphology, function and neurogenesis
Joëls, M., Karst, H., Krugers, H. J., & Lucassen, P. J. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.04.001 · Cited by 381 · see citing works
Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis
Lowry, C. A. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00861.x · Cited by 362 · see citing works
Self-citation
Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets
Hauger, R., Risbrough, V. B., Brauns, O., & Dautzenberg, F. M. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777950684 · Cited by 341 · see citing works
Anatomic and functional topography of the dorsal raphe nucleus
ABRAMS, J. K., JOHNSON, P. L., HOLLIS, J. H., & LOWRY, C. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.005 · Cited by 284 · see citing works
Self-citation
Molecular and anatomical organization of the dorsal raphe nucleus
Huang, K. W., Ochandarena, N. E., Philson, A. C., Hyun, M., Birnbaum, J. E., Cicconet, M., & Sabatini, B. L. (2019) · eLife · doi:10.7554/elife.46464 · Cited by 267 · see citing works
Serotonergic Systems, Anxiety, and Affective Disorder
Lowry, C. A., Hale, M. W., Evans, A. K., Heerkens, J., Staub, D. R., Gasser, P. J., & Shekhar, A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.004 · Cited by 265 · see citing works
Self-citation
A neurodevelopmental model for anorexia nervosa
Connan, F., Campbell, I. C., Katzman, M. A., Lightman, S. L., & Treasure, J. L. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00101-x · Cited by 255 · see citing works
Self-citation
Region-specific roles of the corticotropin-releasing factor–urocortin system in stress
Henckens, M. J. A. G., Deussing, J. M., & Chen, A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.94 · Cited by 245 · see citing works
Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents
Lukkes, J. L. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.018.2009 · Cited by 235 · see citing works
Lesions of the Posterior Paraventricular Thalamus Block Habituation of Hypothalamic‐Pituitary‐Adrenal Responses to Repeated Restraint
Bhatnagar, S., Huber, R., Nowak, N., & Trotter, P. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00792.x · Cited by 227 · see citing works
A Neurochemically Distinct Dorsal Raphe-Limbic Circuit with a Potential Role in Affective Disorders
Commons, K. G., Connolley, K. R., & Valentino, R. J. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300045 · Cited by 211 · see citing works
Differential expression of 5HT‐1A, α1b adrenergic, CRF‐R1, and CRF‐R2 receptor mRNA in serotonergic, γ‐aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
Day, H. E. W., Greenwood, B. N., Hammack, S. E., Watkins, L. R., Fleshner, M., Maier, S. F., & Campeau, S. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20138 · Cited by 201 · see citing works
Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs
Abrams, J. K., Johnson, P. L., Hay‐Schmidt, A., Mikkelsen, J. D., Shekhar, A., & Lowry, C. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.025 · Cited by 199 · see citing works
Self-citation
Glucocorticoids, chronic stress, and obesity
Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198 · see citing works
Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain
Fu, W.-Y., Maître, E. L., Fabre, V., Bernard, J., Xu, Q., & Hökfelt, T. G. M. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22407 · Cited by 186 · see citing works
Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT 4 Receptor Knock-Out Mice
Compan, V., Zhou, M., Grailhe, R., Gazzara, R. A., Martin, R., Gingrich, J. A., Dumuis, A., Brunner, D., Bockaert, J., & Hen, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2806-03.2004 · Cited by 177 · see citing works
Regulation of Serotonin Release in the Lateral Septum and Striatum by Corticotropin-Releasing Factor
Price, M. L., & Lucki, I. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02833.2001 · Cited by 169 · see citing works
The Role of Corticotropin-Releasing Hormone in the Dorsal Raphe Nucleus in Mediating the Behavioral Consequences of Uncontrollable Stress
Hammack, S. E., Richey, K. J., Schmid, M. J., LoPresti, M. L., Watkins, L. R., & Maier, S. F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01020.2002 · Cited by 167 · see citing works
Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men
Austin, M. C., Janosky, J. E., & Murphy, H. A. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001250 · Cited by 162 · see citing works
Regulation of behavioral responses by corticotropin-releasing factor
Lowry, C. A., & Moore, F. L. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.12.006 · Cited by 156 · see citing works
Self-citation
Differential effects of ovarian steroids on anxiety versus fear as measured by open field test and fear-potentiated startle
