Cited by 1,059Bacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyEscherichia coli research studies

The DOI matches its Crossref record; 177 of the 177 references it cites were found in a registry or an index.

Indole as an intercellular signal in microbial communities

Open access

Lee, Jin-Hyung, Lee, Jintae·2010·FEMS Microbiology Reviews

DOI 10.1111/j.1574-6976.2009.00204.x

Open this paper in CoChat — free account Open PDF

Abstract

Bacteria can utilize signal molecules to coordinate their behavior to survive in dynamic multispecies communities. Indole is widespread in the natural environment, as a variety of both Gram-positive and Gram-negative bacteria (to date, 85 species) produce large quantities of indole. Although it has been known for over 100 years that many bacteria produce indole, the real biological roles of this molecule are only now beginning to be unveiled. As an intercellular signal molecule, indole controls diverse aspects of bacterial physiology, such as spore formation, plasmid stability, drug resistance, biofilm formation, and virulence in indole-producing bacteria. In contrast, many non-indole-producing bacteria, plants and animals produce diverse oxygenases which may interfere with indole signaling. It appears indole plays an important role in bacterial physiology, ecological balance, and possibly human health. Here we discuss our current knowledge and perspectives on indole signaling.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1574-6976.2009.00204.x

Cites

177 of 177 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

QUORUM SENSING: Cell-to-Cell Communication in Bacteria
Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,989
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators
Fuqua, W. C., Winans, S. C., & Greenberg, E. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.269-275.1994 · Cited by 2,941
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
Hentzer, M., Wu, H., Andersen, J. B., Riedel, K., Rasmussen, T. B., Bagge, N., Kumar, N., Schembri, M. A., Song, Z., Kristoffersen, P., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg366 · Cited by 1,440
Microbes in Gastrointestinal Health and Disease
Neish, A. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.080 · Cited by 1,423
Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis
Schuster, M., Lostroh, P., Ogi, T., & Greenberg, E. P. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2066-2079.2003 · Cited by 1,127
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound
Hentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, J. B., Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Høiby, N., et al. (2002) · Microbiology · doi:10.1099/00221287-148-1-87 · Cited by 1,053
How bacteria talk to each other: regulation of gene expression by quorum sensing
Bassler, B. L. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00025-9 · Cited by 1,046
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
Higdon, J. V., Delage, B., WILLIAMS, D., & Dashwood, R. H. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.009 · Cited by 1,038

Show all 174 references

Research works printed but not linked: 1

Pittard AJ (1996) Biosynthesis of the aromatic amino acids: the tryptophan pathway. Escherichia coli and Salmonella: Cellular and Molecular Biology ( Neidhardt FC , ed), pp. 458–484. ASM Press, Washington, DC.

