Interactions of gut microbiota with functional food components and nutraceuticals

Laparra, J.M.; Sanz, Y.

doi:10.1016/j.phrs.2009.11.001

Cited by 684Gut microbiota and healthProbiotics and Fermented FoodsMicrobial Metabolites in Food Biotechnology

Interactions of gut microbiota with functional food components and nutraceuticals

Laparra, J.M., Sanz, Y.·2010·Pharmacological Research

DOI 10.1016/j.phrs.2009.11.001

Open this paper in CoChat — free account

Abstract

The human gut is populated by an array of bacterial species, which develop important metabolic and immune functions, with a marked effect on the nutritional and health status of the host. Dietary component also play beneficial roles beyond basic nutrition, leading to the development of the functional food concept and nutraceuticals. Prebiotics, polyunsaturated fatty acids (PUFAs) and phytochemicals are the most well characterized dietary bioactive compounds. The beneficial effects of prebiotics mainly relay on their influence on the gut microbiota composition and their ability to generate fermentation products (short-chain fatty acids) with diverse biological roles. PUFAs include the omega-3 and omega-6 fatty acids, whose balance may influence diverse aspects of immunity and metabolism. Moreover, interactions between PUFAs and components of the gut microbiota may also influence their biological roles. Phytochemicals are bioactive non-nutrient plant compounds, which have raised interest because of their potential effects as antioxidants, antiestrogenics, anti-inflammatory, immunomodulatory, and anticarcinogenics. However, the bioavailability and effects of polyphenols greatly depend on their transformation by components of the gut microbiota. Phytochemicals and their metabolic products may also inhibit pathogenic bacteria while stimulate the growth of beneficial bacteria, exerting prebiotic-like effects. Therefore, the intestinal microbiota is both a target for nutritional intervention and a factor influencing the biological activity of other food compounds acquired orally. This review focuses on the reciprocal interactions between the gut microbiota and functional food components, and the consequences of these interactions on human health.

Integrity signals

Registry

Crossref · 10.1016/j.phrs.2009.11.001

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Polyphenols are bioactive non-nutrient plant compounds whose bioavailability and physiologic effects depend on transformation by gut microbiota; polyphenols alter microbial growth patterns; and polyphenol composition may be more important than macronutrient composition for determining growth effects on gut microbes.
“Polyphenols are bioactive non-nutrient plant compounds whose bioavailability and physiologic effects greatly depend on their transformation by components of the gut microbiota. Polyphenols, in turn, alter microbial growth patterns. The polyphenol composition of an individual's diet may be more important than macronutrient composition for determining growth effects on gut microbes.159”
From The Gut Microbiome and the Brain (2014) · cites this paper as [159]

