Plasma neuropeptide Y-like immunoreactivity and catecholamines during various degrees of sympathetic activation in man
Abstract
Neuropeptide Y-like immunoreactivity (NPY-LI) and catecholamine concentrations in plasma were analysed during and after 60 min of physical exercise at a work load corresponding to 70% of individual maximal oxygen uptake in nine healthy men of average physical fitness. Systemic plasma NPY-LI increased progressively from 18 +/- 3 to 81 +/- 19 pmol X 1(-1) in parallel with a 10-fold increase in noradrenaline (NA) concentration. The increase in plasma NPY-LI during exercise and the decrease after completion of exercise were much slower than the corresponding changes in NA concentration. This difference is probably related to a slower diffusion of NPY into systemic circulation after release, as well as to a longer half-life of NPY than of NA in plasma. Reversed phase HPLC and sephadex G-50 gel-filtration chromatography revealed that the main component of NPY-LI in plasma during exercise eluted in a similar position as synthetic human NPY. During exercise plasma NPY-LI correlated well with the plasma concentration of NA (r = 0.80), but not with that of adrenaline (ADR), suggesting a neuronal origin of NPY. The self-ratings of perceived exertion (RPE) were well correlated with the plasma concentrations of both NPY-LI and NA. No clear-cut veno-arterial concentration difference was observed for NPY-LI. Isometric handgrip and orthostatic test doubled plasma NA concentrations but did not cause any increase in plasma NPY-LI. No change in plasma tachykinin-like immunoreactivity was detected during exercise. The present data suggest that NPY is released together with NA during strong, but probably not during mild, sympathetic activation under physiological conditions in man.
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NPY is an excellent indicator of sympathetic activity, being more stable and having a significantly longer half-life in plasma than norepinephrine.
“NPY is an excellent indicator of sympathetic activity, 34 which is more stable and has a significantly longer half life in plasma.35”
Cites
Perceived exertion as an indicator of somatic stress
Borg, G. (1970) · Journal of Rehabilitation Medicine · doi:10.2340/1650197719702239298 · Cited by 4,723 · see citing works
A Flexible System of Enzymatic Analysis
Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050 · see citing works
Åstrand, P. O., & Ryhming, I. (1954) · Journal of Applied Physiology · doi:10.1152/jappl.1954.7.2.218 · Cited by 1,558 · see citing works
Neuropeptide Y: complete amino acid sequence of the brain peptide.
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.18.5485 · Cited by 1,378 · see citing works
Lundberg, J. M., Terenius, L. Y., Hökfelt, T. G. M., Martling, C., Tatemoto, K., Mutt, V., Polak, J. M., Bloom, S. R., & Goldstein, M. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07171.x · Cited by 1,199 · see citing works
Self-citationNeuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers
Ekblad, E., Edvinsson, L. I., Wahlestedt, C., Uddman, R., Håkanson, R., & Sundler, F. (1984) · Regulatory Peptides · doi:10.1016/0167-0115(84)90064-8 · Cited by 741 · see citing works
High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man
Lundberg, J. M., Terenius, L. Y., Hökfelt, T. G. M., & Goldstein, M. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90401-9 · Cited by 616 · see citing works
Self-citationHjemdahl, P., Daleskog, M., & Kahan, T. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90384-9 · Cited by 574 · see citing works
Self-citationCoexistence of peptides and classical neurotransmitters
Lundberg, J. M., & Hökfelt, T. G. M. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90149-2 · Cited by 562 · see citing works
Self-citationLundberg, J. M., & Tatemoto, K. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07157.x · Cited by 534 · see citing works
Self-citationFitting a Straight Line When Both Variables are Subject to Error
Bartlett, M. S. (1949) · Biometrics · doi:10.2307/3001936 · Cited by 428 · see citing works
Glucagon and plasma catecholamine responses to graded and prolonged exercise in man
Galbo, H., Holst, J. J., & Christensen, N. J. (1975) · Journal of Applied Physiology · doi:10.1152/jappl.1975.38.1.70 · Cited by 406 · see citing works
Sympathetic Nervous Activity During Exercise
Christensen, N. J., & Galbo, H. (1983) · Annual Review of Physiology · doi:10.1146/annurev.ph.45.030183.001035 · Cited by 375 · see citing works
Lundberg, J. M., Rudehill, A., Sollevi, A., Theodorsson, E., & Hamberger, B. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90020-0 · Cited by 359 · see citing works
Self-citationPlasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man
WALLIN, B. G., SUNDLÖF, G., ERIKSSON, B., DOMINIAK, P., GROBECKER, H., & LINDBLAD, L. E. (1981) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1981.tb06706.x · Cited by 316 · see citing works
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine.