Sorted by citations

Items 701–800 of 1,000

The Gut Connection: A Narrative Review on the In-depth Analysis of Gut Microbiota and Metabolites in Depression
Sultana, A., Hussain, M. S., Maqbool, M., Agrawal, M., Bisht, A. S., Khurana, N., Singh, G., & Kumar, R. (2025) · Current Clinical Pharmacology · doi:10.2174/0127724328332998250118182255 · Cited by 7
Indole derivatives display antimicrobial and antibiofilm effects against extensively drug-resistant Acinetobacter baumannii
Li, J., Xie, L., Lin, F., & Ling, B. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.03388-24 · Cited by 7
Antifungal action of β-pinene derivatives containing quaternary ammonium scaffold against Rhizoctonia solani with damaging cell membranes and affecting energy metabolism
Zhang, L., Huang, Y., Xiao, Z. Y., Feng, X., Zhang, J., Chen, S., He, H., Liao, S., Wang, Z., & Si, H. (2025) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2025.106586 · Cited by 7
The Skin Microbiome, Microbial Metabolites and the Epidermal Response to Ultraviolet Radiation—Towards Next Generation Suncare
Mercer, S. D., McBain, A. J., & O’Neill, C. A. (2025) · Experimental Dermatology · doi:10.1111/exd.70142 · Cited by 7
Permethrin Stimulates Fat Accumulation via Regulating Gut Microbiota and Its Metabolites in Mice
Jie, L., Qi, Z., Wang, G., Wu, C., Mumby, W., Huang, Y., Peng, Y., & Sun, Q. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05013 · Cited by 7
Profiling of Volatile Metabolites of Escherichia coli Using Gas Chromatography–Mass Spectrometry
Żuchowska, K., Tracewska, A., Depka, D., Bogiel, T., Włodarski, R., Bojko, B., & Filipiak, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178191 · Cited by 7
Antifungal Activities of Multi-Halogenated Indoles Against Drug-Resistant Candida Species
Jeong, H., Boya, B. R., Kim, Y., Lee, J., & Lee, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210836 · Cited by 8
Trichloroisocyanuric acid and NaNO2 mediated nitration of indoles under acid-free and Vilsmeier–Haack conditions: synthesis and kinetic study
Duguta, G., Bhooshan, M., Saiprakash, P. K., & Rajanna, K. C. (2019) · SN Applied Sciences · doi:10.1007/s42452-019-1023-1 · Cited by 7
Silver Lactoferrin as Antimicrobials: Mechanisms of Action and Resistance Assessed by Bacterial Molecular Profiles
Monedeiro-Milanowski, M., Monedeiro, F., & Pomastowski, P. (2023) · ACS Omega · doi:10.1021/acsomega.3c07562 · Cited by 7
Functional properties of Ganoderma lucidum supplementation in canine nutrition
Kayser, E., Castaneda, P. L., Soto‐Díaz, K., Steelman, A. J., Murphy, A., Spindola, M., He, F., & de Godoy, M. R. C. (2024) · Journal of Animal Science · doi:10.1093/jas/skae051 · Cited by 7
Lumichrome metabolism mediates semiconductor-driven solar energy conversion in non-phototrophic Shewanella
Ding, R., Wu, Y., Wang, Z., Tian, X., Chen, L., & Zhao, F. (2024) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2024.102017 · Cited by 7
Relationship Between the Salivary Microbiome and Oral Malodor Metabolites in Older Thai Individuals with Periodontitis and the Cytotoxic Effects of Malodor Compounds on Human Oral Squamous Carcinoma (HSC-4) Cells
Srila, W., Sripilai, K., Binlateh, T., Thammanichanon, P., Tiskratok, W., Noisa, P., & Jitprasertwong, P. (2025) · Dentistry Journal · doi:10.3390/dj13010036 · Cited by 7
A multi-omics study of the association between insomnia with objective short sleep duration phenotype and high blood pressure
Dai, Y., Vgontzas, A. N., Chen, L., Zheng, D., Chen, B., Wu, J., Shao, R., & Li, Y. (2025) · SLEEP · doi:10.1093/sleep/zsaf030 · Cited by 8
Kynurenic Acid, a Small Foodborne Molecule with the Potential to Affect Human Health
Li, Y., Zhang, L., Wu, D., Zhang, Z., Zhou, Y., & Li, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12355 · Cited by 7
Differentiation of Brachyspira spp. isolated from laying hens using PCR-based methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Harms, M., Schmidt, V., Heydel, T., Hauptmann, J., Ahlers, C., Bergmann, R., & Baums, C. G. (2018) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638718772319 · Cited by 7
Tryptophan Metabolism and the Microbiome-Gut-Brain Axis
Clarke, G. A., Villalobos-Manríquez, F., & Marin, D. C. (2021) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.13 · Cited by 7
Regional Diets Targeting Gut Microbial Dynamics to Support Prolonged Healthspan
Low, D. Y., Hejndorf, S., Tharmabalan, R. T., Poppema, S., & Pettersson, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.659465 · Cited by 7
Bacterial Volatiles in Promotion of Plant Under Biotic Stress
Jain, S., Varma, A. K., Tuteja, N. K., & Choudhary, D. K. (2017) · Springer eBooks · doi:10.1007/978-981-10-5553-9_16 · Cited by 7
Tryptamine‐Derived Schiff Bases: Potent Antimicrobial Agents and Evaluation of Cytotoxicity, ADME and DNA Binding Properties
Marjanović, J. S., Petrović, N., Kosanić, M., Košarić, J. V., Mirić, A. N., Milivojević, N. N., Kostić, M. D., & Divac, V. M. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401699 · Cited by 6
Intestinal short-chain fatty acids spatially regulate the antibiotic tolerance and virulence of avian pathogenic Escherichia coli
Ling, C., Ren, L., Song, Y., Cao, Q., Ye, H., Dong, Z., Zhang, C., Feng, D., Zuo, J., & Wang, W. (2025) · Poultry Science · doi:10.1016/j.psj.2025.104917 · Cited by 6
Cervical artificial insemination with frozen-thawed semen in sheep: the secret is in the cervix of Norwegian ewe breeds
Abril-Parreño, L., & Fair, S. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf084 · Cited by 7
Gut Microbial Tryptophan Metabolism Is Involved in Post‐Cardiac Arrest Brain Injury via Pyroptosis Modulation
Wu, C., Diao, M., Yu, S., Xi, S., Zheng, Z., Cao, Y., Wang, S., Zhu, Y. J., Zhang, M., & Hu, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70381 · Cited by 7
Maternal Tryptophan Supplementation Enhances Sow Reproductive Performance by Influencing Hormones, Tryptophan Metabolism, and Gut Microbiome
Zhu, Z., Xue, B., Li, H., Wang, X., Li, Y., Huang, J., Cai, S., Zeng, X., Chen, M., Zhang, S., et al. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.04.031 · Cited by 7
State of omics-based microbial diagnostics of CRC
Prusa, J., Gorelik, M. G., Blake, K. S., & Dantas, G. A. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2526132 · Cited by 6
Role of gut microbiota metabolites in maintaining intestinal health and preventing weaning-associated diarrhea in piglets
Wu, W., Wang, S., Xue, C., & Dong, N. (2026) · Animal nutrition · doi:10.1016/j.aninu.2025.10.004 · Cited by 6
Integrating host-microbiota metabolic networks: how aromatic amino acids shape immune homeostasis and affect disease progression
Zhang, Y., Zhao, X., Wang, H., Zhang, Z., Shi, H., Wang, Y., & Zhu, S. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01435-6 · Cited by 8
Abiotic/Biotic Stress and Substrate Dictated Metabolic Diversity of Azotobacter Chroococcum: Synthesis of Alginate, Antifungal n-Alkanes, Lactones, and Indoles
Rasulov, B. A., & Pattaeva, M. A. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01212-x · Cited by 6
Patterns of Fitness and Gene Expression Epistasis Generated by Beneficial Mutations in the rho and rpoB Genes of Escherichia coli during High-Temperature Adaptation
González‐González, A., Batarseh, T. N., Rodríguez‐Verdugo, A., & Gaut, B. S. (2024) · Molecular Biology and Evolution · doi:10.1093/molbev/msae187 · Cited by 6
Microbiota and beneficial metabolites in colorectal cancer
González, A., Fullaondo, A., Odriozola, I., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.08.002 · Cited by 6
From Dysbiosis to Cardiovascular Disease: The Impact of Gut Microbiota on Atherosclerosis and Emerging Therapies
Lima, T., Costa, V., Nunes, C., Silva, G., & Domingues, S. (2025) · Applied Sciences · doi:10.3390/app15137084 · Cited by 7
Symmetric trichloro triazine adducts with N, N’-dimethyl formamide and N, N’-dimethyl acetamide as green Vilsmeier –Haack reagents for effective formylation and acylation of Indoles
Duguta, G., Muddam, B., Kamatala, C. R., & Chityala, Y. (2020) · Chemical Data Collections · doi:10.1016/j.cdc.2020.100382 · Cited by 6
How Plants Might Recognize Rhizospheric Bacterial Volatiles
Bailly, A. (2020) · Springer eBooks · doi:10.1007/978-981-15-7293-7_5 · Cited by 6
Longitudinal Metabolomic Analysis Reveals Gut Microbial-Derived Metabolites Related to Formula Feeding and Milk Sensitization Development in Infancy
Tang, C.-M., Lin, G., Chiang, M., Yeh, K., Huang, J., Su, K., Tsai, M., Hua, M., Liao, S., Lai, S., et al. (2022) · Metabolites · doi:10.3390/metabo12020127 · Cited by 6
