The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Epidermal stem cells are retained in vivo throughout skin aging
Open accessAbstract
Summary: In healthy individuals, skin integrity is maintained by epidermal stem cells which self‐renew and generate daughter cells that undergo terminal differentiation. It is currently unknown whether epidermal stem cells influence or are affected by skin aging. We therefore compared young and aged skin stem cell abundance, organization, and proliferation. We discovered that despite age‐associated differences in epidermal proliferation, dermal thickness, follicle patterning, and immune cell abundance, epidermal stem cells were maintained at normal levels throughout life. These findings, coupled with observed dermal gene expression changes, suggest that epidermal stem cells themselves are intrinsically aging resistant and that local environmental or systemic factors modulate skin aging.
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Cites
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
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Cell intrinsic alterations underlie hematopoietic stem cell aging
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Stem cells, ageing and the quest for immortality
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Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448
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Self-citationSharp, L. L., Jameson, J. M., Cauvi, G., & Havran, W. L. (2005) · Nature Immunology · doi:10.1038/ni1152 · Cited by 273
Epidermal stem cells are resistant to cellular aging
Stern, M. M., & Bickenbach, J. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00318.x · Cited by 79
Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency
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Cited by
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Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature · doi:10.1038/nature12783 · Cited by 1,291
Self-citationNatural and Sun-Induced Aging of Human Skin
Rittie, L., & Fisher, G. J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015370 · Cited by 600
Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells
Wagner, W., Bork, S., Horn, P., Krunic, D., Walenda, T., Diehlmann, A., Benes, V., Blake, J., Huber, F.-X., Eckstein, V., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005846 · Cited by 477
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science · doi:10.1126/science.aad4395 · Cited by 416
Focus on the Contribution of Oxidative Stress in Skin Aging
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Metadata
- Authors
- Giangreco, A., Qin, M., Pintar, J. E., & Watt, F. M.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-01-21
- Volume
- 7
- Issue
- 2
- Pages
- 250-259
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1966755977
- Cited by
- 212
- References
- 9
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Giangreco, A., Qin, M., Pintar, J. E., & Watt, F. M. (2008). Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell. https://doi.org/10.1111/j.1474-9726.2008.00372.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
