Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840 · see citing works

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · see citing works

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

Grundke, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38495-8 · Cited by 1,780 · see citing works

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611 · see citing works

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

Kosik, K. S., Joachim, C. L., & Selkoe, D. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4044 · Cited by 1,462 · see citing works

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Lee, V. M.-Y., Balin, B. J., Otvos, L., & Trojanowski, J. Q. (1991) · Science · doi:10.1126/science.1899488 · Cited by 1,418 · see citing works

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416 · see citing works

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268 · see citing works

The GSK3 hypothesis of Alzheimer’s disease

Hooper, C., Killick, R., & Lovestone, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05194.x · Cited by 1,191 · see citing works

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

Goedert, M., Spillantini, M. G., Cairns, N. J., & Crowther, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90117-v · Cited by 1,114 · see citing works

Tau pathology in Alzheimer disease and other tauopathies

Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works

Role of tau protein in both physiological and pathological conditions

AVILA, J., LUCAS, J. J., PÉREZ, M., & HERNÁNDEZ, F. (2004) · Physiological Reviews · doi:10.1152/physrev.00024.2003 · Cited by 1,005 · see citing works

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Wischik, C. M., Novak, M., Thøgersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E., Milstein, C., Roth, M., & Klug, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4506 · Cited by 939 · see citing works

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

Bancher, C., Brunner, C., Lassmann, H., Budka, H., Jellinger, K., Wiche, G., Seitelberger, F., Grundke-Iqbal, I., Iqbal, K., & Wisniewski, H. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91396-6 · Cited by 818 · see citing works

Amyloid β-Protein and the Genetics of Alzheimer's Disease

Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 798 · see citing works

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

Köpke, E., Tung, Y. C., Shaikh, S., Alonso, A. C., Iqbal, K., & Grundke-Iqbal, I. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80536-5 · Cited by 779 · see citing works

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

Wood, J. G., Mirra, S. S., Pollock, N. J., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4040 · Cited by 749 · see citing works

Relative Frequencies of Alzheimer Disease, Lewy Body, Vascular and Frontotemporal Dementia, and Hippocampal Sclerosis in the State of Florida Brain Bank

Barker, W., Luis, C. A., Kashuba, A., Luis, M., Harwood, D. G., Loewenstein, D., Waters, C., Jimison, P., Shepherd, E., Sevush, S., et al. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200210000-00001 · Cited by 706 · see citing works

Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer’s disease

Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638 · see citing works

Neurochemical Correlates of Dementia Severity in Alzheimer's Disease: Relative Importance of the Cholinergic Deficits

Bierer, L. M., Haroutunian, V. H., Gabriel, S., Knott, P. J., Carlin, L. S., Purohit, D. P., Perl, D. P., Schmeidler, J., Kanof, P. D., & Davis, K. L. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020749.x · Cited by 580 · see citing works

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

Ihara, Y., Nukina, N., Miura, R., & OGAWARA, M. (1986) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a135662 · Cited by 527 · see citing works

Genetics of Aging

Finch, C. E., & Tanzi, R. E. (1997) · Science · doi:10.1126/science.278.5337.407 · Cited by 490 · see citing works

ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY

KIDD, M. (1964) · Brain · doi:10.1093/brain/87.2.307 · Cited by 462 · see citing works

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00011 · Cited by 459 · see citing works

Post-translational modifications of tau protein in Alzheimer’s disease

Gong, C.-X., Liu, F., Grundke-Iqbal, I., & Iqbal, K. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-004-0221-0 · Cited by 437 · see citing works

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90288-0 · Cited by 432 · see citing works

Mitotic mechanisms in Alzheimer's disease?

