Remodeling chromatin for senescence.

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works

ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex

Mizuguchi, G., Shen, X., Landry, J., Wu, W.-H., Sen, S., & Wu, C. (2003) · Science · doi:10.1126/science.1090701 · Cited by 1,312 · see citing works

Lamin A-Dependent Nuclear Defects in Human Aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works

Oncogene-induced senescence as an initial barrier in lymphoma development

Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works

p16INK4a induces an age-dependent decline in islet regenerative potential

Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003 · see citing works

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · see citing works

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works

Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

Zhang, R., Poustovoitov, M. V., Ye, X., Santos, H. A., Chen, W., Daganzo, S. M., Erzberger, J. P., Serebriiskii, I. G., Canutescu, A. A., Dunbrack, R. L., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.10.019 · Cited by 699 · see citing works

A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation

Narita, M., Narita, M., Krizhanovsky, V., Nuñez, S., Chicas, A., Hearn, S. A., Myers, M. P., & Lowe, S. W. (2006) · Cell · doi:10.1016/j.cell.2006.05.052 · Cited by 629 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

Molecular dissection of formation of senescence-associated heterochromatin foci

Zhang, R., Chen, W., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02019-06 · Cited by 415 · see citing works

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway

Denoyelle, C., Abou-Rjaily, G., Bezrookove, V., Verhaegen, M., Johnson, T. M., Fullen, D. R., Pointer, J. N., Gruber, S. B., Su, L. D., Nikiforov, M. A., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1471 · Cited by 349 · see citing works

Loss of linker histone H1 in cellular senescence

Funayama, R., Saito, M., Tanobe, H., & Ishikawa, F. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604005 · Cited by 241 · see citing works

Chz1, a Nuclear Chaperone for Histone H2AZ

Luk, E., Vu, N., Patteson, K., Mizuguchi, G., Wu, W.-H., Ranjan, A., Backus, J. D., Sen, S., Lewis, M. S., Bai, Y., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.015 · Cited by 162 · see citing works

Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci

Ye, X., Zerlanko, B. J., Zhang, R., Somaiah, N., Lipinski, M., Salomoni, P., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01592-06 · Cited by 161 · see citing works

p16 Is Required for hSNF5 Chromatin Remodeler-induced Cellular Senescence in Malignant Rhabdoid Tumor Cells

Oruetxebarria, I., Venturini, F., Kekarainen, T., Houweling, A., Zuijderduijn, L. M. P., Mohd-Sarip, A., Vries, R. G. J., Hoeben, R. C., & Verrijzer, C. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309333200 · Cited by 160 · see citing works

Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA

Lorain, S., Quivy, J., Monier-Gavelle, F., Scamps, C., Lécluse, Y., Almouzni, G., & Lipinski, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5546 · Cited by 105 · see citing works

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi

Bandyopadhyay, D., Curry, J. L., Lin, Q., Richards, H. W., Chen, D., Hornsby, P. J., Timchenko, N. A., & Medrano, E. E. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00308.x · Cited by 81 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works

Inflammatory networks during cellular senescence: causes and consequences.

Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354 · see citing works

Mechanisms and functions of cellular senescence

Herranz, N., & Gil, J. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95148 · Cited by 1,232 · see citing works

Senescent cells as a source of inflammatory factors for tumor progression

Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9220-9 · Cited by 636 · see citing works

Mechanisms underlying T cell ageing

Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506 · see citing works

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

Di Micco, R., Sulli, G., Dobreva, M., Liontos, M., Botrugno, O. A., Gargiulo, G., dal Zuffo, R., Matti, V., d'Ario, G., Montani, E., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2170 · Cited by 382 · see citing works

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

Benhamed, M., Herbig, U., Ye, T., Dejean, A., & Bischof, O. (2012) · Nature Cell Biology · doi:10.1038/ncb2443 · Cited by 252 · see citing works

Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer.

Sulli, G., Di Micco, R., & di Fagagna, F. D. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3344 · Cited by 238 · see citing works

Stress-induced senescence in human and rodent astrocytes

Bitto, A., Sell, C., Crowe, E., Lorenzini, A., Malaguti, M., Hrelia, S., & Torres, C. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.06.021 · Cited by 204 · see citing works

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

Tan, F. C. C., Hutchison, E. R., Eitan, E., & Mattson, M. P. (2014) · Biogerontology · doi:10.1007/s10522-014-9532-1 · Cited by 116 · see citing works

The role of epigenetics in renal ageing

Shiels, P. G., McGuinness, D., Eriksson, M., Kooman, J. P., & Stenvinkel, P. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.78 · Cited by 114 · see citing works

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer’s and other neurodegenerative diseases

Golde, T. E., & Miller, V. M. (2009) · Alzheimer's Research & Therapy · doi:10.1186/alzrt5 · Cited by 98 · see citing works

Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

Mao, P., Liu, J., Zhang, Z., Zhang, H., Liu, H., Gao, S., Rong, Y. S., & Zhao, Y. (2016) · Nature Communications · doi:10.1038/ncomms12154 · Cited by 76 · see citing works

Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis

Rübe, C. E., Bäumert, C., Schuler, N., Isermann, A., Schmal, Z., Glanemann, M., Mann, C., & Scherthan, H. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00060-z · Cited by 76 · see citing works

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

Narlikar, G. J., Sundaramoorthy, R., & Owen‐Hughes, T. (2013) · Cell · doi:10.1016/j.cell.2013.07.011 · Cited by 659 · see citing works

Cellular senescence, an unpopular yet trustworthy tumor suppressor mechanism

Ishikawa, F. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01382.x · Cited by 32 · see citing works

Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions

Morris, S. A., Baek, S., Sung, M., John, S., Wiench, M., Johnson, T. A., Schiltz, R. L., & Hager, G. L. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2718 · Cited by 156 · see citing works

Never-ageing cellular senescence

Öğrünç, M., & di Fagagna, F. D. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.04.003 · Cited by 26 · see citing works

Epigenetic Control in Cellular Senescence

Helmbold, H., Deppert, W., & Bohn, W. (2011) · Wiley eBooks · doi:10.1002/9781118005743.ch3