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APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells: APR-246 in acute myeloid leukemia
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“APR-246 has been reported to induce the apoptosis of acute myeloid leukemia (AML) cell lines and primary AML patient cells.329”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [329]
In the citing paper
“APR-246 exerts its effects through a multitude of pathways independent of p53,401–404 such as downregulating glutathione concentrations in tumor cells,405,406 regulating oxidation-reduction homeostasis407–409 in tumor cells to trigger ferroptosis,410–412 and inducing endoplasmic reticulum stress413 or unfolded protein responses.414”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [401]
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Cites
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PRIMA-1 reactivates mutant p53 by covalent binding to the core domain
Lambert, J. M. R., Gorzov, P., Veprintsev, D. B., Söderqvist, M., Segerbäck, D., Bergman, J., Fersht, A. R., Hainaut, P., Wiman, K. G., & Bykov, V. J. N. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.003 · Cited by 592
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
Selivanova, G., & Wiman, K. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210295 · Cited by 186
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Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Targeting mutant p53 for efficient cancer therapy
Bykov, V. J. N., Eriksson, S. E., Bianchi, J., & Wiman, K. G. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.109 · Cited by 889
Lehmann, S., Bykov, V. J. N., Ali, D., Andrén, O., Cherif, H., Tidefelt, U., Uggla, B., Yachnin, J., Juliusson, G., Moshfegh, A., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.7783 · Cited by 406
Self-citationAPR-246 induces early cell death by ferroptosis in acute myeloid leukemia
Birsen, R., Larrue, C., Decroocq, J., Johnson, N., Guiraud, N., Gotanegre, M., Cantero-Aguilar, L., Grignano, E., Huynh, T., Fontenay, M., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.259531 · Cited by 182
PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance
Tessoulin, B., Descamps, G., Moreau, P., Maïga, S., Lodé, L., Godon, C., Marionneau-Lambot, S., Oullier, T., Le Gouill, S., Amiot, M., et al. (2014) · Blood · doi:10.1182/blood-2014-01-548800 · Cited by 166
Metadata
- Authors
- Ali, D., Jönsson-Videsäter, K., Deneberg, S., Bengtzén, S., Nahi, H., Paul, C., & Lehmann, S.
- Venue
- European Journal of Haematology
- Publisher
- Wiley
- Published
- 2011-01-11
- Volume
- 86
- Issue
- 3
- Pages
- 206-215
- ISSN
- 0902-4441
- Cited by
- 65
- References
- 4
- Language
- en
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1694 d)
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- Ali, D., Jönsson-Videsäter, K., Deneberg, S., Bengtzén, S., Nahi, H., Paul, C., & Lehmann, S. (2011). APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells: APR-246 in acute myeloid leukemia. European Journal of Haematology. https://doi.org/10.1111/j.1600-0609.2010.01557.x
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