Production of indole and hydrogen sulfide by the oxygen-tolerant mutant strain Clostridium sp. Aeroto-AUH-JLC108 contributes to form a hypoxic microenvironment
Liu, Y., Dou, S., Li, M., & Wang, X. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03113-3 · Cited by 6
Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro
Roslund, K., Uosukainen, M., Järvik, K., Hartonen, K. M., Lehto, M. J., Pussinen, P. J., Groop, P., & Metsälä, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-26497-0 · Cited by 6
Antibacterial and antibiofilm activity of halogenated phenylboronic acids against Vibrio parahaemolyticus and Vibrio harveyi
Sathiyamoorthi, E., Lee, J., & Lee, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1340910 · Cited by 6
Effects of indole and indoxyl on the intracellular oxidation level and phagocytic activity of differentiated HL-60 human macrophage cells
Tsutsumi, S., Tokunaga, Y., Shimizu, S., Kinoshita, H., Ono, M., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M., & Yasuda, S. (2020) · The Journal of Toxicological Sciences · doi:10.2131/jts.45.569 · Cited by 6
Can herbivore-induced volatiles protect plants by increasing the herbivores’ susceptibility to natural pathogens?Preprint
Gasmi, L., Martínez‐Solís, M., Frattini, A., Ye, M., Collado, M. C., Turlings, T. C. J., Erb, M., & Herrero, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/317560 · Cited by 6
Tryptophan Metabolites And Their Predicted Microbial Sources In Fecal Samples Of Healthy IndividualsPreprint
Chappell, C. L., Hoffman, K. L., Lorenzi, P. L., Tan, L., Petrosino, J. F., Gibbs, R. A., Muzny, D. M., Doddapaneni, H., Ross, M. C., Menon, V. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.20.572622 · Cited by 6
Dietary Protein and Colonic Microbiota
Boudry, G., Le Huërou-Luron, I., & Michel, C. (2016) · The Molecular Nutrition of Amino Acids and Proteins · doi:10.1016/b978-0-12-802167-5.00015-3 · Cited by 5
Deficiency of intestinal alkaline phosphatase affects behavior and microglia activity in mice
Dai, J., Yang, J., Han, S., Li, N., Wang, S., Xia, S., Kim, H.-H., Jun, Y., Lee, S., Kitagawa, Y., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.02.006 · Cited by 5
Indole metabolism and its role in diabetic macrovascular and microvascular complications
Hu, W., Garrison, C., Prasad, R., Boulton, M., & Grant, M. B. (2025) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2025.100532 · Cited by 4
Integrated faecal microbiota and blood metabolic changes following different dietary zinc oxide levels in weaned piglets
Soumeh, E. A., Nielsen, T. S., Hedemann, M. S., & Curtasu, M. V. (2025) · Scientific Reports · doi:10.1038/s41598-025-03103-7 · Cited by 6
Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome
He, J., Tang, Q., Liu, Y., Wang, L., & Chai, Y. (2025) · Antioxidants · doi:10.3390/antiox14060721 · Cited by 6
Longitudinal analysis of fecal tryptophan metabolites and microbiome composition in very preterm infants: impact of birth mode and feeding type
Wieser, N. V., van Schajik, Y., Ghiboub, M., Frerichs, N. M., Weiss, R., Davids, M., de Meij, T. G. J., Niemarkt, H. J., Lefèvre, A., Emond, P., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2541031 · Cited by 5
pH regulates gut bacterial tryptophan metabolism
Brinck, J. E., Laursen, M. F., Pedersen, M., Carey, M. R., Procházková, N., Jørgensen, M. S., Mortensen, M. S., Lauritzen, L., Pedersen, O. B., Roager, H. M., et al. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-00935-7 · Cited by 8
Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown
Zhang, K., Luo, Z., Chen, Y., Li, Y., Wang, L., Liu, Y., Yang, R., Li, Q., Zhao, J., Qi, B., et al. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003685 · Cited by 5
The Gut Gambit: A Review of How Microbial Imbalance Fuels Metabolic Mayhem
Venkata, L. N. S., Mishra, A. K., Mohanta, Y. K., Rustagi, S., Bahuguna, A., Tomar, A., Baek, K.-H., & Mishra, B. (2026) · Nutrients · doi:10.3390/nu18060888 · Cited by 8
Biological studies reveal the role of trpA gene in biofilm formation, motility, hemolysis and virulence in Vibrio anguillarum
Che, J., Liu, B., Fang, Q., Nissa, M. U., Luo, T., Wang, L., & Bao, B. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107331 · Cited by 5
How to sample Listeria monocytogenes culture for volatolomics by headspace extraction-gas chromatography-Q Exactive-Orbitrap mass spectrometry?