Hiroi, R., & Neumaier, J. F. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.021 · Cited by 151 · see citing works
Glutamatergic afferent projections to the dorsal raphe nucleus of the rat
Lee, H. S., Kim, M., Valentino, R. J., & Waterhouse, B. D. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03841-6 · Cited by 149 · see citing works
Pharmacological Evidence Supporting a Role for Central Corticotropin-Releasing Factor2 Receptors in Behavioral, but not Endocrine, Response to Environmental Stress
Pelleymounter, M. A., Joppa, M. A., LING, N. C., & Foster, A. C. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.145 · Cited by 147 · see citing works
Collateralized dorsal raphe nucleus projections: A mechanism for the integration of diverse functions during stress
Waselus, M., Valentino, R. J., & Van Bockstaele, E. J. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.011 · Cited by 142 · see citing works
Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders
Hammack, S. E., Cooper, M. A., & Lezak, K. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.024 · Cited by 142 · see citing works
Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin‐releasing hormone receptor‐dependent mechanism
Linthorst, A. C. E., Peñalva, R. G., Flachskamm, C., Holsboer, F., & Reul, J. M. H. M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02400.x · Cited by 142 · see citing works
The consequences of uncontrollable stress are sensitive to duration of prior wheel running
Greenwood, B. N., Foley, T. E., Burhans, D., Maier, S. F., & Fleshner, M. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.037 · Cited by 141 · see citing works
Causes and Consequences of Stress
Greenberg, N. L. (2002) · Integrative and Comparative Biology · doi:10.1093/icb/42.3.508 · Cited by 140 · see citing works
Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?
Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139 · see citing works
Corticotropin-releasing factor in the dorsal raphe nucleus: Linking stress coping and addiction
Valentino, R. J., Lucki, I., & Bockstaele, E. V. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.100 · Cited by 135 · see citing works
Brain serotonin receptors and transporters: initiation vs. termination of escalated aggression
Takahashi, A., Quadros, I. M., de Almeida, R. M. M., & Miczek, K. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2000-y · Cited by 135 · see citing works
Does Serotonin Influence Aggression? Comparing Regional Activity before and during Social Interaction
Summers, C. H., Korzan, W. J., Lukkes, J. L., Watt, M. J., Forster, G. L., Øverli, Ø., Höglund, E., Larson, E. T., Ronan, P. J., Matter, J. M., et al. (2005) · Physiological and Biochemical Zoology · doi:10.1086/432139 · Cited by 133 · see citing works
Chemical Lesion of the Bed Nucleus of the Stria Terminalis Blocks the Behavioral Consequences of Uncontrollable Stress.
Hammack, S. E., Richey, K. J., Watkins, L. R., & Maier, S. F. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.443 · Cited by 130 · see citing works
The Role of Corticotropin-Releasing Factor in the Median Raphe Nucleus in Relapse to Alcohol
Lê, A. D., Harding, S., Juzytsch, W., Fletcher, P. J., & Shaham, Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07844.2002 · Cited by 130 · see citing works
Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens
Lukkes, J. L., Forster, G. L., Renner, K. J., & Summers, C. H. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.024 · Cited by 126 · see citing works
Brain Monoaminergic Activity in Rainbow Trout Selected for High and Low Stress Responsiveness
Øverli, Ø., Pottinger, T. G., Carrick, T. R., Øverli, E., & Winberg, S. (2001) · Brain Behavior and Evolution · doi:10.1159/000047238 · Cited by 126 · see citing works
Reciprocal connections between subdivisions of the dorsal raphe and the nuclear core of the locus coeruleus in the rat
Kim, M., Lee, H. S., Lee, B. Y., & Waterhouse, B. D. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.022 · Cited by 126 · see citing works
Selective Activation of Corticotropin-Releasing Factor-2 Receptors on Neurochemically Identified Neurons in the Rat Dorsal Raphe Nucleus Reveals Dual Actions
Pernar, L. I. M., Curtis, A. L., Vale, W., Rivier, J., & Valentino, R. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2885-03.2004 · Cited by 124 · see citing works
Corticotropin-Releasing Factor Receptors CRF1and CRF2Exert Both Additive and Opposing Influences on Defensive Startle Behavior
Risbrough, V. B., Hauger, R. L., Roberts, A. L., Vale, W., & Geyer, M. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5760-03.2004 · Cited by 123 · see citing works
From here to paternity: Neural correlates of the onset of paternal behavior in California mice (Peromyscus californicus)
A, T. R. D. J., Miyetani Chauke, A., Harris, B. N., & Wendy Saltzman, A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.05.001 · Cited by 123 · see citing works
