Cited by 247Autism Spectrum Disorder ResearchMitochondrial Function and PathologyGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Brain region‐specific deficit in mitochondrial electron transport chain complexes in children with autism

Open access

Chauhan, Abha, Gu, Feng, Essa, Musthafa M., Wegiel, Jerzy, Kaur, Kulbir, Brown, William Ted, Chauhan, Ved·2011·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2011.07189.xPMC PMC4839269

Open this paper in CoChat — free account

Abstract

J. Neurochem. (2011) 117, 209–220. Mitochondria play important roles in generation of free radicals, ATP formation, and in apoptosis. We studied the levels of mitochondrial electron transport chain (ETC) complexes, that is, complexes I, II, III, IV, and V, in brain tissue samples from the cerebellum and the frontal, parietal, occipital, and temporal cortices of subjects with autism and age‐matched control subjects. The subjects were divided into two groups according to their ages: Group A (children, ages 4–10 years) and Group B (adults, ages 14–39 years). In Group A, we observed significantly lower levels of complexes III and V in the cerebellum (p < 0.05), of complex I in the frontal cortex (p < 0.05), and of complexes II (p < 0.01), III (p < 0.01), and V (p < 0.05) in the temporal cortex of children with autism as compared to age‐matched control subjects, while none of the five ETC complexes was affected in the parietal and occipital cortices in subjects with autism. In the cerebellum and temporal cortex, no overlap was observed in the levels of these ETC complexes between subjects with autism and control subjects. In the frontal cortex of Group A, a lower level of ETC complexes was observed in a subset of autism cases, that is, 60% (3/5) for complexes I, II, and V, and 40% (2/5) for complexes III and IV. A striking observation was that the levels of ETC complexes were similar in adult subjects with autism and control subjects (Group B). A significant increase in the levels of lipid hydroperoxides, an oxidative stress marker, was also observed in the cerebellum and temporal cortex in the children with autism. These results suggest that the expression of ETC complexes is decreased in the cerebellum and the frontal and temporal regions of the brain in children with autism, which may lead to abnormal energy metabolism and oxidative stress. The deficits observed in the levels of ETC complexes in children with autism may readjust to normal levels by adulthood.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1471-4159.2011.07189.x

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010
Mitochondrial Complex I Deficiency in Parkinson's Disease
Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283
MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE
Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757
Histoanatomic observations of the brain in early infantile autism
Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955
Neuroanatomic observations of the brain in autism: a review and future directions
Bauman, M. L., & Kemper, T. L. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.09.006 · Cited by 919
Prevalence of Autism Spectrum Disorders --- Autism and Developmental Disabilities Monitoring Network, United States, 2006
Rice, C. E. (2009) · PsycEXTRA Dataset · doi:10.1037/e562722010-001 · Cited by 762
Mitochondrial defect in Huntington's disease caudate nucleus
Gu, M., Gash, M. T., Mann, V. M., Javoy‐Agid, F., Cooper, J. M., & Schapira, A. H. V. (1996) · Annals of Neurology · doi:10.1002/ana.410390317 · Cited by 758
Oxidative stress in autism
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656
Self-citation
Energetic basis of brain activity: implications for neuroimaging
Shulman, R. G., Rothman, D. L., Behar, K. L., & Hyder, F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.005 · Cited by 590

Show all 88 references

Research works printed but not linked: 1

Muthaiyah B., 2009, Increased lipid peroxidation in cerebellum and temporal cortex of brain in autism, J. Neurochem., 108

