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Cited by 100Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyCognitive Abilities and Testing

Association between tobacco smoking and cognitive functioning in young adults

Chamberlain, Samuel R., Odlaug, Brian L., Schreiber, Liana R. N., Grant, Jon E.·2012·The American Journal on Addictions
DOI 10.1111/j.1521-0391.2012.00290.x
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Abstract

Background: Tobacco smoking represents a considerable public health burden globally. Smoking in older adults is associated with cognitive impairment and more rapid age‐associated cognitive decline, but there is a paucity of studies in younger people. Method: Adults aged 18–29 years were recruited from a longitudinal study investigating impulsivity in young people. Exclusion criteria were presence of any axis‐I morbidity or cannabis use. Subjects undertook neurocognitive assessment using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Demographic, clinical, and cognitive differences between smokers (N = 37) and nonsmokers (N = 177) were characterized. Results: Groups were well matched in terms of age, education, income, and gender. In comparison to nonsmokers, nicotine users showed significant cognitive impairments on sustained attention (target detection: p= .005), spatial working memory (errors: p= .023, strategy use: p= .004), executive planning (p= .002), and did not appropriately adjust behavior as a function of risk (Gamble task risk adjustment: p= .004). Smokers were intact on general response speeds and response inhibition. Conclusions: These data, using objective translational paradigms, support an association between tobacco smoking and cognitive problems in young people, with implications for such individuals and for society. Future studies should extend these results longitudinally to explore causality, and evaluate effects of nicotinic agents (including anti‐smoking medications) on cognition. (Am J Addict 2012;21:S14–S19)

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Crossref · 10.1111/j.1521-0391.2012.00290.x

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  • In young adult non-abstinent smokers and nonsmokers aged 18-29 matched for age, education, income, and sex, smokers showed significant cognitive impairments in sustained attention, spatial working memory, and executive planning.

    “In a study of young adult non-abstinent smokers and non-smokers age 18-29 years who were matched for age, education, income, and sex, smokers showed significant cognitive impairments in sustained attention, spatial working memory, and executive planning.”

    From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [272]

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Authors
Chamberlain, S. R., Odlaug, B. L., Schreiber, L. R. N., & Grant, J. E.
Affiliations
  • University of Cambridge (GB)
  • University of Minnesota Medical Center (US)
ORCID
Venue
The American Journal on Addictions
Publisher
Wiley
Published
2012-11
Volume
21
Issue
s1
Pages
S14-9
ISSN
  • 1055-0496 (ISSN-L)
  • 1521-0391
DOI
10.1111/j.1521-0391.2012.00290.x
OpenAlex
W1557743053
Cited by
100
References
49
Citations by year
2026: 5 · 2025: 2 · 2024: 19 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 1
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1015 d)
Locations
  • American Journal on Addictions (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (acceptedVersion)
Funders
  • National Institutes of Health (5rc1da028279-02)
  • National Institute on Drug Abuse (1RC1DA 028279-01)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
smoking, cognitive function, young adults, nicotine, sustained attention, spatial working memory, executive planning, risk adjustment, impulsivity, cognitive impairment, CANTAB
MeSH terms
Adolescent, Adult, Attention, Cognition, Cognition Disorders, Female, Humans, Male, Memory, Short-Term, Neuropsychological Tests, Smoking, Case-Control Studies, Young Adult, Executive Function

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