Evidence for regional heterogeneity in corticotropin‐releasing factor interactions in the dorsal raphe nucleus
Valentino, R. J., Liouterman, L., & Bockstaele, E. J. V. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1043 · Cited by 122 · see citing works
Behavioral and Pharmacogenetics of Aggressive Behavior
Takahashi, A., Quadros, I. M., de Almeida, R. M. M., & Miczek, K. A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_191 · Cited by 120 · see citing works
Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala
Amat, J., Tamblyn, J. P., Paul, E. D., Bland, S. T., Amat, P., Foster, A. C., Watkins, L. R., & Maier, S. F. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.052 · Cited by 119 · see citing works
Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swimming
Price, M. L., Kirby, L. G., Valentino, R. J., & Lucki, I. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1114-2 · Cited by 115 · see citing works
Localization of corticotropin‐releasing factor, urotensin I, and CRF‐binding protein gene expression in the brain of the zebrafish, Danio rerio
Alderman, S. L., & Bernier, N. J. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21332 · Cited by 115 · see citing works
Corticotropin-Releasing Factor and Acute Stress Prolongs Serotonergic Regulation of GABA Transmission in Prefrontal Cortical Pyramidal Neurons
Tan, H., Zhong, P., & Yan, Z. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0143-04.2004 · Cited by 112 · see citing works
Puberty, hormones, and sex differences in alcohol abuse and dependence
Witt, E. D. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.10.013 · Cited by 112 · see citing works
Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect
Shishkina, G. T., Kalinina, T. S., & Дыгало, Н. Н. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.017 · Cited by 111 · see citing works
Serotonin and the Neuroendocrine Regulation of the Hypothalamic–Pituitary–Adrenal Axis in Health and Disease
Sullivan, N. R., & de Kar, L. D. V. (2003) · Vitamins and hormones · doi:10.1016/s0083-6729(03)01006-9 · Cited by 106 · see citing works
The response of neurons in the bed nucleus of the stria terminalis to serotonin: Implications for anxiety
Hammack, S. E., Guo, J.-D., Hazra, R., Dabrowska, J., Myers, K. M., & Rainnie, D. G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.05.013 · Cited by 103 · see citing works
“The source of DRN CRF is currently unknown; however, multiple studies have shown that DRN 5-HT neurons respond to CRF (Kirby et al., 2000; Lowry et al., 2000; Price et al.,1998; Price and Lucki, 2001), andhave suggested that the source of raphe CRFmaycome from CRF-rich regions like the BNST (see…”
BackgroundInfluential
Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: Relevance for neuropharmacological therapy
Lechín, F., van der Dijs, B., & Hernández-Adrián, G. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.11.025 · Cited by 101 · see citing works
Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system in relation to fear behavior
Forster, G. L., Feng, N., Watt, M. J., Korzan, W. J., Mouw, N. J., Summers, C. H., & Renner, K. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.006 · Cited by 99 · see citing works
A Functional Subset of Serotonergic Neurons in the Rat Ventrolateral Periaqueductal Gray Implicated in the Inhibition of Sympathoexcitation and Panic
Johnson, P. L., Lightman, S. L., & Lowry, C. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.006 · Cited by 98 · see citing works
Self-citation
Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring
Martinez, E. J., Kolb, B., Bell, A., Savage, D. D., & Allan, A. M. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.05.004 · Cited by 94 · see citing works
Serotonin transporter gene, stress and raphe–raphe interactions: a molecular mechanism of depression
Jasinska, A. J., Lowry, C. A., & Burmeister, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.001 · Cited by 92 · see citing works
Self-citation
Acute and chronic effects of corticosterone on 5-HT1A receptor-mediated autoinhibition in the rat dorsal raphe nucleus
Fairchild, G. F. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00269-7 · Cited by 88 · see citing works
Early life adversity programs changes in central 5‐HT neuronal function in adulthood
Gartside, S. E., Johnson, D. A., Leitch, M. M., Troakes, C., & Ingram, C. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02668.x · Cited by 88 · see citing works
Self-citation
Effects of acute treadmill running at different intensities on activities of serotonin and corticotropin-releasing factor neurons, and anxiety- and depressive-like behaviors in rats
Otsuka, T., Nishii, A., Amemiya, S., Kubota, N., Nishijima, T., & Kita, I. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.055 · Cited by 86 · see citing works
Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways
Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13140 · Cited by 85 · see citing works
Differential monoaminergic, neuroendocrine and behavioural responses after central administration of corticotropin‐releasing factor receptor type 1 and type 2 agonists
de Groote, L., Peñalva, R. G., Flachskamm, C., Reul, J. M. H. M., & Linthorst, A. C. E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03164.x · Cited by 84 · see citing works
Sex Differences in Corticotropin-Releasing Factor Receptor-1 Action Within the Dorsal Raphe Nucleus in Stress Responsivity
Howerton, A. R., Roland, A. V., Fluharty, J. M., Marshall, A., Chen, A., Daniels, D., Beck, S. G., & Bale, T. L. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.013 · Cited by 80 · see citing works
The Deakin/Graeff hypothesis: Focus on serotonergic inhibition of panic
Paul, E. D., Johnson, P. L., Shekhar, A., & Lowry, C. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.010 · Cited by 78 · see citing works
Self-citation
Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus
Staub, D. R., Spiga, F., & Lowry, C. A. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.080 · Cited by 77 · see citing works
Self-citation
Organization of projections from the raphe nuclei to the vestibular nuclei in rats
Halberstadt, A. L., & Balaban, C. D. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00952-1 · Cited by 77 · see citing works
Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei
Chamas, F., Underwood, M. D., Arango, V., Serova, L. I., Kassir, S. A., Mann, J. J., & Sabban, E. L. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00788-1 · Cited by 77 · see citing works
Corticotropin releasing factor induces anxiogenic locomotion in trout and alters serotonergic and dopaminergic activity
Carpenter, R. E., Watt, M. J., Forster, G. L., Øverli, Ø., Bockholt, C., Renner, K. J., & Summers, C. H. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.07.012 · Cited by 74 · see citing works
Evidence supporting a role for corticotropin-releasing factor type 2 (CRF2) receptors in the regulation of subpopulations of serotonergic neurons
Staub, D. R., Evans, A. K., & Lowry, C. A. (2006) · Brain Research · doi:10.1016/j.brainres.2005.10.096 · Cited by 74 · see citing works
Self-citation
Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain
Kőrösi, A., Veening, J. G., Kozicz, T., Henckens, M. J. A. G., Dederen, J., Groenink, L., van der Gugten, J., Olivier, B., & Roubos, E. W. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.034 · Cited by 72 · see citing works
Appetitive and Aversive Information Coding in the Primate Dorsal Raphé Nucleus
Hayashi, K., Nakao, K., & Nakamura, K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2860-14.2015 · Cited by 71 · see citing works
Modulation of Neuronal Excitability by Serotonin-NMDA Interactions in Prefrontal Cortex
Zhong, P., Yuen, E. Y., & Yan, Z. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.03.003 · Cited by 71 · see citing works
GABAergic modulation of serotonergic neurons in the dorsal raphe nucleus
Hernández-Vázquez, F., Garduño, J., & Hernández‐López, S. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0014 · Cited by 71 · see citing works
Serotonergic Plasticity in the Dorsal Raphe Nucleus Characterizes Susceptibility and Resilience to Anhedonia
Prakash, N., Stark, C. J., Keisler, M. N., Luo, L., Der‐Avakian, A., & Dulcis, D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1802-19.2019 · Cited by 70 · see citing works
Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice
Peñalva, R. G., Flachskamm, C., Zimmermann, S., Wurst, W., Holsboer, F., Reul, J. M. H. M., & Linthorst, A. C. E. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00475-4 · Cited by 70 · see citing works
Quantitative mapping of tryptophan hydroxylase‐2, 5‐HT1A, 5‐HT1B, and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei
Clark, M. S., McDevitt, R. A., & Neumaier, J. F. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21073 · Cited by 68 · see citing works
Bi-directional modulation of bed nucleus of stria terminalis neurons by 5-HT: molecular expression and functional properties of excitatory 5-HT receptor subtypes
Guo, J.-D., Hammack, S. E., Hazra, R., Levita, L., & Rainnie, D. G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.028 · Cited by 67 · see citing works
Altered Serotonergic Neurotransmission but Normal Hypothalamic–Pituitary–Adrenocortical Axis Activity in Mice Chronically Treated with the Corticotropin-Releasing Hormone Receptor Type 1 Antagonist NBI 30775
Oshima, A., Flachskamm, C., Reul, J. M. H. M., Holsboer, F., & Linthorst, A. C. E. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300267 · Cited by 67 · see citing works
