The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Bowel Habit Subtypes and Temporal Patterns in Irritable Bowel Syndrome: Systematic Review
Abstract
UNLABELLED: Irritable bowel syndrome (IBS) is a heterogeneous condition characterized by the presence of abdominal discomfort or pain and bowel habit alterations: constipation (C-IBS), diarrhea (D-IBS), or alternating C and D (A-IBS). Its clinical course is poorly known. OBJECTIVES: (i) To compare bowel habit subtypes distribution in IBS according to sample origin and diagnosis criteria; (ii) To evaluate IBS temporal patterns based on follow-up studies. METHODS: A literature search (1966-2003) was conducted in the MEDLINE and EMBASE databases. A total of 72 studies were found and 22 were finally selected. RESULTS: Population-based studies from the United States (Manning) found similar distribution among C-IBS, D-IBS, and A-IBS, while European studies (Rome I, Rome II, or self-reporting) showed either C-IBS or A-IBS as the most prevalent subtypes. Primary care office-based studies (Rome I or Rome II) showed A-IBS as the most prevalent group. Gastroenterology specialized office-based studies found either C-IBS or D-IBS as the most frequently reported subtype. Prospective follow-up investigations showed that the most frequent IBS temporal pattern profile consists of mild to moderate symptoms appearing in cluster in an intermittent way, about once a week, and lasting 2-5 days on average. CONCLUSION: IBS clinical subtypes distribution differs depending on the population evaluated, the geographical location, and the criteria employed to define IBS and bowel habit subtypes. In most cases, clinical course is characterized by the presence of mild-to-moderate symptoms appearing sequentially. Prospective studies, using clear and stable diagnostic criteria and subtype definitions, and based on daily data collection should further characterize IBS clinical course.
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“Since IBS symptoms are known to vary considerably over time [44], the mean score of four weekly assessments of GSRS-IBS was used to get reliable estimates of the participants' symptom levels at each assessment point.”
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Self-citationIrritable Bowel Syndrome Subtypes Defined by Rome II and Rome III Criteria are Similar
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“(6) Urgency?”
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ResultChronic constipation: Update on management
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“Most of the available studies reported A-IBS to be the most common subgroup,(26) especially when the investigation is primary care office based.(8) Ersryd and”
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“Other organic causes of these symptoms need to be ruled out before the diagnosis of IBS is made.2 The three types of IBS are IBS diarrhea-predominant (IBS-D), IBS constipation-predominant (IBS-C), and IBS mixed-symptoms (IBS-M), which occur in approximately equal proportions of patients in the United States.3 Current…”
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“Diarrhea-predominant IBS is a debilitating form of IBS which significantly reduces the quality of life of patients, increases health care expenditures, impairs social and occupational functioning, and increases psychological disorders [28].”
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“…present study, we aimed to test rectal hypersensitivity thresholds in different subtypes of IBS patients, because there are evidences in the literature for differences in pathophysiology according to bowel habits, including different disease courses and treatment responses (Guilera et al., 2005).”
BackgroundIrritable bowel syndrome in adolescents in Lagos
Adeniyi, O. F., Lesi, O. A., Olatona, F. A., Esezobor, C. I., & Ikobah, J. M. (2017) · Pan African Medical Journal · doi:10.11604/pamj.2017.28.93.11512 · Cited by 22
“Some reports have also noted that these subtypes may change with time in some children [21].”
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Saad, R. J., & Chey, W. D. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.2.117 · Cited by 21
“Most patients will experience intermittent mild-to-moderate symptoms that occur in clusters rather than randomly [1] .”
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Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice
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“For example, IBS is often split into constipation and diarrhea predominant [4], whereas factor analyses have defined subtypes of FM [5] and CFS [6].”
BackgroundCurrent and emerging drug options in the treatment of diarrhea predominant irritable bowel syndrome
Nee, J. W., Zakari, M., & Lembo, A. J. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1101449 · Cited by 19
“[4] Population-based studies indicate that IBS-D may represent approximately one-third of those diagnosed with IBS, though the prevalence may be higher in specialty practices.[5] The pathophysiology of IBS-D is multifactorial, involving a complex interplay among visceral hypersensitivity, genetics, environment, gut mi…”
BackgroundDo Children Just Grow Out of Irritable Bowel Syndrome?
