Recent advances in arginine metabolism: roles and regulation of the arginases

Vascular endothelial cells synthesize nitric oxide from L-arginine

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Arginine metabolism: nitric oxide and beyond

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Nitric oxide: A cytotoxic activated macrophage effector molecule

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Regulation of immune responses by L-arginine metabolism

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Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

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Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

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Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

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Arginine Metabolism: Boundaries of Our Knowledge

Morris, S. M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.6.1602s · Cited by 649

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

El Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1671 · Cited by 646 · cited 1×

Comparative properties of arginases

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Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils

Darcy, C. J., Woodberry, T., Davis, J. S., Piera, K. A., McNeil, Y., Chen, Y., Yeo, T. W., Weinberg, J. B., & Anstey, N. M. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0698 · Cited by 28

Structural, enzymatic and biochemical studies on Helicobacter pylori arginase

Zhang, X., Zhang, J., Zhang, R., Guo, Y., Wu, C., Mao, X., Guo, G., Zhang, Y., Li, D., & Zou, Q. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.02.008 · Cited by 27

Tumor Antigen-Primed Dendritic Cell-Derived Exosome Synergizes with Colony Stimulating Factor-1 Receptor Inhibitor by Modulating the Tumor Microenvironment and Systemic Immunity

Barnwal, A., Gaur, V., Sengupta, A., Tyagi, W., Das, S., & Bhattacharyya, J. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00469 · Cited by 28

Arginine, histidine and tryptophan: A new hope for cancer immunotherapy

Tantawy, A. A., & Naguib, D. M. (2019) · PharmaNutrition · doi:10.1016/j.phanu.2019.100149 · Cited by 27

Novel molecular targets in hepatocellular carcinoma

Chow, A. K.-M., Yau, S. W.-L., & Ng, L. (2020) · World Journal of Clinical Oncology · doi:10.5306/wjco.v11.i8.589 · Cited by 27

Impact of probiotic Limosilactobacillus reuteri DSM 17938 on amino acid metabolism in the healthy newborn mouse

Liu, Y., Tian, X., Daniel, R. C., Okeugo, B., Armbrister, S. A., Luo, M., Taylor, C. M., Wu, G., & Rhoads, J. M. (2022) · Amino Acids · doi:10.1007/s00726-022-03165-1 · Cited by 29

Serum levels of arginase I are associated with left ventricular function after myocardial infarction

Bekpınar, S., Gürdöl, F., Ünlüçerçi, Y., Develi-İş, S., & Yılmaz, A. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.06.003 · Cited by 26

S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase

Dunn, J., Gutbrod, S. R., Webb, A. K., Pak, A., Jandu, S. K., Bhunia, A. K., Berkowitz, D. E., & Santhanam, L. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0841-2 · Cited by 27

Pulmonary vascular reserve during experimental pulmonary embolism: Effects of a soluble guanylate cyclase stimulator, BAY 41-8543*

Watts, J. A., Gellar, M. A., Fulkerson, M.-B. K., & Kline, J. A. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318226678e · Cited by 27

Opposite Associations of Plasma Homoarginine and Ornithine with Arginine in Healthy Children and Adolescents

Jaźwińska-Kozuba, A., Martens‐Lobenhoffer, J., Kruszelnicka, O., Rycaj, J., Chyrchel, B., Surdacki, A., & Bode‐Böger, S. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121819 · Cited by 26

The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver

Labib, O. H., Harb, O. A., Khalil, O. H., Baiomy, T. A., Gertallah, L. M., & Ahmed, R. Z. (2019) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-019-00211-2 · Cited by 26

Upregulation of arginase activity contributes to intracellular ROS production induced by high glucose in H9c2 cells.

Zhou, L., Sun, C., Liu, C., Fan, Y., Zhu, H., Wu, X., Hu, L., & Li, Q. (2015) · PubMed Central · Cited by 26

Dietary supplementation of tiger nut alters biochemical parameters relevant to erectile function in l -NAME treated rats

Olabiyi, A. A., Carvalho, F. B., Bottari, N. B., Lopes, T. F., da Costa, P., Stefanello, N., Morsch, V. M., Akindahunsi, A. A., Oboh, G., & Schetinger, M. R. C. (2018) · Food Research International · doi:10.1016/j.foodres.2018.04.046 · Cited by 26

Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation

Nguyen, M., Park, J. T., Jeon, Y.-G., Jeon, B. H., Hoe, K., Kim, Y. M., Lim, H. K., & Ryoo, S. (2016) · Yonsei Medical Journal · doi:10.3349/ymj.2016.57.6.1329 · Cited by 25

Effects of Dietary N-Carbamylglutamate on Growth Performance, Apparent Digestibility, Nitrogen Metabolism and Plasma Metabolites of Fattening Holstein Bulls

Yang, J., Zheng, J., Fang, X., Jiang, X. P., Sun, Y., & Zhang, Y. (2021) · Animals · doi:10.3390/ani11010126 · Cited by 25

The Mechanisms of L-Arginine Metabolism Disorder in Endothelial Cells

Mammedova, J. T., Av, S., Is, F., & Старикова, Э. А. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921020036 · Cited by 26

L-arginine as dietary supplement for improving microvascular function

Melik, Ž., Benda, P. Z., Potočnik, T. V., & Cankar, K. (2016) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-16159 · Cited by 25

Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity

Liu, Y., Shen, T., Chen, L., Zhou, J., & Wang, C. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09686-z · Cited by 24

Physiological and proteomics responses of nitrogen assimilation and glutamine/glutamine family of amino acids metabolism in mulberry (Morus alba L.) leaves to NaCl and NaHCO3 stress

Zhang, H., Huo, Y., Xu, Z., Guo, K., Wang, Y., Zhang, X., Xu, N., & Sun, G. (2020) · Plant Signaling & Behavior · doi:10.1080/15592324.2020.1798108 · Cited by 24

Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis

Ma, C., Hunt, J. B., Selenica, M.-L. B., Sanneh, A., Sandusky-Beltran, L. A., Watler, M., Daas, R., Kovalenko, A., Liang, H., Placides, D., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582998 · Cited by 24

Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways

Sanchez‐Pino, M. D., Ochoa, A. C., & Foster, T. P. (2016) · Antiviral Research · doi:10.1016/j.antiviral.2016.05.009 · Cited by 24

SRNAome and degradome sequencing analysis reveals specific regulation of sRNA in response to chilling injury in tomato fruit

Zuo, J., Wang, Q., Han, C., Ju, Z., Cao, D., Zhu, B., Luo, Y., & Gao, L. (2016) · Physiologia Plantarum · doi:10.1111/ppl.12509 · Cited by 24

Effects of Dietary L-arginine Supplementation from Conception to Post- Weaning in Piglets

Che, D., Adams, S., Zhao, B. X., Qin, G., & Jiang, H. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190125104959 · Cited by 24

Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism

Watts, J. A., Gellar, M. A., Fulkerson, M.-B. K., Das, S. K., & Kline, J. A. (2011) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2011.10.005 · Cited by 23

L-Arginine administration attenuates airway inflammation by altering L-arginine metabolism in an NC/Nga mouse model of asthma

Zhang, R., Kubo, M., Murakami, I., Setiawan, H., Takemoto, K., Inoue, K., Fujikura, Y., & Ogino, K. (2015) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.14-140 · Cited by 23

Plasma Arginine and Ornithine Are the Main Citrulline Precursors in Mice Infused with Arginine-Free Diets , ,

Marini, J. C., Didelija, I. C., Castillo, L., & Lee, B. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125377 · Cited by 23

Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

Holzmüller, P., Geiger, A., Nzoumbou‐Boko, R., Pissarra, J., Hamrouni, S., Rodrigues, V., Dauchy, F., Lemesre, J.-L., Vincendeau, P., & Bras‐Gonçalves, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00778 · Cited by 23

Predicting lung adenocarcinoma prognosis, immune escape, and pharmacomic profile from arginine and proline-related genes

Wang, Z., Zhang, J., Shi, S., Ma, H., Wang, D., Zuo, C., Zhang, Q., & Lian, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-42541-z · Cited by 21

Microvascular Endothelial Dysfunction and Enhanced Thromboxane and Endothelial Contractility in Patients with HIV

Wang, D. (2013) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.1000267 · Cited by 22

An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice

Olivares‐González, L., Velasco, S., Gallego, I., Esteban‐Medina, M., Puras, G., Loucera, C., Martínez‐Romero, A., Peña-Chilet, M., Pedraz, J. L., & Rodrigo, R. (2022) · Antioxidants · doi:10.3390/antiox12010098 · Cited by 21

A new metabolomic assay to examine inflammation and redox pathways following LPS challenge

Suh, J. H., Kim, R. Y., & Lee, D. S. (2012) · Journal of Inflammation · doi:10.1186/1476-9255-9-37 · Cited by 22

Macrophage Polarization: Decisions That Affect Health

Mills, C. D. (2015) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000364 · Cited by 21

Platelet Supernatant Suppresses LPS-Induced Nitric Oxide Production from Macrophages Accompanied by Inhibition of NF-κB Signaling and Increased Arginase-1 Expression

Ando, Y., Oku, T., & Tsuji, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162208 · Cited by 22

Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation

Mazrouei, S., Sharifpanah, F., Caldwell, R. W., Franz, M., Shatanawi, A., Muessig, J. M., Fritzenwanger, M., Schulze, P. C., & Jung, C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.05.004 · Cited by 21

An Increased Arginase Activity Is Associated with Corpus Cavernosum Impairment Induced by Hypercholesterolemia

Fraga-Silva, R. A., Costa-Fraga, F. P., Faye, Y., Sturny, M., Santos, R. A. S., da Silva, R., & Stergiopulos, N. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12482 · Cited by 20

Effects of military training on plasma amino acid concentrations and their associations with overreaching

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Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway

Zhang, L., Qu, S., Wang, L., Wang, C., Yu, Q., Zhang, Z., Diao, Y., Zhang, B., Li, Y., Shi, Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.661129 · Cited by 20

Defective Nitric Oxide–Cyclic Guanosine Monophosphate Signaling in Patients With Bipolar Disorder

Fontoura, P. C., Pinto, V. L. M., Matsuura, C., Resende, Â. C., de Bem, G. F., Ferraz, M. R., Cheniaux, E., Brunini, T. M. C., & Mendes‐Ribeiro, A. C. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182689460 · Cited by 20

Metabolic and immune effects of orange-spotted grouper, Epinephelus coioides induced by dietary arginine

Han, F., Chi, S., Tan, B., Dong, X., Yang, Q., Liu, H., Zhang, S., Liu, D., & He, Y. (2018) · Aquaculture Reports · doi:10.1016/j.aqrep.2018.03.002 · Cited by 20

Arginase-1 is a Novel Immunohistochemical Marker of Hepatocellular Differentiation

Ordóǹez, N. G. (2014) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000022 · Cited by 20

Dietary nitrate, nitric oxide, and restenosis

Cooke, J. P., & Ghebremariam, Y. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57193 · Cited by 19

Nutrition Delivery for Obese ICU Patients

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Arginase II inhibition prevents nitrate tolerance

Khong, S. M. L., Andrews, K., Huynh, N. N., Venardos, K. M., Aprico, A., Michell, D., Zarei, M., Moe, K. T., Dusting, G., Kaye, D. M., et al. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01876.x · Cited by 19

Increased Endothelial Inflammation, sTie-2 and Arginase Activity in Umbilical Cords Obtained from Gestational Diabetic Mothers

Giri, H., Chandel, S., DWARAKANATH, L. S., Sreekumar, S., & Dixit, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084546 · Cited by 19

Effect of l-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study

Yeung, S. L. A., Lin, S. L., Lam, H. S., & Schooling, C. M. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.07.021 · Cited by 19

Single- and multiple-dose pharmacokinetics of arginase inhibitor Nω-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats

Havlínová, Z., Hroch, M., Nagy, A., Šišpera, L., Holeček, M., & Chládek, J. (2014) · General Physiology and Biophysics · doi:10.4149/gpb_2013078 · Cited by 19

Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism

Watts, J. A., Marchick, M. R., Gellar, M. A., & Kline, J. A. (2011) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2011.01.009 · Cited by 19

Specific changes in amino acid profiles in monocytes of patients with breast, lung, colorectal and ovarian cancers

Chagovets, V., Starodubtseva, N. L., Tokareva, A., Novoselova, A., Patysheva, M. R., Larionova, I., Prostakishina, E. A., Rakina, M. A., Казакова, А., Topolnitskiy, E. B., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1332043 · Cited by 19

Effects of acute‐liver‐failure‐plasma exposure on hepatic functionality of Hepa RG ‐ AMC ‐Bioartificial Liver