Sorted by citations

Items 101–200 of 247

The BOLD signal and neurovascular coupling in autism
Reynell, C., & Harris, J. J. (2013) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.07.003 · Cited by 41
Gestational Exposure to a Viral Mimetic Poly(I:C) Results in Long-Lasting Changes in Mitochondrial Function by Leucocytes in the Adult Offspring
Giulivi, C., Napoli, E., Schwartzer, J. J., Careaga, M., & Ashwood, P. (2013) · Mediators of Inflammation · doi:10.1155/2013/609602 · Cited by 36
Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum
Blaylock, R. L., Strunecká, A., Patočka, J., & Strunecký, O. (2018) · Surgical Neurology International · doi:10.4103/sni.sni_407_17 · Cited by 36
The variation game: Cracking complex genetic disorders with NGS and omics data
Cui, H., Dhroso, A., Johnson, N. T., & Korkin, D. (2015) · Methods · doi:10.1016/j.ymeth.2015.04.018 · Cited by 36
Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder
Nakhal, M. M., Aburuz, S., Sadek, B. S., & Akour, A. A. (2022) · Molecules · doi:10.3390/molecules27217174 · Cited by 33
Lower Availability of Mitochondrial Complex I in Anterior Cingulate Cortex in Autism: A Positron Emission Tomography Study
Kato, Y., Yokokura, M., Iwabuchi, T., Murayama, C., Harada, T., Goto, T., Tamayama, T., Kameno, Y., Wakuda, T., Kuwabara, H., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.22010014 · Cited by 32
Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity
El-Ansary, A. K., Bjørklund, G., Khemakhem, A. M., AL-Ayadhi, L. Y., Chirumbolo, S., & Bacha, A. G. B. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1091-5 · Cited by 31
Integrated RNA Sequencing Reveals Epigenetic Impacts of Diesel Particulate Matter Exposure in Human Cerebral Organoids
Bilinovich, S. M., Uhl, K. L., Lewis, K., Soehnlen, X., Williams, M. R., Vogt, D. L., Prokop, J. W., & Campbell, D. B. (2020) · Developmental Neuroscience · doi:10.1159/000513536 · Cited by 31
Exploring Dietary Interventions in Autism Spectrum Disorder
Pérez-Cabral, I. D., Bernal-Mercado, A. T., Islas-Rubio, A. R., Suárez-Jiménez, G. M., Robles-García, M. Á., Puebla-Duarte, A. L., & Del‐Toro‐Sánchez, C. L. (2024) · Foods · doi:10.3390/foods13183010 · Cited by 40
Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder
El-Ansary, A. K., Hassan, W. M., Daghestani, M. H., AL-Ayadhi, L. Y., & Bacha, A. G. B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227626 · Cited by 29
Retracted
Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes
Janickova, L., Rechberger, K. F., Wey, L., & Schwaller, B. (2020) · Molecular Autism · doi:10.1186/s13229-020-00323-8 · Cited by 30
Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala
Anderson, G., & Maes, M. H. J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120223757 · Cited by 31
Monoamine oxidase‐A and B activities in the cerebellum and frontal cortex of children and young adults with autism
Gu, F., Chauhan, V. P. S., & Chauhan, A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24027 · Cited by 29
Self-citation
Exploring sulforaphane as neurotherapeutic: targeting Nrf2-Keap & Nf-Kb pathway crosstalk in ASD
Shah, A., Varma, M., & Bhandari, R. (2023) · Metabolic brain disease · doi:10.1007/s11011-023-01224-4 · Cited by 28
Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives
Mehra, S., Ahsan, A. U., Seth, E., & Chopra, M. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02033-7 · Cited by 28
High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq
Simon, J. M., Paranjape, S. R., Wolter, J. M., Salazar, G., & Zylka, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-39016-5 · Cited by 24
Oxidative stress, metabolic and mitochondrial abnormalities associated with autism spectrum disorder
Thorsen, M. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.018 · Cited by 26
Autism and EMF? Plausibility of a pathophysiological link part II
Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.002 · Cited by 28
Disruption of circadian rhythm and risk of autism spectrum disorder: role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways
Abdul, F., Sreenivas, N., Kommu, J. V. S., Banerjee, M., Berk, M., Maes, M. H. J., Leboyer, M., & Debnath, M. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0022 · Cited by 26
Association of IMMP2L deletions with autism spectrum disorder: A trio family study and meta‐analysis
Zhang, Y., Liu, Y., Zarrei, M., Tong, W. W. L., Dong, R., Wang, Y., Zhang, H., Yang, X., MacDonald, J. R., Uddin, M. J., et al. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32608 · Cited by 26
Mitochondrial respiratory chain defects in autism and other neurodevelopmental disorders
Chauhan, A., Gu, F., & Chauhan, V. P. S. (2016) · Journal of Pediatric Biochemistry · doi:10.1055/s-0036-1586418 · Cited by 25
Self-citation
