Cited by 290Inflammatory Bowel DiseaseGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis

Vieira, Erica L.M., Leonel, Alda J., Sad, Alexandre P., Beltrão, Nathália R.M., Costa, Thaís F., Ferreira, Talita M.R., Gomes-Santos, Ana C., Faria, Ana M.C. +3 more·2012·The Journal of Nutritional Biochemistry

Abstract

Butyrate is a four-carbon short-chain fatty acid that improves colonic trophism. Although several studies have shown the benefits of butyrate enemas in ulcerative colitis (UC), studies using the oral route are rare in the literature. In the present study, we evaluated the effect of butyrate intake in the immune response associated to UC. For that, mice were fed control or butyrate (0.5% sodium butyrate) diets for 14 days. Acute UC was induced by dextran sulphate sodium (DSS, 2.5%), replacing drinking water. The results showed that, in UC animals, oral butyrate significantly improved trophism and reduced leukocyte (eosinophil and neutrophil) infiltration in the colon mucosa and improved the inflammatory profile (activated macrophage, B and T lymphocytes) in cecal lymph nodes. In the small intestine, although mucosa histology was similar among groups, DSS treatment reduced duodenal transforming growth factor-β, increased interleukin-10 concentrations and increased memory T lymphocytes and dendritic cells in Peyer's patches. Butyrate supplementation was able to revert these alterations. When cecal butyrate concentration was analyzed in cecal content, it was still higher in the healthy animals receiving butyrate than in the UC+butyrate and control groups. In conclusion, our results show that oral administration of sodium butyrate improves mucosa lesion and attenuates the inflammatory profile of intestinal mucosa, local draining lymph nodes and Peyer's patches of DSS-induced UC. Our results also highlight the potential use of butyrate supplements as adjuvant in UC treatment.

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Crossref · 10.1016/j.jnutbio.2011.01.007

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Authors
Vieira, E. L. M., Leonel, A. J., Sad, A. P., Beltrão, N. R. M., Costa, T. F., Ferreira, T. M. R., Gomes-Santos, A. C., Faria, A. M. C., Peluzio, M. C. G., Cara, D. C., & Alvarez-Leite, J. I.
Affiliations
Universidade Federal de Minas Gerais (BR)
Corresponding author
Alvarez-Leite, Jacqueline I.
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
2012-05
Volume
23
Issue
5
Pages
430-436
ISSN
0955-2863 (ISSN-L)
OpenAlex
W2089298736
Cited by
290
References
36
Citations by year
2026: 7 · 2025: 23 · 2024: 18 · 2023: 24 · 2022: 21 · 2021: 17 · 2020: 41 · 2019: 25 · 2018: 12 · 2017: 24 · 2016: 25 · 2015: 20 · 2014: 15 · 2013: 7 · 2012: 9
FWCI
6.57
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Nutritional Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
sodium butyrate, ulcerative colitis, short-chain fatty acids, oral supplementation, dextran sulfate, colonic inflammation, mucosal healing, macrophage activation, lymphocyte response, Peyer's patches, dendritic cells, IL-10, TGF-beta, adjuvant therapy
MeSH terms
Acute Disease, Administration, Oral, Animals, Butyrates, Colitis, Ulcerative, Intestinal Mucosa, Male, Mice, Inbred BALB C, Interleukin-10, Mice

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