Cited by 173Cellular Mechanics and InteractionsCongenital heart defects researchDevelopmental Biology and Gene Regulation

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The Effects of Hemodynamic Force on Embryonic Development

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CULVER, JAMES C., DICKINSON, MARY E.·2010·Microcirculation

DOI 10.1111/j.1549-8719.2010.00025.xPMC PMC2927969

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Abstract

Blood vessels have long been known to respond to hemodynamic force, and several mechanotransduction pathways have been identified. However, only recently have we begun to understand the effects of hemodynamic force on embryonic development. In this review, we will discuss specific examples illustrating the role of hemodynamic force during the development of the embryo, with particular focus on the development of the vascular system and the morphogenesis of the heart. We will also discuss the important functions served by mechanotransduction and hemodynamic force during placentation, as well as in regulating the maintenance and division of embryonic, hematopoietic, neural, and mesenchymal stem cells. Pathological misregulation of mechanosensitive pathways during pregnancy and embryonic development may contribute to the occurrence of cardiovascular birth defects, as well as to a variety of other diseases, including preeclampsia. Thus, there is a need for future studies focusing on better understanding the physiological effects of hemodynamic force during embryonic development and their role in the pathogenesis of disease.

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Authors: CULVER, J. C., & DICKINSON, M. E.
Affiliations: Baylor College of Medicine (US)
Venue: Microcirculation
Publisher: Wiley
Published: 2010-04
Volume: 17
Issue: 3
Pages: 164-178
ISSN: 1073-9688 (ISSN-L)
1549-8719
DOI: 10.1111/j.1549-8719.2010.00025.x
PMC: PMC2927969
OpenAlex: W1995762323
Cited by: 173
References: 157
Citations by year: 2026: 4 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 13 · 2020: 8 · 2019: 13 · 2018: 13 · 2017: 14 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 11 · 2012: 16
FWCI: 1.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1979 d)
Locations: Microcirculation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL096360, HL077187, R01HL077187)
National Institute of Biomedical Imaging and Bioengineering (EB 005173, EB-007076, R01EB005173, P20EB007076)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: hemodynamic forces, embryonic development, mechanotransduction, vascular development, cardiac morphogenesis, placenta, stem cell maintenance, hematopoietic stem cells, neural stem cells, mesenchymal stem cells, preeclampsia, pregnancy
MeSH terms: Animals, Aorta, Thoracic, Blood Vessels, Female, Fetal Heart, Hematopoiesis, Hemodynamics, Humans, Models, Cardiovascular, Embryo Implantation, Placenta, Placentation, Pregnancy, Signal Transduction, Mechanotransduction, Cellular, Endothelial Cells, Embryonic Development, Embryonic Stem Cells

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The Effects of Hemodynamic Force on Embryonic Development

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