Pharmacology and Biology of Corticotropin-Releasing Factor (CRF) Receptors
Eckart, K., Jahn, O., Radulović, J., Radulović, M., Blank, T., Stiedl, O., Brauns, O., Tezval, H., Zeyda, T., & Spiess, J. (2002) · Receptors and Channels · doi:10.1080/10606820213678 · Cited by 67 · see citing works
Reduced 5-HT1A- and GABABReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats
Cornelisse, L. N., van der Harst, J. E., Lodder, J. C., Baarendse, P. J. J., Timmerman, A., Mansvelder, H. D., Spruijt, B. M., & Brussaard, A. B. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00109.2007 · Cited by 66 · see citing works
Ultrastructural evidence for a role of γ‐aminobutyric acid in mediating the effects of corticotropin‐releasing factor on the rat dorsal raphe serotonin system
Waselus, M., Valentino, R. J., & Bockstaele, E. J. V. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20360 · Cited by 63 · see citing works
Investigation of a central nucleus of the amygdala/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle
Spannuth, B. M., Hale, M. W., Evans, A. K., Lukkes, J. L., Campeau, S., & Lowry, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.042 · Cited by 62 · see citing works
Self-citation
Effect of delta-9-tetrahydrocannabinol on behavioral despair and on pre- and postsynaptic serotonergic transmission
Bambico, F. R., Hattan, P. R., Garant, J.-P., & Gobbi, G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.006 · Cited by 61 · see citing works
Rapid Changes in Monoamine Levels Following Administration of Corticotropin-Releasing Factor or Corticosterone Are Localized in the Dorsomedial Hypothalamus
Lowry, C. A., Burke, K. A., Renner, K. J., Moore, F. L., & Orchinik, M. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1646 · Cited by 61 · see citing works
Self-citation
Activation of Raphe Efferents to the Medial Prefrontal Cortex by Corticotropin-Releasing Factor: Correlation with Anxiety-Like Behavior
Meloni, E. G., Reedy, C. L., Cohen, B. M., & Carlezon, W. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.016 · Cited by 60 · see citing works
CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting
Kuperman, Y., Weiss, M., Dine, J., Staikin, K., Golani, O., Ramot, A., Nahum, T., Kühne, C., Shemesh, Y., Wurst, W., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.017 · Cited by 60 · see citing works
Aggressive encounters alter the activation of serotonergic neurons and the expression of 5-HT1A mRNA in the hamster dorsal raphe nucleus
Cooper, M. A., Grober, M. S., Nicholas, C. R., & Huhman, K. L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.084 · Cited by 60 · see citing works
Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress
Hammack, S. E., Pepin, J. L., DesMarteau, J. S., Watkins, L. R., & Maier, S. F. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00133-5 · Cited by 60 · see citing works
Differential galanin receptor‐1 and galanin expression by 5‐HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species‐dependent modulation of serotonin transmission
Larm, J. A., Shen, P., & Gundlach, A. L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02471.x · Cited by 59 · see citing works
Retrograde study of hypocretin-1 (orexin-A) projections to subdivisions of the dorsal raphe nucleus in the rat
Lee, H. S., Park, S. H., Song, W., & Waterhouse, B. D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.08.016 · Cited by 57 · see citing works
Increased expression of 5-HT1B receptor in dorsal raphe nucleus decreases fear-potentiated startle in a stress dependent manner
Clark, M. S., Vincow, E. S., Sexton, T. J., & Neumaier, J. F. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.070 · Cited by 56 · see citing works
Stress Upregulates TPH1 but not TPH2 mRNA in the Rat Dorsal Raphe Nucleus: Identification of Two TPH2 mRNA Splice Variants
Abumaria, N., Ribic, A., Anacker, C., Fuchs, E., & Flügge, G. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9259-5 · Cited by 56 · see citing works
Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices
Mlinar, B., Montalbano, A., Piszczek, Ł., Gross, C. T., & Corradetti, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00195 · Cited by 53 · see citing works
Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin-releasing factor gene promoter region in the adult rat brain
van der Doelen, R. H. A., Arnoldussen, I. A. C., Ghareh, H., van Och, L., Homberg, J. R., & Kozicz, T. (2015) · Development and Psychopathology · doi:10.1017/s0954579414001345 · Cited by 53 · see citing works
Evidence that acute serotonergic activation potentiates the locomotor-stimulating effects of corticotropin-releasing hormone in juvenile chinook salmon (Oncorhynchus tshawytscha)☆1Supported cooperatively by the U.S.G.S., Oregon State University, and the Oregon Department of Fish and Wildlife.