Vincent, I., Rosado, M., & Davies, P. (1996) · The Journal of cell biology · doi:10.1083/jcb.132.3.413 · Cited by 386 · see citing works

Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain

PEI, J.-J., TANAKA, T., TUNG, Y.-C., BRAAK, E., IQBAL, K., & GRUNDKE-IQBAL, I. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199701000-00007 · Cited by 371 · see citing works

The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine

Arnold, C. S., Johnson, G. W., Cole, R. N., Dong, D. L.-Y., Lee, M., & Hart, G. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.28741 · Cited by 361 · see citing works

Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease

Wang, J.-Z., Grundke-Iqbal, I., & Iqbal, K. (1996) · Nature Medicine · doi:10.1038/nm0896-871 · Cited by 360 · see citing works

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

Hardy, J., Duff, K., Hardy, K. G., Pérez‐Tur, J., & Hutton, M. (1998) · Nature Neuroscience · doi:10.1038/1565 · Cited by 345 · see citing works

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

Ledesma, M. D., Bonay, P., Colaço, C., & Avila, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31849-5 · Cited by 333 · see citing works

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

Delacourte, A., & Défossez, A. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90167-x · Cited by 325 · see citing works

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

Li, X., Alafuzoff, I., Soininen, H., Winblad, B., & Pei, J. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04833.x · Cited by 324 · see citing works

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

An, W.-L., Cowburn, R. F., Li, L., Braak, H., Alafuzoff, I., Iqbal, K., Iqbal, I.-G., Winblad, B., & Pei, J.-J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63687-5 · Cited by 312 · see citing works

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

Alafuzoff, I. I., Iqbal, K., Fridén, H., Adolfsson, R., & Winblad, B. G. (1987) · Acta Neuropathologica · doi:10.1007/bf00688184 · Cited by 265 · see citing works

Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology

Su, J. H., Zhao, M., Anderson, A. J., Srinivasan, A. N., & Cotman, C. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02018-2 · Cited by 260 · see citing works

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo

Žilka, N., Filipčík, P., Koson, P., Fialová, Ľ., Škrabana, R., Žilková, M., Rolkova, G., Kontseková, E., & Novák, M. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.05.029 · Cited by 252 · see citing works

Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases

Williamson, R., Scales, T., Clark, B. R., Gibb, G., Reynolds, C. H., Kellie, S., Bird, I. N., Varndell, I. M., Sheppard, P. W., Everall, I., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00010.2002 · Cited by 227 · see citing works

Alzheimer paired helical filaments: Bulk isolation, solubility, and protein composition

Iqbal, K., Zaidi, T., Thompson, C. H., MERZ, P. A., & Wı́sniewski, H. M. (1984) · Acta Neuropathologica · doi:10.1007/bf00691849 · Cited by 227 · see citing works

Alzheimer Disease: DMA Fragmentation Indicates Increased Neuronal Vulnerability, but not Apoptosis

Stadelmann, C., Brück, W., Bancher, C., Jellinger, K., & Lassmann, H. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199805000-00009 · Cited by 221 · see citing works

Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

Dickson, D. W. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22317 · Cited by 201 · see citing works

Alz‐50 Antibody recognizes alzheimer‐related neuronal changes

Hyman, B. T., Hoesen, G. W. V., Wolozin, B. L., Davies, P., Vogt, L. J., & Damasio, A. R. (1988) · Annals of Neurology · doi:10.1002/ana.410230410 · Cited by 176 · see citing works

Morphology of the Aging Brain, Human and Animal

Wı́sniewski, H. M., & Terry, R. D. (1973) · Progress in brain research · doi:10.1016/s0079-6123(08)60686-x · Cited by 170 · see citing works

The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments

Kenessey, Á., & Yen, S.-H. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90478-6 · Cited by 167 · see citing works

Role of protein kinase B in Alzheimer's neurofibrillary pathology

Pei, J.-J., Khatoon, S., An, W., Nordlinder, M., Tanaka, T., Braak, H., Tsujio, I., Takeda, M., Alafuzoff, I. I., Winblad, B. G., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0657-y · Cited by 165 · see citing works

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

Kins, S., Kurosinski, P., Nitsch, R. M., & Götz, J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63444-x · Cited by 155 · see citing works

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

Grace, E. A., Rabiner, C. A., & Busciglio, J. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00241-5 · Cited by 151 · see citing works

Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer's Disease

Pei, J.-J., Gong, C., An, W., Winblad, B. G., Cowburn, R. F., Grundke, I., & Iqbal, K. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63445-1 · Cited by 142 · see citing works

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

Grundke, I., VORBRODT, A. W., Iqbal, K., Tung, Y. C., Wang, G. P., & Wisniewski, H. M. (1988) · Molecular Brain Research · doi:10.1016/0169-328x(88)90017-4 · Cited by 128 · see citing works

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

Liu, R., Zhou, X. ‐., Tanila, H., Bjorkdahl, C., Wang, J. ‐., Guan, Z. ‐., Cao, Y., Gustafsson, J. ‐., Winblad, B., & Pei, J. ‐. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00249.x · Cited by 125 · see citing works

P70 S6 kinase mediates tau phosphorylation and synthesis

Pei, J.-J., An, W., Zhou, X., Nishimura, T., Norberg, J., Benedikz, E., Götz, J., & Winblad, B. G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.059 · Cited by 119 · see citing works

Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties

Ksiezak‐Reding, H., Binder, L. I., & Yen, S.-H. C. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490250320 · Cited by 113 · see citing works

Self assembly of microtubule associated protein tau into filaments resembling those found in alzheimer disease

de Garcini, E. M., Serrano, L. G., & Ávila, J. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80242-x · Cited by 110 · see citing works

Mechanism of zinc‐induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH‐SY5Y neuroblastoma cells

An, W., Björkdahl, C., Liu, R., Cowburn, R. F., Winblad, B. G., & Pei, J.-J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02948.x · Cited by 106 · see citing works

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

Zhou, X.-W., Gustafsson, J.-Α., Tanila, H., Björkdahl, C., Liu, R., Winblad, B. G., & Pei, J.-J. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.013 · Cited by 101 · see citing works

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

Pei, J.-J., Sersen, E., Iqbal, K., & Grundke-Iqbal, I. (1994) · Brain Research · doi:10.1016/0006-8993(94)91598-9 · Cited by 89 · see citing works

Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

Zhou, X., Li, X., Björkdahl, C., Sjögren, M. J. C., Alafuzoff, I. I., Soininen, H. S., Grundke, I., Iqbal, K., Winblad, B. G., & Pei, J.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.006 · Cited by 65 · see citing works

Deletion Mutation in Drosophila ma-l Homologous, Putative Molybdopterin Cofactor Sulfurase Gene Is Associated with Bovine Xanthinuria Type II

Watanabe, T., Ihara, N., Itoh, T., Fujita, T., & Sugimoto, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000230200 · Cited by 64 · see citing works

Alzheimer disease without neocortical neurofibrillary tangles

Tiraboschi, P., Sabbagh, M. N., Hansen, L. A., Salmon, D. P., Merdes, A., Gamst, A. C., Masliah, E., Alford, M. F., Thal, L. J., & Corey‐Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000118212.41542.e7 · Cited by 62 · see citing works

Amyloid β Pathology in Alzheimer’s Disease and Schizophrenia

Religa, D., Laudon, H., Styczyńska, M., Winblad, B. G., Näslund, J., & Haroutunian, V. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.5.867 · Cited by 52 · see citing works

Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

Pei, J.-J., Braak, H., Gong, C., Grundke, I., Iqbal, K., Winblad, B. G., & Cowburn, R. F. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0565-1 · Cited by 51 · see citing works

The molecular genetics of the tauopathies

vanSlegtenhorst, M., LEWIS, J., & Hutton, M. L. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00114-5 · Cited by 51 · see citing works

Fibrillogenesis of Tau: Insights from Tau Missense Mutations in FTDP‐17

Yen, S.-H. C., Hutton, M. L., Deture, M. A., Ko, L., & Nacharaju, P. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00551.x · Cited by 48 · see citing works

Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms

Liu, R., Pei, J.-J., Wang, X., Zhou, X., Tian, Q., Winblad, B. G., & Wang, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03270.x · Cited by 31 · see citing works

Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Aβ overproduction

Zhou, X., Tanila, H., & Pei, J.-J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.078 · Cited by 31 · see citing works

Alzheimer Research Forum Live Discussion: Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look1

(2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10418 · Cited by 1 · see citing works

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works

Alzheimer’s disease: Clinical trials and drug development

Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217 · see citing works

Tau in Alzheimer Disease and Related Tauopathies

Iqbal, K., Liu, F., Gong, C., & Grundke, I. (2010) · Current Alzheimer Research · doi:10.2174/156720510793611592 · Cited by 1,122 · see citing works

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

Liu, F., Shi, J., Tanimukai, H., Gu, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., & Gong, C.-X. (2009) · Brain · doi:10.1093/brain/awp099 · Cited by 439 · see citing works

Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review

Reitz, C. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/369808 · Cited by 373 · see citing works

Precortical Phase of Alzheimer's Disease ( AD )‐Related Tau Cytoskeletal Pathology

Stratmann, K., Heinsen, H., Korf, H., Turco, D. D., Ghebremedhin, E., Seidel, K., Bouzrou, M., Grinberg, L. T., Böhl, J., Wharton, S. B., et al. (2015) · Brain Pathology · doi:10.1111/bpa.12289 · Cited by 174 · see citing works

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer’s Disease

Santos, R. X., Correia, S., Wang, X.-L., Perry, G., Smith, M. A., Moreira, P., & Zhu, X.-W. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100666 · Cited by 157 · see citing works

Activation of mTOR: a culprit of Alzheimer’s disease?

Cai, Z., Zhou, Y., Xiao, M., Yan, L.-J., & He, W. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75717 · Cited by 161 · see citing works

Pharmacological Treatment of Alzheimer Disease

Massoud, F., & Léger, G. C. (2011) · The Canadian Journal of Psychiatry · doi:10.1177/070674371105601003 · Cited by 122 · see citing works

Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.

Santos, R. X., Correia, S. C., Wang, X., Perry, G. L., Smith, M. A., Moreira, P. I., & Zhu, X. (2010) · Europe PMC (PubMed Central) · Cited by 120 · see citing works

Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease

Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Santacruz, K., Smith, C. D., Patel, E., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181aacbe9 · Cited by 115 · see citing works

Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development

Mueed, Z., Tandon, P., Maurya, S. K., Deval, R., Kamal, M. A., & Poddar, N. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01017 · Cited by 111 · see citing works

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

Chakroborty, S., & Stutzmann, G. E. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.012 · Cited by 91 · see citing works

Recent developments of protein kinase inhibitors as potential AD therapeutics

Tell, V., & Hilgeroth, A. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00189 · Cited by 90 · see citing works

Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyondβ-Amyloid: Insights from Clinical Trials

Jia, Q., Deng, Y., & Qing, H. (2014) · BioMed Research International · doi:10.1155/2014/837157 · Cited by 80 · see citing works

Phenserine Efficacy in Alzheimer's Disease

Winblad, B. G., Giacobini, E., Frölich, L., Friedhoff, L. T., Bruinsma, G., Becker, R. E., & Greig, N. H. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101311 · Cited by 69 · see citing works

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial

Iqbal, K., Wang, X., Blanchard, J., Liu, F., Gong, C., & Grundke, I. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380962 · Cited by 61 · see citing works

Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key?

Ankarcrona, M., Mangialasche, F., & Winblad, B. G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100327 · Cited by 59 · see citing works

Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease

Qian, W., Yin, X., Hu, W. H., Shi, J., Gu, J., Grundke, I., Iqbal, K., Gong, C., & Liu, F. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100987 · Cited by 47 · see citing works

Are Herbal Compounds the Next Frontier for Alleviating Learning and Memory Impairments? An Integrative Look at Memory, Dementia and the Promising Therapeutics of Traditional Chinese Medicines

Jesky, R., & Hailong, C. (2011) · Phytotherapy Research · doi:10.1002/ptr.3388 · Cited by 38 · see citing works

Animal Models for Alzheimer’s Disease and Frontotemporal Dementia: A Perspective

Götz, J., & Götz, N. N. (2009) · ASN NEURO · doi:10.1042/an20090042 · Cited by 37 · see citing works

Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells

Bereczki, E., Re, F., Masserini, M., Winblad, B. G., & Pei, J. J. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.05.009 · Cited by 32 · see citing works

Confocal scanning laser tomography of the optic nerve head on the patients with Alzheimer’s disease compared to glaucoma and control

Kurna, S. A., Akar, G., Altun, A., Agirman, Y., Gözke, E., & Şengör, T. (2014) · International Ophthalmology · doi:10.1007/s10792-014-0004-z · Cited by 28 · see citing works

Increased Tau Phosphorylation and Impaired Presynaptic Function in Hypertriglyceridemic ApoB-100 Transgenic Mice

Lénárt, N., Szegedi, V., Juhász, G., Kasztner, A., Horváth, J., Bereczki, E., Tóth, M. E., Penke, B., & Sántha, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046007 · Cited by 27 · see citing works

Components of a mammalian protein disaggregation/refolding machine are targeted to nuclear speckles following thermal stress in differentiated human neuronal cells

Deane, C. A. S., & Brown, I. R. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0753-x · Cited by 23 · see citing works

Does any drug to treat cancer target mTOR and iron hemostasis in neurodegenerative disorders?

Farshbaf, M. J., & Ghaedi, K. (2016) · BioMetals · doi:10.1007/s10534-016-9981-x · Cited by 22 · see citing works

Pathology of nNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer’s Disease

Choi, S., Won, J., Carroll, S. L., Annamalai, B., Singh, I., & Singh, A. K. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.013 · Cited by 22 · see citing works

Challenges in Designing Therapeutic Agents for Treating Alzheimer’s Disease-from Serendipity to Rationality

Rashid, U., & Ansari, F. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50002-7 · Cited by 23 · see citing works

Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease

Mendsaikhan, A., Tooyama, I., Serrano, G. E., Beach, T. G., & Walker, D. G. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab056 · Cited by 18 · see citing works

CRP gene variation affects early development of Alzheimer's disease-related plaques

Kok, E., Alanne-Kinnunen, M., Isotalo, K., Luoto, T., Haikonen, S., Goebeler, S., Perola, M., Hurme, M. A., Haapasalo, H., & Karhunen, P. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-96 · Cited by 16 · see citing works

The role of neuropathological markers in the interpretation of neuropsychiatric disorders: Focus on fetal and perinatal programming

Fanni, D., Gerosa, C., Rais, M., Ravarino, A., Eyken, P. V., Fanos, V., & Faa, G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.063 · Cited by 16 · see citing works

Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer's disease

Ashwini, P., Bodhankar, S. L., Muthal, A., Kumar, D., Pawar, A., & Kulkarni, R. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.11.016 · Cited by 17 · see citing works

RECENT ADVANCES IN ALZHEIMER'S DISEASE: CAUSES AND TREATMENT

Kaur, K., Kaur, R., & Kaur, M. (2016) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 14 · see citing works

S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease

Sonoda, Y., Tooyama, I., Mukai, H., Maeda, K., Akiyama, H., & Kawamata, T. (2015) · Neuropathology · doi:10.1111/neup.12275 · Cited by 13 · see citing works

Novel aspects in structure–activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of Alzheimer's disease-relevant kinases cdk1, cdk5 and gsk3β

Tell, V., Mahmoud, K., Wichapong, K., Schächtele, C., Totzke, F., Sippl, W., & Hilgeroth, A. (2012) · MedChemComm · doi:10.1039/c2md20201h · Cited by 11 · see citing works

Neuroproteomic profiling of human body fluids

Månberg, A., Schwenk, J. M., & Nilsson, P. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500065 · Cited by 10 · see citing works

Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method

Shin, S., Park, Y., Park, M., Byeon, J., Lee, B. I., Choi, J., & Shin, Y. G. (2020) · Life · doi:10.3390/life10070115 · Cited by 8 · see citing works

