The DOI matches its Crossref record.
Physical activity, trauma, and ALS: a case-control study
Abstract
Aims The association of trauma and physical activity with ALS is controversial. We explored the relation in a pilot case-control study. Material and methods ALS patients were selected from a university muscle disease clinic and paired with two matched controls: one from the clinic, but having different diseases, and one from the community. Results We found several strong and statistically significant differences between ALS cases and the matched controls. These included severe head, neck and back injury (OR = 5.3), the frequency of sweating in work (OR = 1.6) or leisure activity (also OR = 1.6), and earning a school letter (OR = 3.1). Other measures of trauma and activity, while not achieving statistical significance (p Discussion Possible explanations include trauma and vigorous exercise precipitating ALS; trauma as an early sign of disease; or a third factor associated with ALS predisposing to injury. Conclusions Severe head, neck, and back injury and frequency of sweating both in work and leisure activity showed a strong association with ALS. Further study could test narrower and less common exposures with greater statistical power.
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“since trauma is an alleged risk factor for ALS (Strickland et al., 1996).”
From Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players (2005) · cites this paper as Strickland et al., 1996
In the citing paper
“The effect of football-specific traumas/microtraumas cannot be ruled out since trauma is an alleged risk factor for ALS (Strickland et al., 1996).”
From Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players (2005) · cites this paper as Strickland et al., 1996
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Research works printed but not linked: 17
- Lilienfeld, 1989, Rising mortality from motorneuron disease in the USA, 1962-84, Lancet, 710, 10.1016/S0140-6736(89)92218-6 · DOI
- Kurtzke, 1982, Human motorneurone diseases, 281
- Riggs, 1992, Rising mortality due to Parkinson's disease and amyotrophic lateral sclerosis: A manifestation of the competitive nature of human mortality, J Clin Epidemiol, 45, 1007, 10.1016/0895-4356(92)90116-5 · DOI
- Yase, 1984, Neuromuscular diseases, 335
- Williams, 1981, Motor neuron disease (amyotrophic lateral sclerosis), Mayo Clin Proc, 66, 54, 10.1016/S0025-6196(12)61175-6 · DOI
- Anonymous editorial., 271990, What causes motorneuron disease, Lancet, 336, 1033
- Kurland, 1992, Mechanical trauma as a risk factor in classic amyotrophic lateral sclerosis: lack of epidemiologic evidence, J Neurol Sci, 113, 133, 10.1016/0022-510X(92)90241-C · DOI · Paper page
- Rothman, 1995, Causes, Am J Epidemiology, 141, 90, 10.1093/oxfordjournals.aje.a117417 · DOI
- Roelofs-Iverson, 1984, ALS and heavy metals: a pilot case-control study, Neurology, 34, 393, 10.1212/WNL.34.3.393 · DOI
- Breslow, 1980, Statistical methods in cancer research
- EGRET., 1991, Version 0.25.6
- Gresham, 1987, Amyotrophic lateral sclerosis and history of skeletal fracture: a case-control study, Neurology, 37, 717, 10.1212/WNL.37.4.717 · DOI · Paper page
- Kurtzke, 1980, Epidemiology of amyotrophic lateral sclerosis: 1. A case-control comparison based on ALS deaths, Neurology, 30, 453, 10.1212/WNL.30.5.453 · DOI · Paper page
- Kondo, 1981, Case-control studies of motor neuron disease: Association with mechanical injuries, Arch Neurol, 38, 220, 10.1001/archneur.1981.00510040046007 · DOI · Paper page
- Armon, 1991, Epidemiologic correlates of sporadic amyotrophic lateral sclerosis, Neurology, 41, 1077, 10.1212/WNL.41.7.1077 · DOI
- Williams, 1991, Brain injury and neurologic sequelae: a cohort study of dementia, Neurology, 41, 1554, 10.1212/WNL.41.10.1554 · DOI · Paper page
- Riggs, 1993, Antecedent trauma and amyotrophic lateral sclerosis in young adult men, Mil Med, 158, 55, 10.1093/milmed/158.1.55 · DOI
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“These findings contrast previous case series (Chen et al., 2007; Pupillo et al., 2012; Schmidt, Kwee, Allen, & Oddone, 2010; Seelen et al., 2014; Strickland et al., 1996) and a meta- analysis (Chen et al.”
Result
Metadata
- Authors
- Strickland, D., Smith, S. A., Dolliff, G., Goldman, L., & Roelofs, R. I.
- Affiliations
- University of Nebraska Medical Center (US)
- University of Minnesota (US)
- Corresponding author
- Strickland, D.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 94
- Issue
- 1
- Pages
- 45-50
- ISSN
- 0001-6314 (ISSN-L)
- 1600-0404
- OpenAlex
- W1989486717
- Cited by
- 116
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 2 · 2012: 5
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Neurologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Clinic
- Muscular Dystrophy Association
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
- Keywords
- amyotrophic lateral sclerosis, physical activity, trauma (physical injury), traumatic brain injury, cervical spine injury, back injuries, sweating, school sports participation, risk factors
- MeSH terms
- Amyotrophic Lateral Sclerosis, Female, Humans, Male, Middle Aged, Pilot Projects, Wounds and Injuries, Exercise, Case-Control Studies
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