Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis
Abstract
Butyrate is a four-carbon short-chain fatty acid that improves colonic trophism. Although several studies have shown the benefits of butyrate enemas in ulcerative colitis (UC), studies using the oral route are rare in the literature. In the present study, we evaluated the effect of butyrate intake in the immune response associated to UC. For that, mice were fed control or butyrate (0.5% sodium butyrate) diets for 14 days. Acute UC was induced by dextran sulphate sodium (DSS, 2.5%), replacing drinking water. The results showed that, in UC animals, oral butyrate significantly improved trophism and reduced leukocyte (eosinophil and neutrophil) infiltration in the colon mucosa and improved the inflammatory profile (activated macrophage, B and T lymphocytes) in cecal lymph nodes. In the small intestine, although mucosa histology was similar among groups, DSS treatment reduced duodenal transforming growth factor-β, increased interleukin-10 concentrations and increased memory T lymphocytes and dendritic cells in Peyer's patches. Butyrate supplementation was able to revert these alterations. When cecal butyrate concentration was analyzed in cecal content, it was still higher in the healthy animals receiving butyrate than in the UC+butyrate and control groups. In conclusion, our results show that oral administration of sodium butyrate improves mucosa lesion and attenuates the inflammatory profile of intestinal mucosa, local draining lymph nodes and Peyer's patches of DSS-induced UC. Our results also highlight the potential use of butyrate supplements as adjuvant in UC treatment.
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Sodium butyrate treatment has no significant effect on normal animals, including on gut microbiota, intestinal inflammation, neuroinflammation, and motor function.
“The NaB treatment had no significant effect on normal animals, especially on gut microbiota [22], intestinal inflammation [33], neuroinflammation [34], and motor function [35].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [33]
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- Authors
- Vieira, E. L. M., Leonel, A. J., Sad, A. P., Beltrão, N. R. M., Costa, T. F., Ferreira, T. M. R., Gomes-Santos, A. C., Faria, A. M. C., Peluzio, M. C. G., Cara, D. C., & Alvarez-Leite, J. I.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Alvarez-Leite, Jacqueline I.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 23
- Issue
- 5
- Pages
- 430-436
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2089298736
- Cited by
- 290
- References
- 36
- Citations by year
- 2026: 7 · 2025: 23 · 2024: 18 · 2023: 24 · 2022: 21 · 2021: 17 · 2020: 41 · 2019: 25 · 2018: 12 · 2017: 24 · 2016: 25 · 2015: 20 · 2014: 15 · 2013: 7 · 2012: 9
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- sodium butyrate, ulcerative colitis, short-chain fatty acids, oral supplementation, dextran sulfate, colonic inflammation, mucosal healing, macrophage activation, lymphocyte response, Peyer's patches, dendritic cells, IL-10, TGF-beta, adjuvant therapy
- MeSH terms
- Acute Disease, Administration, Oral, Animals, Butyrates, Colitis, Ulcerative, Intestinal Mucosa, Male, Mice, Inbred BALB C, Interleukin-10, Mice
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