Clements, S., Moore, F. L., & Schreck, C. B. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00027-2 · Cited by 51 · see citing works
Corticotropin-Releasing Factor, Corticosteroids, Stress, and Sugar
Dallman, M. F., Viau, V., Bhatnagar, S., Gómez-Oliver, F., Laugero, K. D., & Bell, M. E. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50011-1 · Cited by 51 · see citing works
Dissecting the genetic effect of the CRH system on anxiety and stress-related behaviour
Deussing, J. M., & Wurst, W. (2005) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2005.01.001 · Cited by 49 · see citing works
CRF and urotensin I effects on aggression and anxiety-like behavior in rainbow trout
Bäckström, T., Pettersson, A., Johansson, V., & Winberg, S. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.045070 · Cited by 46 · see citing works
Failure to Mount Adaptive Responses to Stress Results in Dysregulation and Cell Death in the Midbrain Raphe
McEuen, J. G., Beck, S. G., & Bale, T. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0004-08.2008 · Cited by 45 · see citing works

Effects of Corticotropin-Releasing Factor on Brain Serotonergic Activity
M Price, B. A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00197-8 · Cited by 226 · see citing works
Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens
Lukkes, J. L., Forster, G. L., Renner, K. J., & Summers, C. H. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.024 · Cited by 126 · see citing works
Corticotropin‐releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity
Forster, G. L., Pringle, R. B., Mouw, N. J., Vuong, S. M., Watt, M. J., Burke, A. R., Lowry, C. A., Summers, C. H., & Renner, K. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06333.x · Cited by 125 · see citing works
Self-citation
Monoaminergic Activity in Subregions of Raphé Nuclei Elicited by Prior Stress and the Neuropeptide Corticotropin‐Releasing Factor
Summers, C. H., Kampshoff, J. L., Ronan, P. J., Lowry, C. A., Prestbo, A., Korzan, W. J., & Renner, K. J. (2003) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2003.01108.x · Cited by 36 · see citing works
Self-citation
Corticotropin-releasing factor in the dorsal raphe nucleus regulates activity of lateral septal neurons
Thomas, E., Pernar, L. I. M., Lucki, I., & Valentino, R. J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03882-9 · Cited by 43 · see citing works

Authors: Lowry, C. A., Rodda, J. E., Lightman, S. L., & Ingram, C. D.
Affiliations: University of Bristol (GB)
ORCID: Lowry, Christopher A.
Rodda, Joanne E.
Lightman, Stafford L.
Ingram, Colin D.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2000-10-15
Volume: 20
Issue: 20
Pages: 7728-7736
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.20-20-07728.2000
PMC: PMC6772886
OpenAlex: W2109594449
Cited by: 211
References: 113
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 8
FWCI: 5.00
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Wellcome Trust (045843/Z/95/Z)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: corticotropin-releasing factor, dorsal raphe nucleus, serotonergic neurons, neuronal firing rate, CRF receptor antagonists, tryptophan hydroxylase, stress, isolation stress, restraint stress, topographic organization
MeSH terms: Action Potentials, Animals, Axons, Calcium, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Immunohistochemistry, Male, Microelectrodes, Synaptic Transmission, Neurons, Raphe Nuclei, Reaction Time, Restraint, Physical, Serotonin, Stress, Physiological, Tryptophan Hydroxylase, Rats, Wistar, Serotonin Receptor Agonists, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Corticotropin-Releasing Factor Increases In Vitro Firing Rates of Serotonergic Neurons in the Rat Dorsal Raphe Nucleus: Evidence for Activation of a Topographically Organized Mesolimbocortical Serotonergic System

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks