Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo controlled trial in asymptomatic antiphospholipid antibody-positive individuals.
Abstract
OBJECTIVE: To determine the efficacy of a daily dose of 81 mg aspirin in primary thrombosis prevention in asymptomatic, persistently antiphospholipid antibody (aPL)-positive individuals (those with positive aPL but no vascular and/or pregnancy events). METHODS: The Antiphospholipid Antibody Acetylsalicylic Acid (APLASA) study was a multicenter, randomized, double-blind, placebo-controlled clinical trial in which asymptomatic, persistently aPL-positive individuals were randomized to receive a daily dose of 81 mg of aspirin or placebo. In a separate observational and parallel study, asymptomatic, persistently aPL-positive individuals who were taking aspirin or declined randomization were followed up prospectively. RESULTS: In the APLASA study, 98 individuals were randomized to receive aspirin or placebo (mean +/- SD followup period 2.30 +/- 0.95 years), of whom 48 received aspirin and 50 received placebo. In the observational study, 74 nonrandomized individuals were followed up prospectively (mean +/- SD followup period 2.46 +/- 0.76 years); 61 received aspirin and 13 did not. In the APLASA study, the acute thrombosis incidence rates were 2.75 per 100 patient-years for aspirin-treated subjects and 0 per 100 patient-years for the placebo-treated subjects (hazard ratio 1.04, 95% confidence interval 0.69-1.56) (P = 0.83). Similarly, in the observational study, the acute thrombosis incidence rates were 2.70 per 100 patient-years for aspirin-treated subjects and 0 per 100 patient-years for those not treated with aspirin. All but 1 patient with thrombosis in either study had concomitant thrombosis risk factors and/or systemic autoimmune disease at the time of thrombosis. CONCLUSION: Our results suggest that asymptomatic, persistently aPL-positive individuals do not benefit from low-dose aspirin for primary thrombosis prophylaxis, have a low overall annual incidence rate of acute thrombosis, and develop vascular events when additional thrombosis risk factors are present.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the Antiphospholipid Antibody Acetylsalicylic Acid trial, aspirin was no more effective than placebo in patients with persistently positive antiphospholipid antibodies.
“The study was terminated earlier for low rate of events and showed that in patients with persistently positive aPL, aspirin was no more effective than placebo.”
From Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study (2011) · cites this paper as [17]
Cites
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519 · see citing works
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203 · see citing works
Self-citationA Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women
Ridker, P. M., Cook, N. R., Lee, I.-M., Gordon, D., Gaziano, J. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050613 · Cited by 1,945 · see citing works
AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update
Pearson, T. A., Blair, S. N., Daniels, S. R., Eckel, R. H., Fair, J. M., Fortmann, S. P., Franklin, B. A., Goldstein, L. B., Greenland, P., Grundy, S. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020190.45892.75 · Cited by 1,852 · see citing works
The management of thrombosis in the antiphospholipid-antibody syndrome
Khamashta, M. A., Cuadrado, M. J., Mujic, F., Taub, N. A., Hunt, B. J., & Hughes, G. R. V. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321504 · Cited by 1,450 · see citing works
Primary Prevention of Ischemic Stroke
Goldstein, L. B., Adams, R. J., Alberts, M. J., Appel, L. J., Brass, L. M., Bushnell, C., Culebras, A., DeGraba, T. J., Gorelick, P. B., Guyton, J. R., et al. (2006) · Stroke · doi:10.1161/01.str.0000223048.70103.f1 · Cited by 1,359 · see citing works
