Cited by 247Autism Spectrum Disorder ResearchMitochondrial Function and PathologyGenetics and Neurodevelopmental Disorders

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Brain region‐specific deficit in mitochondrial electron transport chain complexes in children with autism

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Chauhan, Abha, Gu, Feng, Essa, Musthafa M., Wegiel, Jerzy, Kaur, Kulbir, Brown, William Ted, Chauhan, Ved·2011·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2011.07189.xPMC PMC4839269

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Abstract

J. Neurochem. (2011) 117, 209–220. Mitochondria play important roles in generation of free radicals, ATP formation, and in apoptosis. We studied the levels of mitochondrial electron transport chain (ETC) complexes, that is, complexes I, II, III, IV, and V, in brain tissue samples from the cerebellum and the frontal, parietal, occipital, and temporal cortices of subjects with autism and age‐matched control subjects. The subjects were divided into two groups according to their ages: Group A (children, ages 4–10 years) and Group B (adults, ages 14–39 years). In Group A, we observed significantly lower levels of complexes III and V in the cerebellum (p < 0.05), of complex I in the frontal cortex (p < 0.05), and of complexes II (p < 0.01), III (p < 0.01), and V (p < 0.05) in the temporal cortex of children with autism as compared to age‐matched control subjects, while none of the five ETC complexes was affected in the parietal and occipital cortices in subjects with autism. In the cerebellum and temporal cortex, no overlap was observed in the levels of these ETC complexes between subjects with autism and control subjects. In the frontal cortex of Group A, a lower level of ETC complexes was observed in a subset of autism cases, that is, 60% (3/5) for complexes I, II, and V, and 40% (2/5) for complexes III and IV. A striking observation was that the levels of ETC complexes were similar in adult subjects with autism and control subjects (Group B). A significant increase in the levels of lipid hydroperoxides, an oxidative stress marker, was also observed in the cerebellum and temporal cortex in the children with autism. These results suggest that the expression of ETC complexes is decreased in the cerebellum and the frontal and temporal regions of the brain in children with autism, which may lead to abnormal energy metabolism and oxidative stress. The deficits observed in the levels of ETC complexes in children with autism may readjust to normal levels by adulthood.

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Authors: Chauhan, A., Gu, F., Essa, M. M., Wegiel, J., Kaur, K., Brown, W. T., & Chauhan, V.
Affiliations: New York State Office for People With Developmental Disabilities (US)
ORCID: Chauhan, Abha
Essa, Musthafa M.
Kaur, Kulbir
Chauhan, Ved
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2011-02-24
Volume: 117
Issue: 2
Pages: 209-220
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2011.07189.x
PMC: PMC4839269
OpenAlex: W1577847097
Cited by: 243
References: 88
Citations by year: 2026: 8 · 2025: 14 · 2024: 26 · 2023: 23 · 2022: 19 · 2021: 17 · 2020: 15 · 2019: 6 · 2018: 17 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 18 · 2013: 19 · 2012: 21
FWCI: 9.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense
Office for People With Developmental Disabilities
National Institute on Aging (P30AG008051)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, cerebellum, frontal cortex, temporal cortex, oxidative stress, lipid hydroperoxides, brain energy metabolism, children versus adults
MeSH terms: Adolescent, Adult, Age Factors, Autistic Disorder, Brain, Child, Child, Preschool, Female, Humans, Lipid Peroxides, Male, Multienzyme Complexes, Postmortem Changes, Case-Control Studies, Reactive Oxygen Species, Young Adult

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Brain region‐specific deficit in mitochondrial electron transport chain complexes in children with autism

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