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Cited by 15Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesCardiovascular Function and Risk FactorsCongenital Heart Disease Studies

Left ventricular hypertrophy in Turner syndrome: a prospective echocardiographic study

Mortensen, Kristian Havmand, Gravholt, Claus Højbjerg, Hjerrild, Britta Eilersen, Stochholm, Kirstine, Andersen, Niels Holmark·2012·Echocardiography
DOI 10.1111/j.1540-8175.2012.01754.x
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Abstract

BACKGROUND: Cardiovascular risk stratification in Turner syndrome (TS) is difficult. Increased left ventricular mass associates with an adverse prognosis in several settings, and this study aimed to elucidate this risk marker in relation to metabolic and cardiovascular status in TS. METHODS: An echocardiographic follow-up study (4.8 years) of 82 adult females with TS. Left ventricular mass was the primary outcome parameter. Metabolic status (glucose, Hemoglobin A1c, lipids), aortic valve function and morphology, and 24-hour ambulatory blood pressure were secondary outcome parameters. Healthy age-matched females served as baseline controls (n = 55). RESULTS: Left ventricular mass was increased in TS (TS vs. controls: 88 ± 21 g/m(2) vs. 77 ± 12 g/m(2), P < 0.05). More participants were treated for hypertension at follow-up (32% at baseline vs. 55% at follow-up). This coincided with a reduction of left ventricular mass in TS (84 ± 20 g/m(2) at follow up, P < 0.05) and favorable remodeling with a contrasting increase in left atrial size. In a baseline multiple regression model, left ventricular mass (r(2) = 0.28, P < 0.05) increased with body surface area, age and the presence of a bicuspid aortic valve. In another model, left ventricular mass increased with blood pressure, ongoing estrogen treatment and body surface area (r(2) = 0.26, P < 0.05). No single factor reached statistically significant levels for prediction of prospective left ventricular mass changes. CONCLUSION: The increased left ventricular mass in TS was associated with aortic valve disease, age, hypertension, physical stature and metabolic status. During follow-up left ventricular mass was only slightly reduced along with blood pressure, whereas the diastolic dysfunction did not seem to improve.

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  • Non-invasive imaging is an essential part of cardiovascular screening and surveillance across the life span of individuals with TS.

    “Non-invasive imaging is an essential part of cardiovascular screening and surveillance across the life span of individuals with TS,233,388,396,418-423 but imaging remains underutilized and not systematically applied.420,424”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [423]

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Authors
Mortensen, K. H., Gravholt, C. H., Hjerrild, B. E., Stochholm, K., & Andersen, N. H.
Affiliations
Aarhus University Hospital (DK)
Corresponding author
Mortensen, Kristian Havmand
ORCID
Venue
Echocardiography
Publisher
Wiley
Published
2012-07-04
Volume
29
Issue
9
Pages
1022-1030
ISSN
  • 0742-2822 (ISSN-L)
  • 1540-8175
DOI
10.1111/j.1540-8175.2012.01754.x
OpenAlex
W1547480934
Cited by
15
References
40
Citations by year
2025: 1 · 2024: 1 · 2021: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 2
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Echocardiography (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute for Health and Care Research (ACF-2011-14-016)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
Keywords
Turner syndrome, left ventricular hypertrophy, left ventricular mass, cardiovascular risk stratification, hypertension, bicuspid aortic valve, aortic valve disease, left ventricular remodeling, left atrial size, estrogen therapy, body surface area, diastolic dysfunction, ambulatory blood pressure, metabolic status
MeSH terms
Adult, Aged, Denmark, Echocardiography, Female, Humans, Male, Middle Aged, Prospective Studies, Sensitivity and Specificity, Turner Syndrome, Reproducibility of Results, Comorbidity, Prevalence, Hypertrophy, Left Ventricular, Risk Assessment, Young Adult

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