Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

Progressive Supranuclear Palsy

Steele, J. C. (1964) · Archives of Neurology · doi:10.1001/archneur.1964.00460160003001 · Cited by 1,930 · see citing works

The effect of age on the non-haemin iron in the human brain

Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427 · see citing works

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

Dexter, D. T., Carter, C. J., Wells, F. R., Javoy-Agid, F., Agid, Y., Lees, A. J., Jenner, P. G., & MARSDEN, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09133.x · Cited by 1,397 · see citing works

Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains

Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383 · see citing works

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · see citing works

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149 · see citing works

Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

GRAHAM, D. G. (1978) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13535-9 · Cited by 1,126 · see citing works

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

Sofic, E., Riederer, P. F., Heinsen, H., Beckmann, H., Reynolds, G. P., Hebenstreit, G. F., & Youdim, M. B. H. (1988) · Journal of Neural Transmission · doi:10.1007/bf01244786 · Cited by 754 · see citing works

Biochemistry: The Molecular Basis of Cell Structure and Function

Lehninger, A. L. (1970) · Cited by 608 · see citing works

ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE

Candy, J., Klinowski, J., Perry, R. H., Perry, E. K., FAIRBAIRN, A. F., Oakley, A. E., Carpenter, T. A., Atack, J. R., Blessed, G., & Edwardson, J. A. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92319-6 · Cited by 450 · see citing works

Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients

Perry, T. L., & Yong, V. W. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90320-4 · Cited by 362 · see citing works

Manganese and extrapyramidal disorders (a critical review and tribute to Dr. George C. Cotzias).

Barbeau, A. (1984) · PubMed · Cited by 303 · see citing works

Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

Youdim, M. B. H., Ben‐Shachar, D., & Riederer, P. F. (1989) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1989.tb01782.x · Cited by 292 · see citing works

Decreased ferritin levels in brain in Parkinson's disease

Dexter, D. T., Carayon, A., Vidailhet, M., Ruberg, M., Agid, F., Agid, Y., Lees, A. J., Wells, F. R., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08814.x · Cited by 258 · see citing works

Iron and free radical reactions: two aspects of antioxidant protection

Halliwell, B. B., & Gutteridge, J. M. C. (1986) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(86)90207-0 · Cited by 249 · see citing works

Studies on Parkinson's Disease Including X-Ray Fluorescent Spectroscopy of Formalin Fixed Brain Tissue

Earle, K. M. (1968) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196801000-00001 · Cited by 227 · see citing works

Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in parkinson's disease: An in situ hybridization study

Javoy-Agid, F., Hirsch, É. C., Dumas, S., Duyckaerts, C. J., Mallet, J. J., & Agid, Y. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90389-l · Cited by 146 · see citing works

ALUMINIUM, CHEMICAL PHYSIOLOGY, AND ALZHEIMER'S DISEASE

Birchall, J. D., & Chappell, J. S. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90754-4 · Cited by 143 · see citing works

Reaction of Lewy bodies with antibodies to phosphorylated and non-phosphorylated neurofilaments

Forno, L. S., Sternberger, L. A., Sternberger, N. H., Strefling, A. M., Swanson, K., & Eng, L. F. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90337-x · Cited by 130 · see citing works

The Incorporation of Various Metal Ions into in Vivo- and in Vitro-Produced Melanin

Bruenger, F. W., Stover, B. J., & Atherton, D. R. (1967) · Radiation Research · doi:10.2307/3572300 · Cited by 83 · see citing works

Progressive supranuclear palsy

Jellinger, K. A. (1971) · Acta Neuropathologica · doi:10.1007/bf00692156 · Cited by 78 · see citing works

Electron microprobe ultrastructural localization of aluminum in rat brain

Galle, P., Berry, J., & Duckett, S. W. (1980) · Acta Neuropathologica · doi:10.1007/bf00707114 · Cited by 43 · see citing works

The Iron, Copper and Manganese Content of the Human Brain

Tingey, A. H. (1937) · Journal of Mental Science · doi:10.1192/bjp.83.345.452 · Cited by 43 · see citing works

The pathophysiology of trace metal: neurotransmitter interaction in the CNS

Donaldson, J. (1981) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(81)90269-8 · Cited by 25 · see citing works

La microscopie ionique analytique des tissus biologiques

Galle, P. R. (1985) · Annales de Physique · doi:10.1051/anphys:01985001004028700 · Cited by 23 · see citing works

Element analysis of lewy and adrenal bodies in Parkinson's disease by electron probe microanalysis

Kimula, Y., Utsuyama, M., Yoshimura, M., et al. (1983) · Acta Neuropathologica · doi:10.1007/bf00703209 · Cited by 22 · see citing works

monoclonal antibodies raised against Lewy bodies in brains from subjects with Parkinson's disease

Hirsch, É. C., Ruberg, M., Dardenne, M., et al. (1985) · Brain Research · doi:10.1016/0006-8993(85)91020-0 · Cited by 14 · see citing works

Cytosiderosis and iron deposits in ventrolateral nucleus of the thalamus in Parkinson's disease. Clinical and experimental study.