P2‐447: Liposomes functionalized with acidic lipids rescue Aβ‐induced toxicity in murine neuroblastoma cells

Bereczki, E., Re, F., Masserini, M., Winblad, B. G., & Pei, J. J. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.1319 · Cited by 6 · see citing works

Alzheimer's Disease: Clinical Trials and Future Perspectives

Lee, K. S., & Suh, H. S. (2012) · 대한정신약물학회지 · Cited by 2 · see citing works

Going beyond ATP binding site as a novel inhibitor design strategy for tau protein kinases in the treatment of Alzheimer's disease: A review

Zaater, M. A., Kerdawy, A. M. E., Mahmoud, W. R., & Abou‐Seri, S. M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142141 · Cited by 2 · see citing works

The Contribution of the Amyloid Hypothesis to the Understanding of Alzheimer's Disease: A Critical Overview

Morelli, L., Perry, G. L., & Tagliavini, F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/709613 · Cited by 2 · see citing works

Frontiers in Clinical Drug Research - Alzheimer Disorders

Atta-ur-rahman, Mavoungou, C., Zimmerman, K. S., Wright, J., Harding, J., Cavallaro, R., Fuso, A., Yoshiyama, Y., Asija, Z., Clifford, A., et al. (2015) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/97816810806801150301 · Cited by 2 · see citing works

Role of noradrenaline in the development of dopamine-induced hyperprolactinemia

Dil’mukhametova, L. K., Pronina, T. S., Ziyazetdinova, G., Кудрин, В. С., & Ugrumov, M. V. (2009) · Neurochemical Journal · doi:10.1134/s1819712409040084

Investigation into the effects and mechanisms of rapamycin treatment in two mouse models of Complex I-deficient neurological pathology

Yanos, M. E. (2014) · ResearchWorks at the University of Washington (University of Washington)

Validation of Animal Models of Dementia: Neurochemical Aspects

Pepeu, G., & Rosi, M. C. (2010) · Neuromethods · doi:10.1007/978-1-60761-898-0_10

Current awareness in geriatric psychiatry

(2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2115

Risk Factors and Current Understanding of Alzheimers Disease

Saini, N. (2018) · Research Journal of Life Sciences Bioinformatics Pharmaceutical and Chemical Sciences · doi:10.26479/2018.0402.03

Studies on the Role of Cellular Heparan Sulfate on Tau Pathology in Alzheimer's Disease and Related Tauopathies

Sepulveda-Diaz, J. E. (2013) · theses.fr (ABES) · doi:10.70675/56c42bcbz41dfz432bzbb78z77110b373285

Rôle des cellules T CD4+ dans la modulation des réponses microgliales au cours de la maladie d’Alzheimer : potentialités thérapeutiques

Ahmed, D. A. (2014) · theses.fr (ABES) · doi:10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c

Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease.

遠山, 育., Mendsaikhan, A., Tooyama, I., SERRANO, G. E., Beach, T. G., & Walker, D. G. (n.d.) · Institutional Repositories DataBase (IRDB)

Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention

Iqbal, K., & Grundke, I. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00225.x · Cited by 238 · see citing works

I.: Alzheimer neurofibrillary degeneration: Significance, etiopathogenesis, therapeutics and prevention

Iqbal, K., & Grundke, I. (2008)

Targeting Tau Protein in Alzheimerʼs Disease

Gong, C., Grundke, I., & Iqbal, K. (2010) · Drugs & Aging · doi:10.2165/11536110-000000000-00000 · Cited by 88 · see citing works

Chapter 7. Alzheimer Neurofibrillary Degeneration: Pivotal Role and Therapeutic Targets

Iqbal, K., & Grundke, I. (2010) · RSC drug discovery/RSC drug discovery series · doi:10.1039/9781849731065-00137

Molecular dissection of the neurofibrillary lesions of Alzheimer's disease.

Goedert, M. (1995) · PubMed · Cited by 8 · see citing works