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Cited by 310Bacterial Genetics and BiotechnologyProbiotics and Fermented FoodsEnzyme Production and Characterization

The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.

The physiology and biochemistry of the proteolytic system in lactic acid bacteria

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Pritchard, Graham G., Coolbear, Tim·1993·FEMS Microbiology Reviews
DOI 10.1111/j.1574-6976.1993.tb00018.x
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Abstract

The inability of lactic acid bacteria to synthesize many of the amino acids required for protein synthesis necessitates the active functioning of a proteolytic system in those environments where protein constitutes the main nitrogen source. Biochemical and genetic analysis of the pathway by which exogenous proteins supply essential amino acids for growth has been one of the most actively investigated aspects of the metabolism of lactic acid bacteria especially in those species which are of importance in the dairy industry, such as the lactococci. Much information has now been accumulated on individual components of the proteolytic pathway in lactococci, namely, the cell envelope proteinase(s), a range of peptidases and the amino acid and peptide transport systems of the cell membrane. Possible models of the proteolytic system in lactococci can be proposed but there are still many unresolved questions concerning the operation of the pathway in vivo. This review will examine current knowledge and outstanding problems regarding the proteolytic system in lactococci and also the extent to which the lactococcal system provides a model for understanding proteolysis in other groups of lactic acid bacteria.

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Citations

Cites

Research works printed but not linked: 16

  1. Law, 1987, General Aspects, 365
  2. Smid, 1991, Ph.D. thesis
  3. Mills, 1978, Release of cell wall-associated proteinase(s) from lactic streptococci, New Zealand J. Dairy Set. Technol., 13, 209
  4. Exterkate, 1976, Comparison of strains of Streptococcus cremoris for proteolytic activities associated with the cell wall, Neth. Milk Dairy J., 30, 95
  5. Baankreis, 1992, Ph.D. thesis
  6. Tan, 1992, Ph.D. thesis
  7. Morihara, 1974, Comparative specificity of microbial proteases, Adv. Enzymol., 41, 179
  8. Driessen, 1987, Proc. Natl. Acad. Sci. USA, 84, 6093
  9. Broome, 1991, The use of proteinase negative starter and lactohacilli in Cheddar cheese manufacture, Aust. J. Dairy Technol., 6
  10. Moon, 1988, A study on the proteolytic action of extracellular protease of Lactobacillus bulgaricus CH-18. I. The isolation and purification of extracellular protease of Lactobacillus bulgaricus CH-18, Korean J. Anim. Sci., 30, 492
  11. Moon, 1988, A study on the proteolytic action of extracellular protease of Lactobacillus bulgaricus CH-18. II. Proteolytic action of extracellular protease of, Korean J. Anim. Sci., 30, 498
  12. Moon, 1989, Study on the proteolytic action of intracellular protease of Lactobacillus bulgaricus CH-18. II. The proteolytic action of intracellular protease of Lactobacillus bulgaricus CH-18, Korean J. Dairy Sci., 11, 42
  13. Moon, 1991, Effect of metal ions on the proteolytic activity of intracellular protease of Lactobacillus bulgaricus CH-18, Korean J. Anim. Sci., 33, 607
  14. Hegazi, 1991, Proteolytic activity of a crude extracellular proteinase of Enterococcus faecalis subsp. liquefaciens, Arch. Lebensmittelhyg., 42, 16
  15. El-Soda, 1992, The peptide hydrolase system of Bifidobacterium species, Milchwissenschaft, 47, 87
  16. El-Soda, 1991, Aminopeptidase and dipeptidyl aminopeptidase activities of several cheese related microorganisms, Milchwissenschaft, 46, 223

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Metadata

Authors
Pritchard, G. G., & Coolbear, T.
Affiliations
Massey University (NZ)
Venue
FEMS Microbiology Reviews
Publisher
Oxford University Press (OUP)
Published
1993-09
Volume
12
Issue
1-3
Pages
179-206
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
DOI
10.1111/j.1574-6976.1993.tb00018.x
OpenAlex
W2133534556
Cited by
310
References
165
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 15
FWCI
14.52
Type
journal article
Language
en
Open access
Locations
  • FEMS Microbiology Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
Keywords
proteolytic system, lactic acid bacteria, lactococci, protein degradation, cell envelope proteinase, proteolytic enzymes, amino acid transport, peptide transport, nitrogen source, dairy industry
MeSH terms
Amino Acid Sequence, Animals, Caseins, Cattle, Cell Membrane, Gram-Positive Bacteria, Lactates, Molecular Sequence Data, Peptide Hydrolases, Lactococcus, Lactic Acid

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