Asenjo, A. (1968) · PubMed · Cited by 6 · see citing works

Reactive Oxygen Species and the Central Nervous System

Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947 · see citing works

Oxidative stress in Parkinson's disease

Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053 · see citing works

The role of iron in brain ageing and neurodegenerative disorders

Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works

Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein

Uversky, V. N., Li, J., & Fink, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105343200 · Cited by 1,103 · see citing works

Nitric oxide synthase and neuronal vulnerability in parkinson's disease

Hunot, S., Boissière, F., Faucheux, B., Brugg, B., Mouatt-Prigent, A., Agid, Y., & Hirsch, E. C. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00578-1 · Cited by 595 · see citing works

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

Good, P. F., Olanow, C. W., & Perl, D. P. (1992) · Brain Research · doi:10.1016/0006-8993(92)91334-b · Cited by 427 · see citing works

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

Salazar, J., Mena, N., Hunot, S., Prigent, A., Alvarez-Fischer, D., Arredondo, M., Duyckaerts, C., Sazdovitch, V., Zhao, L., Garrick, L. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804373105 · Cited by 409 · see citing works

An introduction to the free radical hypothesis in Parkinson's disease

Olanow, C. W. (1992) · Annals of Neurology · doi:10.1002/ana.410320703 · Cited by 382 · see citing works

Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

Scott, L. E., & Orvig, C. (2009) · Chemical Reviews · doi:10.1021/cr9000176 · Cited by 332 · see citing works

A Novel Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin Is Expressed by Mammalian Astrocytes

Patel, B. N., & David, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20185 · Cited by 327 · see citing works

Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis

Jellinger, K., Kienzl, E., Rumpelmair, G., Riederer, P., Stachelberger, H., Ben‐Shachar, D., & Youdim, M. B. H. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08362.x · Cited by 313 · see citing works

Sequestration of iron by Lewy bodies in Parkinson's disease

Castellani, R. J., Siedlak, S. L., Perry, G., & Smith, M. A. (2000) · Acta Neuropathologica · doi:10.1007/s004010050001 · Cited by 265 · see citing works

Ironing Iron Out in Parkinson's Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6‐Hydroxydopamine and Iron Chelators, Desferal and VK‐28

YOUDIM, M. B. H., STEPHENSON, G., & SHACHAR, D. B. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.025 · Cited by 233 · see citing works

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration

Andersen, H. H., Johnsen, K. B., & Moos, T. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1509-8 · Cited by 151 · see citing works

Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease

Faucheux, B. A., Martin, M., Beaumont, C., Hunot, S., Hauw, J., Agid, Y., & Hirsch, E. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01118.x · Cited by 116 · see citing works

Role of brain iron accumulation in cognitive dysfunction: evidence from animal models and human studies

Schröder, N., Figueiredo, L. S., & de Lima, M. N. M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121996 · Cited by 113 · see citing works

Iron Accumulation During Cellular Senescence in Human Fibroblasts <i>In Vitro</i>

Killilea, D. W., Atamna, H., Liao, C., & Ames, B. N. (2003) · Antioxidants &amp; Redox Signaling · doi:10.1089/152308603770310158 · Cited by 92 · see citing works

Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection

da Silva, V. K., de Freitas, B. S., da Silva Dornelles, A., Nery, L. R., Falavigna, L., Ferreira, R. D. P., Bogo, M. R., Hallak, J. E. C., Zuardi, A. W., Crippa, J. A. S., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8514-7 · Cited by 91 · see citing works

Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

Vasquez, V., Mitra, J., Hegde, P. M., Pandey, A., Sengupta, S., Mitra, S., Rao, K. S., & Hegde, M. L. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170342 · Cited by 88 · see citing works

Dose- and time-dependent α-synuclein aggregation induced by ferric iron in SK-N-SH cells

Li, W.-J., Jiang, H., Song, N., & Xie, J.-X. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-1117-7 · Cited by 41 · see citing works

Neuromelanin of the Human Substantia Nigra: An Update

Zucca, F. A., Basso, E., Cupaioli, F. A., Ferrari, E., Sulzer, D., Casella, L., & Zecca, L. (2014) · Neurotoxicity Research · doi:10.1007/s12640-013-9435-y · Cited by 243 · see citing works

Residual substantia nigra neuromelanin in Parkinson’s disease is cross-linked to α-synuclein

Fasano, M., Giraudo, S., Coha, S., Bergamasco, B., & Lopiano, L. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(02)00161-4 · Cited by 70 · see citing works

Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease

Faucheux, B. A., Martin, M., Beaumont, C., Hauw, J., Agid, Y., & Hirsch, E. C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01923.x · Cited by 229 · see citing works

Iron, Neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

Zecca, L., Gallorini, M., Schünemann, V., Trautwein, A. X., Gerlach, M., Riederer, P., Vezzoni, P., & Tampellini, D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00186.x · Cited by 401 · see citing works

Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease

Sasaki, M., Shibata, E., Tohyama, K., Takahashi, J., Otsuka, K., Tsuchiya, K., Takahashi, S., Ehara, S., Terayama, Y., & Sakai, A. (2006) · Neuroreport · doi:10.1097/01.wnr.0000227984.84927.a7 · Cited by 496 · see citing works