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Recent advances in arginine metabolism: roles and regulation of the arginases
Open accessAbstract
As arginine can serve as precursor to a wide range of compounds, including nitric oxide, creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest in elucidating mechanisms underlying regulation of its metabolism. It is now becoming apparent that the two isoforms of arginase in mammals play key roles in regulation of most aspects of arginine metabolism in health and disease. In particular, work over the past several years has focused on the roles and regulation of the arginases in vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. As most of these topics have been considered in recent review articles, this review will focus more closely on results of recent studies on expression of the arginases in endothelial and vascular smooth muscle cells, post‐translational modulation of arginase activity and applications of arginase inhibitors in vivo .
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“At the site of vascular injury, arginase is induced, converting arginine to urea and ornithine (8).”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [8]
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Metadata
- Authors
- Morris Jr, S. M.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2009-07
- Volume
- 157
- Issue
- 6
- Pages
- 922-930
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC2737650
- OpenAlex
- W1996295305
- Cited by
- 485
- References
- 96
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 24 · 2023: 24 · 2022: 20 · 2021: 35 · 2020: 33 · 2019: 24 · 2018: 31 · 2017: 23 · 2016: 35 · 2015: 30 · 2014: 32 · 2013: 43 · 2012: 33
- FWCI
- 20.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM64509, GM57384, R01GM057384, R01GM064509)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- arginine metabolism, arginase, nitric oxide, endothelial cells, vascular smooth muscle cells, post-translational regulation, arginase inhibitors, vascular disease, lung disease, immune cell function, cancer
- MeSH terms
- Animals, Arginase, Arginine, Cytosol, Disease Models, Animal, Endothelium, Vascular, Humans, Isoenzymes, Muscle, Smooth, Vascular, Gene Expression Regulation, Enzymologic, Mitochondrial Proteins
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