Indole as an intercellular signal in microbial communities

QUORUM SENSING: Cell-to-Cell Communication in Bacteria

Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,989

Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators

Fuqua, W. C., Winans, S. C., & Greenberg, E. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.269-275.1994 · Cited by 2,941

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677

Commensal Host-Bacterial Relationships in the Gut

Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

Hentzer, M., Wu, H., Andersen, J. B., Riedel, K., Rasmussen, T. B., Bagge, N., Kumar, N., Schembri, M. A., Song, Z., Kristoffersen, P., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg366 · Cited by 1,440

Microbes in Gastrointestinal Health and Disease

Neish, A. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.080 · Cited by 1,423

Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis

Schuster, M., Lostroh, P., Ogi, T., & Greenberg, E. P. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2066-2079.2003 · Cited by 1,127

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound

Hentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, J. B., Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Høiby, N., et al. (2002) · Microbiology · doi:10.1099/00221287-148-1-87 · Cited by 1,053

How bacteria talk to each other: regulation of gene expression by quorum sensing

Bassler, B. L. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00025-9 · Cited by 1,046

Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis

Higdon, J. V., Delage, B., WILLIAMS, D., & Dashwood, R. H. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.009 · Cited by 1,038

Optimisation of engineered Escherichia coli biofilms for enzymatic biosynthesis of l-halotryptophans

Perni, S., Hackett, L., Goss, R. J. M., Simmons, M. J. H., & Overton, T. W. (2013) · AMB Express · doi:10.1186/2191-0855-3-66 · Cited by 29

Indole-Induced Activities of β-Lactamase and Efflux Pump Confer Ampicillin Resistance in Pseudomonas putida KT2440

Kim, J., Shin, B., Park, C., & Park, W. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00433 · Cited by 29

Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity

Ball, H. C., levari-Shariati, S., Cooper, L. N., & Aliani, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196154 · Cited by 32

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery

West, K., Kanu, C., Maric, T., McDonald, J. A. K., Nicholson, J. K., Li, J. V., Johnson, M. R., Holmes, E. C., & Savvidou, M. D. (2020) · Gut · doi:10.1136/gutjnl-2019-319620 · Cited by 29

The Cell–Cell Communication Signal Indole Controls the Physiology and Interspecies Communication of Acinetobacter baumannii

Cui, B., Chen, X., Guo, Q., Song, S., Wang, M., Liu, J., & Deng, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01027-22 · Cited by 29

Indigo production goes green: a review on opportunities and challenges of fermentative production

Chandel, N., Singh, B. B., Dureja, C., Yang, Y., & Bhatia, S. K. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-023-03871-2 · Cited by 28

Kiwifruit Polysaccharides Alleviate Ulcerative Colitis via Regulating Gut Microbiota-Dependent Tryptophan Metabolism and Promoting Colon Fucosylation

Li, Y., Han, Y., Wang, X., Yang, X., & Ren, D. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06435 · Cited by 28

Inhibitory effect of skatole (3-methylindole) on enterohemorrhagic Escherichia coli O157:H7 ATCC 43894 biofilm formation mediated by elevated endogenous oxidative stress

Choi, S.-H., Kim, Y., Oh, S., Oh, S., Chun, T., & Kim, S. H. (2013) · Letters in Applied Microbiology · doi:10.1111/lam.12212 · Cited by 28

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

Niska-Blakie, J., Gopinathan, L., Low, K. N., Kien, Y. L., Goh, C. M. F., Caldez, M. J., Pfeiffenberger, E., Jones, O. S., Ong, C. B., Kurochkin, I. V., et al. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03359-z · Cited by 28

NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules

Milic, M., Targos, K., Chavez, M. T., Thompson, M. A. M., Jennings, J. J., & Franz, A. K. (2021) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c02876 · Cited by 28

A comprehensive review for gut microbes: technologies, interventions, metabolites and diseases

Qi, C., Wang, P., Fu, T., Lu, M., Cai, Y., Chen, X., & Cheng, L. (2020) · Briefings in Functional Genomics · doi:10.1093/bfgp/elaa029 · Cited by 28