Fakih, A., Ratel, J., Tsoureki, D., Mercier, F., Kondjoyan, N., Caccia, N., Botta, C., Rantsiou, K., & Engel, E. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116043 · Cited by 5
The Response of Regeneration Ability of Myriophyllum spicatum Apical Fragments to Decaying Cladophora oligoclona
Zhang, L., Huang, S., Peng, X., Liu, B., Zhang, Y., Zhou, Q., & Wu, Z. (2019) · Water · doi:10.3390/w11051014 · Cited by 5
Comparative Transcriptomics of Shiga Toxin-Producing and Commensal Escherichia coli and Cytokine Responses in Colonic Epithelial Cell Culture Infections
Harrison, L. M., Lacher, D. W., Mammel, M. K., & Leonard, S. R. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.575630 · Cited by 5
Disruption of biofilm formation by fractions from book gills and carapace of horseshoe crab Tachypleus gigas
Ahmad, M., Ismail, N., & Eldeen, I. M. S. (2020) · Marine Biology Research · doi:10.1080/17451000.2020.1840592 · Cited by 5
Seasonal atmospheric characteristics in a swine finishing barn equipped with a continuous pit recirculation system using aerobically treated manure
Choi, Y., Ha, D., Lee, S.-R., & Kim, D. (2022) · Animal Bioscience · doi:10.5713/ab.22.0111 · Cited by 5
Natural Products: Strategic Tools for Modulation of Biofilm Formation
Řezanka, T., Čejková, A., & Masák, J. (2012) · Studies in natural products chemistry · doi:10.1016/b978-0-444-59530-0.00010-1 · Cited by 6
Rh(III)‐Catalyzed Phosphine Oxide Migration Reactions: Selective Synthesis of 3‐Phosphinoylindoles
Wang, C.-H., & Yang, S. (2018) · Chemistry - An Asian Journal · doi:10.1002/asia.201800516 · Cited by 5
Complete Genome of Vibrio neocaledonicus CGJ02-2, An active Compounds Producing Bacterium Isolated from South China Sea
Tan, L., Gómez-Betancur, I., Guo, S., Ge, Y., Zhao, J., Chen, C., & Wang, N. (2020) · Current Microbiology · doi:10.1007/s00284-020-02047-7 · Cited by 5
Defensive Role of Plant-Derived Secondary Metabolites: Indole and Its’ Derivatives
Mulat, M., Anand, R., & Khan, F. (2020) · Current Biotechnology · doi:10.2174/2211550109999200728153839 · Cited by 5
Identification of an indole biodegradation gene cluster from Providencia rettgeri and its contribution in selectively biosynthesizing Tyrian purple
Li, F., Deng, H., Zhong, B., Ruan, B., Zhao, X., & Luo, X. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1109929 · Cited by 5
Alkaloids and Polyketides from Mangrove Associated Fungi viz. Aspergillus sp., Penicillium sp. and Fusarium sp.: A Review
Awashank, A., Tilvi, S., & Fulke, A. B. (2023) · Mini-Reviews in Organic Chemistry · doi:10.2174/1570193x20666230718115115 · Cited by 4
Virulence regulation of tryptophanase gene tnaA on mesophilic Aeromonas salmonicida SRW-OG1
Xu, G., Xu, X., Zhang, Z., Chen, J., Chen, Y., Yi, X., & Zhu, Z. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741950 · Cited by 4
Functional foods acting on gut microbiota-related wellness: The multi-unit in vitro colon model to assess gut ecological and functional modulation
Marangelo, C., Marsiglia, R., Nissen, L., Scanu, M., Toto, F., Siroli, L., Gottardi, D., Braschi, G., CHIERICO, F. D., Bordoni, A., et al. (2025) · Food Research International · doi:10.1016/j.foodres.2024.115577 · Cited by 5
Pseudoalteromonas ardens sp. nov., Pseudoalteromonas obscura sp. nov. and Pseudoalteromonas umbrosa sp. nov. isolated from the coral Montipora capitata on a reef in Kāneʻohe Bay, Oʻahu, Hawaiʻi
Thomas, E. M., Smith, E. M., Papke, E., Shlafstein, M. D., Grant-Beurmann, S., Coelho, L. C., Trott, A. C., Häse, C. C., Oline, D. K., Videau, P., et al. (2025) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.006681 · Cited by 4
The two-component system CpxAR controls biofilm formation by directly regulating the T3SS needle tip protein EseB in Edwardsiella piscicida
Zhang, S. Y., Sun, S. S., Liu, L. Y., Sivaranjan, T., Nie, P., & Xie, H. X. (2025) · Applied and Environmental Microbiology · doi:10.1128/aem.02264-24 · Cited by 4
Integrated analysis of electrical stimulation effects on Pseudomonas aeruginosa PAO1 inoculated denitrifying community: targeted and untargeted metabolomic analysis of phenazine biosynthesis and quorum sensing
Li, W., Liu, Y., Deng, J., Gui, S., & Nie, H. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1621417 · Cited by 4