The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
The human microbiome project
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091 · see citing works
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699 · see citing works
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336 · see citing works
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721 · see citing works
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works
Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action
Liu, R. H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3479s · Cited by 2,277 · see citing works
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works
Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis
Flint, H. J., Bayer, E. A., Rincón, M. T., Lamed, R., & White, B. A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1817 · Cited by 1,716 · see citing works
Worlds within worlds: evolution of the vertebrate gut microbiota
Ley, R. E., Lozupone, C., Hamady, M., Knight, R. D., & Gordon, J. I. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1978 · Cited by 1,674 · see citing works
H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE
Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623 · see citing works
Prebiotics: The Concept Revisited1,
Roberfroid, M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.830s · Cited by 1,502 · see citing works
Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works
The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract
Schell, M. A., Karmirantzou, M., Snel, ‎., Vilanova, D., Berger, B. W., Pessi, G., Zwahlen, M.-C., Desiere, F., Peer Bork, B., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 942 · see citing works
The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome
Sela, D. A., Chapman, J., Adeuya, A., Kim, J., Chen, F., Whitehead, T. R., Lapidus, A. L., Rokhsar, D. S., Lebrilla, C. B., German, J. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809584105 · Cited by 884 · see citing works
Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V. K., Srivastava, T. P., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm018 · Cited by 869 · see citing works
Introducing inulin-type fructans
Roberfroid, M. B. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041350 · Cited by 799 · see citing works
The Bifidogenic Nature of Chicory Inulin and Its Hydrolysis Products
Roberfroid, M. B., Loo, J. V., & Gibson, G. R. (1998) · Journal of Nutrition · doi:10.1093/jn/128.1.11 · Cited by 781 · see citing works
Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases
Tlaskalová‐Hogenová, H., Štëpánková, R., Hudcovic, T., Tučková, L., Cukrowská, B., Lodinová‐Žádníková, R., Kozáková, H., Rossmann, P., Bártová, J., Sokol, D., et al. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.02.005 · Cited by 755 · see citing works
Prebiotics and probiotics: are they functional foods?
Roberfroid, M. B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1682s · Cited by 729 · see citing works
Absorption and metabolism of polyphenols in the gut and impact on health
Scalbert, A., Morand, C., Manach, C., & Rémésy, C. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00205-6 · Cited by 723 · see citing works
Selected Indigestible Oligosaccharides Affect Large Bowel Mass, Cecal and Fecal Short-Chain Fatty Acids, pH and Microflora in Rats ,
Campbell, J. M., Fahey, G. C., Jr., & Wolf, B. W. (1997) · Journal of Nutrition · doi:10.1093/jn/127.1.130 · Cited by 720 · see citing works
Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota
Lee, H. C., Jenner, A. M., Low, C. S., & Lee, Y. K. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.07.004 · Cited by 697 · see citing works
Regulatory effects of bifidobacteria on the growth of other colonic bacteria
Gibson, G. R., & Wang, X. (1994) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1994.tb03443.x · Cited by 682 · see citing works
In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway
Comalada, M., Camuesco, D., Sierra, S., Ballester, I., Xaus, J., Gálvez, J., & Zarzuelo, A. (2005) · European Journal of Immunology · doi:10.1002/eji.200425778 · Cited by 650 · see citing works
Evolution of Symbiotic Bacteria in the Distal Human Intestine
Xu, J., Mahowald, M. A., Ley, R. E., Lozupone, C., Hamady, M., Martens, E. C., Henrissat, B., Coutinho, P. M., Minx, P. J., Latreille, P., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050156 · Cited by 585 · see citing works