The gut microbiota – A vehicle for the prevention and treatment of hepatocellular carcinoma

Beyoğlu, D., & Idle, J. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115225 · Cited by 28

Recent Advances in Current Uptake Situation, Metabolic and Nutritional Characteristics, Health, and Safety of Dietary Tryptophan

Zhu, H., Yang, X., & Zhao, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06419 · Cited by 28

Assembly of functional microbial ecosystems: from molecular circuits to communities

Wu, S., Zhou, Y., Dai, L., Yang, A., & Qiao, J. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae026 · Cited by 28

Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection

Xing, J.-H., Niu, T., Yu, T., Zou, B., Shi, C., Wang, Y., Fan, S., Li, M., Bao, M., Sun, Y., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02078-x · Cited by 27

Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin

Hodnik, Ž., Łoś, J. M., Žula, A., Zidar, N., Jakopin, Ž., Łoś, M., Dolenc, M. S., Ilaš, J., Węgrzyn, G., Mašič, L. P., et al. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.03.094 · Cited by 27

Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters

Zarkan, A., Matuszewska, M., Trigg, S., Zhang, M., Belgami, D., Croft, C., Liu, J., El-Ouisi, S., Greenhalgh, J. C., Duboff, J. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68693-w · Cited by 28

EmhR is an indole‐sensing transcriptional regulator responsible for the indole‐induced antibiotic tolerance in Pseudomonas fluorescens

Han, J., Li, D., Zhang, M., Yu, X., Jia, X., Xu, H., Yan, X., Jia, W., Niu, S., Kempher, M. L., et al. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15354 · Cited by 27

Microbiota-Mediated Immune Regulation in Atherosclerosis

Eshghjoo, S., Jayaraman, A., Sun, Y., & Alaniz, R. C. (2021) · Molecules · doi:10.3390/molecules26010179 · Cited by 29

Targeted Drug Delivery Technologies Potentiate the Overall Therapeutic Efficacy of an Indole Derivative in a Mouse Cystic Fibrosis Setting

Puccetti, M., Pariano, M., Renga, G., Santarelli, I., D’Onofrio, F., Bellet, M. M., Stincardini, C., Bartoli, A., Costantini, C., Romani, L. R., et al. (2021) · Cells · doi:10.3390/cells10071601 · Cited by 28

Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections

Meza‐Torres, J., Auria, E., Dupuy, B., & Tremblay, Y. D. N. (2021) · Microorganisms · doi:10.3390/microorganisms9091922 · Cited by 24

Regulation of Indole Signalling during the Transition of E. coli from Exponential to Stationary Phase

Gaimster, H., & Summers, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136691 · Cited by 27

Biooxidation of indole and characteristics of the responsible enzymes

Yuan, L.-J. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajbx11.008 · Cited by 27

A chromatographic approach to distinguish Gram-positive from Gram-negative bacteria using exogenous volatile organic compound metabolites

Ramírez-Guízar, S., Sykes, H. E., Perry, J. D., Schwalbe, E. C., Stanforth, S. P., Pérez-Pérez, M. C. I., & Dean, J. R. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.04.015 · Cited by 27

Identification of New Metabolites of Bacterial Transformation of Indole by Gas Chromatography-Mass Spectrometry and High Performance Liquid Chromatography

Arora, P. K., & Bae, H. (2014) · International Journal of Analytical Chemistry · doi:10.1155/2014/239641 · Cited by 38

Polysaccharides to postbiotics: Nurturing bone health via modulating “gut-immune axis”

Yadav, S., Sapra, L., & Srivastava, R. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134655 · Cited by 29

Novel cross-feeding human gut microbes metabolizing tryptophan to indole-3-propionate

Zünd, J. N., Mujezinovic, D., Reichlin, M., Plüss, S., Caflisch, M., Robinson, S. L., Lacroix, C., & Pugin, B. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2501195 · Cited by 28

The Bacterial Metabolite Indole Inhibits Regeneration of the Planarian Flatworm Dugesia japonica