Giannetti, E., Maglione, M., Sciorio, E., Coppola, V., Miele, E., & Staiano, A. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.12.036 · Cited by 18
Síndrome del intestino irritable: nuevos criterios de Roma III
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Self-citationGastrointestinal symptoms - an illness burden that affects daily work in patients with IBS
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“IBS is subtyped according to the predominant symptoms into constipation (IBS-C), diarrhoea (IBS-D) mixed (IBS-M) and unspecified (IBS-U) [6].”
BackgroundIrritable Bowel Syndrome: More Than Abdominal Pain and Bowel Habit Abnormalities
Bond, B., Quinlan, J., Dukes, G. E., Mearin, F., Clouse, R. E., & Alpers, D. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.08.011 · Cited by 17
Self-citationRusu, F., & Dumitrascu, D. L. (2015) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-449 · Cited by 17
“Currently, most studies on the prevalence of IBS are developed on the basis of questionnaires distributed to patients [10-12].”
BackgroundMulti-omics Analysis of Gut Microbiota and Metabolites in Rats With Irritable Bowel Syndrome
Liu, S., Si, C., Yu, Y., Zhao, G., Chen, L., Zhao, Y., Zhang, Z., Li, H., Chen, Y., Min, L., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00178 · Cited by 15
Ríos, C. C. D. L., Falcón, B. S., Argüelles‐Arias, F., Pérez, E., Teruel, C., Geijo, F., & Rey, E. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211020570 · Cited by 15
Novel Therapies in IBS-D Treatment
Nee, J. W., Zakari, M., & Lembo, A. J. (2015) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-015-0068-5 · Cited by 15
Is irritable bowel syndrome associated with chronic hepatitis C?
Fouad, Y. M., Makhlouf, M. M., Khalaf, H., Mostafa, Z., Abdel-Raheem, E. M., & Meneasi, W. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06311.x · Cited by 15
Serotonin transporter gene polymorphisms in irritable bowel syndrome
Geeraerts, B., Oudenhove, L. V., & Tack, J. F. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00854.x · Cited by 15
Sámano, R., Esparza-Juárez, F., Chico‐Barba, G., González-Medina, E., Sánchez-Jiménez, B., & Hernández‐Trejo, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710569 · Cited by 14
Lee, M. J. (2014) · International Journal of Gastroenterology Disorders & Therapy · doi:10.15344/2393-8498/2014/108 · Cited by 13
Penny, K. I., Smith, G. D., Ramsay, D., Steinke, D. T., Kinnear, M., & Penman, I. D. (2008) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2008.04.004 · Cited by 13
“Division into subgroups is widely used in research studies, but its usefulness in clinical practice is unclear and the relative proportion of patients in each subgroup varies across reported series (Guilera et al., 2005).”
BackgroundGuía de práctica clínica sobre el síndrome del intestino irritable
Tort, S., Balboa, A., Marzo‐Castillejo, M., Muñoz, R. C., Mínguez, M., Valdepérez, J., Alonso‐Coello, P., Mascort, J. J., Ferrándiz, J., Bonfill, X., et al. (2006) · Gastroenterología y Hepatología · doi:10.1157/13092567 · Cited by 15
Self-citationClavé, P. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01808.x · Cited by 12
Quénéhervé, L., Drui, D., Blin, J., Péré, M., Coron, E., Barbara, G., Barbaro, M. R., Cariou, B., Neunlist, M., Masson, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-87158-2 · Cited by 11
He, Y., Xu, R., Wang, W., Zhang, J., & Hu, X. (2020) · Medicine · doi:10.1097/md.0000000000021502 · Cited by 11
Xia, X., Xie, Y., Chen, Q., Ding, D., Wang, Z., Xu, Y., Wang, Y., Wang, X., & Ding, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1053103 · Cited by 11
Longstreth, G. F., & Tieu, R. S. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3892-5 · Cited by 11
“The chronic symptoms of IBS tend to occur intermittently for periods of about 2–5 days [25].”
BackgroundStaller, K. D., Goodoory, V. C., Khasawneh, M., Black, C. J., & Ford, A. C. (2026) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(26)00118-4 · Cited by 11
Epidemiology of Irritable Bowel Syndrome in a Large Academic Safety-Net Hospital
Cheng, K., Lee, C., Garniene, R., Cabral, H., & Weber, H. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051314 · Cited by 13
“Although a systematic review in 2005 reported an even distribution of IBS-C, IBS-D, and IBS-M subtypes among IBS patients in the US, there has not yet been a comprehensive study describing the distribution of IBS subtypes across different racial groups [26].”
BackgroundSong, Z., Kwon, T., Lee, J., Won, D. D., Lee, B. J., Choi, H. S., Liao, J. C., Park, W. G., Sonu, I. S., Rogalla, S., et al. (2025) · Advanced Science · doi:10.1002/advs.202503247 · Cited by 11
Irritable bowel syndrome: focus on otilonium bromide
Boeckxstaens, G. E., Clavé, P., Corazziari, E. S., & Tack, J. F. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.869477 · Cited by 10
Développer un médicament dans le syndrome de l’intestin irritable : une mission impossible ?
Duracinský, M., & Chassany, O. (2009) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(09)71522-2 · Cited by 10
New Criteria for Irritable Bowel Syndrome Based on Prospective Symptom Evaluation
Walter, S. A., Ragnarsson, G., & Bodemar, G. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00305_5.x · Cited by 10
Patel, N., & Shackelford, K. (2021) · StatPearls · Cited by 9
Aguilera‐Lizarraga, J., Florens, M. V., Hussein, H., & Boeckxstaens, G. E. (2021) · Acta Clinica Belgica · doi:10.1080/17843286.2021.1996069 · Cited by 9
“with normal bowel habits alternating with either diarrhea and/or constipation with insufficient abnormality of stool consistency, referred to as unclassified (IBS-U, 24–60%) [15,16].”
BackgroundDiet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones
El‐Salhy, M., Gundersen, D., Hatlebakk, J. G., & Hausken, T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407869-7.00001-5 · Cited by 9
Passos, M. D. C. F., Alvariz, R. C., ANDRÉ, E. A., Barbuti, R. C., Fillmann, H. S., MURAD-REGADAS, S. M., Filho, J. R., Perrotti, M., & GUEDES, L. S. (2022) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202200001-23 · Cited by 10
Is national socioeconomic status related to prevalence of irritable bowel syndrome?
Zhu, J., Yan, T., Yu, C., Wan, X., Wang, Y., & Li, Y. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12609 · Cited by 8
Epidemiology of Irritable Bowel Syndrome; A Systematic Review of Literature
Alosaimi, M., Alı̀, A., & Razzak, H. A. (2016) · Journal of health informatics in developing countries · Cited by 7
Pan, Z.-G., Xiao, C., & Su, D. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i20.6345 · Cited by 8
Metadata
- Authors
- Guilera, M., Balboa, A., & Mearin, F.
- Affiliations
- Hospital Quirón Teknon (ES)
- Corresponding author
- Guilera, Magda
- Venue
- The American Journal of Gastroenterology
- Published
- 2005-05
- Volume
- 100
- Issue
- 5
- Pages
- 1174-1184
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2021290527
- Cited by
- 131
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 15 · 2013: 5 · 2012: 7
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, irritable bowel syndrome with constipation, diarrhea-predominant irritable bowel syndrome, clinical course, diagnostic criteria, Rome criteria, Manning criteria, symptom clustering
- MeSH terms
- Constipation, Defecation, Diarrhea, Follow-Up Studies, Humans, Intestines, Prospective Studies, Time Factors, Abdominal Pain, Irritable Bowel Syndrome
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