The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
The Effects of Hemodynamic Force on Embryonic Development
Open accessAbstract
Blood vessels have long been known to respond to hemodynamic force, and several mechanotransduction pathways have been identified. However, only recently have we begun to understand the effects of hemodynamic force on embryonic development. In this review, we will discuss specific examples illustrating the role of hemodynamic force during the development of the embryo, with particular focus on the development of the vascular system and the morphogenesis of the heart. We will also discuss the important functions served by mechanotransduction and hemodynamic force during placentation, as well as in regulating the maintenance and division of embryonic, hematopoietic, neural, and mesenchymal stem cells. Pathological misregulation of mechanosensitive pathways during pregnancy and embryonic development may contribute to the occurrence of cardiovascular birth defects, as well as to a variety of other diseases, including preeclampsia. Thus, there is a need for future studies focusing on better understanding the physiological effects of hemodynamic force during embryonic development and their role in the pathogenesis of disease.
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“Cells in the common ventricle and the outflow tract of the embryonic heart are sensitive to wall and shear forces (342, 442), and increases in these forces can lead to heart defects (135, 260, 379).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [135]
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Piezo1, a mechanically activated ion channel, is required for vascular development in mice
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Metadata
- Authors
- CULVER, J. C., & DICKINSON, M. E.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Microcirculation
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 17
- Issue
- 3
- Pages
- 164-178
- ISSN
- 1073-9688 (ISSN-L)
- 1549-8719
- PMC
- PMC2927969
- OpenAlex
- W1995762323
- Cited by
- 173
- References
- 157
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 13 · 2020: 8 · 2019: 13 · 2018: 13 · 2017: 14 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 11 · 2012: 16
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microcirculation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL096360, HL077187, R01HL077187)
- National Institute of Biomedical Imaging and Bioengineering (EB 005173, EB-007076, R01EB005173, P20EB007076)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- hemodynamic forces, embryonic development, mechanotransduction, vascular development, cardiac morphogenesis, placenta, stem cell maintenance, hematopoietic stem cells, neural stem cells, mesenchymal stem cells, preeclampsia, pregnancy
- MeSH terms
- Animals, Aorta, Thoracic, Blood Vessels, Female, Fetal Heart, Hematopoiesis, Hemodynamics, Humans, Models, Cardiovascular, Embryo Implantation, Placenta, Placentation, Pregnancy, Signal Transduction, Mechanotransduction, Cellular, Endothelial Cells, Embryonic Development, Embryonic Stem Cells
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