The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Exercise Training and Plasma C‐Reactive Protein and Interleukin‐6 in Elderly People
Open accessAbstract
OBJECTIVES: To determine the effects of a long‐term exercise intervention on two prominent biomarkers of inflammation (C‐reactive protein (CRP) and interleukin‐6 (IL‐6)) in elderly men and women. DESIGN: Single‐blind, randomized, controlled trial: The Lifestyle Interventions and Independence for Elders (LIFE) Trial. SETTING: The Cooper Institute, Dallas, Texas; Stanford University, Stanford, California; University of Pittsburgh, Pittsburgh, Pennsylvania; and Wake Forest University, Winston‐Salem, North Carolina. PARTICIPANTS: Four hundred twenty‐four elderly (aged 70–89), nondisabled, community‐dwelling men and women at risk for physical disability. INTERVENTION: A 12‐month moderate‐intensity physical activity (PA) intervention and a successful aging (SA) health education intervention. MEASUREMENTS: CRP and IL‐6. RESULTS: After adjustment for baseline IL‐6, sex, clinic site, diabetes mellitus, treatment group, visit, and group‐by‐visit interaction, the PA intervention resulted in a lower ( P =.02) IL‐6 concentration than the SA intervention. Adjusted mean IL‐6 at month 12 was 8.5% (0.21 pg/mL) higher in the SA than the PA group. There were no significant differences in CRP between the groups at 12 months ( P =.09). Marginally significant interaction effects of the PA intervention according to baseline functional status ( P =.05) and IL‐6 (above vs below the median; P =.06) were observed. There was a greater effect of the PA intervention on participants with lower functional status and those with a higher baseline IL‐6. CONCLUSION: Greater PA results in lower systemic concentrations of IL‐6 in elderly individuals, and this benefit is most pronounced in individuals at the greatest risk for disability and subsequent loss of independence.
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Cites
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor- , in Vivo
Mohamed-Ali, V. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.12.4196 · Cited by 717
Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population
Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.3.242 · Cited by 599
The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly
Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.4.m201 · Cited by 476
Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m709 · Cited by 438
Kohut, M. L., McCann, D. A., Russell, D. W., Konopka, D. N., Cunnick, J. E., Franke, W. D., Castillo, M. C., Reighard, A. E., & Vanderah, E. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.12.002 · Cited by 436
Mattusch, Dufaux, Heine, Mertens, & Rost (2000) · International Journal of Sports Medicine · doi:10.1055/s-2000-8852 · Cited by 389
Reduction in C-reactive protein through cardiac rehabilitation and exercise training
Milani, R. V., Lavie, C. J., & Mehra, M. R. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.041 · Cited by 302
Reuben, D. B., Judd‐Hamilton, L., Harris, T. B., & Seeman, T. E. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51380.x · Cited by 224
Lakka, T. A., Lakka, H.-M., Rankinen, T., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Bouchard, C. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi394 · Cited by 206
Zoppini, G., Targher, G., Zamboni, C., Venturi, C., Cacciatori, V., Moghetti, P., & Muggeo, M. (2006) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.09.004 · Cited by 173
Cited by
Reciprocal regulation of the neural and innate immune systems
Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910
Kenfield, S. A., Stampfer, M. J., Giovannucci, E., & Chan, J. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.5226 · Cited by 601
Exercise Benefits Brain Function: The Monoamine Connection
Lin, T.-W., & Kuo, Y.-M. (2013) · Brain Sciences · doi:10.3390/brainsci3010039 · Cited by 392
Mind–body therapies and control of inflammatory biology: A descriptive review
Bower, J. E., & Irwin, M. R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.012 · Cited by 388
“Indeed, in the exercise literature, year-long physical activity interventions have been required to reduce circulating levels of CRP (e.g., Nicklas et al., 2008).”
BackgroundExercise, inflammation and aging.
(2012) · Europe PMC (PubMed Central) · Cited by 345
Metadata
- Authors
- Nicklas, B. J., Hsu, F., Brinkley, T. J., Church, T., Goodpaster, B. H., Kritchevsky, S. B., & Pahor, M.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2008-11
- Volume
- 56
- Issue
- 11
- Pages
- 2045-2052
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2109227915
- Cited by
- 286
- References
- 11
- FWCI
- 14.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Nicklas, B. J., Hsu, F., Brinkley, T. J., Church, T., Goodpaster, B. H., Kritchevsky, S. B., & Pahor, M. (2008). Exercise Training and Plasma C‐Reactive Protein and Interleukin‐6 in Elderly People. Journal of the American Geriatrics Society. https://doi.org/10.1111/j.1532-5415.2008.01994.x
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