Brandt, J. T., Triplett, D. A., Alving, B. M., & Scharrer, I. (1995) · PubMed · Cited by 1,164 · see citing works
Pulmonary Embolism Prevention (PEP) trial Collaborative Group (2000) · The Lancet · doi:10.1016/s0140-6736(00)02110-3 · Cited by 1,076 · see citing works
Brandt, J. T., Triplett, D. A., Alving, B., & Scharrer, I. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649901 · Cited by 993 · see citing works
Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-02-0441 · Cited by 974 · see citing works
Aspirin for the Primary Prevention of Cardiovascular Events in Women and Men
Berger, J. S., Roncaglioni, M. C., Avanzini, F., Pangrazzi, I., Tognoni, G., & Brown, D. (2006) · JAMA · doi:10.1001/jama.295.3.306 · Cited by 781 · see citing works
Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients
Rosove, M. H., & Brewer, P. M. C. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-4-303 · Cited by 700 · see citing works
(1994) · Europe PMC (PubMed Central) · Cited by 563 · see citing works
Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis
Ginsburg, K. S., Liang, M. H., Newcomer, L., Goldhaber, S. Z., Schur, P. H., Hennekens, C. H., & Stampfer, M. J. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-12-997 · Cited by 526 · see citing works
Finazzi, G., Brancaccio, V., Moia, M., Ciavarella, N., Mazzucconi, M. G., Schinco, P., Ruggeri, M., Pogliani, E. M., Gamba, G., Rossi, E., et al. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00060-5 · Cited by 427 · see citing works
Thrombosis in the Young: Epidemiology and Risk Factors. A Focus on Venous Thrombosis
Rosendaal, F. R. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657492 · Cited by 333 · see citing works
Erkan, D. (2002) · Rheumatology · doi:10.1093/rheumatology/41.8.924 · Cited by 330 · see citing works
Self-citationAn Update on Aspirin in the Primary Prevention of Cardiovascular Disease
Eidelman, R. S., Hebert, P. R., Weisman, S. M., & Hennekens, C. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.17.2006 · Cited by 253 · see citing works
Derksen, R. H. W. M., de Groot, P. G., Kater, L., & Nieuwenhuis, H. K. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.9.689 · Cited by 240 · see citing works
(2004) · PubMed · Cited by 218 · see citing works
Outcome of patients with anticardiolipin antibodies: a 10 year follow-up of 52 patients
Shah, N. M., Khamashta, M. A., Atsumi, T., & Hughes, G. R. (1998) · Lupus · doi:10.1191/096120398678919624 · Cited by 204 · see citing works
(2002) · PubMed · Cited by 191 · see citing works
Self-citationA prospective study of antibodies to β2‐glycoprotein I and prothrombin, and risk of thrombosis
FORASTIERO, R., MARTINUZZO, M., POMBO, G., PUENTE, D., ROSSI, A., CELEBRIN, L., BONACCORSO, S., & AVERSA, L. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01295.x · Cited by 170 · see citing works
Wahl, D. G., Bounameaux, H., de Moerloose, P., & Sarasin, F. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.13.2042 · Cited by 155 · see citing works
Cardiac Remodeling: Mechanism and Treatment
Goldstein, S. (2006) · Circulation · doi:10.1161/circulationaha.105.621086 · Cited by 139 · see citing works
Prophylaxis of the antiphospholipid syndrome: a consensus report
Alarcón-Segovia, D., Boffa, M., Branch, W. D., Cervera, R., Gharavi, A. E., Khamashta, M. A., Shoenfeld, Y., Wilson, W., & Roubey, R. A. S. (2003) · Lupus · doi:10.1191/0961203303lu388oa · Cited by 99 · see citing works
Aspirin in the prevention and treatment of venous thromboembolism
Hovens, M. M. C., Snoep, J. D., Tamsma, J. T., & Huisman, M. V. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01928.x · Cited by 87 · see citing works
NAESS, I. A., CHRISTIANSEN, S. C., CANNEGIETER, S. C., ROSENDAAL, F. R., & HAMMERSTROEM, J. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01691.x · Cited by 74 · see citing works
Collins, R., Baignent, C., Sandercock, P. A., & Peto, R. (1994) · BMJ · doi:10.1136/bmj.309.6963.1215 · Cited by 73 · see citing works