Therapeutic efficacy of Genistein in activation of neuronal AC/cAMP/CREB/PKA and mitochondrial ETC-Complex pathways in experimental model of autism: Evidence from CSF, blood plasma and brain analysis
Kumar, M., Mehan, S., Kumar, A., Sharma, T., Khan, Z., Tiwari, A., Gupta, G. D., & Narula, A. S. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149251 · Cited by 26
The tryptophan catabolite or kynurenine pathway in autism spectrum disorder; a systematic review and meta‐analysis
Almulla, A. F., Thipakorn, Y., Tunvirachaisakul, C., & Maes, M. H. J. (2023) · Autism Research · doi:10.1002/aur.3044 · Cited by 24
Mitochondrial bioenergetics and disease in Caenorhabditis elegans
Rabbitts, B. M. (2015) · Frontiers in bioscience · doi:10.2741/4305 · Cited by 26
Early-Life Exposure to 4‑Hydroxy-4′-Isopropoxydiphenylsulfone Induces Behavioral Deficits Associated with Autism Spectrum Disorders in Mice
Zhang, S., Zhou, Y., Shen, J., Wang, Y., Xia, J., Li, C., Liu, W., Hayat, K., & Qian, M. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c04760 · Cited by 21
A Combined Proteomics and Metabolomics Profiling to Investigate the Genetic Heterogeneity of Autistic Children
Shen, L., Zhang, H., Jing, L., Gao, Y. L., Liu, X., Chen, M., Khan, N. U., Tang, X., Hong, Q., Feng, C., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02801-x · Cited by 23
A Link between Mitochondrial Dysregulation and Idiopathic Autism Spectrum Disorder (ASD): Alterations in Mitochondrial Respiratory Capacity and Membrane Potential
Hassan, H., Zakaria, F., Makpol, S., & Karim, N. A. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030157 · Cited by 22
Efficacy and Safety of Q10 Ubiquinol With Vitamins B and E in Neurodevelopmental Disorders: A Retrospective Chart Review
Cucinotta, F., Ricciardello, A., Turriziani, L., Mancini, A., Keller, R., Sacco, R., & Persico, A. M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.829516 · Cited by 21
Treatment of Autism Spectrum Disorders by Mitochondrial-targeted Drug: Future of Neurological Diseases Therapeutics
Nabi, S. U., Rehman, M. U., Arafah, A. M., Taifa, S., Khan, I. S., Khan, A., Rashid, S., Jan, F., Wani, H. A., & Ahmad, S. F. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221121095618 · Cited by 22
Update on Atypicalities of Central Nervous System in Autism Spectrum Disorder
Shuid, A. N., Jayusman, P. A., Shuid, N., Ismail, J., Nor, N. K., & Mohamed, I. N. (2020) · Brain Sciences · doi:10.3390/brainsci10050309 · Cited by 23
The neurogenic basic helix-loop-helix transcription factor NeuroD6 enhances mitochondrial biogenesis and bioenergetics to confer tolerance of neuronal PC12-NeuroD6 cells to the mitochondrial stressor rotenone
Baxter, K. K., Uittenbogaard, M. N., & Chiaramello, A. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.07.004 · Cited by 20
Comparison of urinary oxidative biomarkers in Iranian children with autism
Ranjbar, A., Rashedi, V., & Rezaei, M. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.07.010 · Cited by 20
Testing the combined effects of probiotics and prebiotics against neurotoxic effects of propionic acid orally administered to rat pups
Suhaibani, A. A., Bacha, A. G. B., Alonazi, M. A., Bhat, R. S., & El-Ansary, A. K. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2418 · Cited by 19
An Investigation of the Dynamic Thiol/Disulfide Homeostasis, As a Novel Oxidative Stress Plasma Biomarker, in Children With Autism Spectrum Disorders
Efe, A., Neşeli̇oğlu, S., & Soykan, A. A. (2020) · Autism Research · doi:10.1002/aur.2436 · Cited by 18
Neuroinflammation, Energy and Sphingolipid Metabolism Biomarkers Are Revealed by Metabolic Modeling of Autistic Brains
Esvap, E., & Ülgen, K. Ö. (2023) · Biomedicines · doi:10.3390/biomedicines11020583 · Cited by 20
Metabolomic biomarkers in autism: identification of complex dysregulations of cellular bioenergetics
Smith, A. M., Donley, E. L. R., Ney, D. M., Amaral, D. G., Burrier, R. E., & Natowicz, M. R. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1249578 · Cited by 18
Gonadal Hormones Impart Male-Biased Behavioral Vulnerabilities to Immune Activation via Microglial Mitochondrial Function
Bordt, E. A., Moya, H., Jo, Y. C., Ravichandran, C. T., Bankowski, I. M., Ceasrine, A. M., McDougle, C. J., Carlezon, W. A., & Bilbo, S. D. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.010 · Cited by 21
Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure
Wong, S., & Giulivi, C. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160413122624 · Cited by 18
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders
Mehta, R., Kuhad, A., & Bhandari, R. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2100252 · Cited by 17
The need for a comprehensive molecular characterization of autism spectrum disorders
Broek, J. A. C., Brombacher, E., Stelzhammer, V., Guest, P. C., Rahmoune, H., & Bahn, S. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571300117x · Cited by 17
NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder
Vallese, A., Cordone, V., Ferrara, F., Guiotto, A., Gemmo, L., Cervellati, F., Hayek, J., Pecorelli, A., & Valacchi, G. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.297 · Cited by 16
Effects of methylmercury and alcohol exposure in Drosophila melanogaster: Potential risks in neurodevelopmental disorders
Chauhan, V. P. S., & Chauhan, A. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.04.010 · Cited by 16
Self-citation
In vivo magnetic resonance spectroscopy in the brain of Cdkl5 null mice reveals a metabolic profile indicative of mitochondrial dysfunctions
Carli, S., Chaabane, L., Butti, C., Palma, C. D., Aimar, P., Salio, C., Vignoli, A., Giustetto, M., Landsberger, N., & Frasca, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15300 · Cited by 17
Neonatal Rotenone Administration Induces Psychiatric Disorder-Like Behavior and Changes in Mitochondrial Biogenesis and Synaptic Proteins in Adulthood
Siena, A., Yuzawa, J. M. C., Ramos, A. C., Henrique, E., Brito, M. D., Calvazara, M. B., & Rosenstock, T. R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02317-w · Cited by 17
Reduced Activity of Protein Kinase C in the Frontal Cortex of Subjects with Regressive Autism: Relationship with Developmental Abnormalities
Ji, L., Chauhan, A., & Chauhan, V. P. S. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4742 · Cited by 16
Self-citation
Targeted Biomedical Treatment for Autism Spectrum Disorders
Pacheva, I. H., & Ivanov, I. S. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191205091312 · Cited by 17
Therapeutic effects of probiotics on neurotoxicity induced by clindamycin and propionic acid in juvenile hamsters
Al-Orf, N., El-Ansary, A. K., Bjørklund, G., Moubayed, N., Bhat, R. S., & Bacha, A. G. B. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0284-5 · Cited by 15
Developmental Stage-Dependent Changes in Mitochondrial Function in the Brain of Offspring Following Prenatal Maternal Immune Activation
Cieślik, M., Zawadzka, A., Czapski, G. A., Wilkaniec, A., & Adamczyk, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087243 · Cited by 15
Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model
Ling, W., Ren, Z., Wang, W., Lü, D., Zhou, Q., Liu, Q. S., & Jiang, G. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c00607 · Cited by 14
Association of NGF and Mitochondrial Respiration with Autism Spectrum Disorder
Gevezova, M., Minchev, D. S., Pacheva, I., Todorova, T., Yordanova, R. V., Timova, E., Ivanov, I. S., & Sarafian, V. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911917 · Cited by 15
Protective Effect of Nimodipine Against Valproic-acid Induced Biochemical and Behavioral Phenotypes of Autism
Kumar, H., Diwan, V., & Sharma, B. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.4.725 · Cited by 13
Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children
Gao, H., Ni, Y., Mo, X., Li, D., Teng, S., Huang, Q., Huang, S., Liu, G., Zhang, S., Tang, Y., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.06.046 · Cited by 13
Unveiling sex-based differences in developing propionic acid-induced features in mice as a rodent model of ASD
Kamalmaz, N., Bacha, A. G. B., Alonazi, M. A., Albasher, G. I., Khayyat, A. I. A., & El-Ansary, A. K. (2023) · PeerJ · doi:10.7717/peerj.15488 · Cited by 11
Exploring the potential of the ketogenic diet in autism spectrum disorder: metabolic, genetic, and therapeutic insights
Schrickel, A., Groeneweg, J., & Dekeyster, E. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-024-01518-1 · Cited by 11
The Inferior Colliculus in Alcoholism and Beyond
Bordia, T., & Zahr, N. M. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.606345 · Cited by 12
Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration
Čorejová, A., Fazekaš, T., Jánošíková, D., Repiský, J., Pospíšilová, V., Miková, M., Rauová, D., Ostatníková, D., Kyselovič, J., & Hrabovská, A. (2022) · Nutrients · doi:10.3390/nu14102035 · Cited by 14
The complex genetics in autism spectrum disorders
Hua, R., Wei, M., & Zhang, C. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4893-5 · Cited by 11
Developmental exposure to mercury chloride does not impair social behavior of C57BL/6 × BTBR F1mice
Zhang, Y., Bolivar, V. J., & Lawrence, D. A. (2012) · Journal of Immunotoxicology · doi:10.3109/1547691x.2012.682663 · Cited by 11
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Erdoğan, M. A., Türk, M., Doğanay, G. D., Sever, İ. H., Özkul, B., Söğüt, İ., Eroğlu, E., Uyanıkgil, Y., & Erbaş, O. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10089-4 · Cited by 10
Neuroprotective effect of PPAR gamma agonist in rat model of autism spectrum disorder: Role of Wnt/β-catenin pathway
