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Cited by 511

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The role of nitric oxide in inflammatory reactions: Nitric oxide: control of immune response

Open access
Tripathi, Parul, Tripathi, Prashant, Kashyap, Luv, Singh, Vinod·2007·FEMS Immunology & Medical Microbiology

Abstract

Nitric oxide (NO) was initially described as a physiological mediator of endothelial cell relaxation, an important role in hypotension. NO is an intercellular messenger that has been recognized as one of the most versatile players in the immune system. Cells of the innate immune system--macrophages, neutrophils and natural killer cells--use pattern recognition receptors to recognize the molecular patterns associated with pathogens. Activated macrophages then inhibit pathogen replication by releasing a variety of effector molecules, including NO. In addition to macrophages, a large number of other immune-system cells produce and respond to NO. Thus, NO is important as a toxic defense molecule against infectious organisms. It also regulates the functional activity, growth and death of many immune and inflammatory cell types including macrophages, T lymphocytes, antigen-presenting cells, mast cells, neutrophils and natural killer cells. However, the role of NO in nonspecific and specific immunity in vivo and in immunologically mediated diseases and inflammation is poorly understood. This Minireview will discuss the role of NO in immune response and inflammation, and its mechanisms of action in these processes.

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Metadata

Authors
Tripathi, P., Tripathi, P., Kashyap, L., & Singh, V.
Venue
FEMS Immunology & Medical Microbiology
Published
2007-09-28
Volume
51
Issue
3
Pages
443-452
ISSN
0928-8244 (ISSN-L)
OpenAlex
W1611522350
Cited by
511
References
7
FWCI
8.11
Type
journal article
Language
en
Status
Retracted
Open access
bronze

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CoChat. (2026). Citation check: The role of nitric oxide in inflammatory reactions: Nitric oxide: control of immune response. https://app.cochat.ai/papers/10.1111/j.1574-695x.2007.00329.x
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Tripathi, P., Tripathi, P., Kashyap, L., & Singh, V. (2007). The role of nitric oxide in inflammatory reactions: Nitric oxide: control of immune response. FEMS Immunology & Medical Microbiology. https://doi.org/10.1111/j.1574-695x.2007.00329.x

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