Multiple human endogenous retrovirus (HERV-K) loci with gag open reading frames in the human genome
Mayer, J. M., Meese, E. U., & Mueller-Lantzsch, N. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134614 · Cited by 65 · see citing works
DeStefano, A. L., Larson, M. G., Mitchell, G. F., Benjamin, E. J., Vasan, R. S., Li, J., Corey, D., & Levy, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000135248.62303.81 · Cited by 63 · see citing works
Therapy Insight: systemic lupus erythematosus as a risk factor for cardiovascular disease
Haque, S., & Bruce, I. N. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0270 · Cited by 61 · see citing works
Antiphospholipid antibodies and thrombosis: strength of association
Galli, M., & Barbui, T. (2003) · The Hematology Journal · doi:10.1038/sj.thj.6200206 · Cited by 61 · see citing works
Mok, C. C. (2006) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740600601526 · Cited by 48 · see citing works
Laskin, C. A., Clark, C. A., & Spitzer, K. A. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2005.01.011 · Cited by 41 · see citing works
Bandt, M. D., Benali, K., Guillevin, L., HACHULLA, E., Job-Deslandre, C., Fautrel, B., Fournié, G. J., Bonnet, C., Fournié, B., Le Goff, P., et al. (1999) · PubMed · Cited by 30 · see citing works
Erkan, D. (2006) · PubMed · Cited by 27 · see citing works
Self-citationAntiphospholipid antibodies: update on detection, pathophysiology, and treatment
de Groot, P. G., & Derksen, R. H. W. M. (2004) · Current Opinion in Hematology · doi:10.1097/01.moh.0000130313.95291.4a · Cited by 27 · see citing works
Aspirin overprescription in primary cardiovascular prevention
Manes, C., Giacci, L., Sciartilli, A., D’Alleva, A., & Caterina, R. D. (2005) · Thrombosis Research · doi:10.1016/j.thromres.2005.09.013 · Cited by 21 · see citing works
Classification of venous thromboembolism (VTE)
Prescott, S. M., Weyrich, A. S., & Zimmerman, G. A. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01659.x · Cited by 14 · see citing works
Molecular Mechanisms of Disseminated Intravascular Coagulation
Cate, H. T., & Levi, M. M. (2003) · Cited by 14 · see citing works
The lady aspirin for cardiovascular disease
Verheugt, F. W. A., & Smith, S. C. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67462-4 · Cited by 12 · see citing works
Classification of venous thromboembolism (VTE)
van der Meijden, P. E. J., Heemskerk, J. W. M., Hamulyák, K., & Cate, H. T. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01661.x · Cited by 10 · see citing works
Wilson (1999) · doi:10.1002/1529-0131(199907)42:7
Self-citationPope (2001) · doi:10.1002/1529-0131(200106)44:6
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Kahn (2012) · doi:10.1378/chest.11-2296 · Cited by 2,693 · see citing works
Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., et al. (2014) · Stroke · doi:10.1161/str.0000000000000046 · Cited by 2,650 · see citing works
Goldstein, L. B., Bushnell, C. D., Adams, R. J., Appel, L. J., Braun, L. T., Chaturvedi, S., Creager, M. A., Culebras, A., Eckel, R. H., Hart, R. G., et al. (2011) · Stroke · doi:10.1161/str.0b013e3181fcb238 · Cited by 1,306 · see citing works
Cervera, R., Serrano, R., Pons-Estel, G. J., Ceberio-Hualde, L., Shoenfeld, Y., de Ramón, E., Buonaiuto, V, Jacobsen, S., Zeher, M. M., Tarr, T., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204838 · Cited by 974 · see citing works
Ruiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 864 · see citing works
Antar, S. A., Ashour, N. A., Sharaky, M. M., Khattab, M., Ashour, N. A., Zaid, R. T., Roh, E. J., Elkamhawy, A., & Al-Karmalawy, A. A. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115734 · Cited by 749 · see citing works
Bertsias, G. K., Ioannidis, J. P. A., Aringer, M., Bollen, E., Bombardieri, S., Bruce, I. N., Cervera, R., Dalakas, M., Doria, A., Hanly, J. G., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.130476 · Cited by 742 · see citing works