Berry Phenolics: Antimicrobial Properties and Mechanisms of Action Against Severe Human Pathogens
Nohynek, L. J., Alakomi, H., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman‐Caldentey, K., & Puupponen‐Pimiä, R. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_4 · Cited by 541 · see citing works
Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents
Santacruz, A., Marcos, A., Wärnberǵ, J., Martí, A., Martín‐Matillas, M., Campoy, C., Moreno, L. A., Veiga, Ó. L., Redondo-Figuero, C. G., Garagorri, J. M., et al. (2009) · Obesity · doi:10.1038/oby.2009.112 · Cited by 474 · see citing works
Self-citation
Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease
Lindsay, J. O. (2006) · Gut · doi:10.1136/gut.2005.074971 · Cited by 471 · see citing works
Flavanol monomer-induced changes to the human faecal microflora
Tzounis, X., Vulevic, J., Kuhnle, G., George, T. W., Leonczak, J., Gibson, G. R., Kwik-Uribe, C. L., & Spencer, J. P. E. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507853384 · Cited by 454 · see citing works
Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Poussa, T. A., & Isolauri, E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.608 · Cited by 453 · see citing works
Collaborative JPEN‐Clinical Nutrition Scientific Publications Role of intestinal bacteria in nutrient metabolism
Cummings, J. H., & Macfarlane, G. T. (1997) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607197021006357 · Cited by 437 · see citing works
The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans
Cerd�, B., Esp�n, J. C., Parra, S., Mart�nez, P., & Tom�s-Barber�n, F. A. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0461-7 · Cited by 435 · see citing works
Berry phenolics selectively inhibit the growth of intestinal pathogens
Puupponen‐Pimiä, R., Nohynek, L. J., Hartmann-Schmidlin, S., Kähkönen, M., Heinonen, M., Riihinen, K., & Oksman‐Caldentey, K. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02547.x · Cited by 420 · see citing works
Microbial metabolism of dietary phenolic compounds in the colon
Aura, A. (2008) · Phytochemistry Reviews · doi:10.1007/s11101-008-9095-3 · Cited by 412 · see citing works
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396 · see citing works
Self-citation
Prebiotic Galactooligosaccharides Reduce Adherence of EnteropathogenicEscherichia colito Tissue Culture Cells
Shoaf‐Sweeney, K. D., Mulvey, G. L., Armstrong, G. D., & Hutkins, R. W. (2006) · Infection and Immunity · doi:10.1128/iai.01030-06 · Cited by 386 · see citing works
Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats
Bowey, E. A., Adlercreutz, H., & Rowland, I. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00324-1 · Cited by 381 · see citing works
The potential influence of fruit polyphenols on colonic microflora and human gut health
Parkar, S. G., Stevenson, D. E., & Skinner, M. A. (2008) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2008.03.017 · Cited by 377 · see citing works
Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model
Larrosa, M., Yañéz-Gascón, M. J., Selma, M. V., González-Sarrías, A., Toti, S., Cerón, J. J., Tomás-Barberán, F., Dolara, P., & Espín, J. C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803638d · Cited by 365 · see citing works
Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation
LoCascio, R. G., Ninonuevo, M. R., Freeman, S. L., Sela, D. A., Grimm, R., Lebrilla, C. B., Mills, D. A., & German, J. B. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0710480 · Cited by 365 · see citing works
Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora
Kleessen, B., Hartmann, L., & Blaut, M. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001403 · Cited by 345 · see citing works
Distribution of Î²-glucosidase and Î²-glucuronidase activity and of Î²-glucuronidase gene gus in human colonic bacteria: Î²-Glycosidase activity in human gut bacteria
Dabek, M., McCrae, S. I., Stevens, V. J., Duncan, S. H., & Louis, P. (2008) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00520.x · Cited by 332 · see citing works
Metabolism of dietary soy isoflavones to equol by human intestinal microflora – implications for health
Yuan, J., Wang, J., & Liu, X. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600262 · Cited by 324 · see citing works
Inulin, oligofructose and immunomodulation
Watzl, B., Girrbach, S., & Roller, M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041357 · Cited by 315 · see citing works