Lee, F. J., Williams, K. B., Levin, M. G., & Wolfe, B. E. (2018) · iScience · doi:10.1016/j.isci.2018.11.021 · Cited by 26

Discerning the role of polymicrobial biofilms in the ascent, prevalence, and extent of heteroresistance in clinical practice

Lopes, S. P., Jorge, P., Sousa, A. M., & Pereira, M. O. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1863329 · Cited by 27

Effect of halogenated indoles on biofilm formation, virulence, and root surface colonization by Agrobacterium tumefaciens

Ahmed, B., Jailani, A., Lee, J., & Lee, J. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133603 · Cited by 26

Auxin biosynthesis by Microbacterium testaceum Y411 associated with orchid aerial roots and their efficacy in micropropagation

Yadav, A., Mudoi, K. D., Kumar, N., Geed, S. R., Gogoi, P., Sharma, R. K., & Saikia, R. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1037109 · Cited by 26

Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies

Ranall, M. V., Butler, M. S., Blaskovich, M. A. T., & Cooper, M. A. (2012) · Current Drug Targets · doi:10.2174/138945012803530251 · Cited by 26

Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram‐Negative and Gram‐Positive Bacteria

Minvielle, M. J., Eguren, K., & Melander, C. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201303510 · Cited by 26

Harbouring public good mutants within a pathogen population can increase both fitness and virulence

Lindsay, R. J., Kershaw, M. J., Smug, B. J., Talbot, N. J., & Gudelj, I. (2016) · eLife · doi:10.7554/elife.18678 · Cited by 26

Viscosity has dichotomous effects on Bdellovibrio bacteriovorus HD100 predation

Im, H., Kwon, H., Cho, G., Kwon, J., Choi, S. Y., & Mitchell, R. J. (2019) · Environmental Microbiology · doi:10.1111/1462-2920.14799 · Cited by 25

Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands

Wisniewski, P. J., Nagarkatti, M., & Nagarkatti, P. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.638725 · Cited by 27

Aroma Properties of Cocoa Fruit Pulp from Different Origins

Haase, T. B., Schweiggert‐Weisz, U., Ortner, E., Zorn, H., & Naumann, S. (2021) · Molecules · doi:10.3390/molecules26247618 · Cited by 25

De novo tryptophanase-based indole production by metabolically engineered Corynebacterium glutamicum

Mindt, M., Ferrer, L., Bosch, D., Cankar, K., & Wendisch, V. F. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12397-4 · Cited by 25

Metagenomic analysis reveals indole signaling effect on microbial community in sequencing batch reactors: Quorum sensing inhibition and antibiotic resistance enrichment

Dai, C., Ma, F., Wu, W., Li, S., Yang, J., Chen, Z., Lian, S., & Qu, Y. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115897 · Cited by 25

Isolation and selection of fluorescent pseudomonads based on multiple plant growth promotion traits and siderotyping

Jayamohan, N. S., & Satyan, K. B. (2014) · Chilean journal of agricultural research · doi:10.4067/s0718-58392014000300010 · Cited by 25

Indole derivatives, microbiome and graft versus host disease

Qayed, M. D., Michonneau, D., Socié, G., & Waller, E. K. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.02.006 · Cited by 25

Mutation of tryptophanase gene tnaA in Edwardsiella tarda reduces lipopolysaccharide production, antibiotic resistance and virulence

Han, Y., Yang, C., Yang, Q., Qi, Z., Liu, W., Xu, Z., Zhu, W., Bossier, P., & Zhang, X. (2011) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2011.00269.x · Cited by 25

Aniline-Induced Tryptophan Production and Identification of Indole Derivatives from Three Purple Bacteria

Mujahid, M., Sasikala, C., & Ramana, C. V. (2010) · Current Microbiology · doi:10.1007/s00284-010-9609-2 · Cited by 25

Indole oxidation enhances electricity production in an E. coli-catalyzed microbial fuel cell

Han, T. H., Cho, M. H., & Lee, J. (2014) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-013-0429-7 · Cited by 24

Thiocillin and micrococcin exploit the ferrioxamine receptor of Pseudomonas aeruginosa for uptake