Sandhu, A., Rawat, K., Gautam, V., Kumar, A., Sharma, A., Bhatia, A., Grover, S., Saini, L. K., & Saha, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111126 · Cited by 11
Autism Spectrum Disorders: The Mitochondria Connection
Wen, Y., & Yao, Y. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.autismspectrumdisorders.2021.mitochondria · Cited by 11
Comparative study on the protective effect of carnosine and carnitine against pro-inflammatory/pro-oxidant effects of clindamycin and propionic acid administrations to hamsters
Afaf, K. E. A., Bacha, A. G. B., Ghada, H. S., & Laila, Y. A. A. (2013) · African Journal of Microbiology Research · doi:10.5897/ajmr12.1178 · Cited by 10
The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism
Lima-Castañeda, L. Á., Bringas, M. E., Aguilar‐Hernández, L., Garcés‐Ramírez, L., Morales‐Medina, J. C., & Flores, G. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102317 · Cited by 10
The role and impact of abnormal vitamin levels in autism spectrum disorders
Cui, J., Zhai, Z., Wang, S., Song, X., Qiu, T., Yu, L., Zhai, Q., & Zhang, H. (2024) · Food & Function · doi:10.1039/d3fo03735e · Cited by 11
Substantial Problems with Measuring Brain Mitochondrial Dysfunction in Autism Spectrum Disorder Using Magnetic Resonance Spectroscopy
Rossignol, D. A., & Frye, R. E. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1276-z · Cited by 9
The effect of nutritional interventions reducing oxidative stress on behavioural and gastrointestinal problems in autism spectrum disorder
Çolak, H., Sarıyer, E. T., & Noğay, N. H. (2023) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10254 · Cited by 10
Seeing beyond words: Visualizing autism spectrum disorder biomarker insights
Xie, X., Zhou, R., Fang, Z., Zhang, Y., Wang, Q., & Liu, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30420 · Cited by 9
Comparison of Serum Neurofilament Light Chain and Tau Protein Levels in Cases with Autism Spectrum Disorder and Their Healthy Siblings and Healthy Controls
Öz, F., Kaya, İ., Tanır, Y., Küçükgergin, C., & Aydin, A. F. (2024) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.23.1153 · Cited by 7
An impaired glycolysis induces ATP deficiency and reduced cell respiration in stem cells of patients with autism spectrum disorders
Feron, F. P., Caillol, D., Fourel, L., Leimkühler, S., Iranzo, O., Gepner, B., & Guiraudie-Capraz, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-22327-1 · Cited by 7
Identification of Neurotransmission and Synaptic Biological Processes Disrupted in Autism Spectrum Disorder Using Interaction Networks and Community Detection Analysis
Vilela, J. E. R., Martiniano, H., Marques, A. R., Santos, J. X., Asif, M., Rasga, C., Oliveira, G., & Vicente, A. M. (2023) · Biomedicines · doi:10.3390/biomedicines11112971 · Cited by 7
Folate receptor alpha autoimmunity and cerebral folate deficiency in autism spectrum disorders
Rossignol, D. A., & Frye, R. E. (2016) · Journal of Pediatric Biochemistry · doi:10.3233/jpb-120067 · Cited by 7
Ameliorating effect of pioglitazone on prenatal valproic acid-induced behavioral and neurobiological abnormalities in autism spectrum disorder in rats
Sandhu, A., Rawat, K., Gautam, V., Bhatia, A., Grover, S., Saini, L. K., & Saha, L. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173721 · Cited by 7
Increased Vulnerability to Oxidative Stress and Mitochondrial Dysfunction in Autism
Chauhan, A., & Chauhan, V. P. S. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_20 · Cited by 7
Self-citation
Contribution of Oxidative Stress to the Pathophysiology of Autism Spectrum Disorders: Impact of Genetic and Environmental Factors
Chauhan, V. P. S., & Chauhan, A. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_4 · Cited by 7
Self-citation
Ketogenic diet, adenosine, and dopamine in addiction and psychiatry
Ruskin, D. N., Martinez, L. A., & Masino, S. A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1492306 · Cited by 6
Neuroinflammatory mechanisms and pharmacological advances in autism spectrum disorder: from inflammatory pathways to targeted interventions
Zhang, X., Xue, H., Zhu, C., Ji, C., Li, Y. M., & Liu, W. T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1829127 · Cited by 6
SETD5 haploinsufficiency affects mitochondrial compartment in neural cells
Zaghi, M., Longo, F., Massimino, L., Rubio, A., Bido, S., Mazzara, P. G., Bellini, E. N., Banfi, F., Podini, P., Maltecca, F., et al. (2023) · Molecular Autism · doi:10.1186/s13229-023-00550-9 · Cited by 6
Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders
Shao, W., Su, Y., Liu, J., Liu, Y., Zhao, J., & Fan, X. (2024) · Diabetes & Metabolism · doi:10.1016/j.diabet.2024.101543 · Cited by 6
Pluripotent Stem Cells for Uncovering the Role of Mitochondria in Human Brain Function and Dysfunction