Minth, C. D., Bloom, S. R., Polak, J. M., & Dixon, J. E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4577 · Cited by 289 · see citing works
Lundberg, J. M., & Stjärne, L. (1984) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1984.tb07410.x · Cited by 272 · see citing works
Self-citationTheodorsson, E., Hemsén, A., & Lundberg, J. M. (1985) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518509161019 · Cited by 262 · see citing works
Self-citationCo-release of neuropeptide Y and catecholamines during physical exercise in man
Lundberg, J. M., Martinsson, A., Hemsén, A., Theodorsson, E., Svedenhag, J., Ekblom, B. T., & Hjemdahl, P. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91837-6 · Cited by 223 · see citing works
Self-citationBrodin, E., Lindefors, N., Dalsgaard, C., Theodorsson, E., & Rosell, S. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90044-3 · Cited by 218 · see citing works
Varndell, I. M., Polak, J. M., Allen, J. M., Terenghi, G., & Bloom, S. R. (1984) · Endocrinology · doi:10.1210/endo-114-4-1460 · Cited by 198 · see citing works
Gräf, K., & Westersten, A. (1959) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1959.tb01733.x · Cited by 196 · see citing works
Lundberg, J. M., Änggård, A., Theodorsson, E., & Pernow, J. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90370-7 · Cited by 193 · see citing works
Self-citationPotter, E. K. (1985) · Neuroscience Letters · doi:10.1016/s0304-3940(85)80065-3 · Cited by 183 · see citing works
Assessment of Sympathetic Nervous Function in Humans from Noradrenaline Plasma Kinetics
Esler, M. (1982) · Clinical Science · doi:10.1042/cs0620247 · Cited by 168 · see citing works
Arterial Noradrenaline Concentration during Exercise in Relation to the Relative Work Levels
Häggendal, J., Hartley, L. H., & Saltin, B. (1970) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517009046242 · Cited by 157 · see citing works
Lundberg, J. M., Hökfelt, T. G. M., Hemsén, A., Theodorsson, E., Pernow, J., Hamberger, B., & Goldstein, M. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90224-7 · Cited by 139 · see citing works
Self-citationNeuropeptide Y and sympathetic vascular control in man
Lundberg, J. M., Torssell, L., Sollevi, A., Pernow, J., Theodorsson, E., Änggård, A., & Hamberger, B. (1985) · Regulatory Peptides · doi:10.1016/0167-0115(85)90085-0 · Cited by 128 · see citing works
Self-citationTheodorsson, E., Brodin, E., Norheim, I., & Rosell, S. (1984) · Regulatory Peptides · doi:10.1016/0167-0115(84)90075-2 · Cited by 112 · see citing works
Dahl�f, C., Dahl�f, P., Tatemoto, K., & Lundberg, J. M. (1985) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00515562 · Cited by 109 · see citing works
Self-citationMonitoring Neurotransmitter Release During Behaviour
Iversen, L. L. (1987) · International Clinical Psychopharmacology · doi:10.1097/00004850-198710000-00013 · Cited by 68 · see citing works
Wu, P., Penman, E., Coy, D. H., & REES, L. H. (1983) · Regulatory Peptides · doi:10.1016/0167-0115(83)90253-7 · Cited by 48 · see citing works
Co‐release of neuropeptide Y (NPY)‐like immunoreactivity and catecholamines in newborn infants
Lundberg, J. M., Hemsén, A., Fried, G. M., THEODORSSON‐NORHEIM, E., & Lagercrantz, H. (1986) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1986.tb07842.x · Cited by 46 · see citing works
Self-citationJansson, E., Hjemdahl, P., & Kaijser, L. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb06969.x · Cited by 41 · see citing works
Self-citationCardiovascular responses and plasma catecholamines in old age
Sachs, C., Hamberger, B., & Kaijser, L. (1985) · Clinical Physiology · doi:10.1111/j.1475-097x.1985.tb00768.x · Cited by 31 · see citing works
Self-citationIvell, R., Emson, P. C., & Richter, D. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)81278-8 · Cited by 18 · see citing works
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Sorted by citations
Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues
Dumont, Y., Martel, J.-C., Fournier, A., St-Pierre, S. A., & Quirion, R. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90038-g · Cited by 380 · see citing works
Impaired sympathetic vascular regulation in humans after acute dynamic exercise.
Halliwill, J. R., Taylor, J. A., & Eckberg, D. L. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021592 · Cited by 377 · see citing works
Plasma neuropeptide-Y concentrations in humans exposed to military survival training
Morgan, C. A., Wang, S., Southwick, S. M., Rasmusson, A., Hazlett, G., Hauger, R. L., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00239-5 · Cited by 298 · see citing works
Neuropeptide Y: the universal soldier
Pedrazzini, T., Pralong, F. P., & Grouzmann, E. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300029 · Cited by 286 · see citing works
Kaye, D. M., Lambert, G. W., Lefkovits, J., Morris, M. J., Jennings, G., & Esler, M. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90738-2 · Cited by 285 · see citing works
Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD
Rasmusson, A. M., Hauger, R. L., Morgan, C. A., Bremner, J. D., Charney, D. S., & Southwick, S. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00185-7 · Cited by 249 · see citing works
Neuropeptide Y as an autonomic neurotransmitter
Potter, E. K. (1988) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(88)90028-9 · Cited by 233 · see citing works
Żukowska-Grójec, Z. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44683.x · Cited by 229 · see citing works
A possible role of neuropeptide Y in depression and stress
Morales‐Medina, J. C., Dumont, Y., & Quirion, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.077 · Cited by 217 · see citing works
Role of hypothalamic neuropeptide Y in feeding and obesity
Gehlert, D. R. (1999) · Neuropeptides · doi:10.1054/npep.1999.0057 · Cited by 209 · see citing works
Chromogranin A in heart failure. A novel neurohumoral factor and a predictor for mortality
Ceconi, C. (2002) · European Heart Journal · doi:10.1053/euhj.2001.2977 · Cited by 205 · see citing works
Lundberg, J. M., Rudehill, A., Sollevi, A., Fried, G. M., & Wallin, G. B. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90193-0 · Cited by 185 · see citing works
Self-citationNeuropeptide Y stimulates neuronal precursor proliferation in the post‐natal and adult dentate gyrus
Howell, O. W., Doyle, K. L., Goodman, J. H., Scharfman, H. E., Herzog, H., Pringle, A. K., Beck‐Sickinger, A. G., & Gray, W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03057.x · Cited by 180 · see citing works
Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans
Eckberg, D. L., Rea, R. F., Andersson, O., Hedner, T., Pernow, J., Lundberg, J. M., & Wallin, B. G. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08401.x · Cited by 171 · see citing works
Self-citationNonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men
Stephens, D. P., Aoki, K., Kosiba, W. A., & Johnson, J. M. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.4.h1496 · Cited by 145 · see citing works
Plasma catecholamines—analytical challenges and physiological limitations
Hjemdahl, P. (1993) · Baillière's Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80179-x · Cited by 143 · see citing works
Self-citationZhang, X.-Q., Bao, L., Xu, Q., Kopp, J., Arvidsson, U., Elde, R., & Hökfelt, T. G. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11738 · Cited by 137 · see citing works
Neuropeptide Y effector systems: perspectives for drug development
Grundemar, L., & Håkanson, R. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90076-0 · Cited by 137 · see citing works
Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans
Stephens, D. P., Saad, A. R., Bennett, L. A. T., Kosiba, W. A., & Johnson, J. M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00061.2004 · Cited by 130 · see citing works
Neuropeptide Y and Sympathetic Neurotransmissiona
Lundberg, J. M., Franco‐Cereceda, A., Lacroix, J., & Pernow, J. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48930.x · Cited by 120 · see citing works
Self-citationKALLIO, J., Pesonen, U., Kaipio, K., Karvonen, M. K., JAAKKOLA, U., Heinonen, O. J., Uusitupa, M. I. J., & Koulu, M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0436fje · Cited by 118 · see citing works
Härle, P., Straub, R. H., Wiest, R., Mayer, A., Schölmerich, J., Atzeni, F., Carrabba, M., Cutolo, M., & Sarzi-Puttini, P. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.038059 · Cited by 114 · see citing works
The Shared Neuroanatomy and Neurobiology of Comorbid Chronic Pain and PTSD
Scioli, E. R., Forman, D. E., Otis, J. D., Gregor, K. L., Valovski, I. T., & Rasmusson, A. M. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000115 · Cited by 111 · see citing works
Erlinge, D., Brunkwall, J. S., & Edvinsson, L. I. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90006-x · Cited by 110 · see citing works
Origin and Actions of Neuropeptide Y in the Cardiovascular System
Żukowska-Grójec, Z., & Wahlestedt, C. (1993) · Humana Press eBooks · doi:10.1007/978-1-59259-465-8_8 · Cited by 109 · see citing works
Region-Specific Neuropeptide Y Overflows at Rest and During Sympathetic Activation in Humans
Morris, M. J., Cox, H. S., Lambert, G. W., Kaye, D. M., Jennings, G., Meredith, I. T., & Esler, M. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.137 · Cited by 107 · see citing works
Pharmacology of noradrenaline and neuropeptide tyrosine (NPY)‐mediated sympathetic cotransmission
Lundberg, J. O., Franco‐Cereceda, A., Hemsén, A., Js, L., & Pernow, J. (1990) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1990.tb00692.x · Cited by 103 · see citing works
Self-citationPhysical stress and catecholamine release
Kjær, M., Secher, N. H., & Galbo, H. (1987) · Baillière's Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(87)80064-2 · Cited by 101 · see citing works
Herring, N., Cranley, J. J., Lokale, M. N., Li, D., Shanks, J. A., Alston, E. N., Girard, B. M., Carter, E., Parsons, R. L., Habecker, B. A., et al. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.11.016 · Cited by 97 · see citing works
Grundemar, L., & Håkanson, R. (1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90151-m · Cited by 94 · see citing works
Pernow, J., Öhlén, A., Hökfelt, T. G. M., Nilsson, O., & Lundberg, J. M. (1987) · Regulatory Peptides · doi:10.1016/0167-0115(87)90173-x · Cited by 88 · see citing works
Self-citationLambert, G. W., Kaye, D. M., Lefkovits, J., Jennings, G., Turner, A., Cox, H. S., & Esler, M. (1995) · Circulation · doi:10.1161/01.cir.92.7.1813 · Cited by 86 · see citing works
Chromogranin A in heart failure
Wollert, K. C. (2002) · European Heart Journal · doi:10.1053/euhj.2001.3132 · Cited by 86 · see citing works
Differential plasma catecholamine and neuropeptide Y responses to acute stress in rats
Żukowska-Grójec, Z., Konarska, M., & McCarty, R. C. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90440-7 · Cited by 84 · see citing works
α‐Adrenergic Vascular Responsiveness during Postexercise Hypotension in Humans
Halliwill, J. R., Dinenno, F. A., & Dietz, N. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042838 · Cited by 83 · see citing works
Botulinum neurotoxin A attenuates release of norepinephrine but not NPY from vasoconstrictor neurons
Morris, J. L., Jobling, P., & Gibbins, I. L. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00477.2002 · Cited by 80 · see citing works
NPY Regulates Catecholamine Secretion from Human Adrenal Chromaffin Cells
Cavadas, C., Silva, A. P., Mosimann, F., Cotrim, M. D., Ribeiro, C., Brunner, H. R., & Grouzmann, E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5956 · Cited by 75 · see citing works
Irwin, M. R., Hauger, R. L., & Brown, M. (1992) · Endocrinology · doi:10.1210/endo.131.3.1505449 · Cited by 75 · see citing works
Release of immunoreactive-neuropeptide Y by rat platelets
Myers, A. K., Farhat, M. Y., Vaz, C. A., Keiser, H. R., & Żukowska-Grójec, Z. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81057-x · Cited by 74 · see citing works
TAKIYYUDDIN, M. A., Brown, M. R., Dinh, T., Cervenka, J. H., Braun, S. D., Parmer, R. J., Kennedy, B. P., & O’Connor, D. T. (1994) · Journal of Autonomic Pharmacology · doi:10.1111/j.1474-8673.1994.tb00601.x · Cited by 70 · see citing works
Evidence for co‐transmitter role of neuropeptide Y in the pig spleen
Lundberg, J. M., Rudehill, A., Sollevi, A., & Hamberger, B. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11868.x · Cited by 70 · see citing works
Self-citationSchalling, M., Franco‐Cereceda, A., Hemsén, A., Dagerlind, Å., Seroogy, K. B., Persson, H., Hökfelt, T. G. M., & Lundberg, J. M. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90365-u · Cited by 68 · see citing works
Self-citationJidéus, L., Joachimsson, P.-O., Stridsberg, M., Ericson, M. O., Tydén, H., Nilsson, L., Blomström, P., & Blomström‐Lundqvist, C. (2001) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(01)02631-5 · Cited by 67 · see citing works
Elevated Insulin, Norepinephrine, and Neuropeptide Y in Hypertension
Solt, V. B., Brown, M. R., Kennedy, B. P., Kolterman, O., & Ziegler, M. G. (1990) · American Journal of Hypertension · doi:10.1093/ajh/3.11.823 · Cited by 67 · see citing works
NPY Y1 Receptors Are Present in Axonal Processes of DRG Neurons
Brumovsky, P. R., Shi, T. J., Matsuda, H., Kopp, J., Villar, M. J., & Hökfelt, T. G. M. (2002) · Experimental Neurology · doi:10.1006/exnr.2001.7845 · Cited by 65 · see citing works
Inhibition of cardiac vagal effects by neurally released and exogenous neuropeptide Y.
Warner, M. R., & Levy, M. N. (1989) · Circulation Research · doi:10.1161/01.res.65.6.1536 · Cited by 64 · see citing works
Lundberg, J. M., Hemsén, A., Rudehill, A., Härfstrand, A., Larsson, O., Sollevi, A., Saria, A., Hökfelt, T. G. M., Fuxé, K., & Fredholm, B. B. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90359-4 · Cited by 63 · see citing works
Self-citationNPY and Gene Therapy for Epilepsy: How, When,... and Y
Cattaneo, S., Verlengia, G., Marino, P., Simonato, M., & Bettegazzi, B. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.608001 · Cited by 61 · see citing works
Nilsson, C. L., Karlsson, G., Blennow, K., Heilig, M. A., & Ekman, R. (1996) · Peptides · doi:10.1016/0196-9781(96)00013-7 · Cited by 60 · see citing works
Cardiovascular, neuropeptide Y, and adrenergic responses in stress are sexually differentiated
Żukowska-Grójec, Z., Shen, G. H., Capraro, P. A., & Vaz, C. A. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90317-h · Cited by 59 · see citing works
Neuropeptide Y and neurovascular control in skeletal muscle and skin
Hodges, G. J., Jackson, D. N., Mattar, L., Johnson, J. M., & Shoemaker, J. K. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00157.2009 · Cited by 58 · see citing works
Role of neuropeptide Y (NPY) in cardiovascular responses to stress
Zukowska‐Grojec, Z., & Vaz, A. (1988) · Synapse · doi:10.1002/syn.890020319 · Cited by 58 · see citing works
Edvinsson, L. I., Ekman, R., & Thulin, T. (1991) · Regulatory Peptides · doi:10.1016/0167-0115(91)90021-8 · Cited by 57 · see citing works
Aaser, E., Gullestad, L. L., Tølløfsrud, S., Lundberg, J. O., Hall, C., Djøseland, O., KJEKSHUS, J. K., & Forfang, K. (1997) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519709099409 · Cited by 54 · see citing works
Self-citationSympathetic stimulation-evoked overflow of norepinephrine and neuropeptide Y from the heart.
Warner, M. R., Senanayake, P. D., Ferrario, C. M., & Levy, M. N. (1991) · Circulation Research · doi:10.1161/01.res.69.2.455 · Cited by 54 · see citing works
Li, L., Jönsson‐Rylander, A., Abe, K., & Żukowska, Z. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000179601.19888.19 · Cited by 50 · see citing works
Mejía, J. A., Pernow, J., von Holst, H., Rudehill, A., & Lundberg, J. M. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.69.6.0913 · Cited by 50 · see citing works
Self-citationMorris, J. L., & Murphy, R. (1988) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(88)90124-5 · Cited by 50 · see citing works
Plasma neuropeptide Y in the symptomatic limb of patients with causalgic pain
Drummond, P. D., Finch, P. M., Edvinsson, L. I., & Goadsby, P. J. (1994) · Clinical Autonomic Research · doi:10.1007/bf01845774 · Cited by 49 · see citing works
Angina pectoris. Clinical characteristics, neurophysiological and molecular mechanisms
Sylvén, C. (1989) · Pain · doi:10.1016/0304-3959(89)90019-5 · Cited by 49 · see citing works
Functional organization of peripheral vasomotor pathways
Gibbins, I. L., Jobling, P., & Morris, J. L. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01079.x · Cited by 46 · see citing works
AHLBORG, G., Weitzberg, E., Sollevi, A., & Lundberg, J. M. (1992) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1992.tb09349.x · Cited by 46 · see citing works
Self-citationStress elicits trans-synaptic activation of adrenal neuropeptide Y gene expression
Hiremagalur, B., Květňanský, R., Nankova, B. B., Fleischer, J., Geertman, R. T., Fukuhara, K., Viskupic, E., & Sabban, E. L. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90194-5 · Cited by 44 · see citing works
Incidence of atrial fibrillation after mild or moderate hypothermic cardiopulmonary bypass
Adams, D. C., Heyer, E. J., Simon, A. E., Delphin, E., Rose, E. A., Öz, M. C., McMahon, D. J., & Sun, L. S. (2000) · Critical Care Medicine · doi:10.1097/00003246-200002000-00003 · Cited by 44 · see citing works
Kaijser, L., Pernow, J., Berglund, B., & Lundberg, J. M. (1990) · Clinical Physiology · doi:10.1111/j.1475-097x.1990.tb00252.x · Cited by 44 · see citing works
Self-citationCardiac neuropeptide Y and noradrenaline balance in patients with congestive heart failure.
Feng, Q., Hedner, T., Andersson, B., Lundberg, J. M., & Waagstein, F. (1994) · Heart · doi:10.1136/hrt.71.3.261 · Cited by 42 · see citing works
Self-citationEffect of neuropeptide Y on jejunal water and ion transport in humans
Holzer‐Petsche, U., Petritsch, W., Hinterleitner, T. A., Eherer, A. J., Sperk, G., & Krejs, G. J. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90007-8 · Cited by 42 · see citing works
Neuroendocrine changes in chronic cardiac failure
Nicholls, D., Onuoha, G. N., McDowell, G., Elborn, J. S., Riley, M., Nugent, A. M., Steele, I. C., Shaw, C., & Buchanan, K. D. (1996) · Basic Research in Cardiology · doi:10.1007/bf00810519 · Cited by 42 · see citing works
Gullestad, L. L., Jørgensen, B., Bjurö, T., Pernow, J., Lundberg, J. M., Dota, C., Hall, C., Simonsen, S., & Åblad, B. (2000) · Circulation · doi:10.1161/01.cir.102.9.987 · Cited by 41 · see citing works
Self-citationUllman, B., Franco-Cereceda, A., Hulting, J., Lundberg, J. M., & Sollevi, A. (1990) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1990.tb00283.x · Cited by 41 · see citing works
Self-citationEdvinsson, L. I., Ekman, R., Hedner, P., & Valdemarsson, S. V. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb01796.x · Cited by 40 · see citing works
Morphological and Molecular Changes of the Myocardium After Left Ventricular Mechanical Support
Baba, H. A., & Wohlschlaeger, J. (2008) · Current Cardiology Reviews · doi:10.2174/157340308785160606 · Cited by 39 · see citing works
Role of Neuropeptide Y in Cold Stress-Induced Hypertension
Han, S., Chen, X., Cox, B. F., Yang, C.-L., Wu, Y., Naes, L., & Westfall, T. C. (1998) · Peptides · doi:10.1016/s0196-9781(97)00297-0 · Cited by 38 · see citing works
Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology
Anderson, Z. T., Dawson, A. D., Slominski, A. T., & Harris, M. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.838434 · Cited by 37 · see citing works
Lacroix, J. S., Stjärne, P., Änggård, A., & Lundberg, J. M. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08398.x · Cited by 37 · see citing works
Self-citationGordon, A., Tyni‐Lenné, R., Jansson, E., Kaijser, L., Theodorsson-Norheim, E., & Sylvén, C. (1997) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(97)90002-6 · Cited by 37 · see citing works
Self-citationUncoupling of sympathetic nervous system and hypothalamic‐pituitary‐adrenal axis in cirrhosis
Wiest, R., Moleda, L., Zietz, B., Hellerbrand, C., Schölmerich, J., & Straub, R. H. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05456.x · Cited by 36 · see citing works
Kallio, J., Pesonen, U., Jaakkola, U., Karvonen, M. K., Helenius, H. Y. M., & Koulu, M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021957 · Cited by 35 · see citing works
Peripheral Autonomic Nervous System
Gibbins, I. L. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-547625-6.50010-6 · Cited by 35 · see citing works
Torres, G. E., Marcela Bitran, C., & Huidobro-Toro, J. P. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90799-d · Cited by 35 · see citing works
The biochemical assessment of sympathoadrenal activity in man
Christensen, N. J. (1991) · Clinical Autonomic Research · doi:10.1007/bf01826215 · Cited by 35 · see citing works
Söderman, C., Eriksson, L. S., JUHLIN‐DANNFELT, A., Lundberg, J. M., Broman, L. M., & Holmgren, A. (1993) · Clinical Physiology · doi:10.1111/j.1475-097x.1993.tb00482.x · Cited by 34 · see citing works
Self-citationLehmann, J. C. (1990) · Drug Development Research · doi:10.1002/ddr.430190402 · Cited by 34 · see citing works
Scioli, E. R., Forman, D. E., Otis, J. D., Tun, C. G., Allsup, K., Marx, C. E., Hauger, R. L., Shipherd, J. C., Higgins, D. M., Tyzik, A. L., et al. (2016) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2014.10.0267 · Cited by 33 · see citing works
Ericson, M. O. (2001) · Scandinavian Cardiovascular Journal · doi:10.1080/14017430152581341 · Cited by 32 · see citing works
Renal hemodynamic responses to dynamic exercise in rabbits
Mueller, P. J., O’Hagan, K. P., Skogg, K. A., Buckwalter, J. B., & Clifford, P. S. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.5.1605 · Cited by 32 · see citing works
AHLBORG, G., & Lundbergt, J. M. (1996) · Clinical Physiology · doi:10.1111/j.1475-097x.1996.tb00741.x · Cited by 31 · see citing works
Żukowska-Grójec, Z., Golczynska, M., Shen, G. H., Torres-Duarte, A. P., Haass, M., Wahlestedt, C., & Myers, A. K. (1993) · Pediatric Nephrology · doi:10.1007/bf01213372 · Cited by 31 · see citing works
Valdemarsson, S. V., Edvinsson, L. I., Ekman, R., Hedner, P., & SJÖHOLM, A. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00452.x · Cited by 30 · see citing works
Neuropeptide Y inhibits relaxations of the guinea pig uterine artery produced by VIP
Morris, J. L. (1990) · Peptides · doi:10.1016/0196-9781(90)90096-n · Cited by 30 · see citing works
Medzikovic, L., van Roomen, C. P. A. A., Baartscheer, A., van Loenen, P. B., de Vos, J., Bakker, E. N. T. P., Koenis, D. S., Damanafshan, A., Creemers, E. E., Arkenbout, E. K., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy125 · Cited by 29 · see citing works
Plasma neuropeptide Y in anxiety disorders: findings in panic disorder and social phobia
Stein, M. B., Hauger, R. L., Dhalla, K. S., Chartier, M., & Asmundson, G. J. G. (1996) · Psychiatry Research · doi:10.1016/0165-1781(95)02776-9 · Cited by 29 · see citing works
Morris, J. L. (1989) · Springer eBooks · doi:10.1007/978-94-009-0835-2_12 · Cited by 29 · see citing works
Straub, R. H., Pongratz, G., Hirvonen, H., Pohjolainen, T., Mikkelsson, M., & Leirisalo‐Repo, M. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.089458 · Cited by 28 · see citing works
Morris, J. L. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90145-7 · Cited by 28 · see citing works
Increased concentrations of plasma neuropeptide Y in patients with eclampsia and preeclampsia
Khatun, S., Kanayama, N., Belayet, H. M., Bhuiyan, A. B., Jahan, S., Begum, A., Kobayashi, T., & Terao, T. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(00)70342-5 · Cited by 28 · see citing works
Morris, J. L. (1991) · Regulatory Peptides · doi:10.1016/0167-0115(91)90023-a · Cited by 28 · see citing works
Is neuropeptide Y a contributor to volume-induced hypertension?
Odar‐Cederlöf, I., ERICSSON, F., Theodorsson, E., & Kjellstrand, C. M. (1998) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(98)70049-6 · Cited by 27 · see citing works
Vasoconstriction in exercising skeletal muscles: a potential role for neuropeptide Y?
Buckwalter, J. B., Hamann, J. J., Kluess, H. A., & Clifford, P. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00071.2004 · Cited by 27 · see citing works
Kennedy, B. P., Shen, G. H., & Ziegler, M. G. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36566-8 · Cited by 27 · see citing works
- Authors
- Pernow, J., Lundberg, J. M., Kaijser, L., Hjemdahl, P., Theodorsson‐Norheim, E., Martinsson, A., & Pernow, B.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Pernow, John
- Venue
- Clinical Physiology
- Publisher
- Wiley
- Published
- 1986-12
- Volume
- 6
- Issue
- 6
- Pages
- 561-578
- ISSN
- 0144-5979 (ISSN-L)
- 1365-2281
- OpenAlex
- W2029651085
- Cited by
- 211
- References
- 36
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- neuropeptide Y, catecholamines, norepinephrine, epinephrine, sympathetic activation, physical activity, perceived exertion, tachykinins, isometric handgrip, orthostatic test
- MeSH terms
- Adult, Blood Pressure, Epinephrine, Physical Exertion, Heart Rate, Humans, Male, Neuropeptide Y, Neuropeptides, Norepinephrine, Radioimmunoassay, Sympathetic Nervous System, Time Factors, Tachykinins
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