Chan, D. C. K., & Burrows, L. L. (2021) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkab124 · Cited by 23

Role of dietary amino acids and microbial metabolites in the regulation of pig intestinal health

Ma, Y., Han, X., Fang, J. Q., & Jiang, H. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.10.004 · Cited by 29

Microbiota: A potential orchestrator of antidiabetic therapy

Liu, B., Zhang, L., Yang, H., Zheng, H., & Liao, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.973624 · Cited by 26

Investigating volatile compounds in the Bacteroides secretome

Shagaleeva, O. Y., Kashatnikova, D. A., Kardonsky, D. A., Konanov, D. N., Efimov, B. A., Bagrov, D. V., Evtushenko, E. G., Chaplin, A. V., Silantiev, A. S., Filatova, J. V., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1164877 · Cited by 23

Theoretical Investigation of Positional Substitution and Solvent Effects on n -Cyanoindole Fluorescent Probes

Abou‐Hatab, S., & Matsika, S. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.9b05961 · Cited by 24

Beyond 'push–pull': unraveling the ecological pleiotropy of plant volatile organic compounds for sustainable crop pest management

Munawar, A., Zhu, Z., Machado, R. A. R., & Zhou, W. (2023) · Crop Health · doi:10.1007/s44297-023-00018-5 · Cited by 27

Phenotyping the Chemical Communications of the Intestinal Microbiota and the Host: Secondary Bile Acids as Postbiotics

Urbani, G., Rondini, E., Distrutti, E., Marchianò, S., Biagioli, M., & Fiorucci, S. (2025) · Cells · doi:10.3390/cells14080595 · Cited by 28

Indole-3-propionic acid function through PXR and AhR, molecular signaling pathways, and antitoxic role in underlying diseases

Jalili, C., Hosseinkhani, F., Dayer, D., Tabandeh, M. R., Abbasi, A., & Nasta, T. Z. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106877 · Cited by 24

Heterologous expression of AHL lactonase AiiK by Lactobacillus casei MCJΔ1 with great quorum quenching ability against Aeromonas hydrophila AH-1 and AH-4

Dong, W., Cai, Y., Xu, Z., Fu, B., Chen, Q., Cui, Y., Ruan, Z., Liang, Y., Peng, N., & Zhao, S. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01448-4 · Cited by 24

Fecal Metabolome Signature in the HIV-1 Elite Control Phenotype: Enrichment of Dipeptides Acts as an HIV-1 Antagonist but a Prevotella Agonist

Sperk, M., Ambikan, A. T., Ray, S., Singh, K. D., Mikaeloff, F., Diez, R. C., Narayanan, A., Vesterbacka, J., Nowak, P., Sönnerborg, A. B., et al. (2021) · Journal of Virology · doi:10.1128/jvi.00479-21 · Cited by 23

Transcriptomic Responses to Coaggregation between Streptococcus gordonii and Streptococcus oralis

Choo, S. W., Mohammed, W. K., Mutha, N. V. R., Rostami, N., Ahmed, H., Krasnogor, N., Tan, G. Y. A., & Jakubovics, N. S. (2021) · Applied and Environmental Microbiology · doi:10.1128/aem.01558-21 · Cited by 25

Untargeted Metabolomics Investigation on Selenite Reduction to Elemental Selenium by Bacillus mycoides SeITE01

Baggio, G., Groves, R. A., Chignola, R., Piacenza, E., Presentato, A., Lewis, I. A., Lampis, S., Vallini, G., & Turner, R. J. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.711000 · Cited by 23

Fermentative Production of Halogenated Tryptophan Derivatives with Corynebacterium glutamicum Overexpressing Tryptophanase or Decarboxylase Genes

Kerbs, A., Burgardt, A., Veldmann, K. H., Schäffer, T., Lee, J., & Wendisch, V. F. (2022) · ChemBioChem · doi:10.1002/cbic.202200007 · Cited by 22

Role of Gut Microbiota in Pulmonary Arterial Hypertension

Wu, P., Zhu, T., Tan, Z. Y. A., Chen, S., & Fang, Z. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.812303 · Cited by 23

Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs

Liu, B., Yu, D., Sun, J., Wu, X., Xin, Z., Deng, B., Fan, L., Fu, J., Ge, L., & Ren, W. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.07.005 · Cited by 23

Current Advances in Transition Metal-Free Access to Indoles. A Review

Mathada, B. S., & Yernale, N. G. (2023) · Organic Preparations and Procedures International · doi:10.1080/00304948.2022.2151810 · Cited by 23

Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance

Hassan, R. M., El-Maksoud, M. S. A., Ghannam, I. A. Y., El‐Azzouny, A. A., & Aboul-Enein, M. N. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115867 · Cited by 23

Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG—Vaccinated cattle prior to and after Mycobacterium bovis challenge

Ellis, C., Rice, S., Maurer, D., Stahl, R. S., Waters, W. R., Palmer, M. V., Nol, P., Rhyan, J. C., VerCauteren, K. C., & Koziel, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179914 · Cited by 23

Profiling of VOCs released from different salivary bacteria treated with non-lethal concentrations of silver nitrate

Monedeiro-Milanowski, M., Monedeiro, F., Złoch, M., Ratiu, I., Pomastowski, P., Ligor, T., Martinis, B. S. D., & Buszewski, B. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.05.007 · Cited by 23

The fly factor phenomenon is mediated by interkingdom signaling between bacterial symbionts and their blow fly hosts

Uriel, Y., Gries, R. M., Tu, L., Carroll, C. S., Zhai, H., Moore, M. M., & Gries, G. (2018) · Insect Science · doi:10.1111/1744-7917.12632 · Cited by 22

Biofilm Formation by Streptococcus mutans is Enhanced by Indole via the Quorum Sensing Pathway

Inaba, T., Obana, N., Habe, H., & Nomura, N. (2020) · Microbes and Environments · doi:10.1264/jsme2.me19164 · Cited by 22

Glucose-6-Phosphate Acts as an Extracellular Signal of SagS To Modulate Pseudomonas aeruginosa c-di-GMP Levels, Attachment, and Biofilm Formation

Park, S., Dingemans, J., Gowett, M., & Sauer, K. (2021) · mSphere · doi:10.1128/msphere.01231-20 · Cited by 22

Late-Stage Photoredox C–H Amidation of N-Unprotected Indole Derivatives: Access to N-(Indol-2-yl)amides

Weng, Y., Ding, B., Liu, Y., Song, C., Chan, L.-Y., & Chiang, C. (2021) · Organic Letters · doi:10.1021/acs.orglett.1c00609 · Cited by 22

The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator

Jovanović, F., Sudhakar, A., & Knežević, N. N. (2022) · International Journal of Tryptophan Research · doi:10.1177/11786469221099214 · Cited by 23

Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach

Lin, S., Li, Q., Xu, Z., Chen, Z., Tao, Y., Tong, Y., Wang, T., Chen, S., & Wang, P. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06239-w · Cited by 22

Transactions Among Microorganisms and Plant in the Composite Rhizosphere Habitat

Tewari, S., & Arora, N. K. (2013) · Springer eBooks · doi:10.1007/978-81-322-1287-4_1 · Cited by 23

The Signaling Molecule Indole Inhibits Induction of the AR2 Acid Resistance System in Escherichia coli

Boon, N., Kaur, M., Aziz, A., Morissa, B., Kenta, S., Eguchi, Y., & Lund, P. A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00474 · Cited by 22

High interindividual variability of indoxyl sulfate production identified by an oral tryptophan challenge test

Lin, T., Wu, W., & Hung, S.-C. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00651-8 · Cited by 25

Indole signaling in Escherichia coli: a target for antivirulence therapy?

Meo, S. R., van de Wiele, T., & Defoirdt, T. (2025) · Gut microbes · doi:10.1080/19490976.2025.2499573 · Cited by 21

The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke

Qin, N., Xie, X., Deng, R., Gao, S., & Zhu, T. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1578018 · Cited by 22

Narrative review on bacteria-derived metabolites in the pathogenesis of ulcerative colitis

Tambovtseva, R. S., ARSLAN, L., Grigoryeva, T., Abdulkhakov, S. R., Doludin, Y. V., Стома, И. О., Rizvanov, A. A., Рифкатовна, М. Р., & Gabdoulkhakova, A. G. (2025) · Clinical Microbiology Reviews · doi:10.1128/cmr.00210-24 · Cited by 23

Soybean oligosaccharides attenuate odour compounds in excreta by modulating the caecal microbiota in broilers

Liu, H. Y., Li, X.-T., Zhu, X., Dong, W., & Yang, G. (2021) · animal · doi:10.1016/j.animal.2020.100159 · Cited by 21

Modeling solvation effects on absorption and fluorescence spectra of indole in aqueous solution

Abou‐Hatab, S., Carnevale, V., & Matsika, S. (2021) · The Journal of Chemical Physics · doi:10.1063/5.0038342 · Cited by 20

The human microbiome: A promising target for lung cancer treatment

Sun, Y. H., Wen, M., Liu, Y., Wang, Y., Jing, P., Gu, Z., Jiang, T., & Wang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1091165 · Cited by 24

Host–Microbiome Interactions: Tryptophan Metabolism and Aromatic Hydrocarbon Receptors after Traumatic Brain Injury

Sun, Y., Wang, S., Liu, B., Hu, W., & Zhu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310820 · Cited by 23

A new suite of tnaA mutants suggests that Escherichia coli tryptophanase is regulated by intracellular sequestration and by occlusion of its active site

Li, G., & Young, K. D. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0346-3 · Cited by 21

Sub-lethal Activity of Small Molecules from Natural Sources and their Synthetic Derivatives Against Biofilm Forming Nosocomial Pathogens

Villa, F., Villa, S., Gelain, A., & Cappitelli, F. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113136660225 · Cited by 21

K 2 CO 3 -Catalyzed Synthesis of 2,5-Dialkyl-4,6,7-tricyano-Decorated Indoles via Carbon–Carbon Bond Cleavage

Pike, R. A. S., Sapkota, R. R., Shrestha, B. L., Dhungana, R. K., Shekhar, K. C., Dickie, D. A., & Giri, R. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c01057 · Cited by 21

Role of Toxin-Antitoxin-Regulated Persister Population and Indole in Bacterial Heat Tolerance

Masuda, Y., Sakamoto, E., Honjoh, K., & Miyamoto, T. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.00935-20 · Cited by 21

Signal transduction in edaphic ecosystems governs sustainability

Seneviratne, G. (2015) · Agriculture Ecosystems & Environment · doi:10.1016/j.agee.2015.05.006 · Cited by 21

Transcriptome Analysis of Early Surface-Associated Growth of Shewanella oneidensis MR-1

Gödeke, J., Binnenkade, L., & Thormann, K. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042160 · Cited by 19

Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818

Merrifield, C. A., Lewis, M. C., Claus, S. P., Pearce, J. T. M., Cloarec, O., Duncker, S. C., Heinzmann, S. S., Dumas, M., Kochhar, S., Rezzi, S., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301656 · Cited by 21

Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer’s Disease

Momen, Y. S., Mishra, J., & Kumar, N. (2024) · Nutrients · doi:10.3390/nu16152558 · Cited by 26

Indole reduces the expression of virulence related genes in Vibrio splendidus pathogenic to sea cucumber Apostichopus japonicus

Zhang, S., Zhang, W., Liu, N., Song, T., Liu, H., Zhao, X., Xu, W., & Li, C. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.08.032 · Cited by 20

Heterologous Expression of the Marine-Derived Quorum Quenching Enzyme MomL Can Expand the Antibacterial Spectrum of Bacillus brevis

Zhang, J., Wang, J., Feng, T., Du, R., Tian, X., Wang, Y., & Zhang, X. (2019) · Marine Drugs · doi:10.3390/md17020128 · Cited by 20

Diffusible Signaling Factor, a Quorum-Sensing Molecule, Interferes with and Is Toxic Towards Bdellovibrio bacteriovorus 109J

Dwidar, M., Jang, H., Sangwan, N., Mun, W., Im, H., Yoon, S., Choi, S., Nam, D., & Mitchell, R. J. (2020) · Microbial Ecology · doi:10.1007/s00248-020-01585-8 · Cited by 20

Nonpharmacological Treatment Strategies for the Management of Canine Chronic Inflammatory Enteropathy—A Narrative Review

Isidori, M., Corbee, R. J., & Trabalza‐Marinucci, M. (2022) · Veterinary Sciences · doi:10.3390/vetsci9020037 · Cited by 24

Quorum‐sensing interference in vibrios

Zhang, S., Yang, Q., Eggermont, M., & Defoirdt, T. (2023) · Reviews in Aquaculture · doi:10.1111/raq.12787 · Cited by 22

Monitoring long-term chemical exposome by characterizing the hair metabolome using a high-resolution mass spectrometry-based suspect screening approach

Chang, C., Hsu, J.-Y., Su, Y.-H., Chen, Y.-C., Hsiao, P.-Z., & Liao, P. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138864 · Cited by 20

Role of Gut Microbiota, Immune Imbalance, and Allostatic Load in the Occurrence and Development of Diabetic Kidney Disease

Han, Y. Z., Zheng, H., Du, B. X., Zhang, Y., Zhu, X. Y., Li, J., Wang, Y., & Liu, W. J. (2023) · Journal of Diabetes Research · doi:10.1155/2023/8871677 · Cited by 21

Impact of gut microbiota and associated mechanisms on postprandial glucose levels in patients with diabetes

Feng, X., Deng, M., Zhang, L., & Pan, Q. (2023) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2023-0116 · Cited by 23

Characterization of an Antibacterial Compound, 2-Hydroxyl Indole-3-Propanamide, Produced by Lactic Acid Bacteria Isolated from Fermented Batter

Jeevaratnam, K., Vidhyasagar, V., Agaliya, P. J., Saraniya, A., & Umaiyaparvathy, M. (2015) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-015-1733-9 · Cited by 20

In silico and in vitro evaluation of tetrahydropyridine compounds as efflux inhibitors in Mycobacterium abscessus

Ramis, I. B., Vianna, J. S., Silva, L., von Groll, A., Ramos, D. F., Lobo, M. M., Zanatta, N., Viveiros, M., & da Silva, P. E. A. (2019) · Tuberculosis · doi:10.1016/j.tube.2019.07.004 · Cited by 20

Bacteria-immune cells dialog and the homeostasis of the systems

Guzman-Bautista, E. R., Suzuki, K., Asami, S., & Fagarasan, S. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.05.010 · Cited by 21

Indolic Structure Metabolites as Potential Biomarkers of Non-infectious Diseases

Nv, B., Chernevskaya, E., & Getsina, M. L. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201022121653 · Cited by 20

Isolation, characterization, and functional groups analysis of Pseudoxanthomonas indica RSA-23 from rhizosphere soil

Nayaka, S., Chakraborty, B., Swamy, S., Bhat, M. P., Airodagi, D., Basavarajappa, D. S., Rudrappa, M., Hiremath, H., Nagaraja, S. K., & Madhappa, C. (2019) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2019.91113 · Cited by 20

Indole: a signaling molecule or a mere metabolic byproduct that alters bacterial physiology at a high concentration?

Kim, J., & Park, W. (2015) · The Journal of Microbiology · doi:10.1007/s12275-015-5273-3 · Cited by 156

[A new interspecies and interkingdom signaling molecule-Indole].

Qu, Y., Dai, C., Zhang, X., & Ma, Q. (2019) · PubMed · doi:10.13345/j.cjb.190158 · Cited by 8

Indole: A novel signaling molecule and its applications

Pandey, R., Swamy, K. V., & Khetmalas, M. B. (2013) · Cited by 18

Indole as a regulator of bacterial physiology

Castillo-Juárez, R. J. (2023) · Mexican Journal of Medical Research ICSA · doi:10.29057/mjmr.v11i21.8894 · Cited by 1

Roles of indole as an interspecies and interkingdom signaling molecule

Lee, J.-H., Wood, T. K., & Lee, J. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.08.001 · Cited by 516