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740 · see citing works
Ruiz-Irastorza, G., Cuadrado, M., Ruiz-Arruza, I., Brey, R., Crowther, M., Derksen, R., Erkan, D., Krilis, S., Machin, S., Pengo, V, et al. (2011) · Lupus · doi:10.1177/0961203310395803 · Cited by 506 · see citing works
Self-citationPengo, V., Ruffatti, A., Legnani, C., Testa, S., Fierro, T., Marongiu, F., De Micheli, V., Gresele, P., Tonello, M., Ghirarduzzi, A., et al. (2011) · Blood · doi:10.1182/blood-2011-03-340232 · Cited by 465 · see citing works
Schreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 437 · see citing works
Tektonidou, M. G., Laskari, K., Panagiotakos, D. B., & Moutsopoulos, H. M. (2009) · Arthritis Care & Research · doi:10.1002/art.24232 · Cited by 356 · see citing works
Diagnosis and classification of the antiphospholipid syndrome
Gómez-Puerta, J. A., & Cervera, R. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.006 · Cited by 301 · see citing works
Cervera, R., Khamashta, M. A., Shoenfeld, Y., Camps, M. T., Jacobsen, S., Kiss, E., Zeher, M. M., Tincani, A., Kontopoulou-Griva, I., Galeazzi, M., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.093179 · Cited by 286 · see citing works
Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management
Knight, J. S., Branch, D. W., & Ortel, T. L. (2023) · BMJ · doi:10.1136/bmj-2021-069717 · Cited by 284 · see citing works
Cervera, R. (2017) · Thrombosis Research · doi:10.1016/s0049-3848(17)30066-x · Cited by 261 · see citing works
Arnaud, L., Mathian, A., Ruffatti, A., Erkan, D., Tektonidou, M., Cervera, R., Forastiero, R., Pengo, V., Lambert, M., Martinez-Zamora, M. A., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.10.014 · Cited by 215 · see citing works
Self-citationThe clinical significance of antiphospholipid antibodies in systemic lupus erythematosus
Ünlü, O., Zuily, S., & Erkan, D. (2015) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2015.0085 · Cited by 210 · see citing works
Self-citationSammaritano, L. R. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.101463 · Cited by 201 · see citing works
Self-citationDiagnosis and management of the antiphospholipid syndrome
Chaturvedi, S., & McCrae, K. R. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.07.006 · Cited by 191 · see citing works
New therapeutic strategies in systemic lupus erythematosus management
Gatto, M., Zen, M., Iaccarino, L., & Doria, A. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0133-2 · Cited by 186 · see citing works
Reynaud, Q., Lega, J.-C., Mismetti, P., Chapelle, C., Wahl, D., Cathébras, P., & Laporte, S. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.11.004 · Cited by 179 · see citing works
Cohen, H., Cuadrado, M. J., Erkan, D., Duarte‐García, A., Isenberg, D. A., Knight, J. S., Ortel, T. L., Rahman, A., Salmon, J. E., Tektonidou, M. G., et al. (2020) · Lupus · doi:10.1177/0961203320950461 · Cited by 165 · see citing works
Self-citationPre-eclampsia in low and middle income countries
Firoz, T., Sanghvi, H., Merialdi, M., & von Dadelszen, P. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2011.04.002 · Cited by 160 · see citing works
Aspirin for Primary Cardiovascular Risk Prevention and Beyond in Diabetes Mellitus
Capodanno, D., & Angiolillo, D. J. (2016) · Circulation · doi:10.1161/circulationaha.116.023164 · Cited by 155 · see citing works
Bertsias, G. K., Salmon, J. E., & Boumpas, D. T. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.135186 · Cited by 152 · see citing works
Arnaud, L., Mathian, A., Devilliers, H., Ruffatti, A., Tektonidou, M., Forastiero, R., Pengo, V., Lambert, M., Lefevre, G., Martinez-Zamora, M. A., et al. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.10.019 · Cited by 146 · see citing works
An update on mortality in systemic lupus erythematosus.
Ippolito, A., & Petri, M. (2008) · PubMed · Cited by 131 · see citing works
Self-citationMustonen, P., Lehtonen, K. V., Javela, K., & Puurunen, M. (2014) · Lupus · doi:10.1177/0961203314545410 · Cited by 127 · see citing works
Pathogenesis and management of antiphospholipid syndrome
Arachchillage, D. J., & Laffan, M. (2017) · British Journal of Haematology · doi:10.1111/bjh.14632 · Cited by 120 · see citing works
REVISTA BRASILEIRA DE REUMATOLOGIA
Danowski, A., & Levy, R. A. (2013) · Cited by 116 · see citing works
Self-citationWasmann, K. A. T. G. M., Wijsman, P. C., van Dieren, S., Bemelman, W. A., & Buskens, C. J. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-031151 · Cited by 113 · see citing works
Gris, J., Bouvier, S., Molinari, N., Galanaud, J. ‐., Cochery-Nouvellon, É., Mercier, É., Fabbro-Péray, P., Balducchi, J.-P., Marès, P., Quéré, I., et al. (2011) · Blood · doi:10.1182/blood-2011-09-381913 · Cited by 108 · see citing works
Ruffatti, A., Ross, T. D., Ciprian, M., Nuzzo, M., Rampudda, M., Bertero, M. T., Bergia, R., Caramaschi, P., Biasi, D., Capsoni, F., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.096669 · Cited by 106 · see citing works
Petri, M. (2020) · Translational research · doi:10.1016/j.trsl.2020.04.006 · Cited by 101 · see citing works
Self-citationTektonidou, M. G., Andréoli, L., Limper, M., Tincani, A., & Ward, M. M. (2019) · RMD Open · doi:10.1136/rmdopen-2019-000924 · Cited by 99 · see citing works
Aspirin for the Primary Prevention of Cardiovascular Events
Calvin, A. D., Aggarwal, N. R., Murad, M. H., Shi, Q., Elamin, M. B., Geske, J. B., Fernández-Balsells, M., Albuquerque, F. N., Lampropulos, J. F., Erwin, P. J., et al. (2009) · Diabetes Care · doi:10.2337/dc09-1297 · Cited by 98 · see citing works
Cuadrado, M. J., Bertolaccini, M. L., Seed, P. T., Tektonidou, M. G., Aguirre, A., Micó, L., Gordon, C., Ruiz‐Irastorza, G., Egurbide, M.-V., Gil, A., et al. (2013) · Rheumatology · doi:10.1093/rheumatology/ket313 · Cited by 92 · see citing works
Cutaneous Manifestations of Antiphospholipid Antibody Syndrome
Weinstein, S., & Piette, W. W. (2008) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2007.10.011 · Cited by 88 · see citing works
Antiphospholipid syndrome – an update
Linnemann, B. (2018) · VASA · doi:10.1024/0301-1526/a000723 · Cited by 85 · see citing works
Xie, M., Shan, Z., Zhang, Y., Chen, S., Yang, W., Bao, W., Rong, Y., Yu, X., Hu, F. B., & Liu, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090286 · Cited by 84 · see citing works
Influence of aspirin on the clinical outcomes of 103 anti-phospholipid antibodies-positive patients
Hereng, T., Lambert, M., HACHULLA, E., Samor, M., Dubucquoi, S., Caron, C., Launay, D., Morell‐Dubois, S., Queyrel, V., & Hatron, P. (2007) · Lupus · doi:10.1177/0961203307084724 · Cited by 84 · see citing works
How I treat the antiphospholipid syndrome
Giannakopoulos, B., & Krilis, S. A. (2009) · Blood · doi:10.1182/blood-2009-05-220756 · Cited by 83 · see citing works
Pediatric Antiphospholipid Syndrome
Cimaz, R., & Descloux, É. (2006) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2006.05.005 · Cited by 81 · see citing works
Venous Thrombosis in the Antiphospholipid Syndrome
Farmer-Boatwright, M. K., & Roubey, R. A. S. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.182204 · Cited by 79 · see citing works
Management of antiphospholipid syndrome
Tuthill, J. I., & Khamashta, M. A. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.05.002 · Cited by 78 · see citing works
Huang, W., Saver, J. L., Wu, Y., Lin, C., Lee, M., & Ovbiagele, B. I. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1120 · Cited by 77 · see citing works
Guidelines on the investigation and management of antiphospholipid syndrome
Arachchillage, D. J., Platton, S., Hickey, K. P., Chu, J., Pickering, M. C., Sommerville, P., MacCallum, P., & Breen, K. A. (2024) · British Journal of Haematology · doi:10.1111/bjh.19635 · Cited by 74 · see citing works
Yelnik, C. M., Urbanski, G., Drumez, E., Sobanski, V, Maillard, H., Lanteri, A., Morell-Dubois, S., Caron, C., Dubucquoi, S., Launay, D., et al. (2017) · Lupus · doi:10.1177/0961203316657433 · Cited by 73 · see citing works
Ocular manifestations of the antiphospholipid syndrome
Utz, V. M., & Tang, J. C. O. (2010) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.182857 · Cited by 72 · see citing works
New approaches for managing antiphospholipid syndrome
Erkan, D., & Lockshin, M. D. (2009) · Nature Reviews Rheumatology · doi:10.1038/ncprheum1017 · Cited by 71 · see citing works
Self-citationGeorge, D., & Erkan, D. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.06.005 · Cited by 70 · see citing works
Self-citationPrimary thrombosis prophylaxis in antiphospholipid antibody-positive patients: where do we stand?
