Left ventricular thickness is increased in nonhypertensive Turner's syndrome
Abstract
BACKGROUND: Turner's syndrome (TS), the most frequent congenital anomaly in newborn girls, is associated with various cardiovascular abnormalities, predominantly bicuspid aortic valves and aortic coarctation. The causes of the left ventricular hypertrophy (LVH) and ECG findings associated with TS are unknown. We used echocardiography to assess cardiac structure and function in normotensive patients with TS. METHOD: Thirty-one patients with TS and 30 healthy women were enrolled in this comparative study. Twelve-lead ECG, 24-hour-ambulatory ECG recording, and echocardiography were performed. RESULTS: With 24-hour-ambulatory ECG recording, the mean heart rate (HR) of TS women was higher than non-TS women. With echocardiographic examination, the interventricular septum diastolic thickness, left ventricle posterior wall diastolic thickness (LVPW), the LV mass index (LVMI), and left atrial diameter index (LADi) were significantly higher in TS women compared with controls. Mitral flow A velocity was significantly higher and the ratio of early to late diastolic filling was significantly lower in TS patients. CONCLUSION: HR, LV wall thicknesses, LVMI and the LADi are significantly increased in normohypertensive TS women. There is also subclinical diastolic dysfunction in these patients.
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Left ventricular hypertrophy and increased ventricular mass are commonly observed in TS, even in those who do not have a diagnosis of hypertension.
“Left ventricular hypertrophy and increased ventricular mass are commonly observed in TS, even in those who do not have a diagnosis of hypertension.460,461”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [461]
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“Lack of this normal mechanism, termed ‘non-dipper’, has been associated with increased morbidity and is likely to play a part in the end-organ damage, including left ventricular hypertrophy observed in ‘normotensive’ women with TS [49, 50].”
BackgroundPeppa, M., Pavlidis, G., Mavroeidi, I., Katogiannis, K., Varoudi, M., Thymis, J., Kostelli, G., Vlastos, D., Plotas, P., Bamias, A., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002903 · Cited by 7 · see citing works
- Authors
- Sozen, A. B., Cefle, K., Kudat, H., Ozturk, S., Oflaz, H., Akkaya, V., Palanduz, S., Demirel, S., Ozcan, M., Goren, T., & Guven, O.
- Affiliations
- Istanbul University (TR)
- ORCID
- Kudat, Hasan
- Venue
- Echocardiography
- Publisher
- Wiley
- Published
- 2009-09
- Volume
- 26
- Issue
- 8
- Pages
- 943-949
- ISSN
- 0742-2822 (ISSN-L)
- 1540-8175
- OpenAlex
- W1997801453
- Cited by
- 19
- References
- 20
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Echocardiography (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Keywords
- left ventricular hypertrophy, left ventricular wall thickness, left ventricular mass index, left atrial diameter, diastolic dysfunction, heart rate, Holter monitoring, normotensive women, congenital heart disease
- MeSH terms
- Adult, Female, Heart Ventricles, Humans, Hypertension, Turner Syndrome, Ultrasonography, Ventricular Dysfunction, Left
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