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Cited by 302Cardiac Health and Mental HealthLipoproteins and Cardiovascular HealthCardiovascular and exercise physiology

Reduction in C-reactive protein through cardiac rehabilitation and exercise training

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Milani, Richard V, Lavie, Carl J, Mehra, Mandeep R·2004·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2003.10.041
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Abstract

Objectives This study was designed to assess the effects of three-month formal phase II cardiac rehabilitation and exercise training programs on high-sensitivity C-reactive protein (HSCRP) levels in patients with coronary heart disease (CHD).Background High-sensitivity C-reactive protein is associated with abdominal adiposity and other CHD risk factors and is a potent independent predictor of CHD events. Although weight reduction and statin therapy reduce HSCRP levels, the independent effects of cardiac rehabilitation programs on HSCRP are not well established.Methods We analyzed plasma levels of HSCRP in 277 patients with CHD (235 consecutive patients before and after formal phase II cardiac rehabilitation and exercise training programs and 42 "control" patients who did not attend cardiac rehabilitation). Additionally, we determined the effects of cardiac rehabilitation on HSCRP independent of statin therapy and weight loss.Results Rehabilitation patients improved significantly in body fat, obesity indices, exercise capacity, and other cardiac risk factors. Mean (5.9 +/- 7.7 to 3.8 +/- 5.8 mg/l; -36%; p < 0.0001) and median levels of HSCRP (-41%; p = 0.002) decreased significantly in the rehabilitation group but not in the control population. Similar significant reductions in HSCRP occurred in the rehabilitation patients regardless of whether they received statin therapy or lost weight.Conclusions Therapeutic lifestyle changes effected through a three-month cardiac rehabilitation program significantly improved numerous cardiac risk factors. Through this holistic approach to secondary prevention, we observed significant reductions in HSCRP levels. These findings identify another clinical modality of reducing HSCRP beyond use of statin drugs and suggest an additional benefit of formal phase II cardiac rehabilitation and exercise training programs.

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  • IL-6 increases by 0.016 pg/ml per year of life.

    “Studies have reported increased plasma/serum levels of the proinflammatory cytokine IL-6 in healthy subjects with advanced age (55-75 v. 26 -54 years) (174) , an increase of 0•016 pg/ml per year of life (175) and a significant increase with overall age (from 20 to 102 years) (176) , and in elderly diabetic subjects (65 -80 years) (177) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [175]

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Authors
Milani, R. V., Lavie, C. J., & Mehra, M. R.
Affiliations
  • Ochsner Health System (US)
  • Ochsner Medical Center (US)
Corresponding author
Milani, Richard V
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2004-03
Volume
43
Issue
6
Pages
1056-1061
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2003.10.041
OpenAlex
W2131340542
Cited by
302
References
54
Citations by year
2026: 3 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 11 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 5 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 15 · 2012: 22
FWCI
15.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
high-sensitivity C-reactive protein, cardiac rehabilitation, exercise training, coronary artery disease, statin therapy, weight loss, abdominal fat, secondary prevention, inflammation, cardiovascular risk factors
MeSH terms
Aged, Blood Glucose, C-Reactive Protein, Cholesterol, Coronary Artery Disease, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Exercise, Body Mass Index, Treatment Outcome

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