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Cited by 107Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsInflammatory Biomarkers in Disease Prognosis

Systemic inflammation following non-surgical and surgical periodontal therapy

Graziani, Filippo, Cei, Silvia, Tonetti, Maurizio, Paolantonio, Michele, Serio, Rossella, Sammartino, Gilberto, Gabriele, Mario, D'Aiuto, Francesco·2010·Journal Of Clinical Periodontology
DOI 10.1111/j.1600-051x.2010.01585.x
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Abstract

AIM: To describe the kinetics of serum inflammatory markers after a course of treatment comprising surgical and non-surgical treatment of chronic periodontitis (CP). MATERIAL AND METHODS: Fourteen CP cases received full-mouth non-surgical treatment and, after 6 months, at least two surgical sessions. Blood samples were collected at various time-points after treatment. Blood markers of systemic inflammation/coagulation including leucocyte counts, C-reactive protein (CRP), serum amyloid-A (SAA) and D-dimers and renal function (cystatin C) were determined using high-sensitivity assays. RESULTS: Periodontal treatment resulted in substantial reductions of the number of pockets, gingival bleeding and plaque at 3 and 6 months after non-surgical therapy (p<0.001). Surgical therapy led to an additional reduction of periodontal pockets (p<0.01). Marked increases in the serum levels of CRP and SAA were noted 24 h after non-surgical therapy (p<0.01) and periodontal surgeries (p<0.05). D-dimer levels increased drastically 24 h after non-surgical therapy (p<0.05). The drastic increase of CRP after non-surgical therapy was greater than both the surgical therapy sessions (p<0.05). CONCLUSIONS: Patients undergoing periodontal treatment experience perturbations of systemic inflammation of a greater magnitude after non-surgical than surgical periodontal therapy.

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Crossref · 10.1111/j.1600-051x.2010.01585.x

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  • Acute increase in endothelial-activation markers including E-selectin, vWF, haemoglobin and haematocrit, D-dimer levels, and neutrophil counts was reported 24 h following periodontal therapy in several publications.

    “Acute increase in endothelial-activation markers including E-selectin, vWF, haemoglobin and haematocrit, D-dimer levels, and neutrophils counts was also reported 24 h following periodontal therapy in several publications.22,44,58”

    From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [58]

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Authors
Graziani, F., Cei, S., Tonetti, M., Paolantonio, M., Serio, R., Sammartino, G., Gabriele, M., & D'Aiuto, F.
Affiliations
  • University of Pisa (IT)
  • University of Chieti-Pescara (IT)
  • Federico II University Hospital (IT)
Corresponding author
Graziani, Filippo
ORCID
Venue
Journal Of Clinical Periodontology
Publisher
Wiley
Published
2010-06-07
Volume
37
Issue
9
Pages
848-854
ISSN
  • 0303-6979 (ISSN-L)
  • 1600-051X
DOI
10.1111/j.1600-051x.2010.01585.x
OpenAlex
W2136781520
Cited by
107
References
36
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 13 · 2014: 5 · 2013: 7 · 2012: 5
FWCI
4.82
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal Of Clinical Periodontology (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • United Kingdom Clinical Research Collaboration
  • National Institute for Health and Care Research
  • Università di Pisa
  • University College London Hospitals NHS Foundation Trust
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
systemic inflammation, chronic periodontitis, non-surgical periodontal therapy, periodontal surgery, C-reactive protein, serum amyloid A, D-dimer, cystatin C, inflammatory markers
MeSH terms
Serum Amyloid A Protein, Blood Pressure, C-Reactive Protein, Dental Plaque, Female, Fibrin Fibrinogen Degradation Products, Follow-Up Studies, Gingival Hemorrhage, Gingival Recession, Humans, Inflammation, Leukocyte Count, Male, Middle Aged, Periodontal Pocket, Dental Scaling, Time Factors, Cohort Studies, Biomarkers, Root Planing, Periodontal Attachment Loss, Inflammation Mediators, Chronic Periodontitis, Cystatin C

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