Quantitative Real-Time PCR Assays To Identify and Quantify Fecal Bifidobacterium Species in Infants Receiving a Prebiotic Infant Formula
Haarman, M., & Knol, J. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.5.2318-2324.2005 · Cited by 295 · see citing works
Effect of Dietary Inulin Supplementation on Inflammation of Pouch Mucosa in Patients With an Ileal Pouch-Anal Anastomosis
Welters, C. F. M., Heineman, E., Thunnissen, E., van den Bogaard, A. E. J. M., Soeters, P. B., & Baeten, C. G. M. I. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6257-2 · Cited by 294 · see citing works
Quercetin Inhibits TNF-Induced NF-κB Transcription Factor Recruitment to Proinflammatory Gene Promoters in Murine Intestinal Epithelial Cells
Ruiz, P. A., Braune, A., Hölzlwimmer, G., Quintanilla-Fend, L., & Haller, D. (2007) · Journal of Nutrition · doi:10.1093/jn/137.5.1208 · Cited by 281 · see citing works
Rudolf Schoenheimer and the Concept of the Dynamic State of Body Constituents
Guggenheim, K. Y. (1991) · Journal of Nutrition · doi:10.1093/jn/121.11.1730 · Cited by 277 · see citing works
Role of intestinal bacteria in nutrient metabolism
Cummings, J. H., & Macfarlane, G. T. (1997) · Clinical Nutrition · doi:10.1016/s0261-5614(97)80252-x · Cited by 277 · see citing works
Prebiotics and resistance to gastrointestinal infections
Gibson, G. R., McCartney, A. L., & Rastall, R. A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041343 · Cited by 276 · see citing works
Polyphenol metabolites from colonic microbiota exert anti‐inflammatory activity on different inflammation models
Larrosa, M., Luceri, C., Vivoli, E., Pagliuca, C., Lodovici, M., Moneti, G., & Dolara, P. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800446 · Cited by 257 · see citing works
Antihypertensive effect of Valyl-Tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects
Kawasaki, T., Seki, E., Osajima, K., et al. (2000) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001065 · Cited by 249 · see citing works
Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?
Das, U. N. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0226 · Cited by 238 · see citing works
The influence of polyunsaturated fatty acids on probiotic growth and adhesion
Kankaanpää, P., Salminen, S., Isolauri, E., & Lee, Y. K. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb09460.x · Cited by 238 · see citing works
Mucin Degradation by Bifidobacterium Strains Isolated from the Human Intestinal Microbiota
Ruas‐Madiedo, P., Gueimonde, M., Fernández-García, M., Reyes‐Gavilán, C. G. D. L., & Margollés, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02509-07 · Cited by 222 · see citing works
Anti-hypertensive Nutraceuticals and Functional Foods
Chen, Z., Peng, C., Jiao, R., Wong, Y. M., Yang, N., & Huang, Y. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900803r · Cited by 218 · see citing works
Reduction of Colitis by Prebiotics in HLA-B27 Transgenic Rats Is Associated with Microflora Changes and Immunomodulation
Hoentjen, F., Welling, G. W., Harmsen, H. J. M., Zhang, X., Snart, J., Tannock, G. W., Lien, K. A., Churchill, T. A., Lupicki, M., & Dieleman, L. A. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000183421.02316.d5 · Cited by 218 · see citing works
Improvement of the probiotic effect of micro-organisms by their combination with maltodextrins, fructo-oligosaccharides and polyunsaturated fatty acids
Bomba, A., Nemcová, R., Gancarčíková, S., Herich, R., Guba, P., & Mudroňová, D. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002634 · Cited by 216 · see citing works
Dietary Inulin Improves Distal Colitis Induced by Dextran Sodium Sulfate in the Rat
Videla, S., Vilaseca, J., Antolín, M., García-Lafuente, A., Guarner, F., Crespo, E., Casalots, J., Salas, A., & Malagelada, J. R. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03802.x · Cited by 209 · see citing works
Comparison of prebiotic effects of arabinoxylan oligosaccharides and inulin in a simulator of the human intestinal microbial ecosystem
Grootaert, C., den Abbeele, P. V., Marzorati, M., Broekaert, W. F., Courtin, C. M., Delcour, J. A., Verstraete, W., & de Wiele, T. V. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00712.x · Cited by 201 · see citing works
Functional Diversity of Flavonoids in the Inhibition of the Proinflammatory NF-κB, IRF, and Akt Signaling Pathways in Murine Intestinal Epithelial Cells
