Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent condition associated with cognitive dysfunction. The Cambridge Neuropsychological Test Automated Battery is a computerized set of tests that has been widely used in ADHD and in translation/back-translation. Following a survey of translational research relevant to ADHD in experimental animals, a comprehensive literature review was conducted of studies that had used core Cambridge Neuropsychological Test Automated Battery tests 1) to evaluate cognitive dysfunction in ADHD and 2) to evaluate effects of salient drugs in patients and in volunteers. Meta-analysis was conducted where four or more independent datasets were available. Meta-analysis revealed medium-large decrements in ADHD for response inhibition (d = .790, p < .001), working memory (d = .883, p < .001), executive planning (d = .491, p < .001), and a small decrement in attentional set shifting (d = .160, p = .040). Qualitative review of the literature showed some consistent patterns. In ADHD, methylphenidate improved working memory, modafinil improved planning, and methylphenidate, modafinil, and atomoxetine improved inhibition. Meta-analysis of modafinil healthy volunteer studies showed no effects on sustained attention or set shifting. Results were paralleled by findings in experimental animals on comparable tests, enabling further analysis of drug mechanisms. Substantial cognitive deficits are present in ADHD, which can be remediated somewhat with curren…
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All medications currently approved for the treatment of ADHD influence norepinephrine transmission, and all can improve at least some aspects of PFC function.
“All medications currently approved for the treatment of ADHD influence NE transmission (Figure 2E), and all can improve at least some aspects of PFC function (82).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [82]
All current pharmacological treatments for ADHD facilitate catecholamine transmission.
“All current pharmacological treatments for ADHD facilitate catecholamine transmission, and basic research suggests that these compounds have prominent actions in the prefrontal cortex (PFC).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [82]
These compounds have prominent actions in the prefrontal cortex.
“All current pharmacological treatments for ADHD facilitate catecholamine transmission, and basic research suggests that these compounds have prominent actions in the prefrontal cortex (PFC).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [82]
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- Authors
- Chamberlain, S. R., Robbins, T. W., Winder-Rhodes, S., Müller, U., Sahakian, B. J., Blackwell, A. D., & Barnett, J. H.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Chamberlain, Samuel R.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 69
- Issue
- 12
- Pages
- 1192-1203
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1978525999
- Cited by
- 178
- References
- 32
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 14 · 2020: 8 · 2019: 9 · 2018: 18 · 2017: 16 · 2016: 16 · 2015: 8 · 2014: 19 · 2013: 17 · 2012: 21
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, CANTAB, frontostriatal dysfunction, cognitive impairment, response inhibition, working memory, executive planning, set-shifting, methylphenidate, modafinil, atomoxetine, ADHD medication, animal model of ADHD, sustained attention
- MeSH terms
- Central Nervous System Stimulants, Animals, Attention Deficit Disorder with Hyperactivity, Cognition, Cognition Disorders, Corpus Striatum, Frontal Lobe, Humans, Neural Pathways, Neuropsychological Tests, Psychomotor Performance, Translational Research, Biomedical
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