Storm-driven overflow disinfection highlights toxicity risk of chlorophenylacetonitriles: Unveiling indole in sewer sediments as a key precursor
Dong, T., Ye, C., Yang, W., Zhang, Y., Wang, F., Xu, Z., Kapelan, Z. S., & Chu, W. (2025) · Water Research · doi:10.1016/j.watres.2025.124700 · Cited by 4
Hydroxytyrosol Gut Microbial Metabolites Promote Tight Junction Protein Expression via the AhR-Nrf2 Pathway
Song, Y., Zhang, J., Liang, S., Cao, Y., & Wang, Q. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.10.014 · Cited by 4
Impact of indole and its derivatives in the environment: Metabolic mechanisms, functional properties, and ecological effects
Wang, Y., Hua, Y., Chen, S., Wang, H., Li, Y., Chen, C., Zhu, Y., Zhang, Y., & Dai, X. (2025) · Journal of Environmental Management · doi:10.1016/j.jenvman.2025.128375 · Cited by 4
From alpha diversity to zeitgebers: Functional implications and potential mechanisms linking the gut microbiome to sleep and circadian disruption (Part II)
Maki, K. A., Barb, J. J., Xu, S., Papneja, S., Alkhatib, J., Butera, G., & Wallen, G. R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106609 · Cited by 5
Gut microbiota-derived indole metabolites in depression: mechanisms and therapeutic potential
Wang, X., Liu, R., Liu, J., Lin, Y., & Zhou, M. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178720 · Cited by 4
Elucidating the biocontrol potential of Trichoderma yunnanense TM10 for managing sheath blight disease ( Rhizoctonia solani Kühn) in rice ( Oryza sativa L.)
Prismantoro, D., Awal, M. A., Jefferson, T. A., Oktavia, D., Permadi, N., Mispan, M. S., Rossiana, N., Miranti, M., & Doni, F. (2026) · Journal of Plant Interactions · doi:10.1080/17429145.2026.2651842 · Cited by 4
Gut microbiota–derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health
Wen, Y. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1807477 · Cited by 5
Cardiovascular–kidney–metabolic syndrome through the lens of gut‑derived uremic toxins
Xu, C., Snelson, M., & Marques, F. Z. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2685906 · Cited by 4
Serum indoxyl sulphate and its relation to albumin and α1-acid glycoprotein as a potential biomarkers of maternal intestinal metabolism during pregnancy and postpartum
Lisowska‐Myjak, B., Zborowska, H., Jaźwiec, R., Karlińska, M., & Skarżyńska, E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259501 · Cited by 4
Gut microbiota and metabolomic profile changes play critical roles in tacrolimus-induced diabetes in rats
Jiang, Z., Qian, M., Zhen, Z., Yang, X., Xu, C., Zuo, L., Jiang, J., Zhang, W., & Hu, N. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1436477 · Cited by 4
Synthesis, Antimicrobial Activities, and Model of Action of Indolyl Derivatives Containing Amino-Guanidinium Moieties
Li, Y., Geng, X., Tao, Q., Hao, R., Yang, Y., Liu, X., & Li, J. (2025) · Molecules · doi:10.3390/molecules30040887 · Cited by 4
Highly Efficient Rhodium‐Catalyzed Oxindole‐Directed Oxidative Heck‐Type Reaction of N‐Aryloxindoles with Alkenes
Li, W., Li, C., & Dong, L. (2018) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201800605 · Cited by 4
Multi-wavelength Fluorescence Monitoring of Faecal Contamination in Waters: A Laboratory-based Quantification
Offenbaume, K. L., Bertone, E., Chen, D., Li, Q., Stratton, H. M., & Stewart, R. A. (2024) · Environmental Processes · doi:10.1007/s40710-024-00696-5 · Cited by 4
The impact of indole and mucin on sporulation, biofilm formation, and enterotoxin production in foodborne Clostridium perfringens
Wang, C., Defoirdt, T., & Rajković, A. (2024) · Journal of Applied Microbiology · doi:10.1093/jambio/lxae083 · Cited by 4
Indole–porphyrin hybrids produced by metagenomics
Yang, X., Wakimoto, T., Takeshige, Y., He, R., Egami, Y., Awakawa, T., & Abe, I. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.04.076 · Cited by 4
Anticancer potential of indole derivatives: an update
Misra, S. K., Pathak, D., & Pathak, K. (2021) · Physical Sciences Reviews · doi:10.1515/psr-2021-0028 · Cited by 4
Physiological and omics analysis of maize inbred lines during late grain development
Jin, X., Zhai, H., Wang, P., Zhang, X., Wu, X., Zhang, H., Chen, S., & Huang, Z. (2022) · Genes & Genomics · doi:10.1007/s13258-022-01279-0 · Cited by 4