Zink, A., Priller, J., & Prigione, A. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.02.005 · Cited by 6
Oxidative Stress and Mitochondrial Dysfunction in ASDs
Gu, F., Chauhan, V. P. S., & Chauhan, A. (2014) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814602167_0016 · Cited by 6
Self-citation
How Is CYP17A1 Activity Altered in Autism? A Pilot Study to Identify Potential Pharmacological Targets
Gasser, B. A., Kurz, J., Dick, B., & Mohaupt, M. G. (2022) · Life · doi:10.3390/life12060867 · Cited by 5
The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism
naghdi, M. R., Ahadi, R., Nezhad, A. M., Tabatabaei, F. S. A., Soleimani, M., & Hajisoltani, R. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148963 · Cited by 5
Shielding Effect of Ryanodine Receptor Modulator in Rat Model of Autism
Kumar, H., Kulkarni, G. T., Diwan, V., & Sharma, B. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2021.2966.1 · Cited by 5
Mitochondria at the Nanoscale: Physics Meets Biology—What Does It Mean for Medicine?
Mourokh, L. G., & Friedman, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052835 · Cited by 5
Evaluation of the protective effect of capric acid on behavioral and biochemical alterations in valproic acid-induced model of autism
Shekhar, N., & Thakur, A. K. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105767 · Cited by 4
Mitochondrial Dysfunction in Autism Spectrum Disorders
Nunes, T., Latini, A., & Gaspar, J. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-42383-3_5 · Cited by 4
Analysis of mitochondrial DNA replisome in autism spectrum disorder: Exploring the role of replisome genes
Rojas, V., Carrasco‐Gallardo, C., Tenorio, L., Olesen, M. A., Tapia, V., Carrasco, M., Araos, P. A., Quintanilla, R. A., & Ruíz, L. M. (2024) · Autism Research · doi:10.1002/aur.3277 · Cited by 4
Remediate Effect of Ryanodine Receptor Antagonist in Valproic-Acid Induced Autism
Kumar, H., Diwan, V., & Sharma, B. (2022) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2343 · Cited by 4
Repurposing Niclosamide as a plausible neurotherapeutic in autism spectrum disorders, targeting mitochondrial dysfunction: a strong hypothesis
Varma, M., Bhandari, R., & Kuhad, A. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01247-x · Cited by 4
Frontal and occipital brain glutathione levels are unchanged in autistic adults
Pereira, A. C., Leonard, A., Velthuis, H., Wong, N. M. L., Ponteduro, F. M., Dimitrov, M., Ellis, C. L., Kowalewski, Ł., Lythgoe, D. J., Rotaru, D., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308792 · Cited by 4
The molecular basis of cognitive deficits in pervasive developmental disorders: Table 1.Preprint
Bhattacharya, A., & Klann, E. (2012) · Learning & Memory · doi:10.1101/lm.025007.111 · Cited by 4
Oxytocin enhances oligodendrocyte development and improves social deficits in autistic rats
Wen, M., Zheng, S., Luo, H., Zhang, Y., & Zhou, B. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1624932 · Cited by 3
Choroid plexus alterations in autism spectrum disorder: A PET-MRI study
Lila, Y., Tseng, C.-E. J., Johnston, E. G., Canales, C., McDougle, C. J., Hooker, J. M., & Zürcher, N. R. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106110 · Cited by 3
Treadmill training protects valproic acid-induced autistic features via cerebellar AMPK/PPAR-γ dependent pathway and improves mitochondrial activity in mice
Shaban, A. M., Ameen, O., Omar, M., Derbaly, S. A. E., Omara, H. R., Bayomi, A. I., Latif, A. A. A., Elakabawy, Z. I., & Khodir, S. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-09089-6 · Cited by 6
Role of oxidative stress in the pathogenesis of autism spectrum disorders
Belokoskova, S. G., & Tsikunov, S. G. (2023) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf567781 · Cited by 5
Nuclear and Mitochondrial Genome Defects in Autism: Genomic Instability and Impact of Epigenetic and Environmental Factors
Smith, M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-4788-7_102 · Cited by 3
Dysregulation of Glu-GABA and reduction of triglycerides contribute to valproic acid-induced autism model in zebrafish
Sun, Q., Huang, X., Long, H., Guo, J., Zhang, R., Daru, L., Yao, H., Jiang, K., & ., Y. P. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100911 · Cited by 2
Deletion of Mex3c gene leads to autistic-like behavior in mice by inhibiting AMPK signal pathway
Cai, H., Zhang, C., Zhang, H., Du, Y., & Wang, K. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1551440 · Cited by 2
Modulating autism spectrum disorder pathophysiology using a trace amine-focused approach: targeting the gut
Pretorius, L., Coetzee, J. A., dos Santos, A. P., & Smith, C. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01232-3 · Cited by 3
Hyperbaric Oxygen Treatment in Autism Spectrum Disorders
Rossignol, D. A. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_27 · Cited by 2

Authors: Chauhan, A., Gu, F., Essa, M. M., Wegiel, J., Kaur, K., Brown, W. T., & Chauhan, V.
Affiliations: New York State Office for People With Developmental Disabilities (US)
ORCID: Chauhan, Abha
Essa, Musthafa M.
Kaur, Kulbir
Chauhan, Ved
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2011-02-24
Volume: 117
Issue: 2
Pages: 209-220
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2011.07189.x
PMC: PMC4839269
OpenAlex: W1577847097
Cited by: 243
References: 88
Citations by year: 2026: 8 · 2025: 14 · 2024: 26 · 2023: 23 · 2022: 19 · 2021: 17 · 2020: 15 · 2019: 6 · 2018: 17 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 18 · 2013: 19 · 2012: 21
FWCI: 9.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense
Office for People With Developmental Disabilities
National Institute on Aging (P30AG008051)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, cerebellum, frontal cortex, temporal cortex, oxidative stress, lipid hydroperoxides, brain energy metabolism, children versus adults
MeSH terms: Adolescent, Adult, Age Factors, Autistic Disorder, Brain, Child, Child, Preschool, Female, Humans, Lipid Peroxides, Male, Multienzyme Complexes, Postmortem Changes, Case-Control Studies, Reactive Oxygen Species, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brain region‐specific deficit in mitochondrial electron transport chain complexes in children with autism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks