Cited by 513Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

Open access
Guarente, Leonard·2008·Cell

Abstract

Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.

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Crossref · 10.1016/j.cell.2008.01.007

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46 of 46 references verified0 citation errors · 0 not checkable

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Authors
Guarente, L.
Affiliations
Massachusetts Institute of Technology (US)
Corresponding author
Guarente, Leonard
Venue
Cell
Publisher
Elsevier BV
Published
2008-01
Volume
132
Issue
2
Pages
171-176
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2066762257
Cited by
513
References
46
Citations by year
2026: 5 · 2025: 14 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 28 · 2019: 20 · 2018: 24 · 2017: 17 · 2016: 22 · 2015: 22 · 2014: 46 · 2013: 46 · 2012: 42
FWCI
4.83
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG015339, R01AG011119)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
mitochondria, caloric restriction, sirtuins, aging, dietary restriction, mitochondrial activity, age-related diseases
MeSH terms
Aging, Animals, Humans, Mitochondria, Models, Biological, Caloric Restriction, Sirtuins

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