Nuclear Receptor Pathways Mediating the Development of Boar Taint
Bone, C., & Squires, E. J. (2022) · Metabolites · doi:10.3390/metabo12090785 · Cited by 4
Expression of the two-component regulator StyS/StyR enhanced transcription of the styrene monooxygenase gene styAB and indigo biosynthesis in Escherichia coli
Yin, S., Li, Y., & Hou, J. (2023) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2023.110381 · Cited by 4
In vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut
Jiang, H., Dong, Y., Xue, J., Tang, B., Feng, T., Li, P., & Fang, J. (2024) · mSystems · doi:10.1128/msystems.00836-24 · Cited by 4
Effects of a novel nutritional formula specially developed for chronic kidney disease patients on protein-restricted diets: a randomized controlled trial
Kanazawa, Y., Morita, S., Sonoki, H., & Nakao, T. (2016) · Renal Replacement Therapy · doi:10.1186/s41100-016-0031-5 · Cited by 4
Gut microbiota and depression
Kazemi, A., & Djafarian, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00048-9 · Cited by 4
Serotonin Pathway in Neuroimmune Network
Mondanelli, G., & Volpi, C. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96733 · Cited by 4
Description of Agathobaculum massiliense sp. nov., a new bacterial species prevalent in the human gut and predicted to produce indole and tryptophan based on genomic analysis
Wasfy, R. M., Zoaiter, M., Bilen, M., Alou, M. T., Lo, C. I., Bellali, S., Caputo, A., Alibar, S., Andrieu, C., Raoult, D., et al. (2023) · Antonie van Leeuwenhoek · doi:10.1007/s10482-023-01824-1 · Cited by 4
5-Methylindole kills various bacterial pathogens and potentiates aminoglycoside against methicillin-resistant Staphylococcus aureus
Li, Z., Sun, F., Fu, X., & Chen, Y. (2022) · PeerJ · doi:10.7717/peerj.14010 · Cited by 4
The cytidine repressor participates in the regulatory pathway of indole in Pantoea agglomerans
Jia, M., Yu, X.-M., Jiang, J., Li, Z., & Feng, Y. (2017) · Research in Microbiology · doi:10.1016/j.resmic.2017.04.006 · Cited by 4
Environmental and Biotic Factors Impacting the Activities of Bdellovibrio bacteriovorus
Im, H., Bäcker, L. E., & Mitchell, R. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-45599-6_6 · Cited by 4
Methane emission of humans is explained by dietary habits, host genetics, local formate availability and a uniform archaeomePreprint
Kumpitsch, C., Fischmeister, F. P. S., Mahnert, A., Lackner, S., Wilding, M., Sturm, C., Springer, A., Madl, T., Holasek, S. J., Högenauer, C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.21.423794 · Cited by 5
A HicA toxin-based counter-selection marker for allelic exchange mutations in Fusobacterium nucleatumPreprint
Bibek, G. C., Zhou, P., & Wu, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.20.524997 · Cited by 4
Microbiota-dependent indole production is required for the development of collagen-induced arthritisPreprint
Seymour, B. J., Trent, B. J., Allen, B. E., Berlinberg, A. J., Tangchittsumran, J., Jubair, W. K., Chriswell, M. E., Liu, S., Ornelas, A., Stahly, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.13.561693 · Cited by 4
Transcriptional profiling elucidates biofilm functionality in the dynamic environment of an enhanced biological phosphorus removal reactor
Villard, D., Snipen, L. G., Rudi, K., Branders, S., Saltnes, T., Eikås, S., & Johansen, W. (2024) · Water Science & Technology · doi:10.2166/wst.2024.314 · Cited by 3
Indolyl-3-Acetic Acid for Medical Use (Review)
Arabova, L. I., Chumikina, L. V., Arabov, R. I., & Topunov, A. F. (2024) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683824604670 · Cited by 3
Bacterial Quorum Sensing: A Double‐Edged Sword in Cancer Development
Paniz, M. I., Tina, R. L., Darbeheshti, F., Bahreini, F., & Rezaei, N. (2025) · Advanced Biology · doi:10.1002/adbi.202500023 · Cited by 3
Discovery of an indole-sensing chemoreceptor in Helicobacter pylori
Wang, X., Xu, W., Yao, F., Liu, S., Zhang, Y., Sourjik, V., & Bi, S. (2025) · Current Biology · doi:10.1016/j.cub.2025.09.021 · Cited by 5
Isolation and screening of Bacillus subtilis for highland barley fermentation and the effect of its fermentation broth on lipid metabolism in high-fat diet-fed mice
Zhao, H., Li, H., Tang, X., Cheng, X., Liu, C., Zheng, S., Zhu, H., & Lu, N. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117961 · Cited by 3

