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Cited by 165Substance Abuse Treatment and OutcomesPrenatal Substance Exposure EffectsAlcohol Consumption and Health Effects

Chronic tolerance and sensitization to alcohol in sons of alcoholics

Newlin, David B., Thomson, James B.·1991·Alcoholism Clinical and Experimental Research
DOI 10.1111/j.1530-0277.1991.tb00537.x
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Abstract

In view of conflicting results concerning differences between sons of alcoholics and sons of nonalcoholics in response to a single alcohol challenge (with a given dose), we exposed these high and low risk groups to several sessions in which they drank alcohol at the same dose in order to measure the development of chronic tolerance or sensitization with repeated doses. Sons of alcoholics and sons of nonalcoholics received a moderate dose of alcohol (0.5 g/kg) in three sessions with alcohol, followed by a placebo session. Sons of alcoholics developed reverse tolerance or chronic sensitization to repeated dosings of alcohol in finger pulse amplitude, while sons of nonalcoholics did not. Sons of alcoholics failed to show chronic tolerance in skin conductance and finger temperature, while sons of alcoholics did show the development of tolerance. Sons of alcoholics demonstrated greater motor activity throughout the sessions, both before and after alcohol. These results indicate that high and low risk groups differ in terms of their developmental adaptation to alcohol, as well as in the temperamental trait of behavioral activity.

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Crossref · 10.1111/j.1530-0277.1991.tb00537.x

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33 of 33 references verified0 citation errors · 0 not checkable

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  • Human studies in this area have been limited to retrospective patient reports, post mortem brain tissue methods, or cross-sectional laboratory paradigms, none of which directly measure alcohol responses in the same individuals over time.

    “Human studies in this area have been limited to retrospective patient reports(23), post mortem brain tissue methods(24), or cross-sectional laboratory paradigms(2, 3, 25–29), none of which directly measure alcohol responses in the same individuals over time.”

    From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [27]

  • Previous studies relying on proxy measures of brain-behavior relationships to alcohol response have not been able to address within-person changes or stabilization in alcohol response over time.

    “Previous studies relying on proxy measures of brain-behavior relationships to alcohol response(2, 3, 23–29) have not been able to address within-person changes or stabilization in alcohol response over time.”

    From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [27]

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Authors
Newlin, D. B., & Thomson, J. B.
Affiliations
Purdue University West Lafayette (US)
Corresponding author
Newlin, David B.
Venue
Alcoholism Clinical and Experimental Research
Publisher
Wiley
Published
1991-06
Volume
15
Issue
3
Pages
399-405
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
DOI
10.1111/j.1530-0277.1991.tb00537.x
OpenAlex
W2129344183
Cited by
165
References
33
Citations by year
2025: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 6 · 2012: 8
FWCI
7.40
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5428 d)
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r23aa006433-03)
  • National Institute on Alcohol Abuse and Alcoholism (AA06433)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
sons of alcoholics, alcohol tolerance, reverse tolerance, alcohol challenge, behavioral activity, skin conductance, finger temperature, motor activity
MeSH terms
Alcohol Drinking, Ethanol, Alcoholism, Arousal, Breath Tests, Conditioning, Classical, Dose-Response Relationship, Drug, Drug Tolerance, Humans, Male, Child of Impaired Parents

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