Barbhaiya, M., & Erkan, D. (2011) · Current Rheumatology Reports · doi:10.1007/s11926-010-0149-3 · Cited by 69 · see citing works
Self-citationErkan, D., Unlu, O., Sciascia, S., Belmont, H. M., Branch, D. W., Cuadrado, M. J., Gonzalez, E., Knight, J. S., Uthman, I., Willis, R., et al. (2018) · Lupus · doi:10.1177/0961203317724219 · Cited by 67 · see citing works
Self-citationChighizola, C. B., Ubiali, T., & Meroni, P. L. (2015) · Journal of Immunology Research · doi:10.1155/2015/951424 · Cited by 67 · see citing works
The treatment of anti-phospholipid syndrome: A comprehensive clinical approach
Chighizola, C. B., Andréoli, L., Gerosa, M., Tincani, A., Ruffatti, A., & Meroni, P. L. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.02.003 · Cited by 66 · see citing works
Antiphospholipid syndrome management: a 2023 update and practical algorithm-based approach
Ambati, A., Knight, J. S., & Zuo, Y. (2023) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000932 · Cited by 65 · see citing works
Kim, K., Baek, I., Yoon, C., Kim, W., & Cho, C. (2013) · British Journal of Haematology · doi:10.1111/bjh.12318 · Cited by 65 · see citing works
Recent advances in the diagnosis and management of neuropsychiatric lupus
Legge, A. C., & Hanly, J. G. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01163-z · Cited by 63 · see citing works
Lupus: improving long-term prognosis
Doria, A., & Briani, C. (2008) · Lupus · doi:10.1177/0961203307087612 · Cited by 58 · see citing works
Antiphospholipid syndrome treatment beyond anticoagulation: are we there yet?
Pierangeli, S., & Erkan, D. (2010) · Lupus · doi:10.1177/0961203310361489 · Cited by 56 · see citing works
Self-citationAntiphospholipid syndrome and the brain in pediatric and adult patients
Muscal, E., & Brey, R. L. (2010) · Lupus · doi:10.1177/0961203309360808 · Cited by 55 · see citing works
Martínez‐Zamora, M. Á., Peralta, S., Creus, M. T., Tàssies, D., Reverter, J. C., Espinosa, G., Cervera, R., Carmona, F., & Balasch, J. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2011.153817 · Cited by 54 · see citing works
Branch, W. D. (2011) · Lupus · doi:10.1177/0961203310395054 · Cited by 53 · see citing works
Bała, M. M., Celińska‐Löwenhoff, M., Szot, W., Padjas, A., Kaczmarczyk, M., Świerz, M. J., & Undas, A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012169.pub2 · Cited by 52 · see citing works
The antiphospholipid syndrome: still an enigma
Chaturvedi, S., & McCrae, K. R. (2015) · Hematology · doi:10.1182/asheducation-2015.1.53 · Cited by 51 · see citing works
Management of Antiphospholipid Syndrome
Ghembaza, A., & Saadoun, D. (2020) · Biomedicines · doi:10.3390/biomedicines8110508 · Cited by 50 · see citing works
Antiphospholipid syndrome: state of the art on clinical practice guidelines
Limper, M., Scirè, C. A., Talarico, R., Amoura, Z., Avčin, T., Basile, M., Burmester, G. R., Carli, L., Cervera, R., Costedoat-Chalumeau, N., et al. (2018) · RMD Open · doi:10.1136/rmdopen-2018-000785 · Cited by 50 · see citing works
Antiphospholipid antibodies — We are not quite there yet
Urbanus, R. T., & de Groot, P. G. (2011) · Blood Reviews · doi:10.1016/j.blre.2010.12.001 · Cited by 48 · see citing works
D-Dimer Level and the Risk for Thrombosis in Systemic Lupus Erythematosus
Wu, H. M., Birmingham, D. J., Rovin, B. H., Hackshaw, K. V., Haddad, N. F., Haden, D. W., Yu, C. Y., & Hebert, L. A. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01480308 · Cited by 47 · see citing works
