The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease
Abstract
Levels of iron, copper, zinc, manganese, and lead were measured by inductively coupled plasma spectroscopy in parkinsonian and age-matched control brain tissue. There was 31-35% increase in the total iron content of the parkinsonian substantia nigra when compared to control tissue. In contrast, in the globus pallidus total iron levels were decreased by 29% in Parkinson's disease. There was no change in the total iron levels in any other region of the parkinsonian brain. Total copper levels were reduced by 34-45% in the substantia nigra in Parkinson's disease; no difference was found in the other brain areas examined. Zinc levels were increased in substantia nigra in Parkinson's disease by 50-54%, and the zinc content of the caudate nucleus and lateral putamen was also raised by 18-35%. Levels of manganese and lead were unchanged in all areas of the parkinsonian brain studied when compared to control brains, except for a small decrease (20%) in manganese content of the medial putamen. Increased levels of total iron in the substantia nigra may cause the excessive formation of toxic oxygen radicals, leading to dopamine cell death.
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In the citing paper
“Increases of iron and a decrease of ferritin in the substantia nigra101,116–119 are indicative of high iron loading of ferritin.120”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [101]
In the citing paper
“Neuropathological studies that used accurate spectroscopic methods to measure total iron concentrations in specific brain regions, such as substantia nigra pars compacta and reticulata showed that iron concentrations in these regions increase with disease severity.100–103”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [101]
In the citing paper
“Several studies have shown increases of total iron concentration in the substantia nigra of patients with Parkinson’s disease.”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [101]
In the citing paper
“In the temporal cortex and globus pallidus of patients with Parkinson’s disease, a decrease of total iron concentration was detected by inductively coupled plasma mass spectrometry.101,117,130”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [101]
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Metadata
- Authors
- Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D.
- Affiliations
- King's College London (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Inserm (FR)
- Corresponding author
- Jenner, P.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1989-06
- Volume
- 52
- Issue
- 6
- Pages
- 1830-1836
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1985613988
- Cited by
- 1,149
- References
- 29
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 31 · 2023: 32 · 2022: 46 · 2021: 42 · 2020: 35 · 2019: 33 · 2018: 35 · 2017: 41 · 2016: 45 · 2015: 21 · 2014: 37 · 2013: 45 · 2012: 41
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- Parkinson's disease, substantia nigra, iron, copper, zinc, manganese, lead, globus pallidus, caudate nucleus, putamen, oxidative stress, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Brain, Female, Humans, Ions, Iron, Male, Metals, Parkinson Disease, Substantia Nigra, Tissue Distribution
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