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Protein phosphatase 2A in Alzheimer's disease

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Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

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Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src

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Sustained postexercise increases in AS160 Thr642and Ser588phosphorylation in skeletal muscle without sustained increases in kinase phosphorylation

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Expression of Alzheimer-like pathological human tau induces a behavioral motor and olfactory learning deficit in Drosophila melanogaster

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Protein Phosphatase 2A: a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders

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Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

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Microcystin-lr induces protein phosphatase 2a alteration in a human liver cell line

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Unveiling Clusters of RNA Transcript Pairs Associated with Markers of Alzheimer’s Disease Progression

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Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease

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Zinc binds to and directly inhibits protein phosphatase 2A in vitro

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Basis for MAP4 Dephosphorylation-related Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy

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Glycogen synthase kinase‐3β regulates leucine‐309 demethylation of protein phosphatase‐2A via PPMT1 and PME‐1

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mTor Is a Signaling Hub in Cell Survival: A Mass-Spectrometry-Based Proteomics Investigation

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Nmnat2 Attenuates Tau Phosphorylation Through Activation of PP2A

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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

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PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability

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Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration

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Interactions Between Glycogen Synthase Kinase 3β, Protein Kinase B, and Protein Phosphatase 2A in Tau Phosphorylation in Mouse N2a Neuroblastoma Cells

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Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice

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Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model

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Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells

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The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia

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Early glycogen synthase kinase‐3β and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway

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Morin exerts protective effects on encephalopathy and sepsis-associated cognitive functions in a murine sepsis model

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Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia

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Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats

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Pleiotropy of PP2A Phosphatases in Cancer with a Focus on Glioblastoma IDH Wildtype

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Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

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Neuroprotective Effects of Green Tea Seed Isolated Saponin Due to the Amelioration of Tauopathy and Alleviation of Neuroinflammation: A Therapeutic Approach to Alzheimer’s Disease

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Neurosteroid metabolites of testosterone and progesterone differentially inhibit ERK phosphorylation induced by amyloid β in SH-SY5Y cells and primary cortical neurons

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Folate is related to phosphorylated neurofilament‐H and P‐tau (Ser396) in rat brain

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Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A

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Abnormal phosphorylation of tau protein and neuroinflammation induced by laparotomy in an animal model of postoperative delirium

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Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation

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The testosterone metabolite 3α-androstanediol inhibits oxidative stress-induced ERK phosphorylation and neurotoxicity in SH-SY5Y cells through an MKP3/DUSP6-dependent mechanism

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Blockade of AMPA Receptor Regulates Mitochondrial Dynamics by Modulating ERK1/2 and PP1/PP2A-Mediated DRP1-S616 Phosphorylations in the Normal Rat Hippocampus

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Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity

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Inhibition of PP2A enhances the osteogenic differentiation of human aortic valvular interstitial cells via ERK and p38 MAPK pathways

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Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation

Zhang, Y., Zhang, J., Wang, E., Qian, W., Fan, Y., Feng, Y., Yin, H., Li, Y., Wang, Y., & Yuan, T. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx271 · Cited by 19 · see citing works

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

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Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease

Mendsaikhan, A., Tooyama, I., Serrano, G. E., Beach, T. G., & Walker, D. G. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab056 · Cited by 17 · see citing works

Designing composite cryogel carriers for tyrosine adsorption

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Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis

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Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling

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Could protein phosphatase 2A and glycogen synthase kinase-3 beta be targeted by natural compounds to ameliorate Alzheimer’s pathologies?

Manoharan, S. D., Hamid, H. A., Hashim, N. F. M., Cheema, M. S., Chiroma, S. M., Mustapha, M., & Mehat, M. Z. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148793 · Cited by 14 · see citing works

Arsenic Induces GSK3β-Dependent p-Tau, Neuronal Apoptosis, and Cognitive Impairment via an Interdependent Hippocampal ERα and IL-1/IL-1R1 Mechanism in Female Rats

Gupta, K., Vishwakarma, J., Garg, A., Pandey, R., Jain, V., Gupta, R., Das, U., Roy, S. K., & Bandyopadhyay, S. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac087 · Cited by 14 · see citing works

Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity

Park, S. S., Jung, H., Kim, Y., Park, T. K., Kim, C., Choi, H., Mook‐Jung, I. H., Koo, E. H., & Park, S. A. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12032 · Cited by 14 · see citing works

High fructose induces dysfunctional vasodilatation via PP2A-mediated eNOS Ser1177 dephosphorylation

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SCR-1693 inhibits tau phosphorylation and improves insulin resistance associated cognitive deficits

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Hyperhomocysteinemia selectively alters expression and stoichiometry of intermediate filament and induces glutamate‐ and calcium‐mediated mechanisms in rat brain during development

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Progesterone regulates the phosphorylation of protein phosphatases in the brain

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PKCα Isoform Inhibits Insulin Signaling and Aggravates Neuronal Insulin Resistance

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Protein Phosphatase 2A Deficiency in Macrophages Increases Foam Cell Formation and Accelerates Atherosclerotic Lesion Development

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P3–300: Increased tyrosine 307 phosphorylation of protein phosphatase–2A correlates with tau associated pathologies in Alzheimer's disease

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P3–301: Aβ mediates tau hyperphosphorylation via down–regulating PP2A in Alzheimer's disease

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Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

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Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

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P4–037: PTPA reduces phosphorylated PP2A level with upregulation of protein tyrosine phosphatase 1B

Liu, G. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1425