Authors: Lee, J.-H., & Lee, J.
Affiliations: Yeungnam University (KR)
Corresponding author: Lee, Jintae
ORCID: Lee, Jin-Hyung
Lee, Jintae
Venue: FEMS Microbiology Reviews
Publisher: Oxford University Press (OUP)
Published: 2010-07
Volume: 34
Issue: 4
Pages: 426-444
ISSN: 0168-6445 (ISSN-L)
1574-6976
DOI: 10.1111/j.1574-6976.2009.00204.x
OpenAlex: W2049821596
Cited by: 1,059
References: 174
Citations by year: 2026: 82 · 2025: 113 · 2024: 94 · 2023: 115 · 2022: 112 · 2021: 99 · 2020: 89 · 2019: 62 · 2018: 61 · 2017: 42 · 2016: 36 · 2015: 44 · 2014: 42 · 2013: 27 · 2012: 17
FWCI: 1.02
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: FEMS Microbiology Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Yeungnam University
Directorate for Education and Human Resources
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: intercellular communication, bacterial quorum sensing, microbial communities, sporulation, plasmid stability, drug resistance, biofilm formation, virulence, Gram-positive bacteria, Gram-negative bacteria
MeSH terms: Bacteria, Indoles, Plasmids, Virulence, Signal Transduction, Gene Expression Regulation, Bacterial, Bacterial Physiological Phenomena, Biofilms, Drug Resistance, Bacterial, Quorum Sensing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Indole as an intercellular signal in microbial communities

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks