Cited by 495Nitric Oxide and Endothelin EffectsAmino Acid Enzymes and MetabolismPolyamine Metabolism and Applications

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Recent advances in arginine metabolism: roles and regulation of the arginases

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Morris Jr, Sidney M·2009·British Journal of Pharmacology

DOI 10.1111/j.1476-5381.2009.00278.xPMC PMC2737650

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Abstract

As arginine can serve as precursor to a wide range of compounds, including nitric oxide, creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest in elucidating mechanisms underlying regulation of its metabolism. It is now becoming apparent that the two isoforms of arginase in mammals play key roles in regulation of most aspects of arginine metabolism in health and disease. In particular, work over the past several years has focused on the roles and regulation of the arginases in vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. As most of these topics have been considered in recent review articles, this review will focus more closely on results of recent studies on expression of the arginases in endothelial and vascular smooth muscle cells, post‐translational modulation of arginase activity and applications of arginase inhibitors in vivo .

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Authors: Morris Jr, S. M.
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2009-07
Volume: 157
Issue: 6
Pages: 922-930
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/j.1476-5381.2009.00278.x
PMC: PMC2737650
OpenAlex: W1996295305
Cited by: 485
References: 96
Citations by year: 2026: 19 · 2025: 22 · 2024: 24 · 2023: 24 · 2022: 20 · 2021: 35 · 2020: 33 · 2019: 24 · 2018: 31 · 2017: 23 · 2016: 35 · 2015: 30 · 2014: 32 · 2013: 43 · 2012: 33
FWCI: 20.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Pharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (GM64509, GM57384, R01GM057384, R01GM064509)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Keywords: arginine metabolism, arginase, nitric oxide, endothelial cells, vascular smooth muscle cells, post-translational regulation, arginase inhibitors, vascular disease, lung disease, immune cell function, cancer
MeSH terms: Animals, Arginase, Arginine, Cytosol, Disease Models, Animal, Endothelium, Vascular, Humans, Isoenzymes, Muscle, Smooth, Vascular, Gene Expression Regulation, Enzymologic, Mitochondrial Proteins

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Recent advances in arginine metabolism: roles and regulation of the arginases

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