Ruiz, P. A., & Haller, D. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.664 · Cited by 147 · see citing works
Complete Genome Sequence of Bifidobacterium longum subsp. longum KACC 91563
Ham, J.-S., Lee, T., Byun, M.-J., Lee, K., Kim, M., Han, G.-S., Jeong, S.-G., Oh, M., Kim, D., & Kim, H. (2011) · Journal of Bacteriology · doi:10.1128/jb.05620-11 · Cited by 143 · see citing works
Anti-Inflammatory Mechanisms of Isoflavone Metabolites in Lipopolysaccharide-Stimulated Microglial Cells
Park, J., Woo, M.-S., Kim, D., Hyun, J., Kim, W.-K., Lee, J., & Kim, H.-S. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.114322 · Cited by 131 · see citing works
Dietary Fructooligosaccharide, Xylooligosaccharide and Gum Arabic Have Variable Effects on Cecal and Colonic Microbiota and Epithelial Cell Proliferation in Mice and Rats
Howard, M. D., & Gordon, D. T. (1995) · Journal of Nutrition · doi:10.1093/jn/125.10.2604 · Cited by 131 · see citing works
Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol
Wang, W.-B., Lai, H., Hsueh, P., Chiou, R. Y. ‐., Lin, S., & Liaw, S. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46661-0 · Cited by 130 · see citing works
The Role of the Gastrointestinal Microbiota in Colorectal Cancer
Rowland, I. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168191 · Cited by 129 · see citing works
Effects of Polyunsaturated Fatty Acids in Growth Medium on Lipid Composition and on Physicochemical Surface Properties of Lactobacilli
Kankaanpää, P., Yang, B., Kallio, H. P. T., Isolauri, E., & Salminen, S. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.1.129-136.2004 · Cited by 122 · see citing works
Polyphenolic Compounds: Interactions with the Gut and Implications for Human Health
Gee, J. M. W., & Johnson, I. T. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372256 · Cited by 120 · see citing works
Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: Involvement of NF‐κB pathway
Borthakur, A., Saksena, S., Gill, R. K., Alrefai, W. A., Ramaswamy, K., & Dudeja, P. K. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21532 · Cited by 116 · see citing works
The Role of Gut Microbiota in Drug Response
Wilson, I. D., & Nicholson, J. K. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168173 · Cited by 115 · see citing works
Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecal microbiota in vitro
Bazzocco, S., Mattila, I. M., Guyot, S., Renard, C. M. G. C., & Aura, A. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0747-2 · Cited by 113 · see citing works
Conversion of cholic acid and chenodeoxycholic acid into their 7-oxo derivatives byBacteroides intestinalisAM-1 isolated from human feces
Fukiya, S., 荒田美紀, Kawashima, H., Yoshida, D., Kaneko, M. A. N., Minamida, K., Watanabe, J., Ogura, Y., Uchida, K., Itoh, K., et al. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01531.x · Cited by 111 · see citing works
Inulin and Oligofructose in Chronic Inflammatory Bowel Disease
Leenen, C. H., & Dieleman, L. A. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2572s · Cited by 107 · see citing works
Bifidogenic Effects of Solid Weaning Foods With Added Prebiotic Oligosaccharides
Scholtens, P. A. M. J., Alles, M. S., BINDELS, J. G., van der Linde, E. G. M., Tolboom, J. J. M., & Knol, J. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000221887.28877.c7 · Cited by 107 · see citing works
Neutral detergent-soluble fiber improves gut barrier function in twenty-five-day-old weaned rabbits1
Gómez-Conde, M. S., García, J., Chamorro, S., Eiras, P., Rebollar, P. G., de Rozas, A. M. P., Badiola, I., Blas, C. D., & Carabaño, R. (2007) · Journal of Animal Science · doi:10.2527/jas.2006-777 · Cited by 101 · see citing works
Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat
Meinl, W., Sczesny, S., Brigelius‐Flohé, R., Blaut, M., & Glatt, H. R. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.025916 · Cited by 96 · see citing works
Potential prebiotic activity of oligosaccharides obtained by enzymatic conversion of durum wheat insoluble dietary fibre into soluble dietary fibre
Napolitano, A., Costabile, A., Martín‐Peláez, S., Vitaglione, P., Klinder, A., Gibson, G. R., & Fogliano, V. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.07.005 · Cited by 86 · see citing works
Gut Microbiota and Probiotics in Modulation of Epithelium and Gut-Associated Lymphoid Tissue Function
Sanz, Y., & Palma, G. D. (2009) · International Reviews of Immunology · doi:10.3109/08830180903215613 · Cited by 86 · see citing works