Nibourg, G. A. A., Hoekstra, R., van der Hoeven, T. V., Ackermans, M. T., Hakvoort, T. B. M., van Gulik, T. M., & Chamuleau, R. A. F. M. (2012) · Liver International · doi:10.1111/liv.12090 · Cited by 18

Effects of a chronic l -arginine supplementation on the arginase pathway in aged rats

Moretto, J., Guglielmetti, A.-S., Tournier-Nappey, M., Martin, H., Prigent‐Tessier, A., Marie, C., & Demougeot, C. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.023 · Cited by 18

Structures of bacterial biosynthetic arginine decarboxylases

Forouhar, F., Lew, S., Seetharaman, J., Xiao, R., Acton, T., Montelione, G. T., & Tong, L. (2010) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309110040649 · Cited by 18

Genetics of NO Deficiency

Leineweber, K., Moosmang, S., & Paulson, D. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2017.06.013 · Cited by 18

Effects of combined crude alkaloid-rich extracts from alligator pepper (Aframomum melegueta) and bastered melegueta (Aframomum danielli) on the enzymes crucial to erectile dysfunction-in vitro

Okeke, B. M., Adefegha, S. A., Oyeleye, S. I., & Oboh, G. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12550 · Cited by 18

High in situ mRNA levels of IL-22, TFG-β, and ARG-1 in keloid scars

Tiveron, L. R. D. C. C., da Silva, I. R., da Silva, M. V., Peixoto, A. B., Rodrigues, D. B. R., & Rodrigues, V. (2018) · Immunobiology · doi:10.1016/j.imbio.2018.08.010 · Cited by 20

Ruminal microbiota and muscle metabolome characteristics of Tibetan plateau yaks fed different dietary protein levels

Pang, K., Wang, J., Chai, S., Yang, Y., Wang, X., Liu, S., Ding, C., & Wang, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1275865 · Cited by 17

A Non-Targeted Capillary Electrophoresis-Mass Spectrometry Strategy to Study Metabolic Differences in an In Vitro Model of High-Glucose Induced Changes in Human Proximal Tubular HK-2 Cells

Bernardo‐Bermejo, S., Sánchez‐López, E., Castro‐Puyana, M., Martínez, S. B., Lucio-Cazaña, F. J., & Marina, M. L. (2020) · Molecules · doi:10.3390/molecules25030512 · Cited by 17

Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma

Mittal, A. K., Wang, M., Vidyarthi, A., Yanez, D. A., Pizzurro, G. A., Thakral, D., Tracy, E., & Colegio, O. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-90200-y · Cited by 17

Growth Factors in the Pathogenesis of Retinal Neurodegeneration in Diabetes Mellitus

Beń‐Skowronek, I. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160813182009 · Cited by 21

Short communication: Effects of dietary addition of N-carbamoylglutamate on milk composition in mid-lactating dairy cows

Gu, F., Liang, S., Wei, Z., Wang, C. P., Liu, H., Liu, J., & Wang, D. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-15162 · Cited by 17

How endothelial cell metabolism shapes blood–brain barrier integrity in neurodegeneration

Wang, J., Chen, Y., Chen, S., Mu, Z., & Chen, J. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1623321 · Cited by 19

Immune, metabolic landscapes of prognostic signatures for lung adenocarcinoma based on a novel deep learning framework

Qin, S., Sun, S., Wang, Y., Li, C., Fu, L., Wu, M., Yan, J., Wan, L., Lv, J., & Chen, L. (2024) · Scientific Reports · doi:10.1038/s41598-023-51108-x · Cited by 16

Cytokines Modulate the “Immune-Metabolism” Interactions during Behçet Disease: Effect on Arginine Metabolism

Belguendouz, H., Lahmar-Belguendouz, K., Messaoudene, D., Djeraba, Z., Otmani, F., Hakem, D. J., Lahlou-Boukoffa, O. S., Youinou, P., & Touil–Boukoffa, C. (2015) · International Journal of Inflammation · doi:10.1155/2015/241738 · Cited by 16

Detection and functional evaluation of arginase-1 isolated from human PMNs and murine MDSC

Canè, S., & Bronte, V. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.07.022 · Cited by 16

Urea Excretion and Arginase Activity as New Biomarkers for Nitrite Stress in Freshwater Aquatic Animals

Napolitano, G., Fasciolo, G., Agnisola, C., & Venditti, P. (2021) · Water · doi:10.3390/w13243521 · Cited by 15

Inflammation, Immunity and Redox Signaling

Jabaut, J., & Ckless, K. (2012) · InTech eBooks · doi:10.5772/27242 · Cited by 15

Biochemical and biological activity of arginine deiminase from Streptococcus pyogenes M22

Старикова, Э. А., Av, S., Vlasenko, A. Y., Burova, L. A., Is, F., & Vasilyev, V. B. (2015) · Biochemistry and Cell Biology · doi:10.1139/bcb-2015-0069 · Cited by 15

Effects of specific nutrients on immune modulation in patients with gastrectomy

Wu, J., & Lin, M. (2019) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12299 · Cited by 15

Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer’s Disease: A Targeted Transcriptome Analysis

Ma, C., Hunt, J. B., Kovalenko, A., Liang, H., Selenica, M. B., Orr, M. B., Zhang, B., Gensel, J. C., Feola, D. J., Gordon, M. N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628156 · Cited by 16

Optical biosensing of markers of mucosal inflammation

Covarrubias‐Zambrano, O., Motamedi, M., Ameredes, B. T., Tian, B., Calhoun, W. J., Zhao, Y., Brasier, A. R., Kalubowilage, M., Malalasekera, A. P., Yapa, A. S., et al. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102476 · Cited by 15

Arginase Activity in Patients with Breast Cancer: An Analysis of Plasma, Tumors, and Its Relationship with the Presence of the Estrogen Receptor

Perez, G. M., Olivares-Corichi, I. M., Rodriguez, M. G., Ceballos, G. M., & García-Sánchez, J. R. (2012) · Onkologie · doi:10.1159/000343005 · Cited by 15

An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes

Trittmann, J. K. B., Jin, Y., Chicoine, L. G., Liu, Y., Chen, B., & Nelin, L. D. (2016) · Physiological Reports · doi:10.14814/phy2.13041 · Cited by 15

Effects of dietary supplementation of N-carbamylglutamate on lactation performance of lactating goats and growth performance of their suckling kidlets

Wang, Z., Wang, R., Meng, C., Ji, Y., Sun, L., Nie, H., Mao, D., & Wang, F. (2019) · Small Ruminant Research · doi:10.1016/j.smallrumres.2019.01.008 · Cited by 15

Nitric oxide-modulating biomaterials for therapeutic Immunoengineering

Boo, Y., Choi, S., Kim, J., & Kim, W. J. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115718 · Cited by 16

Supplementing N-carbamoylglutamate in late gestation increases newborn calf weight by enhanced placental expression of mTOR and angiogenesis factor genes in dairy cows

Gu, F., Jiang, L., Xie, L., Wang, D., Zhao, F., & Liu, J. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.05.007 · Cited by 16

Metabolomics and Biomarkers in Retinal and Choroidal Vascular Diseases

Hou, X.-W., Wang, Y., Ke, C., Li, M., & Pan, C. (2022) · Metabolites · doi:10.3390/metabo12090814 · Cited by 14

An update review of new therapies in sickle cell disease: the prospects for drug combinations

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Arginine promotes the activation of human lung fibroblasts independent of its metabolism

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Involvement of Arginase in Methyl Jasmonate–induced Tomato Fruit Chilling Tolerance

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Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters

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Dietary supplementation with N-carbamoylglutamate initiated from the prepartum stage improves lactation performance of postpartum dairy cows

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Arginine: What You Need to Know for Pressure Injury Healing

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Dynamics of arginase gene evolution in metazoans

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Arginase Promotes Skeletal Muscle Arteriolar Endothelial Dysfunction in Diabetic Rats

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A Slow- Compared with a Fast-Release Form of Oral Arginine Increases Its Utilization for Nitric Oxide Synthesis in Overweight Adults with Cardiometabolic Risk Factors in a Randomized Controlled Study

Deveaux, A., Fouillet, H., Petzke, K. J., Hermier, D., André, E., Bunouf, P., Lantoine, F., Benamouzig, R., Mathé, V., Huneau, J., et al. (2016) · Journal of Nutrition · doi:10.3945/jn.116.231910 · Cited by 15

Association of plasma arginine with breast cancer molecular subtypes in women of Liaoning province

Hu, L., Gao, Y. J., Cao, Y., Zhang, Y., Xu, M., Wang, Y., Jing, Y., Guo, S., Jing, F., Hu, X., et al. (2016) · IUBMB Life · doi:10.1002/iub.1581 · Cited by 14

Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice

Didelija, I. C., Mohammad, M. A., & Marini, J. C. (2017) · Journal of Nutrition · doi:10.3945/jn.117.251249 · Cited by 14

Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia

Trittmann, J. K. B., Bartenschlag, A., Zmuda, E. J., Frick, J., Stewart, W. C. L., & Nelin, L. D. (2018) · Acta Paediatrica · doi:10.1111/apa.14600 · Cited by 14

The arginase inhibitor Nω−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target

Ng, K. P., Manjeri, A., Lee, L. M., Chan, Z. E., Tan, C. Y., Tan, Q. D., Majeed, A., Lee, K. L., Chuah, C. T. H., Suda, T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205254 · Cited by 14

Quercetin boosts nitric oxide levels and modulates the activities of arginase, acetylcholinesterase and adenosine deaminase in the corpus cavernosum of cyclosporine‐treated rats

Olabiyi, A. A., Tope‐Eniola, O. S., Oluwatuyi, A. O., Alabi, O., Ademola, O. G., Oguntimehin, O. M., & AlliSmith, Y. R. (2022) · Andrologia · doi:10.1111/and.14404 · Cited by 13

Novel orally bioavailable piperidine derivatives as extracellular arginase inhibitors developed by a ring expansion

Gzik, A., Borek, B., Chrzanowski, J., Jedrzejczak, K., Dzięgielewski, M., Brzezinska, J., Nowicka, J., Grzybowski, M. M., Rejczak, T. P., Niedziałek, D., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116033 · Cited by 13

Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats

Shin, S., Na, S., Kim, O. S., Choi, Y. S., Kim, S. H., & Oh, Y. J. (2015) · Yonsei Medical Journal · doi:10.3349/ymj.2016.57.1.238 · Cited by 13

Putative Agmatinase Inhibitor for Hypoxic-Ischemic New Born Brain Damage

Piletz, J. E., Klenotich, S. J., Lee, K. S., Zhu, Q. L., Valente, E. J., Collins, M. A., Jones, V., Lee, S. N., & Yangzheng, F. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9376-5 · Cited by 13

Human cytomegalovirus induces upregulation of arginase II: possible implications for vasculopathies

Yaiw, K.-C., Mohammad, A., Taher, C., Wilhelmi, V., Davoudi, B., Strååt, K., Assinger, A., Овчинникова, О. А., Shlyakhto, E. V., Rahbar, A., et al. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0401-5 · Cited by 13

Catalytic divergencies in the mechanism of L-arginine hydroxylating nonheme iron enzymes

Ali, H. S., & de Visser, S. P. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1365494 · Cited by 12

Metabolic adaptation of myeloid cells in the glioblastoma microenvironment

Essakhi, N., Bertucci, A., Baeza, N., Colin, C., Lavignolle, R., García-González, P. A., Argüello, R. J., Tchoghandjian, A., & Tabouret, É. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1431112 · Cited by 12

Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini‐pigs

Duan, Y., Yue, Z., Zhu, Q., Cai, Q., Li, H., Yin, Y., Wang, Z., & Kong, X. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9405 · Cited by 12

Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Rest and During Exercise

Holz, O., DeLuca, D., Roepcke, S., Illig, T., Weinberger, K., Schudt, C., & Hohlfeld, J. (2020) · International Journal of COPD · doi:10.2147/copd.s217474 · Cited by 12

Kidney transcriptome analysis of tiger puffer (Takifugu rubripes) uncovers key pathways and genes in response to low-temperature stress

Liu, Z., Ma, A., Yuan, C., Zhu, L., Chang, H., Yu, L., & Meng, X. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101287 · Cited by 12

The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging

Wang, Y., Li, Y., Li, Y., Cui, Y., Zhang, Y., Shi, W., Wang, J., Wu, X., Liang, R., Wang, X., et al. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2216382 · Cited by 12

Role of Arginase in Vessel Wall Remodeling

Durante, W. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00111 · Cited by 94

Arginase in vascular disease: Mechanisms, measurement, and medicine

Durante, W. (2026) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2026.09.053

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION

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doi: 10.3389/fimmu.2013.00111 Role of arginase in vessel wall remodeling

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Biochemistry, pharmacology, and in vivo function of arginases

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