Bała, M. M., Paszek, E., Leśniak, W., Włoch-Kopeć, D., Jasińska, K., & Undas, A. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012534.pub2 · Cited by 47 · see citing works
Membranous Lupus Nephritis: A Clinical Review
Almaani, S. J., & Parikh, S. V. (2019) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2019.08.009 · Cited by 47 · see citing works
Iudici, M., Fasano, S., Falcone, L. G., Pantano, I., MONTAGNA, G. L., Migliaresi, S., & Valentini, G. (2016) · Rheumatology · doi:10.1093/rheumatology/kew231 · Cited by 46 · see citing works
de Jesús, G., Sciascia, S., Andrade, D., Barbhaiya, M., Tektonidou, M., Banzato, A., Pengo, V, Ji, L., Meroni, P., Ugarte, A., et al. (2019) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15469 · Cited by 45 · see citing works
Self-citationGrossesse et syndrome des antiphospholipides
Costedoat-Chalumeau, N., Guettrot-Imbert, G., Guern, V. L., Leroux, G., Huong, D. U. L. T., Wechsler, B., Morel, N., Vauthier-Brouzes, D., Dommergues, M., Cornet, A., et al. (2012) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2012.01.003 · Cited by 45 · see citing works
Bała, M. M., Celińska‐Löwenhoff, M., Szot, W., Padjas, A., Kaczmarczyk, M., Świerz, M. J., & Undas, A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012169.pub3 · Cited by 45 · see citing works
Clinical Management of Thrombotic Antiphospholipid Syndrome
Tumian, N. R., & Hunt, B. J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030735 · Cited by 43 · see citing works
Inhibition of Nitric Oxide and Antiphospholipid Antibody-Mediated Thrombosis
Mineo, C. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0324-4 · Cited by 43 · see citing works
Thrombophilia testing in young patients with ischemic stroke
Pahus, S. H., Hansen, A. T., & Hvas, A. (2015) · Thrombosis Research · doi:10.1016/j.thromres.2015.11.006 · Cited by 43 · see citing works
van Middendorp, J. J., Barbagallo, G. M. V., Schuetz, M., & Hosman, A. J. F. (2012) · Spinal Cord · doi:10.1038/sc.2012.34 · Cited by 40 · see citing works
The Differences Between Childhood and Adult Onset Antiphospholipid Syndrome
Wincup, C., & Ioannou, Y. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00362 · Cited by 39 · see citing works
Pediatric Antiphospholipid Syndrome
Aguiar, C. L., Soybilgic, A., Avčin, T., & Myones, B. L. (2015) · Current Rheumatology Reports · doi:10.1007/s11926-015-0504-5 · Cited by 39 · see citing works
Treatment of the antiphospholipid syndrome
Galli, M. (2013) · Autoimmunity Highlights · doi:10.1007/s13317-013-0056-5 · Cited by 38 · see citing works
Clinical Features, Diagnosis, and Management of the Antiphospholipid Syndrome
Wong, R. C. W., & Favaloro, E. J. (2008) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0028-1082275 · Cited by 38 · see citing works
Leggio, M., Bendini, M. G., Caldarone, E., Lombardi, M., Severi, P., D’Emidio, S., Stavri, D. C., Armeni, M., Bravi, V., & Mazza, A. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2017.11.002 · Cited by 37 · see citing works
Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events
Zuo, Y., Navaz, S. A., Liang, W., Li, C., Ayers, C. R., Rysenga, C. E., Harbaugh, A., Norman, G. L., Solow, E. B., Bermas, B. L., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.6530 · Cited by 37 · see citing works
Watanabe, T., Oku, K., Amengual, O., Hisada, R., Ohmura, K., Nakagawa, I., Shida, H., Bohgaki, T., Horita, T., Yasuda, S., et al. (2017) · Lupus · doi:10.1177/0961203317716787 · Cited by 37 · see citing works
Calderone, D., Greco, A., Ingala, S., Agnello, F. G., Franchina, A. G., Scalia, L., Buccheri, S., & Capodanno, D. (2021) · Thrombosis and Haemostasis · doi:10.1055/a-1667-7427 · Cited by 37 · see citing works