Self-citation
Intestinal immune system of young rats influenced by cocoa-enriched diet
Ramiro‐Puig, E., Pérez-Cano, F. J., Ramos‐Romero, S., Pérez, T., Castellote, C., Permanyer, J., Franch, À., Izquierdo-Pulido, M., & Castell, M. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.07.002 · Cited by 84 · see citing works
Research Communication: Butyrate Impairs Lipid Transport by Inhibiting Microsomal Triglyceride Transfer Protein in Caco-2 Cells
Marcil, V., Garofalo, C., Levy, E. H., & DELVIN, E. E. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2180 · Cited by 83 · see citing works
Changes in bacterial populations in the colon of pigs fed different sources of dietary fibre, and the development of swine dysentery after experimental infection
Durmic, Z., Pethick, D. W., Pluske, J. R., et al. (1998) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1998.853539.x · Cited by 75 · see citing works
Presence of specific antibiotic (tet) resistance genes in infant faecal microbiota
Gueimonde, M., Salminen, S., & Isolauri, E. (2006) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2006.00112.x · Cited by 63 · see citing works
Non-digestible oligosaccharides and bifidobacteria - implications for health
Gibson, G. R., Willis, C. L., & Loo, J. V. (1994) · International sugar journal · Cited by 62 · see citing works
Influence of probiotic supplemented infant formula on composition of plasma lipids in atopic infants
Kankaanpää, P., Yang, B., Kallio, H. P. T., Isolauri, E., & Salminen, S. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00185-7 · Cited by 51 · see citing works
Phytoestrogen and breast cancer prevention
Ganry, O. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200212000-00002 · Cited by 46 · see citing works
Resveratrol Alters Proliferative Responses and Apoptosis in Human Activated B Lymphocytes in Vitro ,
Zunino, S. J., & Storms, D. H. (2009) · Journal of Nutrition · doi:10.3945/jn.109.105064 · Cited by 44 · see citing works
Study of the anti‐lactic acid bacteria compounds in table olives
Medina, E., García-Borrego, A., Romero, C., de Castro, A., & Brenes, M. (2009) · International Journal of Food Science & Technology · doi:10.1111/j.1365-2621.2009.01950.x · Cited by 38 · see citing works
Omega-3 polyunsaturated fatty acid supplements and ambulatory blood pressure monitoring parameters in patients with mild essential hypertension.
Russo, C. A., Olivieri, O., Girelli, D., Azzini, M., Stanzial, A. M., Guarini, P., Friso, S., Franceschi, L. D., & Corrocher, R. (1995) · PubMed · Cited by 32 · see citing works
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donat, E., Ribes‐Koninckx, C., et al. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47854-0 · Cited by 30 · see citing works
Functional and nutritional foods containing bifidogenic factors
Mizota, T. (1996) · Bulletin. International Dairy Federation · Cited by 28 · see citing works
Induction of α-l-arabinofuranosidase activity by monomeric carbohydrates in Bifidobacterium longum and ubiquity of encoding genes
Gueimonde, M., Noriega, L., Margollés, A., & Reyes‐Gavilán, C. G. D. L. (2006) · Archives of Microbiology · doi:10.1007/s00203-006-0181-x · Cited by 26 · see citing works
Omega-3 polyunsaturated fatty acid supplements and ambulatory blood pressure monitoring parameters in patients with mild essential hypertension
Russo, C. A., Olivieri, O., Girelli, D., Azzini, M., Guarini, P., Friso, S., Franceschi, L. D., & Corrocher, R. (1995) · Journal of Hypertension · doi:10.1097/00004872-199512010-00059 · Cited by 26 · see citing works
Effects of Tea Catechins on the Gastrointestinal Mucosa in Rats
Ito, Y., Ichikawa, T., Iwai, T., et al. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802142n · Cited by 14 · see citing works
Mutagen excretion and cytochrome P-450-dependent activity in germfree and conventional rats fed a diet containing fried meat
Övervik, E., Lindeskog, P., Midtvedt, T., et al. (1990) · Food and Chemical Toxicology · doi:10.1016/0278-6915(90)90037-n · Cited by 14 · see citing works
Child nutrition physiology
Overton, L. T., & Ewente, M. R. (2008) · Cited by 9 · see citing works
Deficiency and supplementation of PUFA in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels
Straniero, S., Cavallini, G., Donati, A., Metelli, M. R., Tamburini, I., Pietrini, P., & Bergamini, E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.09.009 · Cited by 5 · see citing works

Flagged first, then by citations

Sorted by citations

You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works
The Role of Polyphenols in Human Health and Food Systems: A Mini-Review
Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00087 · Cited by 1,297 · see citing works
The influence of diet on the gut microbiota
Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052 · see citing works
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review
Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0852-y · Cited by 599 · see citing works
Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host
Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.005 · Cited by 548 · see citing works
Self-citation
Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works
A survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396 · see citing works
Gut microbiota role in dietary protein metabolism and health-related outcomes: The two sides of the coin
Portune, K. J., Beaumont, M., Davila, A.-M., Tomé, D., Blachier, F., & Sanz, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.011 · Cited by 356 · see citing works
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics
Carmody, R. N., & Turnbaugh, P. J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72335 · Cited by 268 · see citing works
Natural Deep Eutectic Solvents (NADES) as a Tool for Bioavailability Improvement: Pharmacokinetics of Rutin Dissolved in Proline/Glycine after Oral Administration in Rats: Possible Application in Nutraceuticals
Faggian, M., Sut, S., Perissutti, B., Baldan, V., Grabnar, I., & Dall’Acqua, S. (2016) · Molecules · doi:10.3390/molecules21111531 · Cited by 237 · see citing works
Re-print of “Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host”
Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.01.003 · Cited by 231 · see citing works
Self-citation
Differences of small intestinal bacteria populations in adults and children with/without celiac disease: Effect of age, gluten diet, and disease
Nistal, E., Caminero, A., Herrán, A. R., Arias, L., Vivas, S., de Morales, J. M. R., Calleja, S., de Miera, L. E. S., Arroyo, P., & Casqueiro, J. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21830 · Cited by 187 · see citing works
L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP
Collins, H. L., Drazul-Schrader, D., Sulpizio, A. C., Koster, P. D., Williamson, Y., Adelman, S. J., Owen, K., Sanli, T., & Bellamine, A. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.108 · Cited by 189 · see citing works
Developing a metagenomic view of xenobiotic metabolism
Haiser, H. J., & Turnbaugh, P. J. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.07.009 · Cited by 186 · see citing works
“Hydrolysis of conjugated hydroxycinnimates gives rise to free acids including ferulic, p-coumaric, and caffeic acid, all of which possess antioxidant properties [75].”
Background
Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia
Picca, A., Fanelli, F., Calvani, R., Mulè, G., Pesce, V., Sisto, A., Pantanelli, C., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/7026198 · Cited by 181 · see citing works
Understanding the prebiotic potential of different dietary fibers using an in vitro continuous adult fermentation model (PolyFermS)
Poeker, S. A., Geirnaert, A., Berchtold, L., Greppi, A., Krych, L., Steinert, R. E., de Wouters, T., & Lacroix, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-22438-y · Cited by 176 · see citing works
Gut microbiota and attention deficit hyperactivity disorder: new perspectives for a challenging condition
Cenit, M. C., Nuevo, I. C., Codoñer-Franch, P., Dinan, T. G., & Sanz, Y. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0969-z · Cited by 163 · see citing works
Self-citation
Food inhibits the oral bioavailability of the major green tea antioxidant epigallocatechin gallate in humans
Naumovski, N., Blades, B., & Roach, P. (2015) · Antioxidants · doi:10.3390/antiox4020373 · Cited by 108 · see citing works
Chia seeds (<i>Salvia hispanica</i> L.): A therapeutic weapon in metabolic disorders
Khalid, W., Arshad, M. S., Aziz, A., Rahim, M. A., Qaisrani, T. B., Afzal, F., Ali, A., Ranjha, M. M. A. N., Khalid, M. Z., & Anjum, F. M. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3035 · Cited by 108 · see citing works
Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E-/- mice
Ryan, P. M., London, L. E. E., Bjorndahl, T. C., Mandal, R., Murphy, K., Fitzgerald, G. F., Shanahan, F., Ross, R. P., Wishart, D. S., Caplice, N. M., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0246-x · Cited by 97 · see citing works
An exploratory study on the influence of orange juice on gut microbiota using a dynamic colonic model
Duque, A. L. R. F., Monteiro, M., Adorno, M. A. T., Sakamoto, I. K., & Sivieri, K. (2016) · Food Research International · doi:10.1016/j.foodres.2016.03.028 · Cited by 81 · see citing works
Effect of Breadmaking Process on In Vitro Gut Microbiota Parameters in Irritable Bowel Syndrome
Costabile, A., Santarelli, S., Claus, S. P., Sanderson, J., Hudspith, B. N., Brostoff, J., Ward, J. L., Lovegrove, A., Shewry, P. R., Jones, H. E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111225 · Cited by 52 · see citing works
Interactions between prebiotics, probiotics, polyunsaturated fatty acids and polyphenols: diet or supplementation for metabolic syndrome prevention?
Peluso, I., Romanelli, L., & Palmery, M. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.880670 · Cited by 48 · see citing works

