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N‐Methyl‐d‐Aspartate‐Sensitive Glutamate Receptors Induce Calcium‐Mediated Arachidonic Acid Release in Primary Cultures of Cerebellar Granule Cells

Lazarewicz, J. W., Wroblewski, J. T., Costa, E.·1990·Journal of Neurochemistry
DOI 10.1111/j.1471-4159.1990.tb05771.x
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Abstract

Abstract: In primary cultures of cerebellar granule cells, glutamate, aspartate, and N‐methyl‐d‐aspartate (NMDA) induced a dose‐dependent release of [3 H]arachidonic acid ([3 H]AA) which was selective for these agonists and was inhibited by NMDA receptor antagonists. The agonist‐induced [3 H]AA release was reduced by quinacrine at concentrations that inhibited phospholipase A 2 (PLA 2) but affected neither the activity of phospholipase C (PLC) nor the hydrolysis of phosphoinositides induced by glutamate or quisqualate. Thus, the increased formation of AA was due to the receptor‐mediated activation of PLA 2 rather than to the action of PLC followed by diacylglycerol lipase. The receptor‐mediated [3 H]AA release was dependent on the presence of extracellular Ca 2+ and was mimicked by the Ca 2+ ionophore ionomycin. Pretreatment of granule cells with either pertussis or cholera toxin failed to inhibit the receptor‐mediated [3 H]AA release. Hence, in cerebellar granule cells, the stimulation of NMDA‐sensitive glutamate receptors leads to the activation of PLA 2 that is mediated by Ca 2+ ions entering through the cationic channels functioning as effectors of NMDA receptors. A coupling through a toxin‐sensitive GTP‐binding protein can be excluded.

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Metadata

Authors
Lazarewicz, J. W., Wroblewski, J. T., & Costa, E.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1990-12
Volume
55
Issue
6
Pages
1875-1881
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1111/j.1471-4159.1990.tb05771.x
OpenAlex
W2018138199
Cited by
167
References
0
FWCI
3.69
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5787 d)

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CoChat. (2026). Citation check: N‐Methyl‐d‐Aspartate‐Sensitive Glutamate Receptors Induce Calcium‐Mediated Arachidonic Acid Release in Primary Cultures of Cerebellar Granule Cells. https://app.cochat.ai/papers/10.1111/j.1471-4159.1990.tb05771.x
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Lazarewicz, J. W., Wroblewski, J. T., & Costa, E. (1990). N‐Methyl‐d‐Aspartate‐Sensitive Glutamate Receptors Induce Calcium‐Mediated Arachidonic Acid Release in Primary Cultures of Cerebellar Granule Cells. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1990.tb05771.x

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