Anticardiolipin antibodies and recurrent early pregnancy loss: a century of equivocal evidence
Clark, C. A., Laskin, C. A., & Spitzer, K. A. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms020 · Cited by 37 · see citing works
Muscal, E., & Brey, R. L. (2008) · Current Rheumatology Reports · doi:10.1007/s11926-008-0012-y · Cited by 37 · see citing works
Antiphospholipid syndrome: a clinical perspective
Zuo, Y., Shi, H., Li, C., & Knight, J. S. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000705 · Cited by 36 · see citing works
Pharmacotherapy of systemic lupus erythematosus
Francis, L., & Perl, A. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902971003 · Cited by 35 · see citing works
de Jesús, G. R., Benson, A. E., Chighizola, C. B., Sciascia, S., & Branch, D. W. (2020) · Lupus · doi:10.1177/0961203320954520 · Cited by 35 · see citing works
Seizures in Primary Antiphospholipid Syndrome: The Relevance of Smoking to Stroke
de Carvalho, J. F., Pasoto, S. G., & Appenzeller, S. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/981519 · Cited by 35 · see citing works
High Prevalence of Prothrombotic Abnormalities in Multifocal Osteonecrosis
Gómez-Puerta, J. A., Peris, P., Reverter, J. C., Espinosa, G., Martinez-Ferrer, A., Monegal, A., Ruiz, J. M. M., Tàssies, D., & Guañabens, N. (2013) · Medicine · doi:10.1097/md.0000000000000007 · Cited by 35 · see citing works
Persistent antiphospholipid antibodies do not contribute to adverse pregnancy outcomes
Soh, M. C., Pasupathy, D., Gray, G., & Nelson‐Piercy, C. (2013) · Rheumatology · doi:10.1093/rheumatology/ket173 · Cited by 35 · see citing works
Transient ischemic attack and stroke in systemic lupus erythematosus
Timlin, H., & Petri, M. (2013) · Lupus · doi:10.1177/0961203313497416 · Cited by 34 · see citing works
Self-citationThrombosis in systemic lupus erythematosus: risk and protection
Burgos, P. I., & Alarcón, G. S. (2009) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.09.137 · Cited by 34 · see citing works
Anti‐β2‐glycoprotein I antibodies
Willis, R., & Pierangeli, S. S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12080 · Cited by 34 · see citing works
Primary and secondary prevention of cardiovascular disease in diabetes with aspirin
Schnell, O., Erbach, M., & Hummel, M. (2012) · Diabetes and Vascular Disease Research · doi:10.1177/1479164112441486 · Cited by 33 · see citing works
- Authors
- Erkan, D., Harrison, M. J., Levy, R., Peterson, M., Petri, M., Sammaritano, L., Unalp‐Arida, A., Vilela, V., Yazici, Y., & Lockshin, M. D.
- Affiliations
- Hospital for Special Surgery (US)
- Hospital Universitário Pedro Ernesto (BR)
- Johns Hopkins University (US)
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2007-06-28
- Volume
- 56
- Issue
- 7
- Pages
- 2382-2391
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2068492012
- Cited by
- 401
- References
- 46
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 10 · 2021: 16 · 2020: 16 · 2019: 18 · 2018: 19 · 2017: 23 · 2016: 24 · 2015: 16 · 2014: 27 · 2013: 32 · 2012: 37
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- aspirin, antiphospholipid syndrome, antiphospholipid antibodies, thromboprophylaxis, low-dose aspirin, thrombosis risk factors, vascular events
- MeSH terms
- Adult, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Double-Blind Method, Ethnicity, Female, Humans, Male, Middle Aged, Placebos, Thrombosis, Antiphospholipid Syndrome, Patient Selection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