Gamma-irradiation of inulin improves its biological functionality and feasibility as a functional ingredient in synbiotic food
Sudesh, S., Maurya, D. K., & Jamdar, S. N. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135217 · Cited by 16 · see citing works
Cereal β‐glucan: a promising prebiotic polysaccharide and its impact on the gut health
Shoukat, M., & Sorrentino, A. (2021) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14971 · Cited by 82 · see citing works
Inulin from Globe Artichoke Roots: A Promising Ingredient for the Production of Functional Fresh Pasta
Difonzo, G., de Gennaro, G., Caponio, G. R., et al. (2022) · Foods · doi:10.3390/foods11193032 · Cited by 34 · see citing works
An overview of current scenario of Nutraceutical foods
Singh, A. K. (2021) · Journal of Drug Discovery and Therapeutics
A review on nutritional composition, antinutritional components and health benefits of green gram ( Vigna radiata (L.) Wilczek )
Sudhakaran, S. M. N., & Shakappa, D. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13743 · Cited by 39 · see citing works

Authors: Laparra, J. M., & Sanz, Y.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Sanz, Y.
ORCID: Laparra, J.M.
Sanz, Y.
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2010-03
Volume: 61
Issue: 3
Pages: 219-225
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2009.11.001
OpenAlex: W2050822595
Cited by: 684
References: 98
Citations by year: 2026: 15 · 2025: 24 · 2024: 45 · 2023: 55 · 2022: 69 · 2021: 42 · 2020: 52 · 2019: 56 · 2018: 54 · 2017: 50 · 2016: 43 · 2015: 35 · 2014: 45 · 2013: 33 · 2012: 35
FWCI: 8.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: gut microbiota, functional foods, nutraceuticals, prebiotics, polyunsaturated fatty acids, omega-3 fatty acids, omega-6 fatty acids, phytochemicals, polyphenols, short-chain fatty acids, bioavailability, anti-inflammatory activity, immunomodulation, gut health
MeSH terms: Animals, Humans, Dietary Supplements, Gastrointestinal Tract, Metagenome, Functional Food

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interactions of gut microbiota with functional food components and nutraceuticals

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks