Anxiety disorders, subsyndromic depressive episodes, and major depressive episodes: do they differ on their impact on the quality of life of patients with epilepsy?
Open accessAbstract
AIMS OF THE STUDY: To compare the impact of anxiety disorders, major depressive episodes (MDEs), and subsyndromic depressive episodes (SSDEs) on the quality of life of patients with epilepsy (PWEs), and to identify the variables predictive of poor quality of life. METHODS: A psychiatric diagnosis according to DSM-IV-TR criteria was established in 188 consecutive PWEs with the MINI International Neuropsychiatric Interview. Patients also completed the Beck Depression Inventory-II (BDI-II), the Centers for Epidemiologic Studies-Depression (CES-D), and the Quality of Life in Epilepsy-89 (QOLIE-89). A diagnosis of SSDE was made in any patient with total scores of the BDI-II >12 or CES-D >16 in the absence of any DSM-IV diagnosis of mood disorder according to the MINI. RESULTS: Patients with SSDEs (n = 26) had a worse quality of life than asymptomatic patients (n = 103). This finding was also observed among patients with MDEs only (n = 10), anxiety disorders only (n = 21), or mixed MDEs/anxiety disorders (n = 28). Furthermore, having mixed SSDEs/anxiety disorders yielded a worse quality of life than having only SSDEs. Independent predictors of poor quality of life included having a psychiatric disorder and persistent epileptic seizures in the last 6 months. CONCLUSIONS: Although isolated mood and anxiety disorders, including SSDE, have a comparable negative impact on the quality of life of PWEs; the comorbid occurrence of mood and anxiety disorders yields a worse impact. In addition, seizure freedom in the previous 6 months predicts a better quality of life.
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There is a strong inverse correlation between QoL and depressive symptoms.
“This finding is in accordance with the literature,56-60 which reports that there is a strong inverse correlation between QoL and depressive symptoms.”
From Improved quality of life and reduced depressive symptoms in medical students after a single-session intervention (2020) · cites this paper as [57]
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- Authors
- Kanner, A. M., Barry, J. J., Gilliam, F., Hermann, B., & Meador, K. J.
- Affiliations
- Rush University Medical Center (US)
- Stanford Medicine (US)
- University of Florida (US)
- Corresponding author
- Kanner, Andres M.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 51
- Issue
- 7
- Pages
- 1152-1158
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2126445331
- Cited by
- 182
- References
- 29
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 18 · 2023: 6 · 2022: 12 · 2021: 20 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 16 · 2016: 9 · 2015: 8 · 2014: 20 · 2013: 11 · 2012: 13
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute of Neurological Disorders and Stroke (K24NS047551, R01NS040808)
- UCB Pharma
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- epilepsy, quality of life, anxiety disorders, major depressive episode, comorbidities, mood disorders, seizure freedom, predictors of poor quality of life
- MeSH terms
- Adult, Anxiety Disorders, Depression, Major Depressive Disorder, Depressive Disorder, Epilepsy, Female, Humans, Male, Middle Aged, Quality of Life
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