Brain‐derived neurotrophic factor facilitates TrkB down‐regulation and neuronal injury after status epilepticus in the rat hippocampus
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Brain‐derived neurotrophic factor (BDNF) is involved in many aspects of neuronal biology and hippocampal physiology. Status epilepticus (SE) is a condition in which prolonged seizures lead to neuronal degeneration. SE‐induced in rodents serves as a model of Temporal Lobe Epilepsy with hippocampal sclerosis, the most frequent epilepsy in humans. We have recently described a strong correlation between TrkB decrease and p75ntr increase with neuronal degeneration (Neuroscience 154:978, 2008). In this report, we report that local, acute intra‐hippocampal infusion of function‐blocking antibodies against BDNF prevented both early TrkB down‐regulation and neuronal degeneration after SE. Conversely, the infusion of recombinant human BDNF protein after SE greatly increased neuronal degeneration. The inhibition of BDNF mRNA translation by the infusion of antisense oligonucleotides induced a rapid decrease of BDNF protein levels, and a delayed increase. If seizures were induced at the time endogenous BDNF was decreased, SE‐induced neuronal damage was prevented. On the other hand, if seizures were induced at the time endogenous BDNF was increased, SE‐induced neuronal damage was exacerbated. These results indicate that under a pathological condition BDNF exacerbates neuronal injury.
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Seizures increase hippocampal and cortical BDNF protein levels in animal models of epilepsy.
“Seizures also increased hippocampal and cortical BDNF protein levels in animal model of epilepsy [181–183].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [181]
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- Ó 2009 The Authors Journal Compilation Ó 2009 International Society for Neurochemistry, J. Neurochem. (2009) 111, 428-440 BDNF increases neuronal injury after SE | 439 14714159, 2009, 2, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2009.06342.x by Readcube (Labtiva Inc.), Wiley Online Library on [23/06/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
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- Journal Compilation Ó 2009 International Society for Neurochemistry, J. Neurochem. (2009) 111, 428-440
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Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
- Authors
- Unsain, N., Montroull, L. E., & Mascó, D. H.
- Affiliations
- Universidad Nacional de Córdoba (AR)
- Corresponding author
- Mascó, Daniel Hugo
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2009-09-23
- Volume
- 111
- Issue
- 2
- Pages
- 428-440
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1974183565
- Cited by
- 32
- References
- 57
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Fondo para la Investigación Científica y Tecnológica (33106)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- brain-derived neurotrophic factor, TrkB receptor, status epilepticus, hippocampus, neuronal injury, p75 neurotrophin receptor, temporal lobe epilepsy, hippocampal sclerosis, neuroprotection, excitotoxicity
- MeSH terms
- Animals, Antibodies, Disease Models, Animal, Hippocampus, Humans, Male, Neurons, Pilocarpine, Protein Precursors, RNA, Messenger, Status Epilepticus, Down-Regulation, Cell Death, Rats, Wistar, Muscarinic Agonists, Brain-Derived Neurotrophic Factor, Oligoribonucleotides, Antisense, Receptor, trkB, Rats
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