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Cited by 16Cardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmiasHeart Rate Variability and Autonomic Control

Anatomy and physiology of the right interganglionic nerve: implications for the pathophysiology of inappropriate sinus tachycardia

ZHOU, JING, SCHERLAG, BENJAMIN J., NIU, GUODONG, HOU, YINGLONG, LU, ZHIBING, ZHANG, YUAN, DING, YANSHENG, LAZZARA, RALPH +2 more·2008·Journal of Cardiovascular Electrophysiology
DOI 10.1111/j.1540-8167.2008.01146.x
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Abstract

OBJECTIVE: To simulate inappropriate sinus tachycardia (IST) in experimental animals. BACKGROUND: We recently found that epinephrine injected into the anterior right ganglionated plexi (ARGP) adjacent to the sinoatrial (SA) node induced an arrhythmia simulating IST. METHODS: In 19 anesthetized dogs, via a right thoracotomy, the course of the interganglionic nerve (IGN) from the right stellate ganglion along the superior vena cava to the heart was delineated. High-frequency stimulation (HFS; 0.1 msec duration, 20 Hz, 4.5-9.3 V) was applied to IGN at the junction of innominate vein and SVC. RESULTS: HFS of the IGN significantly increased the sinus rate (SR) (baseline: 156 +/- 19 beats/minutes [bpm], 4.5 V: 191 +/- 28 bpm*, 8.0 V: 207 +/- 23 bpm*, 9.3 V: 216 +/- 18 bpm*; *P < 0.01 compared to baseline) without significant changes in A-H interval or blood pressure. P-wave morphology, ice mapping, and noncontact mapping indicated that this tachycardia was sinus tachycardia. In 8 of 19 dogs, injecting hexamethonium (5 mg), a ganglionic blocker, into the ARGP attenuated the response elicited by IGN stimulation (baseline: 160 +/- 21 bpm, 4.5 V: 172 +/- 32 bpm, 8.0 V: 197 +/- 32 bpm*, 9.3 V: 206 +/- 26 bpm*; *P < 0.05 compared to baseline). In 19 of 19 animals, after formaldehyde injection into the ARGP, SR acceleration induced by IGN stimulation was markedly attenuated (baseline: 149 +/- 17 bpm, 4.5 V: 151 +/- 21 bpm, 8.0 V: 155 +/- 23 bpm, 9.3 V: 167 +/- 24 bpm*; *P < 0.05 compared to baseline). CONCLUSIONS: HFS of the IGN caused a selective and significant acceleration of the SR. A significant portion of IGN traverses the ARGP or synapses with the autonomic ganglia in the ARGP before en route to the SA node. Dysautonomia involving the IGN and/or ARGP may play an important role in IST.

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  • While animal models of IST have been proposed, no compelling model exists.

    “While animal models of IST have been proposed 38,39 no compelling model exists. 1”

    From Inappropriate sinus tachycardia (2019) · cites this paper as [38]

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Authors
ZHOU, J., SCHERLAG, B. J., NIU, G., HOU, Y., LU, Z., ZHANG, Y., DING, Y., LAZZARA, R., JACKMAN, W. M., & PO, S. S.
Affiliations
  • Peking University (CN)
  • University of Oklahoma Health Sciences Center (US)
Corresponding author
PO, SUNNY S.
ORCID
Venue
Journal of Cardiovascular Electrophysiology
Publisher
Wiley
Published
2008-08-28
Volume
19
Issue
9
Pages
971-976
ISSN
  • 1045-3873 (ISSN-L)
  • 1540-8167
DOI
10.1111/j.1540-8167.2008.01146.x
OpenAlex
W2127176586
Cited by
16
References
26
Citations by year
2022: 1 · 2019: 2 · 2018: 2 · 2015: 2 · 2013: 1 · 2012: 3
FWCI
1.21
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Cardiovascular Electrophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (K23HL069972)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
inappropriate sinus tachycardia, stellate ganglion, sinoatrial node, sinus tachycardia, hexamethonium, ganglionic blockade, epinephrine, atrioventricular conduction, dogs
MeSH terms
Animals, Dogs, Heart Conduction System, Stellate Ganglion, Tachycardia, Sinus, Autonomic Pathways

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