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Cited by 617Musculoskeletal pain and rehabilitationMental Health Treatment and AccessPsychosomatic Disorders and Their Treatments

Using Chronic Pain to Predict Depressive Morbidity in the General Population

Ohayon, Maurice M., Schatzberg, Alan F.·2003·Archives of General Psychiatry
DOI 10.1001/archpsyc.60.1.39
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Abstract

Background Pain syndrome is thought to play a role in depression. This study assesses the prevalence of chronic (>or= 6 months' duration) painful physical conditions (CPPCs) (joint/articular, limb, or back pain, headaches, or gastrointestinal diseases) and their relationship with major depressive disorder. Methods We conducted a cross-sectional telephone survey of a random sample of 18 980 subjects from 15 to 100 years old representative of the general populations of the United Kingdom, Germany, Italy, Portugal, and Spain. Answers provided during telephone interviews using the Sleep-EVAL system were the main outcome measure. Interviews included questions about mental disorders and medical conditions. Data on painful physical conditions were obtained through questions about medical treatment, consultations, and/or hospitalizations for medical conditions and a list of 42 diseases. Results Of all subjects interviewed, 17.1% reported having at least 1 CPPC (95% confidence interval [CI], 16.5%-17.6%). At least 1 depressive symptom (sadness, depression, hopelessness, loss of interest, or lack of pleasure) was present in 16.5% of subjects (95% CI, 16.0%-17.1%); 27.6% of these subjects had at least 1 CPPC. Major depressive disorder was diagnosed in 4.0% of subjects; 43.4% of these subjects had at least 1 CPPC, which was 4 times more often than in subjects without major depressive disorder (odds ratio [OR], 4.0; 95% CI, 3.5-4.7). In a logistic regression model, CPPC was strongly assoc…

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  • Chronic pain is a strong, independent predictor of both onset and duration of depressive symptoms in the general population.

    “chronic pain is a strong, independent predictor of both onset and duration of depressive symptoms in the general population”

    From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Ohayon & Schatzberg, 2003

  • The prevalence of chronic painful physical symptoms is increased in patients with mood disorders and in patients with anxiety disorders.

    “Epidemiological studies show that the prevalence of chronic painful physical symptoms is increased in patients with mood disorders and in patients with anxiety disorders, suggesting they are not speci fi c to depressive disorders (Ohayon and Schatzberg, 2003; Demyttenaere et al., 2006, 2008).”

    From Presence and predictors of pain in depression: Results from the FINDER study (2010) · cites this paper as Ohayon and Schatzberg, 2003

  • Previous studies report that the duration of depressive episodes is longer in patients with pain than in those without pain.

    “Previous studies report that the duration of depressive episodes is longer in patients with pain than in those without pain (Ohayon and Schatzberg, 2003)”

    From Presence and predictors of pain in depression: Results from the FINDER study (2010) · cites this paper as Ohayon and Schatzberg, 2003

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Authors
Ohayon, M. M., & Schatzberg, A. F.
Affiliations
Stanford Medicine (US)
Corresponding author
Ohayon, Maurice M.
ORCID
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
2003-01-01
Volume
60
Issue
1
Pages
39
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.60.1.39
OpenAlex
W2124613380
Cited by
617
References
3
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 20 · 2022: 20 · 2021: 16 · 2020: 25 · 2019: 29 · 2018: 29 · 2017: 23 · 2016: 15 · 2015: 40 · 2014: 29 · 2013: 40 · 2012: 35
FWCI
21.86
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
chronic pain, major depressive disorder, pain syndromes, depressive symptoms, comorbidities, depression screening
MeSH terms
Adult, Aged, Chronic Disease, Cross-Sectional Studies, Depressive Disorder, Female, Germany, United Kingdom, Health Surveys, Humans, Italy, Male, Middle Aged, Pain, Portugal, Probability, Risk Factors, Spain, Comorbidity, Prevalence

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